The anti-neurodegeneration drug clioquinol inhibits the aging-associated protein CLK-1

Journal of Biological Chemistry

Volumn 284, Issue 1, 2009, Pages 314-323

  Wang, Ying ^a   Branicky, Robyn ^a   Stepanyan, Zaruhi ^a   Carroll, Melissa ^b   Guimond, Marie Pierre ^b   Hihi, Abdelmadjid ^b   Hayes, Steve ^b   McBride, Kevin ^b,c   Hekimi, Siegfried ^a  

^a MCGILL UNIVERSITY   (Canada)

^b Chronogen Inc   (Canada)

^c NONE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; CHELATION; COBALT; MAMMALS; TRANSITION METALS;

ALZHEIMER; ALZHEIMER DISEASE (AD); ANIMAL MODELS; CLIOQUINOL; COBALT CATIONS; HIGH RATES; HUNTINGTON DISEASE (HD); METAL CHELATOR; NEURO-DEGENERATIVE DISEASE; PARKINSON;

ENZYME ACTIVITY;

AGING ASSOCIATED PROTEIN CLK 1; CATION; CLIOQUINOL; COBALT; IRON; MITOCHONDRIAL ENZYME; QUINONE DERIVATIVE; UNCLASSIFIED DRUG;

AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CAENORHABDITIS ELEGANS; CELL CULTURE; CHELATION; CONTROLLED STUDY; DEGENERATIVE DISEASE; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN CELL; MOUSE; NEMATODE; NERVE DEGENERATION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL;

AGING; ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CHELATING AGENTS; CLIOQUINOL; DISEASE MODELS, ANIMAL; HELA CELLS; HUMANS; MEMBRANE PROTEINS; MICE; MITOCHONDRIAL PROTEINS; NEURODEGENERATIVE DISEASES;

ANIMALIA; MAMMALIA; MUS; NEMATODA;

EID: 58649090275     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M807579200     Document Type: Article

References (40)

1. Wong, A., Boutis, P., and Hekimi, S. (1995) Genetics 139, 1247-1259
2. Liu, X., Jiang, N., Hughes, B., Bigras, E., Shoubridge, E., and Hekimi, S. (2005) Genes Dev. 19, 2424-2434
3. Turunen, M., Olsson, J., and Dallner, G. (2004) Biochim. Biophys. Acta 1660, 171-199
4. Lapointe, J., and Hekimi, S. (2008) J. Biol. Chem. 283, 26217-26227
5. Lakowski, B., and Hekimi, S. (1996) Science 272, 1010-1013
6. Lakowski, B., and Hekimi, S. (1998) Proc. Natl. Acad. Sci. U.S.A. 95, 13091-13096
7. Kenyon, C. (2005) Cell 120, 449-460
8. Hekimi, S. (2006) Nat. Genet. 38, 985-991
9. Taguchi, A., Wartschow, L. M., and White, M. F. (2007) Science 317, 369-372
10. Ewbank, J. J., Barnes, T. M., Lakowski, B., Lussier, M., Bussey, H., and Hekimi, S. (1997) Science 275, 980 -983
11. Levavasseur, F., Miyadera, H., Sirois, J., Tremblay, M. L., Kita, K., Shoubridge, E., and Hekimi, S. (2001) J. Biol. Chem. 276, 46160-46164
12. Miyadera, H., Amino, H., Hiraishi, A., Taka, H., Murayama, K., Miyoshi, H., Sakamoto, K., Ishii, N., Hekimi, S., and Kita, K. (2001) J. Biol. Chem. 276, 7713-7716
13. Jonassen, T., Larsen, P. L., and Clarke, C. F. (2001) Proc. Natl. Acad. Sci. U.S.A. 98, 421-426
14. Hihi, A. K., Kebir, H., and Hekimi, S. (2003) J. Biol. Chem. 278, 41013- 41018
15. Li, Y., Huang, T. T., Carlson, E. J., Melov, S., Ursell, P. C., Olson, J. L., Noble, L. J., Yoshimura, M. P., Berger, C., Chan, P. H., Wallace, D. C., and Epstein, C. J. (1995) Nat. Genet. 11, 376-381
16. Williams, M. D., Van Remmen, H., Conrad, C. C., Huang, T. T., Epstein, C.J., and Richardson, A. (1998) J. Biol. Chem. 273, 28510-28515
17. Tsubaki, T., Honma, Y., and Hoshi, M. (1971) Lancet 1, 696-697
18. Cherny, R. A., Atwood, C. S., Xilinas, M. E., Gray, D. N., Jones, W. D., McLean, C. A., Barnham, K. J., Volitakis, I., Fraser, F. W., Kim, Y., Huang, X., Goldstein, L. E., Moir, R. D., Lim, J. T., Beyreuther, K., Zheng, H., Tanzi, R. E., Masters, C. L., and Bush, A. I. (2001) Neuron 30, 665-676
19. Kaur, D., Yantiri, F., Rajagopalan, S., Kumar, J., Mo, J. Q., Boonplueang, R., Viswanath, V., Jacobs, R., Yang, L., Beal, M. F., DiMonte, D., Volitaskis, I., Ellerby, L., Cherny, R. A., Bush, A. I., and Andersen, J. K. (2003) Neuron 37, 899 -909
20. Nguyen, T., Hamby, A., and Massa, S. M. (2005) Proc. Natl. Acad. Sci. U.S.A. 102, 11840-11845
21. Ding, W. Q., Liu, B., Vaught, J. L., Yamauchi, H., and Lind, S. E. (2005) Cancer Res. 65, 3389 -3395
22. Chen, D., Cui, Q. C., Yang, H., Barrea, R. A., Sarkar, F.H., Sheng, S., Yan, B., Reddy, G. P., and Dou, Q. P. (2007) Cancer Res. 67, 1636-1644
23. Adlard, P. A., Cherny, R. A., Finkelstein, D. I., Gautier, E., Robb, E., Cortes, M., Volitakis, I., Liu, X., Smith, J. P., Perez, K., Laughton, K., Li, Q. X., Charman, S. A., Nicolazzo, J. A., Wilkins, S., Deleva, K., Lynch, T., Kok, G., Ritchie, C. W., Tanzi, R. E., Cappai, R., Masters, C. L., Barnham, K. J., and Bush, A. I. (2008) Neuron 59, 43-55
24. Ibach, B., Haen, E., Marienhagen, J., and Hajak, G. (2005) Pharmacopsychiatry 38, 178-179
25. Regland, B., Lehmann, W., Abedini, I., Blennow, K., Jonsson, M., Karlsson, I., Sjogren, M., Wallin, A., Xilinas, M., and Gottfries, C. G. (2001) Dementia Geriatric Cognitive Disorders 12, 408-414
26. Ritchie, C. W., Bush, A. I., and Masters, C. L. (2004) Exp. Opin. Investig. Drugs 13, 1585-1592
27. White, A. R., Du, T., Laughton, K. M., Volitakis, I., Sharples, R. A., Xilinas, M. E., Hoke, D. E., Holsinger, R. M., Evin, G., Cherny, R. A., Hill, A. F., Barnham, K. J., Li, Q. X., Bush, A. I., and Masters, C. L. (2006) J.Biol. Chem. 281, 17670-17680
28. Caragounis, A., Du, T., Filiz, G., Laughton, K. M., Volitakis, I., Sharples, R. A., Cherny, R. A., Masters, C. L., Drew, S. C., Hill, A. F., Li, Q. X., Crouch, P. J., Barnham, K. J., and White, A. R. (2007) Biochem. J. 407, 435-450
29. Du, T., Filiz, G., Caragounis, A., Crouch, P. J., and White, A. R. (2008) J. Pharmacol. Exp. Ther. 324, 360-367
30. Jiang, N., Levavasseur, F., McCright, B., Shoubridge, E. A., and Hekimi, S. (2001) J. Biol. Chem. 276, 29218-29225
31. Branicky, R., Nguyen, P. A., and Hekimi, S. (2006) Mol. Cell. Biol. 26, 3976-3985
32. Hausladen, A., and Fridovich, I. (1996) Methods Enzymol. 269, 37- 41
33. Hekimi, S., McBride, K., Hihi, A., Kianicka, I., Wang, Y., Hayes, S., Guimond, M.-P., Sévigny, G., Dumas, D., and Smith, J. (July 2, 2008) International Patent WO/2008/014602
34. Marbois, B. N., and Clarke, C. F. (1996) J. Biol. Chem. 271, 2995-3004
35. Stenmark, P., Grunler, J., Mattsson, J., Sindelar, P. J., Nordlund, P., and Berthold, D. A. (2001) J. Biol. Chem. 276, 33297-33300
36. Kwon, O., Kotsakis, A., and Meganathan, R. (2000) FEMS Microbiol. Lett. 186, 157-161
37. Larsen, P. L., and Clarke, C. F. (2002) Science 295, 120-123
38. Saiki, R., Lunceford, A. L., Bixler, T., Dang, P., Lee, W., Furukawa, S., Larsen, P. L., and Clarke, C. F. (2008) Aging Cell 7, 291-304
39. Feng, J., Bussiere, F., and Hekimi, S. (2001) Dev. Cell 1, 633-644
40. Yang, W., Li, J., and Hekimi, S. (2007) Genetics 177, 2063-2074