-
1
-
-
67651178630
-
Oxidative damage is the earliest change of Alzheimer disease: Therapeutic opportunities
-
Sun M-K, ed. Nova Science Publishers, Inc., New York
-
Moreira PI, Nunomura A, Zhu X, Smith MA, Perry G (2007) Oxidative damage is the earliest change of Alzheimer disease: therapeutic opportunities In Research Progress in Alzheimer's Disease and Dementia, Sun M-K, ed. Nova Science Publishers, Inc., New York, pp. 301-317.
-
(2007)
Research Progress in Alzheimer's Disease and Dementia
, pp. 301-317
-
-
Moreira, P.I.1
Nunomura, A.2
Zhu, X.3
Smith, M.A.4
Perry, G.5
-
2
-
-
0028946289
-
Radical AGEing in Alzheimer's disease
-
Smith MA, Sayre LM, Monnier VM, Perry G (1995) Radical AGEing in Alzheimer's disease. Trends Neurosci 18, 172-176.
-
(1995)
Trends Neurosci
, vol.18
, pp. 172-176
-
-
Smith, M.A.1
Sayre, L.M.2
Monnier, V.M.3
Perry, G.4
-
3
-
-
0346386580
-
Widespread peroxynitrite-mediated damage in Alzheimer's disease
-
Smith MA, Richey Harris PL, Sayre LM, Beckman JS, Perry G (1997) Widespread peroxynitrite-mediated damage in Alzheimer's disease. J Neurosci 17, 2653-2657.
-
(1997)
J Neurosci
, vol.17
, pp. 2653-2657
-
-
Smith, M.A.1
Richey Harris, P.L.2
Sayre, L.M.3
Beckman, J.S.4
Perry, G.5
-
4
-
-
0030921323
-
Abnormal expression of the cell cycle regulators P16 and CDK4 in Alzheimer's disease
-
McShea A, Harris PL, Webster KR, Wahl AF, Smith MA (1997) Abnormal expression of the cell cycle regulators P16 and CDK4 in Alzheimer's disease. Am J Pathol 150, 1933-1939. (Pubitemid 27233067)
-
(1997)
American Journal of Pathology
, vol.150
, Issue.6
, pp. 1933-1939
-
-
McShea, A.1
Harris, P.L.R.2
Webster, K.R.3
Wahl, A.F.4
Smith, M.A.5
-
5
-
-
0038388955
-
Ectopic localization of phosphorylated histone H3 in Alzheimer's disease: A mitotic catastrophe?
-
Ogawa O, Zhu X, Lee HG, Raina A, Obrenovich ME, Bowser R, Ghanbari HA, Castellani RJ, Perry G, Smith MA (2003) Ectopic localization of phosphorylated histone H3 in Alzheimer's disease: a mitotic catastrophe? Acta Neuropathol (Berl) 105, 524-528. (Pubitemid 36798850)
-
(2003)
Acta Neuropathologica
, vol.105
, Issue.5
, pp. 524-528
-
-
Ogawa, O.1
Zhu, X.2
Lee, H.-G.3
Raina, A.4
Obrenovich, M.E.5
Bowser, R.6
Ghanbari, H.A.7
Castellani, R.J.8
Perry, G.9
Smith, M.A.10
-
6
-
-
0033634994
-
Neuronal polo-like kinase in Alzheimer disease indicates cell cycle changes
-
Harris PL, Zhu X, Pamies C, Rottkamp CA, Ghanbari HA, McShea A, Feng Y, Ferris DK, Smith MA (2000) Neuronal polo-like kinase in Alzheimer disease indicates cell cycle changes. Neurobiol Aging 21, 837-841.
-
(2000)
Neurobiol Aging
, vol.21
, pp. 837-841
-
-
Harris, P.L.1
Zhu, X.2
Pamies, C.3
Rottkamp, C.A.4
Ghanbari, H.A.5
McShea, A.6
Feng, Y.7
Ferris, D.K.8
Smith, M.A.9
-
7
-
-
33947178563
-
Alzheimer disease, the two-hit hypothesis: An update
-
DOI 10.1016/j.bbadis.2006.10.014, PII S0925443906002304
-
Zhu X, Lee HG, Perry G, Smith MA (2007) Alzheimer disease, the two-hit hypothesis: an update. Biochim Biophys Acta 1772, 494-502. (Pubitemid 46400383)
-
(2007)
Biochimica et Biophysica Acta - Molecular Basis of Disease
, vol.1772
, Issue.4
, pp. 494-502
-
-
Zhu, X.1
Lee, H.-G.2
Perry, G.3
Smith, M.A.4
-
8
-
-
1642358352
-
Alzheimer's disease: The two-hit hypothesis
-
Zhu X, Raina AK, Perry G, Smith MA (2004) Alzheimer's disease: the two-hit hypothesis. Lancet Neurol 3, 219-226.
-
(2004)
Lancet Neurol
, vol.3
, pp. 219-226
-
-
Zhu, X.1
Raina, A.K.2
Perry, G.3
Smith, M.A.4
-
9
-
-
77954500206
-
Two hits and you're out? A novel mechanistic hypothesis of Alzheimer disease
-
Fisher A, Memo M, Stocchi F, Hanin I, eds. Springer Science + Business Media, LLC, New York
-
Zhu X, Perry G, Smith MA (2008) Two hits and you're out? A novel mechanistic hypothesis of Alzheimer disease In Advances in Behavioral Biology, Volume 57, Advances in Alzheimer's and Parkinson's Disease: Insights, Progress and Perspectives, Fisher A, Memo M, Stocchi F, Hanin I, eds. Springer Science + Business Media, LLC, New York, pp. 191-204.
-
(2008)
Advances in Behavioral Biology, Volume 57, Advances in Alzheimer's and Parkinson's Disease: Insights, Progress and Perspectives
, pp. 191-204
-
-
Zhu, X.1
Perry, G.2
Smith, M.A.3
-
10
-
-
0034277471
-
Atherosclerosis and diabetes: The RAGE connection
-
Schmidt AM, Stern D (2000) Atherosclerosis and diabetes: the RAGE connection. Curr Atheroscler Rep 2, 430-436.
-
(2000)
Curr Atheroscler Rep
, vol.2
, pp. 430-436
-
-
Schmidt, A.M.1
Stern, D.2
-
11
-
-
0030071573
-
Diabetes mellitus and Alzheimer's disease: Glycation as a biochemical link
-
Smith MA, Sayre LM, Perry G (1996) Diabetes mellitus and Alzheimer's disease: glycation as a biochemical link. Diabetologia 39, 247.
-
(1996)
Diabetologia
, vol.39
, pp. 247
-
-
Smith, M.A.1
Sayre, L.M.2
Perry, G.3
-
12
-
-
34548356689
-
Causes of oxidative stress in Alzheimer disease
-
DOI 10.1007/s00018-007-7218-4
-
Zhu X, Su B, Wang X, Smith MA, Perry G (2007) Causes of oxidative stress in Alzheimer disease. Cell Mol Life Sci 64, 2202-2210. (Pubitemid 47347959)
-
(2007)
Cellular and Molecular Life Sciences
, vol.64
, Issue.17
, pp. 2202-2210
-
-
Zhu, X.1
Su, B.2
Wang, X.3
Smith, M.A.4
Perry, G.5
-
13
-
-
2342634253
-
Biological significance of the defense mechanisms against oxidative damage in nucleic acids caused by reactive oxygen species: From mitochondria to nuclei
-
DOI 10.1196/annals.1293.011
-
Nakabeppu Y, Tsuchimoto D, Ichinoe A, Ohno M, Ide Y, Hirano S, Yoshimura D, Tominaga Y, Furuichi M, Sakumi K (2004) Biological significance of the defense mechanisms against oxidative damage in nucleic acids caused by reactive oxygen species: from mitochondria to nuclei. Ann N Y Acad Sci 1011, 101-111. (Pubitemid 38608396)
-
(2004)
Annals of the New York Academy of Sciences
, vol.1011
, pp. 101-111
-
-
Nakabeppu, Y.1
Tsuchimoto, D.2
Ichinoe, A.3
Ohno, M.4
Ide, Y.5
Hirano, S.6
Yoshimura, D.7
Tominaga, Y.8
Furuichi, M.9
Sakumi, K.10
-
14
-
-
67651195144
-
The role of oxidative damage to nucleic acids in the pathogenesis of neurological disease
-
Evans MD, Cooke MS, eds. Landes Bioscience and Springer Science+Business Media, LLC, Austin
-
Reddy VP, Beyaz A, Perry G, Cooke MS, Sayre LM, Smith MA (2007) The role of oxidative damage to nucleic acids in the pathogenesis of neurological disease In Oxidative Damage to Nucleic Acids, Evans MD, Cooke MS, eds. Landes Bioscience and Springer Science+Business Media, LLC, Austin, pp. 123-140.
-
(2007)
Oxidative Damage to Nucleic Acids
, pp. 123-140
-
-
Reddy, V.P.1
Beyaz, A.2
Perry, G.3
Cooke, M.S.4
Sayre, L.M.5
Smith, M.A.6
-
16
-
-
33845390864
-
Protein adducts generated from products of lipid oxidation: Focus on HNE and ONE
-
DOI 10.1080/03602530600959508, PII X078211547323X23
-
Sayre LM, Lin D, Yuan Q, Zhu X, Tang X (2006) Protein adducts generated from products of lipid oxidation: focus on HNE and one. Drug Metab Rev 38, 651-675. (Pubitemid 44903261)
-
(2006)
Drug Metabolism Reviews
, vol.38
, Issue.4
, pp. 651-675
-
-
Sayre, L.M.1
Lin, D.2
Yuan, Q.3
Zhu, X.4
Tang, X.5
-
17
-
-
34248383624
-
The biology of RAGE and its ligands: Uncovering mechanisms at the heart of diabetes and its compilcations
-
DOI 10.1007/s11892-007-0024-4
-
Yan SF, Barile GR, D'Agati V, Du Yan S, Ramasamy R, Schmidt AM (2007) The biology of RAGE and its ligands: uncovering mechanisms at the heart of diabetes and its complications. Curr Diab Rep 7, 146-153. (Pubitemid 46730741)
-
(2007)
Current Diabetes Reports
, vol.7
, Issue.2
, pp. 146-153
-
-
Yan, S.F.1
Barile, G.R.2
D'Agati, V.3
Yan, S.D.4
Ramasamy, R.5
Schmidt, A.M.6
-
18
-
-
27744453362
-
Understanding RAGE, the receptor for advanced glycation end products
-
DOI 10.1007/s00109-005-0688-7
-
Bierhaus A, Humpert PM, Morcos M, Wendt T, Chavakis T, Arnold B, Stern DM, Nawroth PP (2005) Understanding RAGE, the receptor for advanced glycation end products. J Mol Med 83, 876-886. (Pubitemid 41598688)
-
(2005)
Journal of Molecular Medicine
, vol.83
, Issue.11
, pp. 876-886
-
-
Bierhaus, A.1
Humpert, P.M.2
Morcos, M.3
Wendt, T.4
Chavakis, T.5
Arnold, B.6
Stern, D.M.7
Nawroth, P.P.8
-
19
-
-
38349143353
-
RAGE: A potential target for Abeta-mediated cellular perturbation in Alzheimer's disease
-
Chen X, Walker DG, Schmidt AM, Arancio O, Lue LF, Yan SD (2007) RAGE: a potential target for Abeta-mediated cellular perturbation in Alzheimer's disease. Curr Mol Med 7, 735-742.
-
(2007)
Curr Mol Med
, vol.7
, pp. 735-742
-
-
Chen, X.1
Walker, D.G.2
Schmidt, A.M.3
Arancio, O.4
Lue, L.F.5
Yan, S.D.6
-
20
-
-
41549161900
-
Antioxidant agents in Alzheimer's disease
-
Mecocci P, Mariani E, Polidori MC, Hensley K, Butterfield DA (2008) Antioxidant agents in Alzheimer's disease. Cent Nerv Syst Agents Med Chem 8, 48-63.
-
(2008)
Cent Nerv Syst Agents Med Chem
, vol.8
, pp. 48-63
-
-
Mecocci, P.1
Mariani, E.2
Polidori, M.C.3
Hensley, K.4
Butterfield, D.A.5
-
21
-
-
0031992238
-
Markers of protein oxidation by hydroxyl radical and reactive nitrogen species in tissues of aging rats
-
Leeuwenburgh C, Hansen P, Shaish A, Holloszy JO, Heinecke JW (1998) Markers of protein oxidation by hydroxyl radical and reactive nitrogen species in tissues of aging rats. Am J Physiol 274, R453-461. (Pubitemid 28103032)
-
(1998)
American Journal of Physiology - Heart and Circulatory Physiology
, vol.274
, Issue.2
-
-
Leeuwenburgh, C.1
Hansen, P.2
Shaish, A.3
Holloszy, J.O.4
Heinecke, J.W.5
-
22
-
-
0343867142
-
Increased 3-nitrotyrosine in brains of Apo E-deficient mice
-
Matthews RT, Beal MF (1996) Increased 3-nitrotyrosine in brains of Apo E-deficient mice. Brain Res 718, 181-184.
-
(1996)
Brain Res
, vol.718
, pp. 181-184
-
-
Matthews, R.T.1
Beal, M.F.2
-
23
-
-
54949144344
-
Involvement of inducible nitric oxide synthase in hydroxyl radical-mediated lipid peroxidation in streptozotocin-induced diabetes
-
Stadler K, Bonini MG, Dallas S, Jiang J, Radi R, Mason RP, Kadiiska MB (2008) Involvement of inducible nitric oxide synthase in hydroxyl radical-mediated lipid peroxidation in streptozotocin-induced diabetes. Free Radic Biol Med 45, 866-874.
-
(2008)
Free Radic Biol Med
, vol.45
, pp. 866-874
-
-
Stadler, K.1
Bonini, M.G.2
Dallas, S.3
Jiang, J.4
Radi, R.5
Mason, R.P.6
Kadiiska, M.B.7
-
24
-
-
0030885482
-
Iron accumulation in Alzheimer disease is a source of redox-generated free radicals
-
Smith MA, Harris PL, Sayre LM, Perry G (1997) Iron accumulation in Alzheimer disease is a source of redox-generated free radicals. Proc Natl Acad Sci U S A 94, 9866-9868.
-
(1997)
Proc Natl Acad Sci U S A
, vol.94
, pp. 9866-9868
-
-
Smith, M.A.1
Harris, P.L.2
Sayre, L.M.3
Perry, G.4
-
25
-
-
0033964859
-
In situ oxidative catalysis by neurofibrillary tangles and senile plaques in Alzheimer's disease: A central role for bound transition metals
-
DOI 10.1046/j.1471-4159.2000.0740270.x
-
Sayre LM, Perry G, Harris PL, Liu Y, Schubert KA, Smith MA (2000) In situ oxidative catalysis by neurofibrillary tangles and senile plaques in Alzheimer's disease: a central role for bound transition metals. J Neurochem 74, 270-279. (Pubitemid 30012778)
-
(2000)
Journal of Neurochemistry
, vol.74
, Issue.1
, pp. 270-279
-
-
Sayre, L.M.1
Perry, G.2
Harris, P.L.R.3
Liu, Y.4
Schubert, K.A.5
Smith, M.A.6
-
27
-
-
46649116988
-
Investigation of DNA-protein cross-link formation between lysozyme and oxanine by mass spectrometry
-
Chen HJ, Chiu WL, Lin WP, Yang SS (2008) Investigation of DNA-protein cross-link formation between lysozyme and oxanine by mass spectrometry. Chembiochem 9, 1074-1081.
-
(2008)
Chembiochem
, vol.9
, pp. 1074-1081
-
-
Chen, H.J.1
Chiu, W.L.2
Lin, W.P.3
Yang, S.S.4
-
28
-
-
34047214541
-
Characterization of DNA-protein cross-links induced by oxanine: Cellular damage derived from nitric oxide and nitrous acid
-
Chen HJ, Hsieh CJ, Shen LC, Chang CM (2007) Characterization of DNA-protein cross-links induced by oxanine: cellular damage derived from nitric oxide and nitrous acid. Biochemistry (Mosc) 46, 3952-3965.
-
(2007)
Biochemistry (Mosc)
, vol.46
, pp. 3952-3965
-
-
Chen, H.J.1
Hsieh, C.J.2
Shen, L.C.3
Chang, C.M.4
-
29
-
-
3042730823
-
Solution structure of a nitrous acid induced DNA interstrand cross-link
-
Edfeldt NB, Harwood EA, Sigurdsson ST, Hopkins PB, Reid BR (2004) Solution structure of a nitrous acid induced DNA interstrand cross-link. Nucleic Acids Res 32, 2785-2794.
-
(2004)
Nucleic Acids Res
, vol.32
, pp. 2785-2794
-
-
Edfeldt, N.B.1
Harwood, E.A.2
Sigurdsson, S.T.3
Hopkins, P.B.4
Reid, B.R.5
-
30
-
-
0036080646
-
Involvement of Maillard reactions in Alzheimer disease
-
DOI 10.1080/1029840290007321
-
Reddy VP, Obrenovich ME, Atwood CS, Perry G, Smith MA (2002) Involvement of Maillard reactions in Alzheimer disease. Neurotox Res 4, 191-209. (Pubitemid 34679370)
-
(2002)
Neurotoxicity Research
, vol.4
, Issue.3
, pp. 191-209
-
-
Prakash Reddy, V.1
Obrenovich, M.E.2
Atwood, C.S.3
Perry, G.4
Smith, M.A.5
-
31
-
-
0035787070
-
Protein glycation, diabetes, and aging
-
Ulrich P, Cerami A (2001) Protein glycation, diabetes, and aging. Recent Prog Horm Res 56, 1-21.
-
(2001)
Recent Prog Horm Res
, vol.56
, pp. 1-21
-
-
Ulrich, P.1
Cerami, A.2
-
32
-
-
42549138755
-
Peroxyl radicals are essential reagents in the oxidation steps of the Maillard reaction leading to generation of advanced glycation end products
-
Spiteller G (2008) Peroxyl radicals are essential reagents in the oxidation steps of the Maillard reaction leading to generation of advanced glycation end products. Ann NY Acad Sci 1126, 128-133.
-
(2008)
Ann NY Acad Sci
, vol.1126
, pp. 128-133
-
-
Spiteller, G.1
-
33
-
-
33745190013
-
Inhibitors of the Maillard reaction and AGE breakers as therapeutics for multiple diseases
-
Reddy VP, Beyaz A (2006) Inhibitors of the Maillard reaction and AGE breakers as therapeutics for multiple diseases. Drug Discov Today 11, 646-654.
-
(2006)
Drug Discov Today
, vol.11
, pp. 646-654
-
-
Reddy, V.P.1
Beyaz, A.2
-
34
-
-
42549117517
-
The dicarbonyl proteome: Proteins susceptible to dicarbonyl glycation at functional sites in health, aging, and disease
-
DOI 10.1196/annals.1433.043, The Maillard Reaction Recent Advances in Food and Biomedical Sciences
-
Rabbani N, Thornalley PJ (2008) The dicarbonyl proteome: proteins susceptible to dicarbonyl glycation at functional sites in health, aging, and disease. Ann N Y Acad Sci 1126, 124-127. (Pubitemid 351589305)
-
(2008)
Annals of the New York Academy of Sciences
, vol.1126
, pp. 124-127
-
-
Rabbani, N.1
Thornalley, P.J.2
-
35
-
-
57449105064
-
Advanced glycation end products of DNA: Quantification of N2-(1-carboxyethyl)-2'-deoxyguanosine in biological samples by liquid chromatography electrospray ionization tandem mass spectrometry
-
in press
-
Synold T, Xi B, Wuenschell GE, Tamae D, Figarola JL, Rahbar S, Termini J (2009) Advanced glycation end products of DNA: Quantification of N2-(1-carboxyethyl)-2'-deoxyguanosine in biological samples by liquid chromatography electrospray ionization tandem mass spectrometry. Chem Res Toxicol, in press.
-
(2009)
Chem Res Toxicol
-
-
Synold, T.1
Xi, B.2
Wuenschell, G.E.3
Tamae, D.4
Figarola, J.L.5
Rahbar, S.6
Termini, J.7
-
36
-
-
42549096883
-
Aging, diabetes, and renal failure catalyze the oxidation of lysyl residues to 2-aminoadipic acid in human skin collagen: Evidence for metal-catalyzed oxidation mediated by α-dicarbonyls
-
DOI 10.1196/annals.1433.065, The Maillard Reaction Recent Advances in Food and Biomedical Sciences
-
Sell DR, Strauch CM, Shen W, Monnier VM (2008) Aging, diabetes, and renal failure catalyze the oxidation of lysyl residues to 2-aminoadipic acid in human skin collagen: evidence for metal-catalyzed oxidation mediated by alpha-dicarbonyls. Ann N Y Acad Sci 1126, 205-209. (Pubitemid 351589327)
-
(2008)
Annals of the New York Academy of Sciences
, vol.1126
, pp. 205-209
-
-
Sell, D.R.1
Strauch, C.M.2
Shen, W.3
Monnier, V.M.4
-
37
-
-
0032198548
-
DNA-glycation leads to depurination by the loss of N2-carboxyethylguanine in vitro
-
Seidel W, Pischetsrieder M (1998) DNA-glycation leads to depurination by the loss of N2-carboxyethylguanine in vitro. Cell Mol Biol (Noisy-le-grand) 44, 1165-1170.
-
(1998)
Cell Mol Biol (Noisy-le-grand)
, vol.44
, pp. 1165-1170
-
-
Seidel, W.1
Pischetsrieder, M.2
-
38
-
-
40649129674
-
Immunochemical detection of Nepsilon-(carboxyethyl)lysine using a specific antibody
-
Nagai R, Fujiwara Y, Mera K, Yamagata K, Sakashita N, Takeya M (2008) Immunochemical detection of Nepsilon-(carboxyethyl)lysine using a specific antibody. J Immunol Methods 332, 112-120.
-
(2008)
J Immunol Methods
, vol.332
, pp. 112-120
-
-
Nagai, R.1
Fujiwara, Y.2
Mera, K.3
Yamagata, K.4
Sakashita, N.5
Takeya, M.6
-
39
-
-
0028233977
-
Advanced Maillard reaction end products are associated with Alzheimer disease pathology
-
DOI 10.1073/pnas.91.12.5710
-
Smith MA, Taneda S, Richey PL, Miyata S, Yan SD, Stern D, Sayre LM, Monnier VM, Perry G (1994) Advanced Maillard reaction end products are associated with Alzheimer disease pathology. Proc Natl Acad Sci U S A 91, 5710-5714. (Pubitemid 24174398)
-
(1994)
Proceedings of the National Academy of Sciences of the United States of America
, vol.91
, Issue.12
, pp. 5710-5714
-
-
Smith, M.A.1
Taneda, S.2
Richey, P.L.3
Miyata, S.4
Yan, S.-D.5
Stern, D.6
Sayre, L.M.7
Monnier, V.M.8
Perry, G.9
-
40
-
-
0028023944
-
Glycated tau protein in Alzheimer disease: A mechanism for induction of oxidant stress
-
DOI 10.1073/pnas.91.16.7787
-
Yan SD, Chen X, Schmidt AM, Brett J, Godman G, Zou YS, Scott CW, Caputo C, Frappier T, Smith MA (1994) Glycated tau protein in Alzheimer disease: a mechanism for induction of oxidant stress. Proc Natl Acad Sci U S A 91, 7787-7791. (Pubitemid 24238270)
-
(1994)
Proceedings of the National Academy of Sciences of the United States of America
, vol.91
, Issue.16
, pp. 7787-7791
-
-
Yan, S.-D.1
Chen, X.2
Schmidt, A.-M.3
Brett, J.4
Godman, G.5
Zou, Y.-S.6
Scott, C.W.7
Caputo, C.8
Frappier, T.9
Smith, M.A.10
Perry, G.11
Yen, S.-H.12
Stern, D.13
-
41
-
-
0035879693
-
ε-(Carboxymethyl) lysine and hexitol-lysine
-
DOI 10.1016/S0891-5849(01)00570-6, PII S0891584901005706
-
Castellani RJ, Harris PL, Sayre LM, Fujii J, Taniguchi N, Vitek MP, Founds H, Atwood CS, Perry G, Smith MA (2001) Active glycation in neurofibrillary pathology of Alzheimer disease: N(epsilon)-(carboxymethyl) lysine and hexitollysine. Free Radic Biol Med 31, 175-180. (Pubitemid 32607584)
-
(2001)
Free Radical Biology and Medicine
, vol.31
, Issue.2
, pp. 175-180
-
-
Castellani, R.J.1
Harris, P.L.R.2
Sayre, L.M.3
Fujii, J.4
Taniguchi, N.5
Vitek, M.P.6
Founds, H.7
Atwood, C.S.8
Perry, G.9
Smith, M.A.10
-
42
-
-
0031778629
-
Advanced glycation end products co-localized with astrocytes and microglial cells in Alzheimer's disease brain
-
DOI 10.1007/s004010050839
-
Takeda A, Yasuda T, Miyata T, Goto Y, Wakai M, Watanabe M, Yasuda Y, Horie K, Inagaki T, Doyu M, Maeda K, Sobue G (1998) Advanced glycation end products co-localized with astrocytes and microglial cells in Alzheimer's disease brain. Acta Neuropathol 95, 555-558. (Pubitemid 28254562)
-
(1998)
Acta Neuropathologica
, vol.95
, Issue.6
, pp. 555-558
-
-
Takeda, A.1
Yasuda, T.2
Miyata, T.3
Goto, Y.4
Wakai, M.5
Watanabe, M.6
Yasuda, Y.7
Horie, K.8
Inagaki, T.9
Doyu, M.10
Maeda, K.11
Sobue, G.12
-
43
-
-
0035412127
-
Alternative Routes for the Formation of Immunochemically Distinct Advanced Glycation End-products in Vivo
-
Takeuchi M, Makita Z (2001) Alternative routes for the formation of immunochemically distinct advanced glycation end-products in vivo. Curr Mol Med 1, 305-315. (Pubitemid 33772959)
-
(2001)
Current Molecular Medicine
, vol.1
, Issue.3
, pp. 305-315
-
-
Takeuchi, M.1
Makita, Z.2
-
44
-
-
0037093336
-
ε-(1-carboxyethyl)lysine-modified albumin
-
Ahmed N, Argirov OK, Minhas HS, Cordeiro CA, Thornalley PJ (2002) Assay of advanced glycation endproducts (AGEs): surveying AGEs by chromatographic assay with derivatization by 6-aminoquinolyl-N-hydroxysuccinimidylcarbamate and application to Nepsilon-carboxymethyllysine- and Nepsilon-(1-carboxyethyl) lysine-modified albumin. Biochem J 364, 1-14. (Pubitemid 34538940)
-
(2002)
Biochemical Journal
, vol.364
, Issue.1
, pp. 1-14
-
-
Ahmed, N.1
Argirov, O.K.2
Minhas, H.S.3
Cordeiro, C.A.A.4
Thornalley, P.J.5
-
45
-
-
0034923434
-
Oxidative damage is the earliest event in Alzheimer disease
-
Nunomura A, Perry G, Aliev G, Hirai K, Takeda A, Balraj EK, Jones PK, Ghanbari H, Wataya T, Shimohama S, Chiba S, Atwood CS, Petersen RB, Smith MA (2001) Oxidative damage is the earliest event in Alzheimer disease. J Neuropathol Exp Neurol 60, 759-767. (Pubitemid 32678256)
-
(2001)
Journal of Neuropathology and Experimental Neurology
, vol.60
, Issue.8
, pp. 759-767
-
-
Nunomura, A.1
Perry, G.2
Aliev, G.3
Hirai, K.4
Takeda, A.5
Balraj, E.K.6
Jones, P.K.7
Ghanbari, H.8
Wataya, T.9
Shimohama, S.10
Chiba, S.11
Atwood, C.S.12
Petersen, R.B.13
Smith, M.A.14
-
46
-
-
42549135904
-
Inflammation and the redox-sensitive AGE-RAGE pathway as a therapeutic target in Alzheimer's disease
-
DOI 10.1196/annals.1433.026, The Maillard Reaction Recent Advances in Food and Biomedical Sciences
-
Maczurek A, Shanmugam K, Munch G (2008) Inflammation and the redox-sensitive AGE-RAGE pathway as a therapeutic target in Alzheimer's disease. Ann N Y Acad Sci 1126, 147-151. (Pubitemid 351589288)
-
(2008)
Annals of the New York Academy of Sciences
, vol.1126
, pp. 147-151
-
-
Maczurek, A.1
Shanmugam, K.2
Munch, G.3
-
47
-
-
42549088057
-
Receptor for advanced glycation end products - Fundamental roles in the inflammatory response: Winding the way to the pathogenesis of endothelial dysfunction and atherosclerosis
-
DOI 10.1196/annals.1433.056, The Maillard Reaction Recent Advances in Food and Biomedical Sciences
-
Ramasamy R, Yan SF, Herold K, Clynes R, Schmidt AM (2008) Receptor for advanced glycation end products: fundamental roles in the inflammatory response: winding the way to the pathogenesis of endothelial dysfunction and atherosclerosis. Ann N Y Acad Sci 1126, 7-13. (Pubitemid 351589318)
-
(2008)
Annals of the New York Academy of Sciences
, vol.1126
, pp. 7-13
-
-
Ramasamy, R.1
Yan, S.F.2
Herold, K.3
Clynes, R.4
Schmidt, A.M.5
-
48
-
-
42449109476
-
Mechanisms of Disease: Advanced glycation end-products and their receptor in inflammation and diabetes complications
-
DOI 10.1038/ncpendmet0786, PII NCPENDMET0786
-
Yan SF, Ramasamy R, Schmidt AM (2008) Mechanisms of disease: advanced glycation end-products and their receptor in inflammation and diabetes complications. Nat Clin Pract Endocrinol Metab 4, 285-293. (Pubitemid 351571138)
-
(2008)
Nature Clinical Practice Endocrinology and Metabolism
, vol.4
, Issue.5
, pp. 285-293
-
-
Yan, S.F.1
Ramasamy, R.2
Schmidt, A.M.3
-
49
-
-
41949091078
-
N(epsilon)-carboxymethyllysine-modified proteins are unable to bind to RAGE and activate an inflammatory response
-
Buetler TM, Leclerc E, Baumeyer A, Latado H, Newell J, Adolfsson O, Parisod V, Richoz J, Maurer S, Foata F, Piguet D, Junod S, Heizmann CW, Delatour T (2008) N(epsilon)-carboxymethyllysine-modified proteins are unable to bind to RAGE and activate an inflammatory response. Mol Nutr Food Res 52, 370-378.
-
(2008)
Mol Nutr Food Res
, vol.52
, pp. 370-378
-
-
Buetler, T.M.1
Leclerc, E.2
Baumeyer, A.3
Latado, H.4
Newell, J.5
Adolfsson, O.6
Parisod, V.7
Richoz, J.8
Maurer, S.9
Foata, F.10
Piguet, D.11
Junod, S.12
Heizmann, C.W.13
Delatour, T.14
-
50
-
-
42049109529
-
Receptor for advanced glycation end products (RAGE): A novel therapeutic target for diabetic vascular complication
-
Yamagishi S, Nakamura K, Matsui T, Noda Y, Imaizumi T (2008) Receptor for advanced glycation end products (RAGE): a novel therapeutic target for diabetic vascular complication. Curr Pharm Des 14, 487-495.
-
(2008)
Curr Pharm Des
, vol.14
, pp. 487-495
-
-
Yamagishi, S.1
Nakamura, K.2
Matsui, T.3
Noda, Y.4
Imaizumi, T.5
-
51
-
-
27544450342
-
The influence of long chain polyunsaturate supplementation on docosahexaenoic acid and arachidonic acid in baboon neonate central nervous system
-
DOI 10.1186/1741-7015-3-11
-
Diau GY, Hsieh AT, Sarkadi-Nagy EA, Wijendran V, Nathanielsz PW, Brenna JT (2005) The influence of long chain polyunsaturate supplementation on docosahexaenoic acid and arachidonic acid in baboon neonate central nervous system. BMC Med 3, 11. (Pubitemid 41534984)
-
(2005)
BMC Medicine
, vol.3
, pp. 11
-
-
Diau, G.-Y.1
Hsieh, A.T.2
Sarkadi-Nagy, E.A.3
Wijendran, V.4
Nathanielsz, P.W.5
Brenna, J.T.6
-
52
-
-
0036798125
-
2 receptor-dependent
-
DOI 10.1046/j.1471-4159.2002.01157.x
-
Montine TJ, Milatovic D, Gupta RC, Valyi-Nagy T, Morrow JD, Breyer RM (2002) Neuronal oxidative damage from activated innate immunity is EP2 receptor-dependent. J Neurochem 83, 463-470. (Pubitemid 35191411)
-
(2002)
Journal of Neurochemistry
, vol.83
, Issue.2
, pp. 463-470
-
-
Montine, T.J.1
Milatovic, D.2
Gupta, R.C.3
Valyi-Nagy, T.4
Morrow, J.D.5
Breyer, R.M.6
-
53
-
-
14944338510
-
Mechanisms of 4-hydroxynonenal-induced neuronal microtubule dysfunction
-
DOI 10.1016/j.brainres.2004.12.027
-
Neely MD, Boutte A, Milatovic D, Montine TJ (2005) Mechanisms of 4-hydroxynonenal-induced neuronal microtubule dysfunction. Brain Res 1037, 90-98. (Pubitemid 40362384)
-
(2005)
Brain Research
, vol.1037
, Issue.1-2
, pp. 90-98
-
-
Neely, M.D.1
Boutte, A.2
Milatovic, D.3
Montine, T.J.4
-
54
-
-
0030989545
-
4-Hydroxynonenal-derived advanced lipid peroxidation end products are increased in Alzheimer's disease
-
Sayre LM, Zelasko DA, Harris PL, Perry G, Salomon RG, Smith MA (1997) 4-Hydroxynonenal-derived advanced lipid peroxidation end products are increased in Alzheimer's disease. J Neurochem 68, 2092-2097. (Pubitemid 27176147)
-
(1997)
Journal of Neurochemistry
, vol.68
, Issue.5
, pp. 2092-2097
-
-
Sayre, L.M.1
Zelasko, D.A.2
Harris, P.L.R.3
Perry, G.4
Salomon, R.G.5
Smith, M.A.6
-
55
-
-
0043172460
-
Hydroxynonenal, toxic carbonyls, and Alzheimer disease
-
DOI 10.1016/S0098-2997(03)00025-6
-
Liu Q, Raina AK, Smith MA, Sayre LM, Perry G (2003) Hydroxynonenal, toxic carbonyls, and Alzheimer disease. Mol Aspects Med 24, 305-313. (Pubitemid 36945030)
-
(2003)
Molecular Aspects of Medicine
, vol.24
, Issue.4-5
, pp. 305-313
-
-
Liu, Q.1
Raina, A.K.2
Smith, M.A.3
Sayre, L.M.4
Perry, G.5
-
56
-
-
0033836580
-
In Alzheimer's disease, heme oxygenase is coincident with Alz50, an epitope of τ induced by 4-hydroxy-2-nonenal modification
-
DOI 10.1046/j.1471-4159.2000.0751234.x
-
Takeda A, Smith MA, Avila J, Nunomura A, Siedlak SL, Zhu X, Perry G, Sayre LM (2000) In Alzheimer's disease, heme oxygenase is coincident with Alz50, an epitope of tau induced by 4-hydroxy-2-nonenal modification. J Neurochem 75, 1234-1241. (Pubitemid 30660513)
-
(2000)
Journal of Neurochemistry
, vol.75
, Issue.3
, pp. 1234-1241
-
-
Takeda, A.1
Smith, M.A.2
Avila, J.3
Nunomura, A.4
Siedlak, S.L.5
Zhu, X.6
Perry, G.7
Sayre, L.M.8
-
57
-
-
42449100496
-
Trans-4-hydroxy-2-hexenal is a neurotoxic product of docosahexaenoic (22:6; n-3) acid oxidation
-
Long EK, Murphy TC, Leiphon LJ, Watt J, Morrow JD, Milne GL, Howard JR, Picklo MJ, Sr. (2008) Trans-4-hydroxy-2-hexenal is a neurotoxic product of docosahexaenoic (22:6; n-3) acid oxidation. J Neurochem 105, 714-724.
-
(2008)
J Neurochem
, vol.105
, pp. 714-724
-
-
Long, E.K.1
Murphy, T.C.2
Leiphon, L.J.3
Watt, J.4
Morrow, J.D.5
Milne, G.L.6
Howard, J.R.7
Picklo Sr., M.J.8
-
58
-
-
34548477636
-
Residue-specific adduction of tubulin by 4-hydroxynonenal and 4-oxononenal causes cross-linking and inhibits polymerization
-
Stewart BJ, Doorn JA, Petersen DR (2007) Residue-specific adduction of tubulin by 4-hydroxynonenal and 4-oxononenal causes cross-linking and inhibits polymerization. Chem Res Toxicol 20, 1111-1119.
-
(2007)
Chem Res Toxicol
, vol.20
, pp. 1111-1119
-
-
Stewart, B.J.1
Doorn, J.A.2
Petersen, D.R.3
-
59
-
-
23844448026
-
4-Oxo-2-nonenal is both more neurotoxic and more protein reactive than 4-hydroxy-2-nonenal
-
DOI 10.1021/tx050080q
-
Lin D, Lee HG, Liu Q, Perry G, Smith MA, Sayre LM (2005) 4-Oxo-2-nonenal is both more neurotoxic and more protein reactive than 4-hydroxy-2-nonenal. Chem Res Toxicol 18, 1219-1231. (Pubitemid 41170246)
-
(2005)
Chemical Research in Toxicology
, vol.18
, Issue.8
, pp. 1219-1231
-
-
Lin, D.1
Lee, H.-G.2
Liu, Q.3
Perry, G.4
Smith, M.A.5
Sayre, L.M.6
-
60
-
-
23844442198
-
Cysteine modification by lipid peroxidation products inhibits protein disulfide isomerase
-
DOI 10.1021/tx050078z
-
Carbone DL, Doorn JA, Kiebler Z, Petersen DR (2005) Cysteine modification by lipid peroxidation products inhibits protein disulfide isomerase. Chem Res Toxicol 18, 1324-1331. (Pubitemid 41174583)
-
(2005)
Chemical Research in Toxicology
, vol.18
, Issue.8
, pp. 1324-1331
-
-
Carbone, D.L.1
Doorn, J.A.2
Kiebler, Z.3
Petersen, D.R.4
-
61
-
-
40749120342
-
Oxidative stress and cellular stress response in diabetic nephropathy
-
Calabrese V, Mancuso C, Sapienza M, Puleo E, Calafato S, Cornelius C, Finocchiaro M, Mangiameli A, Di Mauro M, Stella AM, Castellino P (2007) Oxidative stress and cellular stress response in diabetic nephropathy. Cell Stress Chaperones 12, 299-306.
-
(2007)
Cell Stress Chaperones
, vol.12
, pp. 299-306
-
-
Calabrese, V.1
Mancuso, C.2
Sapienza, M.3
Puleo, E.4
Calafato, S.5
Cornelius, C.6
Finocchiaro, M.7
Mangiameli, A.8
Di Mauro, M.9
Stella, A.M.10
Castellino, P.11
-
62
-
-
38949123654
-
Lipid peroxidation and antioxidant enzyme activities in vascular and alzheimer dementias
-
DOI 10.1007/s11064-007-9453-3
-
Casado A, Encarnacion Lopez-Fernandez M, Concepcion Casado M, de La Torre R (2008) Lipid peroxidation and antioxidant enzyme activities in vascular and Alzheimer dementias. Neurochem Res 33, 450-458. (Pubitemid 351230446)
-
(2008)
Neurochemical Research
, vol.33
, Issue.3
, pp. 450-458
-
-
Casado, A.1
Encarnacion Lopez-Fernandez, Ma.2
Concepcion Casado, Ma.3
De La Torre, R.4
-
63
-
-
33646482095
-
Age-dependent changes of glyoxalase I expression in human brain
-
Kuhla B, Boeck K, Luth HJ, Schmidt A, Weigle B, Schmitz M, Ogunlade V, Munch G, Arendt T (2006) Age-dependent changes of glyoxalase I expression in human brain. Neurobiol Aging 27, 815-822.
-
(2006)
Neurobiol Aging
, vol.27
, pp. 815-822
-
-
Kuhla, B.1
Boeck, K.2
Luth, H.J.3
Schmidt, A.4
Weigle, B.5
Schmitz, M.6
Ogunlade, V.7
Munch, G.8
Arendt, T.9
-
64
-
-
0028304705
-
Heme oxygenase-1 is associated with the neurofibrillary pathology of Alzheimer's disease
-
Smith MA, Kutty RK, Richey PL, Yan SD, Stern D, Chader GJ, Wiggert B, Petersen RB, Perry G (1994) Heme oxygenase-1 is associated with the neurofibrillary pathology of Alzheimer's disease. Am J Pathol 145, 42-47. (Pubitemid 24217481)
-
(1994)
American Journal of Pathology
, vol.145
, Issue.1
, pp. 42-47
-
-
Smith, M.A.1
Kutty, R.K.2
Richey, P.L.3
Yan, S.-D.4
Stern, D.5
Chader, G.J.6
Wiggert, B.7
Petersen, R.B.8
Perry, G.9
-
65
-
-
0029157442
-
Induction of heme oxygenase-1 mRNA and protein in neocortex and cerebral vessels in Alzheimer's disease
-
Premkumar DR, Smith MA, Richey PL, Petersen RB, Castellani R, Kutty RK, Wiggert B, Perry G, Kalaria RN (1995) Induction of heme oxygenase-1 mRNA and protein in neocortex and cerebral vessels in Alzheimer's disease. J Neurochem 65, 1399-1402.
-
(1995)
J Neurochem
, vol.65
, pp. 1399-1402
-
-
Premkumar, D.R.1
Smith, M.A.2
Richey, P.L.3
Petersen, R.B.4
Castellani, R.5
Kutty, R.K.6
Wiggert, B.7
Perry, G.8
Kalaria, R.N.9
-
66
-
-
49049106536
-
Low-density lipoprotein has an enormous capacity to bind (E)-4-hydroxynon-2-enal (HNE): Detection and characterization of lysyl and histidyl adducts containing multiple molecules of HNE
-
Annangudi SP, Deng Y, Gu X, Zhang W, Crabb JW, Salomon RG (2008) Low-density lipoprotein has an enormous capacity to bind (E)-4-hydroxynon-2-enal (HNE): detection and characterization of lysyl and histidyl adducts containing multiple molecules of HNE. Chem Res Toxicol 21, 1384-1395.
-
(2008)
Chem Res Toxicol
, vol.21
, pp. 1384-1395
-
-
Annangudi, S.P.1
Deng, Y.2
Gu, X.3
Zhang, W.4
Crabb, J.W.5
Salomon, R.G.6
-
67
-
-
0037085455
-
High molecular weight neurofilament proteins are physiological substrates of adduction by the lipid peroxidation product hydroxynonenal
-
DOI 10.1074/jbc.M110913200
-
Wataya T, Nunomura A, Smith MA, Siedlak SL, Harris PL, Shimohama S, Szweda LI, Kaminski MA, Avila J, Price DL, Cleveland DW, Sayre LM, Perry G (2002) High molecular weight neurofilament proteins are physiological substrates of adduction by the lipid peroxidation product hydroxynonenal. J Biol Chem 277, 4644-4648. (Pubitemid 34968493)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.7
, pp. 4644-4648
-
-
Wataya, T.1
Nunomura, A.2
Smith, M.A.3
Siedlak, S.L.4
Harris, P.L.R.5
Shimohama, S.6
Szweda, L.I.7
Kaminski, M.A.8
Avila, J.9
Price, D.L.10
Cleveland, D.W.11
Sayre, L.M.12
Perry, G.13
-
68
-
-
13844267510
-
Alzheimer-specific epitopes of tau represent lipid peroxidation-induced conformations
-
DOI 10.1016/j.freeradbiomed.2004.11.005
-
Liu Q, Smith MA, Avila J, DeBernardis J, Kansal M, Takeda A, Zhu X, Nunomura A, Honda K, Moreira PI, Oliveira CR, Santos MS, Shimohama S, Aliev G, de la Torre J, Ghanbari HA, Siedlak SL, Harris PL, Sayre LM, Perry G (2005) Alzheimer-specific epitopes of tau represent lipid peroxidation-induced conformations. Free Radic Biol Med 38, 746-754. (Pubitemid 40249745)
-
(2005)
Free Radical Biology and Medicine
, vol.38
, Issue.6
, pp. 746-754
-
-
Liu, Q.1
Smith, M.A.2
Avila, J.3
Debernardis, J.4
Kansal, M.5
Takeda, A.6
Zhu, X.7
Nunomura, A.8
Honda, K.9
Moreira, P.I.10
Oliveira, C.R.11
Santos, M.S.12
Shimohama, S.13
Aliev, G.14
De La Torre, J.15
Ghanbari, H.A.16
Siedlak, S.L.17
Harris, P.L.R.18
Sayre, L.M.19
Perry, G.20
more..
-
69
-
-
0345701340
-
Effect of the lipid peroxidation product acrolein on tau phosphorylation in neural cells
-
DOI 10.1002/jnr.10525
-
Gomez-Ramos A, Diaz-Nido J, Smith MA, Perry G, Avila J (2003) Effect of the lipid peroxidation product acrolein on tau phosphorylation in neural cells. J Neurosci Res 71, 863-870. (Pubitemid 36293007)
-
(2003)
Journal of Neuroscience Research
, vol.71
, Issue.6
, pp. 863-870
-
-
Gomez-Ramos, A.1
Diaz-Nido, J.2
Smith, M.A.3
Perry, G.4
Avila, J.5
-
70
-
-
20444428693
-
Effect of quinones on microtubule polymerization: A link between oxidative stress and cytoskeletal alterations in Alzheimer's disease
-
DOI 10.1016/j.bbadis.2004.11.024, PII S0925443904002388
-
Santa-Maria I, Smith MA, Perry G, Hernandez F, Avila J, Moreno FJ (2005) Effect of quinones on microtubule polymerization: a link between oxidative stress and cytoskeletal alterations in Alzheimer's disease. Biochim Biophys Acta 1740, 472-480. (Pubitemid 40804759)
-
(2005)
Biochimica et Biophysica Acta - Molecular Basis of Disease
, vol.1740
, Issue.3
, pp. 472-480
-
-
Santa-Maria, I.1
Smith, M.A.2
Perry, G.3
Hernandez, F.4
Avila, J.5
Moreno, F.J.6
-
71
-
-
0013222143
-
Mass spectroscopic characterization of protein modification by 4-hydroxy-2-(E)-nonenal and 4-oxo-2-(E)-nonenal
-
Liu Z, Minkler PE, Sayre LM (2003) Mass spectroscopic characterization of protein modification by 4-hydroxy-2-(E)-nonenal and 4-oxo-2-(E)-nonenal. Chem Res Toxicol 16, 901-911. (Pubitemid 36899005)
-
(2003)
Chemical Research in Toxicology
, vol.16
, Issue.7
, pp. 901-911
-
-
Liu, Z.1
Minkler, P.E.2
Sayre, L.M.3
-
73
-
-
0036770144
-
The role of mitogen-activated protein kinase pathways in Alzheimer's disease
-
DOI 10.1159/000067426
-
Zhu X, Lee HG, Raina AK, Perry G, Smith MA (2002) The role of mitogen-activated protein kinase pathways in Alzheimer's disease. Neurosignals 11, 270-281. (Pubitemid 37494394)
-
(2002)
NeuroSignals
, vol.11
, Issue.5
, pp. 270-281
-
-
Zhu, X.1
Lee, H.-G.2
Raina, A.K.3
Perry, G.4
Smith, M.A.5
-
74
-
-
0034797352
-
Differential activation of neuronal ERK, JNK/SAPK and p38 in Alzheimer disease: The 'two hit' hypothesis
-
Zhu X, Castellani RJ, Takeda A, Nunomura A, Atwood CS, Perry G, Smith MA (2001) Differential activation of neuronal ERK, JNK/SAPK and p38 in Alzheimer disease: the 'two hit' hypothesis. Mech Ageing Dev 123, 39-46.
-
(2001)
Mech Ageing Dev
, vol.123
, pp. 39-46
-
-
Zhu, X.1
Castellani, R.J.2
Takeda, A.3
Nunomura, A.4
Atwood, C.S.5
Perry, G.6
Smith, M.A.7
-
75
-
-
0037382957
-
H2O2 and 4-hydroxynonenal mediate amyloid beta-induced neuronal apoptosis by activating JNKs and p38MAPK
-
Tamagno E, Robino G, Obbili A, Bardini P, Aragno M, Parola M, Danni O (2003) H2O2 and 4-hydroxynonenal mediate amyloid beta-induced neuronal apoptosis by activating JNKs and p38MAPK. Exp Neurol 180, 144-155.
-
(2003)
Exp Neurol
, vol.180
, pp. 144-155
-
-
Tamagno, E.1
Robino, G.2
Obbili, A.3
Bardini, P.4
Aragno, M.5
Parola, M.6
Danni, O.7
-
76
-
-
39149122810
-
Amyloid beta, mitochondrial dysfunction and synaptic damage: Implications for cognitive decline in aging and Alzheimer's disease
-
Reddy PH, Beal MF (2008) Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease. Trends Mol Med 14, 45-53.
-
(2008)
Trends Mol Med
, vol.14
, pp. 45-53
-
-
Reddy, P.H.1
Beal, M.F.2
-
77
-
-
0035341254
-
Mitochondrial abnormalities in Alzheimer's disease
-
Hirai K, Aliev G, Nunomura A, Fujioka H, Russell RL, Atwood CS, Johnson AB, Kress Y, Vinters HV, Tabaton M, Shimohama S, Cash AD, Siedlak SL, Harris PL, Jones PK, Petersen RB, Perry G, Smith MA (2001) Mitochondrial abnormalities in Alzheimer's disease. J Neurosci 21, 3017-3023.
-
(2001)
J Neurosci
, vol.21
, pp. 3017-3023
-
-
Hirai, K.1
Aliev, G.2
Nunomura, A.3
Fujioka, H.4
Russell, R.L.5
Atwood, C.S.6
Johnson, A.B.7
Kress, Y.8
Vinters, H.V.9
Tabaton, M.10
Shimohama, S.11
Cash, A.D.12
Siedlak, S.L.13
Harris, P.L.14
Jones, P.K.15
Petersen, R.B.16
Perry, G.17
Smith, M.A.18
-
78
-
-
3042806534
-
A mitochondrial cascade hypothesis for sporadic Alzheimer's disease
-
DOI 10.1016/j.mehy.2003.12.045, PII S0306987704001252
-
SwerdlowRH, KhanSM(2004)Amitochondrial cascade hypothesis for sporadic Alzheimer's disease. Med Hypotheses 63, 8-20. (Pubitemid 38887104)
-
(2004)
Medical Hypotheses
, vol.63
, Issue.1
, pp. 8-20
-
-
Swerdlow, R.H.1
Khan, S.M.2
-
79
-
-
33746048750
-
Mitochondrial genomic contribution to mitochondrial dysfunction in Alzheimer's disease
-
Onyango I, Khan S, Miller B, Swerdlow R, Trimmer P, Bennett P, Jr. (2006) Mitochondrial genomic contribution to mitochondrial dysfunction in Alzheimer's disease. J Alzheimers Dis 9, 183-193.
-
(2006)
J Alzheimers Dis
, vol.9
, pp. 183-193
-
-
Onyango, I.1
Khan, S.2
Miller, B.3
Swerdlow, R.4
Trimmer, P.5
Bennett Jr., P.6
-
80
-
-
34848890388
-
Lipoic acid and N-acetyl cysteine decrease mitochondrial-related oxidative stress in Alzheimer disease patient fibroblasts
-
Mini-Forum "Mitochondria in Alzheimer Disease"
-
Moreira PI, Harris PL, Zhu X, Santos MS, Oliveira CR, Smith MA, Perry G (2007) Lipoic acid and N-acetyl cysteine decrease mitochondrial-related oxidative stress in Alzheimer disease patient fibroblasts. J Alzheimers Dis 12, 195-206. (Pubitemid 47509369)
-
(2007)
Journal of Alzheimer's Disease
, vol.12
, Issue.2
, pp. 195-206
-
-
Moreira, P.I.1
Harris, P.L.R.2
Zhu, X.3
Santos, M.S.4
Oliveira, C.R.5
Smith, M.A.6
Perry, G.7
-
81
-
-
20044376702
-
The pathobiology of diabetic complications: A unifying mechanism
-
Brownlee M (2005) The pathobiology of diabetic complications: a unifying mechanism. Diabetes 54, 1615-1625.
-
(2005)
Diabetes
, vol.54
, pp. 1615-1625
-
-
Brownlee, M.1
-
82
-
-
20144388830
-
ABAD enhances Abeta-induced cell stress via mitochondrial dysfunction
-
Takuma K, Yao J, Huang J, Xu H, Chen X, Luddy J, Trillat AC, Stern DM, Arancio O, Yan SS (2005) ABAD enhances Abeta-induced cell stress via mitochondrial dysfunction. FASEB J 19, 597-598.
-
(2005)
FASEB J
, vol.19
, pp. 597-598
-
-
Takuma, K.1
Yao, J.2
Huang, J.3
Xu, H.4
Chen, X.5
Luddy, J.6
Trillat, A.C.7
Stern, D.M.8
Arancio, O.9
Yan, S.S.10
-
83
-
-
0034643340
-
Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage
-
DOI 10.1038/35008121
-
Nishikawa T, Edelstein D, Du XL, Yamagishi S, Matsumura T, Kaneda Y, Yorek MA, Beebe D, Oates PJ, Hammes HP, Giardino I, Brownlee M (2000) Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage. Nature 404, 787-790. (Pubitemid 30212409)
-
(2000)
Nature
, vol.404
, Issue.6779
, pp. 787-790
-
-
Nishikawa, T.1
Edelstein, D.2
Du, X.L.3
Yamagishi, S.-I.4
Matsumura, T.5
Kaneda, Y.6
Yorek, M.A.7
Beebe, D.8
Oates, P.J.9
Hammes, H.-P.10
Glardino, I.11
Brownlee, M.12
-
84
-
-
5444229093
-
Oxidative damage in cultured human olfactory neurons from Alzheimer's disease patients
-
DOI 10.1111/j.1474-9728.2004.00083.x
-
Ghanbari HA, Ghanbari K, Harris PL, Jones PK, Kubat Z, Castellani RJ, Wolozin BL, Smith MA, Perry G (2004) Oxidative damage in cultured human olfactory neurons from Alzheimer's disease patients. Aging Cell 3, 41-44. (Pubitemid 40246661)
-
(2004)
Aging Cell
, vol.3
, Issue.1
, pp. 41-44
-
-
Ghanbari, H.A.1
Ghanbari, K.2
Harris, P.L.R.3
Jones, P.K.4
Kubat, Z.5
Castellani, R.J.6
Wolozin, B.L.7
Smith, M.A.8
Perry, G.9
-
85
-
-
10744231081
-
Oxidative damage in the olfactory system in Alzheimer's disease
-
DOI 10.1007/s00401-003-0761-7
-
Perry G, Castellani RJ, Smith MA, Harris PL, Kubat Z, Ghanbari K, Jones PK, Cordone G, Tabaton M, Wolozin B, Ghanbari H (2003) Oxidative damage in the olfactory system in Alzheimer's disease. Acta Neuropathol (Berl) 106, 552-556. (Pubitemid 37441611)
-
(2003)
Acta Neuropathologica
, vol.106
, Issue.6
, pp. 552-556
-
-
Perry, G.1
Castellani, R.J.2
Smith, M.A.3
Harris, P.L.4
Kubat, Z.5
Ghanbari, K.6
Jones, P.K.7
Cordone, G.8
Tabaton, M.9
Wolozin, B.10
Ghanbari, H.11
-
86
-
-
0029878826
-
Quantitative solubilization and analysis of insoluble paired helical filaments from Alzheimer disease
-
DOI 10.1016/0006-8993(95)01473-X
-
Smith MA, Siedlak SL, Richey PL, Nagaraj RH, Elhammer A, Perry G (1996) Quantitative solubilization and analysis of insoluble paired helical filaments from Alzheimer disease. Brain Res 717, 99-108. (Pubitemid 26153441)
-
(1996)
Brain Research
, vol.717
, Issue.1-2
, pp. 99-108
-
-
Smith, M.A.1
Siedlak, S.L.2
Richey, P.L.3
Nagaraj, R.H.4
Elhammer, A.5
Perry, G.6
-
87
-
-
33847776693
-
Prevention and treatment of Alzheimer disease and aging: Antioxidants
-
DOI 10.2174/138955707779802552
-
Liu Q, Xie F, Rolston R, Moreira PI, Nunomura A, Zhu X, Smith MA, Perry G (2007) Prevention and treatment of Alzheimer disease and aging: antioxidants. Mini Rev Med Chem 7, 171-180. (Pubitemid 46592180)
-
(2007)
Mini-Reviews in Medicinal Chemistry
, vol.7
, Issue.2
, pp. 171-180
-
-
Liu, Q.1
Xie, F.2
Rolston, R.3
Moreira, P.I.4
Nunomura, A.5
Zhu, X.6
Smith, M.A.7
Perry, G.8
-
88
-
-
25844458981
-
Protein aggregation in Alzheimer's disease and other neoropathological disorders
-
DOI 10.2174/1567205052772795
-
Dimakopoulos AC (2005) Protein aggregation in Alzheimer's disease and other neoropathological disorders. Curr Alzheimer Res 2, 19-28. (Pubitemid 41389256)
-
(2005)
Current Alzheimer Research
, vol.2
, Issue.1
, pp. 19-28
-
-
Dimakopoulos, A.C.1
-
89
-
-
34347378629
-
Screening for inhibitors of tau protein aggregation into Alzheimer paired helical filaments: A ligand based approach results in successful scaffold hopping
-
DOI 10.2174/156720507781077250
-
Larbig G, Pickhardt M, Lloyd DG, Schmidt B, Mandelkow E (2007) Screening for inhibitors of tau protein aggregation into Alzheimer paired helical filaments: a ligand based approach results in successful scaffold hopping. Curr Alzheimer Res 4, 315-323. (Pubitemid 47025430)
-
(2007)
Current Alzheimer Research
, vol.4
, Issue.3
, pp. 315-323
-
-
Larbig, G.1
Pickhardt, M.2
Lloyd, D.G.3
Schmidt, B.4
Mandelkow, E.5
-
90
-
-
15844378818
-
The carbonyl scavengers aminoguanidine and tenilsetam protect against the neurotoxic effects of methylglyoxal
-
Webster J, Urban C, Berbaum K, Loske C, Alpar A, Gartner U, de Arriba SG, Arendt T, Munch G (2005) The carbonyl scavengers aminoguanidine and tenilsetam protect against the neurotoxic effects of methylglyoxal. Neurotox Res 7, 95-101.
-
(2005)
Neurotox Res
, vol.7
, pp. 95-101
-
-
Webster, J.1
Urban, C.2
Berbaum, K.3
Loske, C.4
Alpar, A.5
Gartner, U.6
De Arriba, S.G.7
Arendt, T.8
Munch, G.9
-
91
-
-
0029870323
-
Thiamine pyrophosphate and pyridoxamine inhibit the formation of antigenic advanced glycation end-products: Comparison with aminoguanidine 1
-
DOI 10.1006/bbrc.1996.0366
-
Booth AA, Khalifah RG, Hudson BG (1996) Thiamine pyrophosphate and pyridoxamine inhibit the formation of antigenic advanced glycation end-products: comparison with aminoguanidine. Biochem Biophys Res Commun 220, 113-119. (Pubitemid 126351245)
-
(1996)
Biochemical and Biophysical Research Communications
, vol.220
, Issue.1
, pp. 113-119
-
-
Booth, A.A.1
Khalifah, R.G.2
Hudson, B.G.3
-
92
-
-
0033735327
-
Novel inhibitors of advanced glycation endproducts (part II)
-
DOI 10.1006/mcbr.2000.0239
-
Rahbar S, Yerneni KK, Scott S, Gonzales N, Lalezari I (2000) Novel inhibitors of advanced glycation endproducts (part II). Mol Cell Biol Res Commun 3, 360-366. (Pubitemid 30803128)
-
(2000)
Molecular Cell Biology Research Communications
, vol.3
, Issue.6
, pp. 360-366
-
-
Rahbar, S.1
Yerneni, K.K.2
Scott, S.3
Gonzales, N.4
Lalezari, I.5
-
93
-
-
21444449221
-
The role of AGEs and AGE inhibitors in diabetic cardiovascular disease
-
DOI 10.2174/1389450054021873
-
Thomas MC, Baynes JW, Thorpe SR, Cooper ME(2005) The role of AGEs and AGE inhibitors in diabetic cardiovascular disease. Curr Drug Targets 6, 453-474. (Pubitemid 40916272)
-
(2005)
Current Drug Targets
, vol.6
, Issue.4
, pp. 453-474
-
-
Thomas, M.C.1
Baynes, J.W.2
Thorpe, S.R.3
Cooper, M.E.4
-
94
-
-
43949083722
-
The pyridoxamine action on Amadori compounds: A reexamination of its scavenging capacity and chelating effect
-
DOI 10.1016/j.bmc.2008.04.002, PII S0968089608003155
-
Adrover M, Vilanova B, Frau J, Munoz F, Donoso J (2008) The pyridoxamine action on Amadori compounds: A reexamination of its scavenging capacity and chelating effect. Bioorg Med Chem 16, 5557-5569. (Pubitemid 351699280)
-
(2008)
Bioorganic and Medicinal Chemistry
, vol.16
, Issue.10
, pp. 5557-5569
-
-
Adrover, M.1
Vilanova, B.2
Frau, J.3
Munoz, F.4
Donoso, J.5
-
95
-
-
34547843594
-
Pyridoxal phosphate prevents progression of diabetic nephropathy
-
DOI 10.1093/ndt/gfm166
-
Nakamura S, Li H, Adijiang A, Pischetsrieder M, Niwa T (2007) Pyridoxal phosphate prevents progression of diabetic nephropathy. Nephrol Dial Transplant 22, 2165-2174. (Pubitemid 47244693)
-
(2007)
Nephrology Dialysis Transplantation
, vol.22
, Issue.8
, pp. 2165-2174
-
-
Nakamura, S.1
Li, H.2
Adijiang, A.3
Pischetsrieder, M.4
Niwa, T.5
-
96
-
-
33947671901
-
Advanced glycation endproducts: What is their relevance to diabetic complications?
-
DOI 10.1111/j.1463-1326.2006.00595.x
-
Ahmed N, Thornalley PJ (2007) Advanced glycation endproducts: what is their relevance to diabetic complications? Diabetes Obes Metab 9, 233-245. (Pubitemid 46502041)
-
(2007)
Diabetes, Obesity and Metabolism
, vol.9
, Issue.3
, pp. 233-245
-
-
Ahmed, N.1
Thornalley, P.J.2
-
98
-
-
34347343978
-
Could carnosine or related structures suppress Alzheimer's disease?
-
Hipkiss AR (2007) Could carnosine or related structures suppress Alzheimer's disease? J Alzheimers Dis 11, 229-240.
-
(2007)
J Alzheimers Dis
, vol.11
, pp. 229-240
-
-
Hipkiss, A.R.1
-
99
-
-
27844577676
-
Emerging drugs for diabetic nephropathy
-
Bruno S, Cattaneo D, Perico N, Remuzzi G (2005) Emerging drugs for diabetic nephropathy. Expert Opin Emerg Drugs 10, 747-771.
-
(2005)
Expert Opin Emerg Drugs
, vol.10
, pp. 747-771
-
-
Bruno, S.1
Cattaneo, D.2
Perico, N.3
Remuzzi, G.4
-
100
-
-
0034950643
-
Effects of OPB-9195, anti-glycation agent, on experimental diabetic neuropathy
-
DOI 10.1046/j.1365-2362.2001.00826.x
-
Wada R, Nishizawa Y, Yagihashi N, Takeuchi M, Ishikawa Y, Yasumura K, Nakano M, Yagihashi S (2001) Effects of OPB-9195, anti-glycation agent, on experimental diabetic neuropathy. Eur J Clin Invest 31, 513-520. (Pubitemid 32579388)
-
(2001)
European Journal of Clinical Investigation
, vol.31
, Issue.6
, pp. 513-520
-
-
Wada, R.1
Nishizawa, Y.2
Yagihashi, N.3
Takeuchi, M.4
Ishikawa, Y.5
Yasumura, K.6
Nakano, M.7
Yagihashi, S.8
-
101
-
-
36749037376
-
Cross-link breakers as a new therapeutic approach to cardiovascular disease
-
DOI 10.1042/BST0350853
-
Susic D (2007) Cross-link breakers as a new therapeutic approach to cardiovascular disease. Biochem Soc Trans 35, 853-856. (Pubitemid 350206381)
-
(2007)
Biochemical Society Transactions
, vol.35
, Issue.5
, pp. 853-856
-
-
Susic, D.1
-
102
-
-
41849096928
-
AGE and RAGE inhibitors in the treatment of diabetic retinopathy
-
Bhatwadekar A, Stitt AW (2007) AGE and RAGE inhibitors in the treatment of diabetic retinopathy. Expert Rev Ophthalmol 2, 105-120.
-
(2007)
Expert Rev Ophthalmol
, vol.2
, pp. 105-120
-
-
Bhatwadekar, A.1
Stitt, A.W.2
-
103
-
-
33845776585
-
Prevention and reversal of diabetic nephropathy in db/db mice treated with alagebrium (ALT-711)
-
DOI 10.1159/000095786
-
Peppa M, Brem H, Cai W, Zhang JG, Basgen J, Li Z, Vlassara H, Uribarri J (2006) Prevention and reversal of diabetic nephropathy in db/db mice treated with alagebrium (ALT-711). Am J Nephrol 26, 430-436. (Pubitemid 44971733)
-
(2006)
American Journal of Nephrology
, vol.26
, Issue.5
, pp. 430-436
-
-
Peppa, M.1
Brem, H.2
Cai, W.3
Zhang, J.-G.4
Basgen, J.5
Li, Z.6
Vlassara, H.7
Uribarri, J.8
-
104
-
-
34548684314
-
Role of advanced glycation end products in hypertension and atherosclerosis: Therapeutic implications
-
DOI 10.1007/s12013-007-0039-0
-
Vasdev S, Gill V, Singal P (2007) Role of advanced glycation end products in hypertension and atherosclerosis: therapeutic implications. Cell Biochem Biophys 49, 48-63. (Pubitemid 47415346)
-
(2007)
Cell Biochemistry and Biophysics
, vol.49
, Issue.1
, pp. 48-63
-
-
Vasdev, S.1
Gill, V.2
Singal, P.3
-
105
-
-
34447331279
-
Soluble RAGE in type 2 diabetes: Association with oxidative stress
-
DOI 10.1016/j.freeradbiomed.2007.03.015, PII S0891584907002110
-
Devangelio E, Santilli F, Formoso G, Ferroni P, Bucciarelli L, Michetti N, Clissa C, Ciabattoni G, Consoli A, Davi G (2007) Soluble RAGE in type 2 diabetes: association with oxidative stress. Free Radic Biol Med 43, 511-518. (Pubitemid 47058227)
-
(2007)
Free Radical Biology and Medicine
, vol.43
, Issue.4
, pp. 511-518
-
-
Devangelio, E.1
Santilli, F.2
Formoso, G.3
Ferroni, P.4
Bucciarelli, L.5
Michetti, N.6
Clissa, C.7
Ciabattoni, G.8
Consoli, A.9
Davi, G.10
-
106
-
-
67651195145
-
Soluble receptor for advanced glycation end products (sRAGE) and cardiovascular disease
-
Prasad K (2006) Soluble receptor for advanced glycation end products (sRAGE) and cardiovascular disease. Int J Angiol 15, 57-68.
-
(2006)
Int J Angiol
, vol.15
, pp. 57-68
-
-
Prasad, K.1
-
107
-
-
34547659641
-
Thiazolidinedione increases serum soluble receptor for advanced glycation end-products in type 2 diabetes
-
DOI 10.1007/s00125-007-0759-0
-
Tan KC, Chow WS, Tso AW, Xu A, Tse HF, Hoo RL, Betteridge DJ, Lam KS (2007) Thiazolidinedione increases serum soluble receptor for advanced glycation end-products in type 2 diabetes. Diabetologia 50, 1819-1825. (Pubitemid 47222871)
-
(2007)
Diabetologia
, vol.50
, Issue.9
, pp. 1819-1825
-
-
Tan, K.C.B.1
Chow, W.S.2
Tso, A.W.K.3
Xu, A.4
Tse, H.F.5
Hoo, R.L.C.6
Betteridge, D.J.7
Lam, K.S.L.8
-
108
-
-
33947408459
-
Association between serum levels of soluble receptor for advanced glycation end products and circulating advanced glycation end products in type 2 diabetes
-
Tan KC, Shiu SW, Chow WS, Leng L, Bucala R, Betteridge DJ (2006) Association between serum levels of soluble receptor for advanced glycation end products and circulating advanced glycation end products in type 2 diabetes. Diabetologia 49, 2756-2762.
-
(2006)
Diabetologia
, vol.49
, pp. 2756-2762
-
-
Tan, K.C.1
Shiu, S.W.2
Chow, W.S.3
Leng, L.4
Bucala, R.5
Betteridge, D.J.6
-
109
-
-
38149048613
-
sRAGE and esRAGE are not associated with peripheral or autonomic neuropathy in type 2 diabetes
-
Humpert PM, Papadopoulos G, Schaefer K, Djuric Z, Konrade I, Morcos M, Nawroth PP, Bierhaus A (2007) sRAGE and esRAGE are not associated with peripheral or autonomic neuropathy in type 2 diabetes. Horm Metab Res 39, 899-902.
-
(2007)
Horm Metab Res
, vol.39
, pp. 899-902
-
-
Humpert, P.M.1
Papadopoulos, G.2
Schaefer, K.3
Djuric, Z.4
Konrade, I.5
Morcos, M.6
Nawroth, P.P.7
Bierhaus, A.8
-
110
-
-
0035865905
-
Redox-active iron mediates amyloid-β toxicity
-
DOI 10.1016/S0891-5849(00)00494-9, PII S0891584900004949
-
Rottkamp CA, Raina AK, Zhu X, Gaier E, Bush AI, Atwood CS, Chevion M, Perry G, Smith MA (2001) Redox-active iron mediates amyloid-beta toxicity. Free Radic Biol Med 30, 447-450. (Pubitemid 32155543)
-
(2001)
Free Radical Biology and Medicine
, vol.30
, Issue.4
, pp. 447-450
-
-
Rottkamp, C.A.1
Raina, A.K.2
Zhu, X.3
Gaier, E.4
Bush, A.I.5
Atwood, C.S.6
Chevion, M.7
Perry, G.8
Smith, M.A.9
-
111
-
-
84911439662
-
Antioxidant therapies in the prevention and treatment of Alzheimer disease
-
Luo Y, Packer L, eds. Taylor & Francis Group, Boca Raton
-
Moreira PI, Zhu X, Smith MA, Perry G, Nunomura A (2006) Antioxidant therapies in the prevention and treatment of Alzheimer disease In Oxidative Stress and Age-Related Neurodegeneration, Luo Y, Packer L, eds. Taylor & Francis Group, Boca Raton, pp. 131-145.
-
(2006)
Oxidative Stress and Age-Related Neurodegeneration
, pp. 131-145
-
-
Moreira, P.I.1
Zhu, X.2
Smith, M.A.3
Perry, G.4
Nunomura, A.5
|