In Alzheimer's disease, heme oxygenase is coincident with Alz50, an epitope of τ induced by 4-hydroxy-2-nonenal modification

Journal of Neurochemistry

Volumn 75, Issue 3, 2000, Pages 1234-1241

  Takeda, Atsushi ^a,b,c   Smith, Mark A ^a,b,c   Avilá, Jesus ^a,b,c   Nunomura, Akihiko ^a,b,c   Siedlak, Sandra L ^a,b,c   Zhu, Xiongwei ^a,b,c   Perry, George ^a,b,c   Sayre, Lawrence M ^a,b,c  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b CENTRO DE BIOLOGÍA MOLECULAR SEVERO OCHOA   (Spain)

^c ASAHIKAWA MEDICAL COLLEGE   (Japan)

Author keywords

; 4 Hydroxy 2 nonenal; Alz50; Alzheimer's disease; Heme oxygenase 1; Lipid peroxidation

Indexed keywords

4 HYDROXYNONENAL; EPITOPE; HEME OXYGENASE;

ADULT; AGED; ALZHEIMER DISEASE; ANTIOXIDANT ACTIVITY; ARTICLE; ENZYME ACTIVITY; ENZYME INDUCTION; HUMAN; HUMAN TISSUE; NEUROFIBRILLARY TANGLE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN CONFORMATION;

AGED; AGED, 80 AND OVER; ALDEHYDES; ALZHEIMER DISEASE; ANTIGENS; CYSTEINE PROTEINASE INHIBITORS; HEME OXYGENASE (DECYCLIZING); HEME OXYGENASE-1; HIPPOCAMPUS; HUMANS; MEMBRANE PROTEINS; NERVE TISSUE PROTEINS; NEURONS; REFERENCE VALUES; TAU PROTEINS;

EID: 0033836580     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2000.0751234.x     Document Type: Article

References (44)

1. Accumulation of abnormally phosphorylated tau precedes the formation of neurofibrillary tangles in Alzheimer's disease
2. Evidence that transmitter-containing dystrophic neurites precede paired helical filament and Alz-50 formation within senile plaques in the amygdala of nondemented elderly and patients with Alzheimer's disease
3. A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads
4. Protein-bound acrolein: A novel maker of oxidative stress in Alzheimer's disease
5. The structural basis of monoclonal antibody Alz50's selectivity for Alzheimer's disease pathology
6. Transglutaminase catalyzes the formation of sodium dodecyl sulfate-insoluble, Alz-50-reactive polymers of tau
7. Role of oxidative stress in frontotemporal dementia
8. A preparation of Alzheimer paired helical filaments that displays distinct tau proteins by polyacrylamide gel electrophoresis
9. Hydrofluoric acid-treated tau PHF proteins display the same biochemical properties as normal tau
10. The nature of the cross-linking of proteins by glutaraldehyde. Part 2. The formation of quaternary pyridinium compounds by the action of glutaraldehyde on proteins and the identification of a 3-(2-piperidyl)pyridinium derivative, anabilysine, as a cross-linking entity
11. Neuronal RNA oxidation and mitochondrial proliferation denote profound metabolic abnormalities in Alzheimer disease
12. Structure of a fluorescent compound formed from 4-hydroxy-2-nonenal and N(α)-hippuryl-lysine: A model for fluorophores derived from protein modification by lipid peroxidation
13. Alz-50 and MC-1, a new monoclonal antibody raised to paired helical filaments, recognize conformational epitopes on recombinant tau
14. Cleavage of structural proteins during the assembly of the head of the bacteriophage T4
15. Phosphorylation affects the ability of tau protein to promote microtubule assembly
16. Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau
17. A tombstone in Alzheimer's?
18. 4-Hydroxynonenal, a product of lipid peroxidation, inhibits dephosphorylation of the microtubule-associated protein tau
19. Immunohistochemical detection of 4-hydroxy-2-nonenal adducts in Alzheimer's disease is associated with inheritance of APOE4
20. Structural definition of early lysine and histidine adduction chemistry of 4-hydroxynonenal
21. The lipid peroxidation product 4-hydroxynonenal inhibits neurite outgrowth, disrupts neuronal microtubules, and modifies cellular tubulin
22. RNA oxidation is a prominent feature of vulnerable neurons in Alzheimer's disease
23. Lipoperoxidation is selectively involved in progressive supranuclear palsy
24. Regulation of human heme oxygenase-1 gene expression under thermal stress
25. Ferritin is associated with the aberrant tau filaments present in progressive supranuclear palsy
26. β protein immunoreactivity is found in the majority of neurofibrillary tangles of Alzheimer's disease
27. Immunocytochemical evidence that the β-protein precursor is an integral component of neurofibrillary tangles of Alzheimer's disease
28. Immunochemical evidence supporting 2-pentylpyrrole formation on proteins exposed to 4-hydroxy-2-nonenal
29. 4-Hydroxynonenal-derived advanced lipid peroxidation end products are increased in Alzheimer's disease
30. Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC
31. Basic fibroblast growth factor binding is a marker for extracellular neurofibrillary tangles in Alzheimer disease
32. Heme oxygenase-1 is associated with the neurofibrillary pathology of Alzheimer's disease
33. Carbonyl-related posttranslational modification of neurofilament protein in the neurofibrillary pathology of Alzheimer's disease
34. Oxidative damage in Alzheimer's
35. Widespread peroxynitrite-mediated damage in Alzheimer's disease
36. Ultrastructural localization of β-amyloid, τ and ubiquitin epitopes in extracellular neurofibrillary tangles
37. Overexpression of heme oxygenase in neuronal cells, the possible interaction with tau
38. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications
39. Structural characterization and immunochemical detection of a fluorophore derived from 4-hydroxy-2-nonenal and lysine
40. Immunochemical detection of 4-hydroxynonenal protein adducts in oxidized hepatocytes
41. A neuronal antigen in the brains of Alzheimer patients
42. Structural characterization of a 4-hydroxy-2-alkenal-derived fluorophore that contributes to lipoperoxidation-dependent protein cross-linking in aging and degenerative disease
43. Independent synthesis, solution behavior, and studies on the mechanism of formation of a primary amine-derived fluorophore representing cross-linking of proteins by (E)-4-hydroxy-2-nonenal