H2O2 and 4-hydroxynonenal mediate amyloid β-induced neuronal apoptosis by activating JNKs and p38MAPK

Experimental Neurology

Volumn 180, Issue 2, 2003, Pages 144-155

  Tamagno, E ^a   Robino, G ^a   Obbili, A ^a   Bardini, P ^a   Aragno, M ^a   Parola, M ^a   Danni, O ^a  

^a UNIVERSITY OF TURIN   (Italy)

Author keywords

Alzheimer's disease; Amyloid peptides; Apoptosis; H2O2; HNE; JNK; p38MAPK

Indexed keywords

4 HYDROXYNONENAL; ACETYLCYSTEINE; ALPHA TOCOPHEROL; AMYLOID BETA PROTEIN; ANTIOXIDANT; ENZYME INHIBITOR; HYDROGEN PEROXIDE; LIPID; MITOGEN ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; THIOBARBITURIC ACID REACTIVE SUBSTANCE; 4-HYDROXY-2-NONENAL; ALDEHYDE; AMYLOID BETA PROTEIN (1 42); AMYLOID BETA PROTEIN (25 35); AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA-PROTEIN (1-42); AMYLOID BETA-PROTEIN (25-35); MITOGEN ACTIVATED PROTEIN KINASE P38; NEUROPROTECTIVE AGENT; PEPTIDE FRAGMENT;

APOPTOSIS; ARTICLE; CELL ASSAY; CELL LINE; CONCENTRATION (PARAMETERS); ENZYME ACTIVATION; MONITORING; NERVE CELL; NICK END LABELING; OXIDATIVE STRESS; PRIORITY JOURNAL; STAINING; TIME; ALZHEIMER DISEASE; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; HUMAN; METABOLISM;

ALDEHYDES; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANTIOXIDANTS; APOPTOSIS; CELL LINE; ENZYME ACTIVATION; ENZYME INHIBITORS; HUMANS; HYDROGEN PEROXIDE; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; NEURONS; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PEPTIDE FRAGMENTS;

EID: 0037382957     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-4886(02)00059-6     Document Type: Article

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