4-Oxo-2-nonenal is both more neurotoxic and more protein reactive than 4-hydroxy-2-nonenal

Chemical Research in Toxicology

Volumn 18, Issue 8, 2005, Pages 1219-1231

  Lin, De ^a   Lee, Hyoung Gon ^a   Liu, Quan ^a   Perry, George ^a   Smith, Mark A ^a   Sayre, Lawrence M ^a  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROXYNONENAL; 4 OXO 2 NONENAL; ALDEHYDE DERIVATIVE; AMINE; BETA LACTOGLOBULIN; LYSINE DERIVATIVE; POLYNUCLEOTIDE; POLYUNSATURATED FATTY ACID; RIBONUCLEASE A; SCHIFF BASE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CELL DEATH; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME KINETICS; HALF LIFE TIME; HUMAN; HUMAN CELL; MICHAEL ADDITION; NEUROBLASTOMA CELL; NEUROTOXICITY; OXIDATION; OXIDATIVE STRESS; PROTEIN BINDING; REACTION ANALYSIS; SPECTROPHOTOMETRY;

ALDEHYDES; BUTYLAMINES; CELL LINE; CELL SURVIVAL; CYSTEINE; CYSTEINE PROTEINASE INHIBITORS; HISTIDINE; HUMANS; IMMUNOHISTOCHEMISTRY; INDICATORS AND REAGENTS; KINETICS; LYSINE; NEURONS; NEUROTOXICITY SYNDROMES; OXIDATIVE STRESS; PROTEINS; SCHIFF BASES; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 23844448026     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx050080q     Document Type: Article

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