Biological significance of the defense mechanisms against oxidative damage in nucleic acids caused by reactive oxygen species: From mitochondria to nuclei

Annals of the New York Academy of Sciences

Volumn 1011, Issue , 2004, Pages 101-111

  Nakabeppu, Yusaku ^a   Tsuchimoto, Daisuke ^b   Ichinoe, Akimasa ^b   Ohno, Mizuki ^b   Ide, Yasuhito ^b   Hirano, Seiki ^b   Yoshimura, Daisuke ^b   Tominaga, Yohei ^b   Furuichi, Masato ^b   Sakumi, Kunihiko ^b  

^a KYUSHU UNIVERSITY   (Japan)

^b NONE

Author keywords

Carcinogenesis; DNA repair; Mitochondria; Neurodegeneration; Nucleotide pool; Oxidative damage

Indexed keywords

8 HYDROXYGUANINE; 8 OXOGUANINE DNA GLYCOSYLASE; ADENINE DNA GLYCOSYLASE; DNA; DNA GLYCOSYLTRANSFERASE; ENDONUCLEASE; GUANINE DERIVATIVE; NUCLEIC ACID; PHOSPHORUS DERIVATIVE; PROTEIN; PROTEIN MTH1; PURINE NUCLEOTIDE TRIPHOSPHATE; REACTIVE OXYGEN METABOLITE; RNA; UNCLASSIFIED DRUG;

CANCER SUSCEPTIBILITY; CARCINOGENESIS; CELL DAMAGE; CELL FUNCTION; CELL NUCLEUS; CONFERENCE PAPER; CYTOPLASM; DEFENSE MECHANISM; DEGENERATIVE DISEASE; DNA REPAIR; ENZYME ACTIVITY; EXCISION REPAIR; GENE DISRUPTION; HUMAN; HYDROLYSIS; KNOCKOUT MOUSE; LUNG TUMOR; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION;

MAMMALIA; ZIZIPHUS MAURITIANA;

EID: 2342634253     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1293.011     Document Type: Conference Paper

References (39)

1. SHIBUTANI, S., M. TAKESHITA & A.P. GROLLMAN. 1991. Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG. Nature 349: 431-434.
2. NAKABEPPU, Y., Y. TOMINAGA, D. TSUCHIMOTO, et al. 2001. Mechanisms protecting genomic integrity from damage caused by reactive oxygen species: implications for carcinogenesis and neurodegeneration. Environ. Mutagen. Res. 23: 197-209.
3. SEKIGUCHI, M. 1996. MutT-related error avoidance mechanism for DNA synthesis. Genes Cells 1: 139-145.
4. FOWLER, R.G., S.J. WHITE, C. KOYAMA, et al. 2003. Interactions among the Escherichia coli mutT, mutM, and mutY damage prevention pathways. DNA Repair 2: 159-173.
5. CUNNINGHAM, R.P., S.M. SAPORITO, S.G. SPITZER, et al. 1986. Endonuclease IV (nfo) mutant of Escherichia coli. J. Bacteriol. 168: 1120-1127.
6. LU, A.L., X. LI, Y. GU, et al. 2001. Repair of oxidative DNA damage: mechanisms and functions. Cell. Biochem. Biophys. 35: 141-170.
7. SHIGENAGA, M.K., T.M. HAGEN & B.N. AMES. 1994. Oxidative damage and mitochondrial decay in aging. Proc. Natl. Acad. Sci. USA 91: 10771-10778.
8. NAKABEPPU, Y. 2001. Regulation of intracellular localization of human MTH1, OGG1, and MYH proteins for repair of oxidative DNA damage. Prog. Nucleic Acid Res. Mol. Biol. 68: 75-94.
9. TSUCHIMOTO, D., Y. SAKAI, K. SAKUMI, et al. 2001. Human APE2 protein is mostly localized in the nuclei and to some extent in the mitochondria, while nuclear APE2 is partly associated with proliferating cell nuclear antigen. Nucleic Acids Res. 29: 2349-2360.
10. IDE, Y., D. TSUCHIMOTO, Y. TOMINAGA, et al. 2003. Characterization of the genomic structure and expression of the mouse Apex2 gene. Genomics 81: 47-57.
11. MAKI, H. & M. SEKIGUCHI. 1992. MutT protein specifically hydrolyses a potent mutagenic substrate for DNA synthesis. Nature 355: 273-275.
12. SAKUMI, K., M. FURUICHI, T. TSUZUKI, et al. 1993. Cloning and expression of cDNA for a human enzyme that hydrolyzes 8-oxo-dGTP, a mutagenic substrate for DNA synthesis. J. Biol. Chem. 268: 23524-23530.
13. NAKABEPPU, Y. 2001. Molecular genetics and structural biology of human MutT homolog, MTH1. Mutat. Res. 477: 59-70.
14. SAKAI, Y., M. FURUICHI, M. TAKAHASHI, et al. 2002. A molecular basis for the selective recognition of 2-hydroxy-dATP and 8-Oxo-dGTP by human MTH1. J. Biol. Chem. 277: 8579-8587.
15. NISHIOKA, K., T. OHTSUBO, H. ODA, et al. 1999. Expression and differential intracellular localization of two major forms of human 8-oxoguanine DNA glycosylase encoded by alternatively spliced OGG1 mRNAs. Mol. Biol. Cell 10: 1637-1652.
16. BOITEUX, S. & J.P. RADICELLA. 1999. Base excision repair of 8-hydroxyguanine protects DNA from endogenous oxidative stress. Biochimie 81: 59-67.
17. BRUNER, S.D., H.M. NASH, W.S. LANE, et al. 1998. Repair of oxidatively damaged guanine in Saccharomyces cerevisiae by an alternative pathway. Curr. Biol. 8: 393-403.
18. OHTSUBO, T., K. NISHIOKA, Y. IMAISO, et al. 2000. Identification of human MutY homolog (hMYH) as a repair enzyme for 2-hydroxyadenine in DNA and detection of multiple forms of hMYH located in nuclei mitochondria. Nucleic Acids Res. 28: 1355-1364.
19. MATSUMOTO, Y. 2001. Molecular mechanism of PCNA-dependent base excision repair. Prog. Nucleic Acid Res. Mol. Biol. 68: 129-138.
20. HAYASHI, H., Y. TOMINAGA, S. HIRANO, et al. 2002. Replication-associated repair of adenine:8-oxoguanine mispairs by MYH. Curr. Biol. 12: 335-339.
21. HADI, M.Z. & D.M. WILSON III. 2000. Second human protein with homology to the Escherichia coli abasic endonuclease exonuclease III. Environ. Mol. Mutagen 36: 312-324.
22. FURUICHI, M., M.C. YOSHIDA, H. ODA, et al. 1994. Genomic structure and chromosome location of the human mutT homologue gene MTH1 encoding 8-oxo-dGTPase for prevention of A:T to C:G transversion. Genomes 24: 485-490.
23. ODA, H., Y. NAKABEPPU, M. FURUICHI, et al. 1997. Regulation of expression of the human MTH1 gene encoding 8-oxo-dGTPase. Alternative splicing of transcription products. J. Biol. Chem. 272: 17843-17850.
24. ODA, H., A. TAKETOMI, R. MARUYAMA, et al. 1999. Multi-forms of human MTH1 polypeptides produced by alternative translation initiation and single nucleotide polymorphism. Nucleic Acids Res. 27: 4335-4343.
25. KANG, D., J. NISHIDA, A. IYAMA, et al. 1995. Intracellular localization of 8-oxo-dGTPase in human cells, with special reference to the role of the enzyme in mitochondria. J. Biol. Chem. 270: 14659-14665.
26. BOITEUX, S., C. DHERIN, F. REILLE, et al. 1998. Excision repair of 8-hydroxyguanine in mammalian cells: the mouse Ogg1 protein as a model. Free Radic. Res. 29: 487-497.
27. SLUPSKA, M.M., C. BAIKALOV, W.M. LUTHER, et al. 1996. Cloning and sequencing a human homolog (hMYH) of the Escherichia coli mutY gene whose function is required for the repair of oxidative DNA damage. J. Bacteriol. 178: 3885-3892.
28. YAMAGUCHI, S., K. SHINMURA, T. SAITOH, et al. 2002. A single nucleotide polymorphism at the splice donor site of the human MYH base excision repair genes results in reduced translation efficiency of its transcripts. Genes Cells 7: 461-474.
29. TSUZUKI, T., A. EGASHIRA, H. IGARASHI, et al. 2001. Spontaneous tumorigenesis in mice defective in the MTH1 gene encoding 8-oxo-dGTPase. Proc. Natl. Acad. Sci. USA 98: 11456-11461.
30. SAKUMI, K., Y. TOMINAGA, M. FURUICHI, et al. 2003. Ogg1 knockout-associated lung tumorigenesis and its suppression by Mth1 gene disruption. Cancer Res. 63: 902-905.
31. OKAMOTO, K., S. TOYOKUNI, W.J. KIM, et al. 1996. Overexpression of human mutT homologue gene messenger RNA in renal-cell carcinoma: evidence of persistent oxidative stress in cancer. Int. J. Cancer 65: 437-441.
32. KENNEDY, C.H., R. CUETO, S.A. BELINSKY, et al. 1998. Overexpression of hMTH1 mRNA: a molecular marker of oxidative stress in lung cancer cells. FEBS Lett. 429: 17-20.
33. IIDA, T., A. FURUTA, M. KAWASHIMA, et al. 2001. Accumulation of 8-oxo-2′-deoxyguanosine and increased expression of hMTH1 protein in brain tumors. Neurooncology 3: 73-81.
34. SHIMURA-MIURA, H., N. HATTORI, D. KANG, et al. 1999. Increased 8-oxo-dGTPase in the mitochondria of substantia nigral neurons in Parkinson's disease. Ann. Neurol. 46: 920-924.
35. FURUTA, A., T. IIDA, Y. NAKABEPPU, et al. 2001. Expression of hMTH1 in the hippocampi of control and Alzheimer's disease. Neuroreport 12: 2895-2899.
36. IIDA, T., A. FURUTA, K. NISHIOKA, et al. 2002. Expression of 8-oxoguanine DNA glycosylase is reduced and associated with neurofibrillary tangles in Alzheimer's disease brain. Acta Neuropathol. 103: 20-25.
37. KIKUCHI, H., A. FURUTA, K. NISHIOKA, et al. 2002. Impairment of mitochondrial DNA repair enzymes against accumulation of 8-oxo-guanine in the spinal motor neurons of amyotrophic lateral sclerosis. Acta Neuropathol. 103: 408-414.
38. TSURUYA, K., M. FURUICHI, Y. TOMINAGA, et al. 2003. Accumulation of 8-oxoguanine in the cellular DNA and the alteration of the OGG1 expression during ischemia-reperfusion injury in the rat kidney. DNA Repair 2: 211-229.
39. JAISWAL, M., N.F. LARUSSO, K. NISHIOKA, et al. 2001. Human Ogg1, a protein involved in the repair of 8-oxoguanine, is inhibited by nitric oxide. Cancer Res. 61: 6388-6393.