Advanced glycation end products co-localized with astrocytes and microglial cells in Alzheimer's disease brain

Acta Neuropathologica

Volumn 95, Issue 6, 1998, Pages 555-558

  Takeda, Akinori ^a,b   Yasuda, Takeshi ^a   Miyata, Toshio ^c   Goto, Yoji ^a   Wakai, Masakazu ^a   Watanabe, Masaki ^d   Yasuda, Yoshinari ^e   Horie, Katsunori ^e   Inagaki, Toshiaki ^f   Doyu, Manabu ^a   Maeda, Kenji ^e   Sobue, Gen ^a  

^a NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b Oyamada Memorial Spa Hospital   (Japan)

^c TOKAI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d JAPANESE RED CROSS NAGOYA FIRST HOSPITAL   (Japan)

^e NAGOYA UNIVERSITY HOSPITAL   (Japan)

^f Nagoya shi Kouseiin Geriatric Hosp   (Japan)

Author keywords

Advanced glycation end products; Alzheimer's disease; Astrocytes; Microglia

Indexed keywords

GLIAL FIBRILLARY ACIDIC PROTEIN;

AGED; ALZHEIMER DISEASE; ARTICLE; ASTROCYTE; BRAIN; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; MICROGLIA; PATHOGENESIS; PRIORITY JOURNAL;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; ARGININE; ASTROCYTES; CYTOPLASMIC GRANULES; EXTRACELLULAR SPACE; GLYCOCONJUGATES; HIPPOCAMPUS; HUMANS; LYSINE; MICROGLIA; STAINING AND LABELING;

EID: 0031778629     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004010050839     Document Type: Article

References (22)

1. Boyles JK, Pitas RE, Wilson E, Mahley RW, Taylor JM (1985) Apolipoproteon E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system. J Clin Invest 76:1501-1513
2. Dickson DW, Sinicropi S, Yen SH, Ko LW, Mattiace LA, Bucala R, Vlassara H (1996) Glycation and microglial reaction in lesions of Alzheimer's disease. Neurobiol Aging 17:733-743
3. Flemming PD, Cordoza ME, Woods SG, Griesbach EJ (1987) Corpora amylacea increased in Alzheimer's disease. Neurology 37 [Suppl 1]: 157
4. Griffin WST, Stanley LC, Ling C, White L, MacLeod V, Perrot LJ, White LJ, Araoz C (1989) Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease. Proc Natl Acad Sci USA 86:7611-7615
5. Horie K, Miyata T, Yasuda T, Takeda A, Yasuda Y, Maeda K, Sobue G, Kurokawa K (1997) Immunohistochemical localization of advanced glycation end products, pentosidine and carboxymethyllysine in lipofuscin pigments of Alzheimer's disease and aged neurons. Biochem Biophys Res Commun 236: 327-332
6. Iwaki T, Hamada Y, Tateishi J (1996) Advanced glycosylation end products and heat shock proteins accumulate in the basophilic degeneration of the myocardium and the corpora amylacea of the glia. Pathol Int 46:757-763
7. Ledesma MD, Bonay P, Avila J (1995) B-protein from Alzheimer's disease patients is glycated at its tubulin-binding domain. J Neurochem 65: 1658-1664
8. Mark RE, Sheng JG, Griffin WST (1995) Glial cytokines in Alzheimer's disease: review and pathogenic implications. Hum Pathol 26:816-823
9. Miyata T, Iida Y, Ueda Y, Shinzato T, Seo H, Monnier VM, Maeda K (1996) Monocyte/macrophage response to β2-microglobulin modified with the advanced glycation end products. Kidney Int 49: 538-550
10. 2-microglobulin containing amyloid fibrils in patients with dialysis-related amyloidosis. Proc Natl Acad Sci USA 93:2353-2358
11. Mydlarski MB, Schipper HM (1993) Stress protein co-localization to autofluorescent astrocytic inclusions in situ and in cysteamine-treated glial cultures. Brain Res 627:113-121
12. Schechter R, Yen SH, Terry RD (1981) Fibrous astrocytes in senile dementia of the Alzheimer type. J Neuropathol Exp Neurol 40:95-101
13. Schipper HM (1991) Gomori-positive astrocytes: biological properties and implications for neurologic and neuroendocrine disorders. Glia 4: 365-377
14. Schipper HM, Cisse S (1995) Mitochondrial constituents of corpora amylacea and autofluorescent astrocytic inclusions in senescent human brain. Glia 14: 55-64
15. Smith MA, Taneda S, Richey PI, Miyata S, Yan SD, Stern D, Sayre LM, Monnier VN, Perry G (1994) Advanced Maillard reaction end products are associated with Alzheimer disease pathology. Proc Natl Acad Sci USA 91:5710-5714
16. Smith MA, Sayre LM, Monnier VM, Perry G (1995) Racial AGEing in Alzheimer's disease. Trend Neurosci 18:172-176
17. Takeda A, Yasuda T, Miyata T, Mizuno K, Li M, Yoneyama S, Horie K, Maeda K, Sobue G (1996) Immunohistochemical study of advanced glycation end products in aging and Alzheimer's disease brain. Neurosci Lett 221:17-20
18. Vijayan VK, Geddes JW, Anderson KI, Chang-Chui H, Ellis WG, Cotman CW (1991) Astrocyte hypertrophy in the Alzheimer's disease hippocampal formation. Exp Neurol 112:72-78
19. Vitek MP, Bhattacharya K, Glendening M, Stopa E, Vlassara H, Bucala R, Manogue K, Cerami A (1994) Advanced glycation end products contribute to amyloidosis in Alzheimer disease. Proc Natl Acad Sci USA 91:4766-4770
20. Wood JA, Wood PL, Ryan R, Graff-Radford NR, Pilapil C, Robitaille Y, Quirion R (1993) Cytokine indices in Alzheimer's temporal cortex: no changes in mature IL-1β or IL-1RA but increases in associated acute phase proteins IL-6, β2-macroglobulin and C-reactive protein. Brain Res 629:245-252
21. Yan SD, Chen X, Schmidt AM, Brett J, Godman G, Zou YS, Scott CW, Caputo C, Frappier T, Smith MA, Perry G, Yen SH, Stern D (1994) Glycated tau protein in Alzheimer disease: a mechanism for induction of oxidant stress. Proc Natl Acad Sci USA 91:7787-7791
22. Yan SD, Chen X, Fu J, Chen M, Zhu H, Roher A, Slattery T, Zhao L, Nagashima M, Morser J, Migheli A, Nawroth P, Stern D, Schmidt AM (1996) RAGE and amyloid-β peptide neuro-toxicity in Alzheimer's disease. Nature 382: 685-691