메뉴 건너뛰기




Volumn 4, Issue 4, 2008, Pages 246-253

Update on targets of biologic therapies for rheumatoid arthritis

Author keywords

Biologics; Cytokines; Rheumatoid arthritis; Signal transduction

Indexed keywords

CYTOKINE; INTERLEUKIN 15; INTERLEUKIN 17; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE; NUCLEAR FACTOR; PROTEIN C JUN; TUMOR NECROSIS FACTOR;

EID: 67649643011     PISSN: 15733971     EISSN: 18756360     Source Type: Journal    
DOI: 10.2174/157339708786263915     Document Type: Article
Times cited : (26)

References (106)
  • 1
    • 34249867399 scopus 로고    scopus 로고
    • Emerging targets of biologic therapies for rheumatoid arthritis
    • Tarner IH, Muller-Ladner U, Gay S. Emerging targets of biologic therapies for rheumatoid arthritis. Nat Clin Pract Rheum 2007; 3: 336-45.
    • (2007) Nat Clin Pract Rheum , vol.3 , pp. 336-345
    • Tarner, I.H.1    Muller-Ladner, U.2    Gay, S.3
  • 2
    • 0035056003 scopus 로고    scopus 로고
    • Anti-TNF alpha therapy of rheumatoid arthritis: What have we learned?
    • Feldmann M, Maini RN. Anti-TNF alpha therapy of rheumatoid arthritis: what have we learned? Annu Rev Immunol 2001; 19: 163-96.
    • (2001) Annu Rev Immunol , vol.19 , pp. 163-196
    • Feldmann, M.1    Maini, R.N.2
  • 3
    • 33748997948 scopus 로고    scopus 로고
    • Cytokine networks-towards new therapies for rheumatoid arthritis
    • McInnes IB, Liew FY. Cytokine networks-towards new therapies for rheumatoid arthritis. Nat Clin Pract Rheum 2005; 1: 31-9.
    • (2005) Nat Clin Pract Rheum , vol.1 , pp. 31-39
    • McInnes, I.B.1    Liew, F.Y.2
  • 4
    • 84925549112 scopus 로고    scopus 로고
    • The paradigm of IL-6: From basic science to medicine
    • Naka T, Nishimoto N, Kishimoto T. The paradigm of IL-6: from basic science to medicine. Arthritis Res 2002; 4(Suppl 3): S233-S42.
    • (2002) Arthritis Res , vol.4 , pp. S233-S242
    • Naka, T.1    Nishimoto, N.2    Kishimoto, T.3
  • 5
    • 0032536542 scopus 로고    scopus 로고
    • Interleukin 6 is required for the development of collagen-induced arthritis
    • Alonzi T, Fattori E, Lazzaro D, et al. Interleukin 6 is required for the development of collagen-induced arthritis. J Exp Med 1998; 187: 461-8.
    • (1998) J Exp Med , vol.187 , pp. 461-468
    • Alonzi, T.1    Fattori, E.2    Lazzaro, D.3
  • 6
    • 0027293104 scopus 로고
    • Soluble forms of the interleukin-6 signal-transducing receptor component gp130 in human serum possessing a potential to inhibit signals through membrane-anchored gp130
    • Narazaki M, Yasukawa K, Saito T, et al. Soluble forms of the interleukin-6 signal-transducing receptor component gp130 in human serum possessing a potential to inhibit signals through membrane-anchored gp130. Blood 1993; 82: 1120-6.
    • (1993) Blood , vol.82 , pp. 1120-1126
    • Narazaki, M.1    Yasukawa, K.2    Saito, T.3
  • 7
    • 0034810738 scopus 로고    scopus 로고
    • Tissue-specific autoregulation of the stat3 gene and its role in interleukin-6-induced survival signals in T cells
    • Narimatsu M, Maeda H, Itoh S, et al. Tissue-specific autoregulation of the stat3 gene and its role in interleukin-6-induced survival signals in T cells. Mol Cell Biol 2001; 21: 6615-25.
    • (2001) Mol Cell Biol , vol.21 , pp. 6615-6625
    • Narimatsu, M.1    Maeda, H.2    Itoh, S.3
  • 8
    • 0031838041 scopus 로고    scopus 로고
    • Osteoclastic activation is the principal mechanism leading to secondary osteoporosis in rheumatoid arthritis
    • Gough A, Sambrook P, Devlin J, et al. Osteoclastic activation is the principal mechanism leading to secondary osteoporosis in rheumatoid arthritis. J Rheumatol 1998; 25: 1282-9.
    • (1998) J Rheumatol , vol.25 , pp. 1282-1289
    • Gough, A.1    Sambrook, P.2    Devlin, J.3
  • 9
    • 0037323278 scopus 로고    scopus 로고
    • Diagnostic Implications of C-Reactive protein
    • Zimmerman MA, Selzman CH, Cothren C, et al. Diagnostic Implications of C-Reactive protein. Arch Surg 2003; 138: 220-4.
    • (2003) Arch Surg , vol.138 , pp. 220-224
    • Zimmerman, M.A.1    Selzman, C.H.2    Cothren, C.3
  • 10
    • 33847701356 scopus 로고    scopus 로고
    • Characterization of the interleukin (IL)-6 inhibitor IL-6-RFP: Fused receptor domains act as high affinity cytokine binding proteins
    • Metz S, Wiesinger M, Vogt M, et al. Characterization of the interleukin (IL)-6 inhibitor IL-6-RFP: fused receptor domains act as high affinity cytokine binding proteins. J Biol Chem 2007; 282: 1238-48.
    • (2007) J Biol Chem , vol.282 , pp. 1238-1248
    • Metz, S.1    Wiesinger, M.2    Vogt, M.3
  • 11
    • 85049127046 scopus 로고    scopus 로고
    • Study to assess the effect of tocilizumab plus methotrexate on signs and symptoms in patients with moderate to severe active rheumatoid arthritis, accessed 28 March 2007
    • Study to assess the effect of tocilizumab plus methotrexate on signs and symptoms in patients with moderate to severe active rheumatoid arthritis. [http://www.clinicaltrials.gov/ct/show/NCT 00106548?order =1] (accessed 28 March 2007).
  • 12
    • 0036899812 scopus 로고    scopus 로고
    • Therapeutic benefit of blocking interleukin-6 activity with an anti-interleukin-6 receptor monoclonal antibody in rheumatoid arthritis: A randomized, doubleblind, placebo-controlled, dose-escalation trial
    • Choy EH, Isenberg DA, Garrood T, et al. Therapeutic benefit of blocking interleukin-6 activity with an anti-interleukin-6 receptor monoclonal antibody in rheumatoid arthritis: a randomized, doubleblind, placebo-controlled, dose-escalation trial. Arthritis Rheum 2002; 46: 3143-50.
    • (2002) Arthritis Rheum , vol.46 , pp. 3143-3150
    • Choy, E.H.1    Isenberg, D.A.2    Garrood, T.3
  • 13
    • 2642558925 scopus 로고    scopus 로고
    • Treatment of rheumatoid arthritis with humanized antiinterleukin-6 receptor antibody: A multicenter, doubleblind, placebo-controlled trial
    • Nishimoto N, Yoshizaki K, Miyasaka N, et al. Treatment of rheumatoid arthritis with humanized antiinterleukin-6 receptor antibody: a multicenter, doubleblind, placebo-controlled trial. Arthritis Rheum 2004; 50: 1761-9.
    • (2004) Arthritis Rheum , vol.50 , pp. 1761-1769
    • Nishimoto, N.1    Yoshizaki, K.2    Miyasaka, N.3
  • 14
    • 0033046593 scopus 로고    scopus 로고
    • The multifaceted regulation of interleukin-15 expression and the role of this cytokine in NK cell differentiation and host response to intracellular pathogens
    • Waldmann TA, Tagaya Y. The multifaceted regulation of interleukin-15 expression and the role of this cytokine in NK cell differentiation and host response to intracellular pathogens. Annu Rev Immunol 1999; 17: 19-49.
    • (1999) Annu Rev Immunol , vol.17 , pp. 19-49
    • Waldmann, T.A.1    Tagaya, Y.2
  • 15
    • 33746488770 scopus 로고    scopus 로고
    • Clinical significance of IL-18, IL-15, IL-12 and TNF-α measurement in rheumatoid arthritis
    • Petrovic-Rackov L, Pejnovic N. Clinical significance of IL-18, IL-15, IL-12 and TNF-α measurement in rheumatoid arthritis. Clin Rheumatol 2006; 25: 448-52.
    • (2006) Clin Rheumatol , vol.25 , pp. 448-452
    • Petrovic-Rackov, L.1    Pejnovic, N.2
  • 16
    • 0030022275 scopus 로고    scopus 로고
    • The role of interleukin-15 in T-cell migration and activation in rheumatoid arthritis
    • McInnes IB, Al-Mughales J, Field M, et al. The role of interleukin-15 in T-cell migration and activation in rheumatoid arthritis. Nat Med 1996; 2: 175-82.
    • (1996) Nat Med , vol.2 , pp. 175-182
    • McInnes, I.B.1    Al-Mughales, J.2    Field, M.3
  • 17
    • 0034161692 scopus 로고    scopus 로고
    • High levels of IL-17 in rheumatoid arthritis patients: IL-15 triggers in vitro IL-17 production via cyclosporin A-sensitive mechanism
    • Ziolkowska M, Koc A, Luszczykiewicz G, et al. High levels of IL-17 in rheumatoid arthritis patients: IL-15 triggers in vitro IL-17 production via cyclosporin A-sensitive mechanism. J Immunol 2000; 164: 2832-8.
    • (2000) J Immunol , vol.164 , pp. 2832-2838
    • Ziolkowska, M.1    Koc, A.2    Luszczykiewicz, G.3
  • 18
    • 34247155347 scopus 로고    scopus 로고
    • Emerging cytokine targets in rheumatoid arthritis
    • Asqith DL, McInnes IB. Emerging cytokine targets in rheumatoid arthritis. Curr Opin Rheum 2007; 19: 246-51.
    • (2007) Curr Opin Rheum , vol.19 , pp. 246-251
    • Asqith, D.L.1    McInnes, I.B.2
  • 19
    • 0032103993 scopus 로고    scopus 로고
    • Soluble IL-15 receptor α-chain administration prevents murine collagen-induced arthritis: A role for IL-15 in development of antigen-induced immunopathology
    • Ruchatz H, Leung BP, Wei XQ, et al. Soluble IL-15 receptor α-chain administration prevents murine collagen-induced arthritis: a role for IL-15 in development of antigen-induced immunopathology. J Immunol 1998; 160: 5654-60
    • (1998) J Immunol , vol.160 , pp. 5654-5660
    • Ruchatz, H.1    Leung, B.P.2    Wei, X.Q.3
  • 20
    • 0343183719 scopus 로고    scopus 로고
    • Targeting the IL-15receptor with an antagonist IL-15 mutant/Fc gamma2a protein blocks delayedtype hypersensitivity
    • Kim YS, Maslinski W, Zheng XX, et al. Targeting the IL-15receptor with an antagonist IL-15 mutant/Fc gamma2a protein blocks delayedtype hypersensitivity. J Immunol 1998; 160: 5742-8.
    • (1998) J Immunol , vol.160 , pp. 5742-5748
    • Kim, Y.S.1    Maslinski, W.2    Zheng, X.X.3
  • 21
    • 6344269986 scopus 로고    scopus 로고
    • Targeting IL-15 receptor-bearing cells with an antagonist mutant IL-15/Fc protein prevents disease development and progression in murine collageninduced arthritis
    • Ferrari-Lacraz S, Zanelli E, Neuberg M, et al. Targeting IL-15 receptor-bearing cells with an antagonist mutant IL-15/Fc protein prevents disease development and progression in murine collageninduced arthritis. J Immunol 2004; 173: 5818-26.
    • (2004) J Immunol , vol.173 , pp. 5818-5826
    • Ferrari-Lacraz, S.1    Zanelli, E.2    Neuberg, M.3
  • 22
    • 34247155347 scopus 로고    scopus 로고
    • Emerging cytokine targets in rheumatoid arthritis
    • Asqith DL, McInnes IB. Emerging cytokine targets in rheumatoid arthritis. Curr Opin Rheum 2007; 19: 246-51.
    • (2007) Curr Opin Rheum , vol.19 , pp. 246-251
    • Asqith, D.L.1    McInnes, I.B.2
  • 23
    • 14844289358 scopus 로고    scopus 로고
    • Safety and efficacy of a human monoclonal antibody to IL-15 (AMG 714) in patients with rheumatoid arthritis (RA): Results from a multicenter, randomized, double-blind, placebo-controlled trial
    • McInnes I, Martin R, Zimmerman-Gorska I, et al. Safety and efficacy of a human monoclonal antibody to IL-15 (AMG 714) in patients with rheumatoid arthritis (RA): results from a multicenter, randomized, double-blind, placebo-controlled trial. Arthritis Rheum 2004; (50 Suppl): S241.
    • (2004) Arthritis Rheum , Issue.50
    • McInnes, I.1    Martin, R.2    Zimmerman-Gorska, I.3
  • 24
    • 25444519432 scopus 로고    scopus 로고
    • Targeting interleukin-15 in patients with rheumatoid arthritis: A proof-of-concept study
    • Baslund B, Tvede N, Danneskiold-Samsoe B, et al. Targeting interleukin-15 in patients with rheumatoid arthritis: a proof-of-concept study. Arthritis Rheum 2005; 52: 2686-92.
    • (2005) Arthritis Rheum , vol.52 , pp. 2686-2692
    • Baslund, B.1    Tvede, N.2    Danneskiold-Samsoe, B.3
  • 25
    • 5644289875 scopus 로고    scopus 로고
    • IL-17 induces production of IL-6 and IL-8 in rheumatoid arthritis synovial fibroblasts via NF-kB-and PI3-kinase/Akt-dependent pathways
    • Hwang SY, Kim JY, Kim KW, et al. IL-17 induces production of IL-6 and IL-8 in rheumatoid arthritis synovial fibroblasts via NF-kB-and PI3-kinase/Akt-dependent pathways. Arthritis Res Ther 2004; 6: R120-8.
    • (2004) Arthritis Res Ther , vol.6 , pp. R120-R128
    • Hwang, S.Y.1    Kim, J.Y.2    Kim, K.W.3
  • 26
    • 0038518197 scopus 로고    scopus 로고
    • The role of IL-17 and family members in the pathogenesis of arthritis
    • Lubberts E. The role of IL-17 and family members in the pathogenesis of arthritis. Curr Opin Investig Drugs 2003; 4: 572-7.
    • (2003) Curr Opin Investig Drugs , vol.4 , pp. 572-577
    • Lubberts, E.1
  • 27
    • 13444256307 scopus 로고    scopus 로고
    • The role of T-cell interleukin-17 in conducting destructive arthritis: Lessons from animal models
    • Lubberts E, Koenders MI, van den Berg WB. The role of T-cell interleukin-17 in conducting destructive arthritis: lessons from animal models. Arthritis Res Ther 2005; 7: 29-37.
    • (2005) Arthritis Res Ther , vol.7 , pp. 29-37
    • Lubberts, E.1    Koenders, M.I.2    Van Den Berg, W.B.3
  • 28
    • 35748973565 scopus 로고    scopus 로고
    • IL-17 enhances chemokine gene expression through mRNA stabilization
    • Hartupee J, Liu C, Novotny M, Li X, Hamilton T. IL-17 enhances chemokine gene expression through mRNA stabilization. J Immunol 2007; 179: 4135-41.
    • (2007) J Immunol , vol.179 , pp. 4135-4141
    • Hartupee, J.1    Liu, C.2    Novotny, M.3    Li, X.4    Hamilton, T.5
  • 29
    • 5644277476 scopus 로고    scopus 로고
    • Interleukin 17 family members and information
    • Kalb JK, Linden A. Interleukin 17 family members and information. Immunity 2004; 21: 467-76.
    • (2004) Immunity , vol.21 , pp. 467-476
    • Kalb, J.K.1    Linden, A.2
  • 30
    • 33845576001 scopus 로고    scopus 로고
    • Up-regulation of IL-23p19 expression in rheumatoid arthritis synovial fibroblasts by IL-17 through PI3-kinase-, NF-kB and p38 MAPK dependent signaling pathways
    • Kim HR, Cho ML, Kim KW, et al. Up-regulation of IL-23p19 expression in rheumatoid arthritis synovial fibroblasts by IL-17 through PI3-kinase-, NF-kB and p38 MAPK dependent signaling pathways. Rheumatology 2007; 46: 57-64.
    • (2007) Rheumatology , vol.46 , pp. 57-64
    • Kim, H.R.1    Cho, M.L.2    Kim, K.W.3
  • 31
    • 0344585384 scopus 로고    scopus 로고
    • Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice
    • Nakae S, Nambu A, Sudo K, Iwakura Y. Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice. J Immunol 2003; 171: 6173-7.
    • (2003) J Immunol , vol.171 , pp. 6173-6177
    • Nakae, S.1    Nambu, A.2    Sudo, K.3    Iwakura, Y.4
  • 32
    • 1642317684 scopus 로고    scopus 로고
    • Interleukin-17: The missing link between T-cell accumulation and effector cell actions in rheumatoid arthritis?
    • Stamp LK, James MJ, Cleland LG. Interleukin-17: the missing link between T-cell accumulation and effector cell actions in rheumatoid arthritis? Immunol Cell Biol 2004; 82: 1-9.
    • (2004) Immunol Cell Biol , vol.82 , pp. 1-9
    • Stamp, L.K.1    James, M.J.2    Cleland, L.G.3
  • 33
    • 0036188478 scopus 로고    scopus 로고
    • Reduction of joint inflammation and bone erosion in rat adjuvant arthritis by treatment with interleukin-17 receptor IgG1 Fc fusion protein
    • Bush KA, Farmer KM, Walker JS, Kirkham BW. Reduction of joint inflammation and bone erosion in rat adjuvant arthritis by treatment with interleukin-17 receptor IgG1 Fc fusion protein. Arthritis Rheum 2002; 46: 802-5.
    • (2002) Arthritis Rheum , vol.46 , pp. 802-805
    • Bush, K.A.1    Farmer, K.M.2    Walker, J.S.3    Kirkham, B.W.4
  • 34
    • 1042267236 scopus 로고    scopus 로고
    • Treatment with a neutralizing antimurine interleukin-17 antibody after the onset of collagen induced arthritis reduces joint inflammation, cartilage destruction, and bone erosion
    • Lubberts E, Koenders MI, Oppers-Walgreen B, et al. Treatment with a neutralizing antimurine interleukin-17 antibody after the onset of collagen induced arthritis reduces joint inflammation, cartilage destruction, and bone erosion. Arthritis Rheum 2004; 50: 650-9.
    • (2004) Arthritis Rheum , vol.50 , pp. 650-659
    • Lubberts, E.1    Koenders, M.I.2    Oppers-Walgreen, B.3
  • 35
    • 33646490259 scopus 로고    scopus 로고
    • Interleukin-17 acts independently of TNF-α under arthritic conditions
    • Koenders MI, Lubberts E, van de Loo FA, et al. Interleukin-17 acts independently of TNF-α under arthritic conditions. J Immunol 2006; 176: 6262-9.
    • (2006) J Immunol , vol.176 , pp. 6262-6269
    • Koenders, M.I.1    Lubberts, E.2    Van De Loo, F.A.3
  • 36
    • 33751254750 scopus 로고    scopus 로고
    • Vaccination against IL-17 suppresses autoimmune arthritis and encephalomyelitis
    • Rohn TA, Jennings GT, Hernandez M, et al. Vaccination against IL-17 suppresses autoimmune arthritis and encephalomyelitis. Eur J Immunol 2006; 36: 2857-67.
    • (2006) Eur J Immunol , vol.36 , pp. 2857-2867
    • Rohn, T.A.1    Jennings, G.T.2    Hernandez, M.3
  • 37
    • 0032939156 scopus 로고    scopus 로고
    • Human interleukin-17: A T cell-derived proinflammatory cytokine produced by the rheumatoid synovium
    • Chabaud M, Durand JM, Buchs N, et al. Human interleukin-17: a T cell-derived proinflammatory cytokine produced by the rheumatoid synovium. Arthritis Rheum 1999; 42: 963-70.
    • (1999) Arthritis Rheum , vol.42 , pp. 963-970
    • Chabaud, M.1    Durand, J.M.2    Buchs, N.3
  • 38
    • 0033134608 scopus 로고    scopus 로고
    • IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis
    • Kotake S, Udagawa N, Takahashi N, et al. IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis. J Clin Invest 1999; 103: 1345-52.
    • (1999) J Clin Invest , vol.103 , pp. 1345-1352
    • Kotake, S.1    Udagawa, N.2    Takahashi, N.3
  • 39
    • 33751231101 scopus 로고    scopus 로고
    • Anticytokine vaccines and the immunotherapy of autoimmune diseases
    • Wraith DC. Anticytokine vaccines and the immunotherapy of autoimmune diseases. Eur J Immunol 2006; 36: 2844-8.
    • (2006) Eur J Immunol , vol.36 , pp. 2844-2848
    • Wraith, D.C.1
  • 40
    • 0033538468 scopus 로고    scopus 로고
    • BLyS: Member of the tumor necrosis factor family and B lymphocyte stimulator
    • Moore PA, Belvedere O, Orr A, et al. BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator. Science 1999; 285: 260-3.
    • (1999) Science , vol.285 , pp. 260-263
    • Moore, P.A.1    Belvedere, O.2    Orr, A.3
  • 41
    • 0033522907 scopus 로고    scopus 로고
    • Identification and characterization of a novel cytokine, THANK, a TNF homologue that activates apoptosis, nuclear factor-kB, and c-Jun NH2-terminal kinase
    • Mukhopadhyay A, Ni J, Zhai Y, Yu G-L. Aggarwal BB. Identification and characterization of a novel cytokine, THANK, a TNF homologue that activates apoptosis, nuclear factor-kB, and c-Jun NH2-terminal kinase. J Biol Chem 1999; 274: 15978-81.
    • (1999) J Biol Chem , vol.274 , pp. 15978-15981
    • Mukhopadhyay, A.1    Ni, J.2    Zhai, Y.3    Yu, G.-L.4    Aggarwal, B.B.5
  • 42
    • 0034729769 scopus 로고    scopus 로고
    • Interaction of the TNF homologues BLyS and APRIL with the receptor homologues BCMA and TACI
    • Marsters SA, Yan M, Pitti RM, Haas PE, Dixit VM, Ashkenazi A. Interaction of the TNF homologues BLyS and APRIL with the receptor homologues BCMA and TACI. Curr Biol 2000; 10: 785-8.
    • (2000) Curr Biol , vol.10 , pp. 785-788
    • Marsters, S.A.1    Yan, M.2    Pitti, R.M.3    Haas, P.E.4    Dixit, V.M.5    Ashkenazi, A.6
  • 43
    • 0034606225 scopus 로고    scopus 로고
    • A soluble form of B cell maturation antigen, a receptor for the tumor necrosis factor family member APRIL, inhibits tumor cell growth
    • Rennert P, Schneider P, Cachero TG, et al. A soluble form of B cell maturation antigen, a receptor for the tumor necrosis factor family member APRIL, inhibits tumor cell growth. J Exp Med 2000; 192: 1677-84.
    • (2000) J Exp Med , vol.192 , pp. 1677-1684
    • Rennert, P.1    Schneider, P.2    Cachero, T.G.3
  • 45
    • 0034972257 scopus 로고    scopus 로고
    • Elevated serum B lymphocyte stimulator levels in patients with systemic immune based rheumatic diseases
    • Cheema GS, Roschke V, Hilbert DM, Stohl W. Elevated serum B lymphocyte stimulator levels in patients with systemic immune based rheumatic diseases. Arthritis Rheum 2001; 44: 1313-9.
    • (2001) Arthritis Rheum , vol.44 , pp. 1313-1319
    • Cheema, G.S.1    Roschke, V.2    Hilbert, D.M.3    Stohl, W.4
  • 46
    • 27644461904 scopus 로고    scopus 로고
    • BLyS and APRIL in rheumatoid arthritis
    • Seyler TM, Park YW, Takemura S, et al. BLyS and APRIL in rheumatoid arthritis. J Clin Invest 2005; 115: 3083-92.
    • (2005) J Clin Invest , vol.115 , pp. 3083-3092
    • Seyler, T.M.1    Park, Y.W.2    Takemura, S.3
  • 47
    • 0036144353 scopus 로고    scopus 로고
    • Association of BAFF/BLyS over expression and altered B cell differentiation with Sjögren’s syndrome
    • Groom J, Kalled SL, Cutler AH, et al. Association of BAFF/BLyS over expression and altered B cell differentiation with Sjögren’s syndrome. J Clin Invest 2002; 109: 59-68.
    • (2002) J Clin Invest , vol.109 , pp. 59-68
    • Groom, J.1    Kalled, S.L.2    Cutler, A.H.3
  • 48
    • 0034918211 scopus 로고    scopus 로고
    • TACI-ligand interactions are required for T cell activation and collagen-induced arthritis in mice
    • Wang H, Marsters SA, Baker T, et al. TACI-ligand interactions are required for T cell activation and collagen-induced arthritis in mice. Nat Immunol 2001; 2: 632-7.
    • (2001) Nat Immunol , vol.2 , pp. 632-637
    • Wang, H.1    Marsters, S.A.2    Baker, T.3
  • 49
    • 17944375043 scopus 로고    scopus 로고
    • TACI-Ig neutralizes molecules critical for B cell development and autoimmune disease: Impaired B cell maturation in mice lacking BLyS
    • Gross JA, Dillon SR, Mudri S, et al. TACI-Ig neutralizes molecules critical for B cell development and autoimmune disease: impaired B cell maturation in mice lacking BLyS. Immunity 2001; 15: 289-302.
    • (2001) Immunity , vol.15 , pp. 289-302
    • Gross, J.A.1    Dillon, S.R.2    Mudri, S.3
  • 51
    • 1942500129 scopus 로고    scopus 로고
    • Signal transduction in rheumatoid arthritis
    • Sweeney SE, Firestein GS. Signal transduction in rheumatoid arthritis. Curr Opin Rheumatol 2004; 16: 231-7.
    • (2004) Curr Opin Rheumatol , vol.16 , pp. 231-237
    • Sweeney, S.E.1    Firestein, G.S.2
  • 52
    • 0142156224 scopus 로고    scopus 로고
    • Signal transduction networks in rheumatoid arthritis
    • Hammaker D, Sweeney SE, Firestein GS. Signal transduction networks in rheumatoid arthritis. Ann Rheum Dis 2003; 62(Suppl 2): ii86-9.
    • (2003) Ann Rheum Dis , vol.62
    • Hammaker, D.1    Sweeney, S.E.2    Firestein, G.S.3
  • 53
    • 0037216749 scopus 로고    scopus 로고
    • Mitogen activated protein (MAP) kinase signal transduction pathways and novel anti-inflammatory targets
    • Hommes DW, Peppelenbosch MP, von Deventer SJH. Mitogen activated protein (MAP) kinase signal transduction pathways and novel anti-inflammatory targets. Gut 2003; 52: 144-51.
    • (2003) Gut , vol.52 , pp. 144-151
    • Hommes, D.W.1    Peppelenbosch, M.P.2    Von Deventer, S.J.H.3
  • 54
    • 0037032817 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases
    • Johnson GL, Lapadat R. Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science 2002; 298: 1911-2.
    • (2002) Science , vol.298 , pp. 1911-1912
    • Johnson, G.L.1    Lapadat, R.2
  • 55
    • 0036162009 scopus 로고    scopus 로고
    • Mitogen-activated protein kinases
    • Saman A, Ronald M. Mitogen-activated protein kinases. Crit Care Med 2002; 30: S74-9.
    • (2002) Crit Care Med , vol.30 , pp. S74-S79
    • Saman, A.1    Ronald, M.2
  • 56
    • 0033758633 scopus 로고    scopus 로고
    • Activation, differential localization, and regulation of the stress-activated protein kinases, extracellular signal-regulated kinase, c-JUN Nterminal kinase, and p38 mitogen-activated protein kinase, in synovial tissue and cells in rheumatoid arthritis
    • Schett G, Tohidast-Akrad M, Smolen JS, et al. Activation, differential localization, and regulation of the stress-activated protein kinases, extracellular signal-regulated kinase, c-JUN Nterminal kinase, and p38 mitogen-activated protein kinase, in synovial tissue and cells in rheumatoid arthritis. Arthritis Rheum 2000; 43: 2501-2.
    • (2000) Arthritis Rheum , vol.43 , pp. 2501-2502
    • Schett, G.1    Tohidast-Akrad, M.2    Smolen, J.S.3
  • 57
    • 0035000643 scopus 로고    scopus 로고
    • Suppression of the clinical and cytokine response to endotoxin by RWJ-67657, a p38 mitogenactivated protein kinase inhibitor, in healthy human volunteers
    • Fijen J, Zijlstra J, De Boer P, et al. Suppression of the clinical and cytokine response to endotoxin by RWJ-67657, a p38 mitogenactivated protein kinase inhibitor, in healthy human volunteers. Clin Exp Immunol 2001; 124: 16-20.
    • (2001) Clin Exp Immunol , vol.124 , pp. 16-20
    • Fijen, J.1    Zijlstra, J.2    De Boer, P.3
  • 58
    • 1542784431 scopus 로고    scopus 로고
    • Expression and activation of mitogenactivated protein kinase kinases-3 and-6 in rheumatoid arthritis
    • Chabaud-Riou M, Firestein GS. Expression and activation of mitogenactivated protein kinase kinases-3 and-6 in rheumatoid arthritis. Am J Pathol 2004; 164: 177-84.
    • (2004) Am J Pathol , vol.164 , pp. 177-184
    • Chabaud-Riou, M.1    Firestein, G.S.2
  • 59
    • 0033145354 scopus 로고    scopus 로고
    • MAPKAP kinase 2 is essential for LPS-induced TNF-alpha biosynthesis
    • Kotlyarov A, Neininger A, Schubert C, et al. MAPKAP kinase 2 is essential for LPS-induced TNF-alpha biosynthesis. Nat Cell Biol 1999; 1: 94-7.
    • (1999) Nat Cell Biol , vol.1 , pp. 94-97
    • Kotlyarov, A.1    Neininger, A.2    Schubert, C.3
  • 60
    • 15444370901 scopus 로고    scopus 로고
    • Regulation of p38 MAPK by MAPK kinases 3 and 6 in fibroblast-like synoviocytes
    • Inoue T, Hammaker D, Boyle DL, Firestein GS. Regulation of p38 MAPK by MAPK kinases 3 and 6 in fibroblast-like synoviocytes. J Immunol 2005; 174: 4301-6.
    • (2005) J Immunol , vol.174 , pp. 4301-4306
    • Inoue, T.1    Hammaker, D.2    Boyle, D.L.3    Firestein, G.S.4
  • 61
    • 0038179379 scopus 로고    scopus 로고
    • Inhibitors of p38 mitogen-activated protein kinase for the treatment of rheumatoid arthritis
    • Pargellis C, Regan J. Inhibitors of p38 mitogen-activated protein kinase for the treatment of rheumatoid arthritis. Curr Opin Investig Drugs 2003; 4: 566-71.
    • (2003) Curr Opin Investig Drugs , vol.4 , pp. 566-571
    • Pargellis, C.1    Regan, J.2
  • 62
    • 0028605318 scopus 로고
    • A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
    • Lee JC, Laydon JT, McDonnell PC, et al. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature 1994; 372: 739-46.
    • (1994) Nature , vol.372 , pp. 739-746
    • Lee, J.C.1    Laydon, J.T.2    McDonnell, P.C.3
  • 63
    • 7244254315 scopus 로고    scopus 로고
    • Effects of RWJ 67657, a p38 mitogen activated protein kinase (MAPK) inhibitor, on the production of inflammatory mediators by rheumatoid synovial fibroblasts
    • Westra J, Limburg PC, de Boer P, van Rijswijk MH. Effects of RWJ 67657, a p38 mitogen activated protein kinase (MAPK) inhibitor, on the production of inflammatory mediators by rheumatoid synovial fibroblasts. Ann Rheum Dis 2004; 63: 1453-9.
    • (2004) Ann Rheum Dis , vol.63 , pp. 1453-1459
    • Westra, J.1    Limburg, P.C.2    De Boer, P.3    Van Rijswijk, M.H.4
  • 64
    • 0033136947 scopus 로고    scopus 로고
    • The Role of p38 mitogen-activated protein kinase in IL-1β transcription
    • Baldassare JJ, Bi Y, Bellone CJ. The Role of p38 mitogen-activated protein kinase in IL-1β transcription. J Immunol 1999; 162: 5367-73.
    • (1999) J Immunol , vol.162 , pp. 5367-5373
    • Baldassare, J.J.1    Bi, Y.2    Bellone, C.J.3
  • 65
    • 9144251043 scopus 로고    scopus 로고
    • A novel mechanism for TNF-α regulation by p38 MAPK: Involvement of NF-kB with implications for therapy in rheumatoid arthritis
    • Campbell J, Ciesielsk CJ, Hunt AE, et al. A novel mechanism for TNF-α regulation by p38 MAPK: Involvement of NF-kB with implications for therapy in rheumatoid arthritis. J Immunol 2004; 173: 6928-37.
    • (2004) J Immunol , vol.173 , pp. 6928-6937
    • Campbell, J.1    Ciesielsk, C.J.2    Hunt, A.E.3
  • 66
    • 31144468296 scopus 로고    scopus 로고
    • Protein expression of TNF-α in psoriatic skin is regulated at a posttranscriptional level by MAPKactivated protein kinase 2
    • Johansen C, Funding AT, Otkjaer K, et al. Protein expression of TNF-α in psoriatic skin is regulated at a posttranscriptional level by MAPKactivated protein kinase 2. J Immunol 2006; 176: 1431-8.
    • (2006) J Immunol , vol.176 , pp. 1431-1438
    • Johansen, C.1    Funding, A.T.2    Otkjaer, K.3
  • 67
    • 0141788311 scopus 로고    scopus 로고
    • Prevention of the onset and progression of collagen-induced arthritis in rats by the potent p38 mitogen-activated protein kinase inhibitor FR 167653.
    • Nishikawa M, Myoui A, Tomita T, et al. Prevention of the onset and progression of collagen-induced arthritis in rats by the potent p38 mitogen-activated protein kinase inhibitor FR 167653. Arthritis Rheum 2003; 48: 2670-81.
    • (2003) Arthritis Rheum , vol.48 , pp. 2670-2681
    • Nishikawa, M.1    Myoui, A.2    Tomita, T.3
  • 68
    • 0034613188 scopus 로고    scopus 로고
    • Involvement of p38 mitogen-activated protein kinase signaling pathway in osteoclastogenesis mediated by receptor activator of NF-kappaB ligand (RANKL)
    • Matsumoto M, Sudo T, Saito T, Osada H, Tsujimoto M. Involvement of p38 mitogen-activated protein kinase signaling pathway in osteoclastogenesis mediated by receptor activator of NF-kappaB ligand (RANKL). J Biol Chem 2000; 275: 31155-61.
    • (2000) J Biol Chem , vol.275 , pp. 31155-31161
    • Matsumoto, M.1    Sudo, T.2    Saito, T.3    Osada, H.4    Tsujimoto, M.5
  • 69
    • 0036321005 scopus 로고    scopus 로고
    • P38 MAPK-mediated signals are required for inducing osteoclast differentiation but not for osteoclast function
    • Li X, Udagawa N, Itoh K, et al. p38 MAPK-mediated signals are required for inducing osteoclast differentiation but not for osteoclast function. Endocrinology 2002; 143: 3105-13
    • (2002) Endocrinology , vol.143 , pp. 3105-3113
    • Li, X.1    Udagawa, N.2    Itoh, K.3
  • 70
    • 0025259989 scopus 로고
    • IL-6 is produced by osteoblasts and induces bone resorption
    • Ishimi Y, Miyaura C, Jin CH, et al. IL-6 is produced by osteoblasts and induces bone resorption. J Immunol 1990; 145: 3297-303.
    • (1990) J Immunol , vol.145 , pp. 3297-3303
    • Ishimi, Y.1    Miyaura, C.2    Jin, C.H.3
  • 71
    • 0035040946 scopus 로고    scopus 로고
    • IL-1-and TNF-induced bone resorption is mediated by p38 mitogen activated protein kinase
    • Kumar S, Votta BJ, Rieman DJ, Badger AM, Gowen M, Lee JC. IL-1-and TNF-induced bone resorption is mediated by p38 mitogen activated protein kinase. J Cell Physiol 2002; 187: 294-303.
    • (2002) J Cell Physiol , vol.187 , pp. 294-303
    • Kumar, S.1    Votta, B.J.2    Rieman, D.J.3    Badger, A.M.4    Gowen, M.5    Lee, J.C.6
  • 72
    • 43049158204 scopus 로고    scopus 로고
    • MAPKs and their relevance to arthritis and inflammation
    • PMID: 18187523
    • Thalhamer T, McGrath MA, Harnett MM. MAPKs and their relevance to arthritis and inflammation. Rheumatology 2008; (PMID: 18187523).
    • (2008) Rheumatology
    • Thalhamer, T.1    McGrath, M.A.2    Harnett, M.M.3
  • 73
    • 29144443866 scopus 로고    scopus 로고
    • Therapies for rheumatoid arthritis; hope springs eternal
    • Smit RJ. Therapies for rheumatoid arthritis; hope springs eternal. Drug Discov Today 2005; 10: 1598-6.
    • (2005) Drug Discov Today , vol.10 , pp. 1598-1606
    • Smit, R.J.1
  • 74
    • 33750341495 scopus 로고    scopus 로고
    • Mitogen activated protein kinase inhibitors: Where are we now and where are we going?
    • Sweeney SE, Firestein GS. Mitogen activated protein kinase inhibitors: where are we now and where are we going? Ann Rheum Dis 2006; 65: iii83-8.
    • (2006) Ann Rheum Dis , vol.65
    • Sweeney, S.E.1    Firestein, G.S.2
  • 75
    • 0034931503 scopus 로고    scopus 로고
    • C-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis
    • Han Z, Boyle D, Chang L, et al. c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis. J Clin Invest 2001; 108: 73-81.
    • (2001) J Clin Invest , vol.108 , pp. 73-81
    • Han, Z.1    Boyle, D.2    Chang, L.3
  • 76
    • 0036188479 scopus 로고    scopus 로고
    • Joint damage and inflammation in c-Jun N-terminal kinase 2 knockout mice with passive murine collagen-induced arthritis
    • Han Z, Chang L, Yamanishi Y, et al. Joint damage and inflammation in c-Jun N-terminal kinase 2 knockout mice with passive murine collagen-induced arthritis. Arthritis Rheum 2002; 46: 818-23.
    • (2002) Arthritis Rheum , vol.46 , pp. 818-823
    • Han, Z.1    Chang, L.2    Yamanishi, Y.3
  • 77
    • 0141676444 scopus 로고    scopus 로고
    • Expression of the MAPK kinases MKK-4 and MKK-7 in rheumatoid arthritis and their role as key regulators of JNK
    • Sundarrajan M, Boyle DL, Chabaud-Riou M, et al. Expression of the MAPK kinases MKK-4 and MKK-7 in rheumatoid arthritis and their role as key regulators of JNK. Arthritis Rheum 2003; 48: 2450-60.
    • (2003) Arthritis Rheum , vol.48 , pp. 2450-2460
    • Sundarrajan, M.1    Boyle, D.L.2    Chabaud-Riou, M.3
  • 79
    • 1842583599 scopus 로고    scopus 로고
    • Tumor promoter-induced MMP-13 gene expression in a model of initiated epidermis
    • Zeliadt NA, Warmka JK, Winston SE, et al. Tumor promoter-induced MMP-13 gene expression in a model of initiated epidermis. Biochem Biophys Res Commun 2004; 317: 570-7.
    • (2004) Biochem Biophys Res Commun , vol.317 , pp. 570-577
    • Zeliadt, N.A.1    Warmka, J.K.2    Winston, S.E.3
  • 80
    • 4344697340 scopus 로고    scopus 로고
    • Critical roles of c-Jun signaling in regulation of NFAT family and RANKL-regulated osteoclast differentiation
    • Ikeda F, Nishimura R, Matsubara T, et al. Critical roles of c-Jun signaling in regulation of NFAT family and RANKL-regulated osteoclast differentiation. J Clin Invest 2004; 114: 475-84.
    • (2004) J Clin Invest , vol.114 , pp. 475-484
    • Ikeda, F.1    Nishimura, R.2    Matsubara, T.3
  • 81
    • 0035937747 scopus 로고    scopus 로고
    • Estrogen decreases osteoclast formation by down-regulating receptor activator of NFkappa B ligand (RANKL)-induced JNK activation
    • Srivastava S, Toraldo G, Weitzmann MN, et al. Estrogen decreases osteoclast formation by down-regulating receptor activator of NFkappa B ligand (RANKL)-induced JNK activation. J Biol Chem 2001; 276: 8836-40.
    • (2001) J Biol Chem , vol.276 , pp. 8836-8840
    • Srivastava, S.1    Toraldo, G.2    Weitzmann, M.N.3
  • 82
    • 0037236049 scopus 로고    scopus 로고
    • Control of fibroblast-like synoviocyte proliferation by macrophage migration inhibitory factor
    • Lacey D, Sampey A, Mitchell R, et al. Control of fibroblast-like synoviocyte proliferation by macrophage migration inhibitory factor. Arthritis Rheum 2003; 48: 103-9.
    • (2003) Arthritis Rheum , vol.48 , pp. 103-109
    • Lacey, D.1    Sampey, A.2    Mitchell, R.3
  • 85
    • 21844449963 scopus 로고    scopus 로고
    • Inhibition of ERK phosphorylation decreases nociceptive behavior in monoarthritic rats
    • Cruz CD, Neto FL, Castro-Lopes J, McMahon SB, Cruz F. Inhibition of ERK phosphorylation decreases nociceptive behavior in monoarthritic rats. Pain 2005; 116: 411-9.
    • (2005) Pain , vol.116 , pp. 411-419
    • Cruz, C.D.1    Neto, F.L.2    Castro-Lopes, J.3    McMahon, S.B.4    Cruz, F.5
  • 86
    • 0344222192 scopus 로고    scopus 로고
    • Sequence DNA damage-independent and-dependent activation of NF-kB by UV
    • Bender K, Gottlicher M, Whiteside S, Rahmsdorf HJ, Herrlich P. Sequence DNA damage-independent and-dependent activation of NF-kB by UV. EMBO J 1998; 17: 5170-81.
    • (1999) EMBO J , vol.17 , pp. 5170-5181
    • Bender, K.1    Gottlicher, M.2    Whiteside, S.3    Rahmsdorf, H.J.4    Herrlich, P.5
  • 87
    • 0029563524 scopus 로고
    • Nuclear factor-kB in rheumatoid synovium: Localization of p50 and p 65
    • Handel ML, McMorrow LB, Gravallese EM. Nuclear factor-kB in rheumatoid synovium: localization of p50 and p 65. Arthritis Rheum 1995; 38: 1762-70.
    • (1995) Arthritis Rheum , vol.38 , pp. 1762-1770
    • Handel, M.L.1    McMorrow, L.B.2    Gravallese, E.M.3
  • 88
    • 0035865090 scopus 로고    scopus 로고
    • NF-kB regulation by IkB kinase-2 in rheumatoid arthritis synoviocytes
    • Aupperle K, Bennett B, Han Z, et al. NF-kB regulation by IkB kinase-2 in rheumatoid arthritis synoviocytes. J Immunol 2001; 166: 2705-11.
    • (2001) J Immunol , vol.166 , pp. 2705-2711
    • Aupperle, K.1    Bennett, B.2    Han, Z.3
  • 89
    • 0030201173 scopus 로고    scopus 로고
    • Inflammatory cytokines induce intercellular adhesion molecule-1 (ICAM-1) mRNA synthesis and protein secretion by human retinal pigment epithelial cell cultures
    • Nagineni CN, Kutty RK, Detrick B, Hooks JJ. Inflammatory cytokines induce intercellular adhesion molecule-1 (ICAM-1) mRNA synthesis and protein secretion by human retinal pigment epithelial cell cultures. Cytokine 1996; 8: 622-30.
    • (1996) Cytokine , vol.8 , pp. 622-630
    • Nagineni, C.N.1    Kutty, R.K.2    Detrick, B.3    Hooks, J.J.4
  • 90
    • 0034892866 scopus 로고    scopus 로고
    • Inhibitor of nuclear factor kB kinase βis a key regulator of synovial inflammation
    • Tak PP, Gerlag DM, Aupperle KB, et al. Inhibitor of nuclear factor kB kinase βis a key regulator of synovial inflammation. Arthritis Rheum 2001; 44: 1897-901.
    • (2001) Arthritis Rheum , vol.44 , pp. 1897-1901
    • Tak, P.P.1    Gerlag, D.M.2    Aupperle, K.B.3
  • 91
    • 0038575364 scopus 로고    scopus 로고
    • Heterogeneous requirement of IkB kinase 2 for inflammatory cytokine and matrix metalloproteinase production in rheumatoid arthritis. Implications for therapy
    • Andreakos E, Smith C, Kiriakidis S, et al. Heterogeneous requirement of IkB kinase 2 for inflammatory cytokine and matrix metalloproteinase production in rheumatoid arthritis. Implications for therapy. Arthritis Rheum 2003; 48: 1901-12.
    • (2003) Arthritis Rheum , vol.48 , pp. 1901-1912
    • Andreakos, E.1    Smith, C.2    Kiriakidis, S.3
  • 92
    • 0041355495 scopus 로고    scopus 로고
    • A selective IKK-2 inhibitor blocks NF-kB-dependent gene expression in interleukin-1k-stimulated synovial fibroblasts
    • Kishore N, Sommers C, Mathialagan S, et al. A selective IKK-2 inhibitor blocks NF-kB-dependent gene expression in interleukin-1k-stimulated synovial fibroblasts. J Biol Chem 2003; 278: 32861-71.
    • (2003) J Biol Chem , vol.278 , pp. 32861-32871
    • Kishore, N.1    Sommers, C.2    Mathialagan, S.3
  • 93
    • 0141676361 scopus 로고    scopus 로고
    • A highly selective inhibitor of IkB kinase, BMS-345541, blocks both joint inflammation and destruction in collagen-induced arthritis in mice
    • McIntyre KW, Shuster DJ, Gillooly KM, et al. A highly selective inhibitor of IkB kinase, BMS-345541, blocks both joint inflammation and destruction in collagen-induced arthritis in mice. Arthritis Rheum 2003; 48: 2652-9.
    • (2003) Arthritis Rheum , vol.48 , pp. 2652-2659
    • McIntyre, K.W.1    Shuster, D.J.2    Gillooly, K.M.3
  • 94
    • 0038363463 scopus 로고    scopus 로고
    • Triggering the interferon antiviral response through an IKK-related pathway
    • Sharma S, TenOever BR, Grandvaux N, et al. Triggering the interferon antiviral response through an IKK-related pathway. Science 2003; 300: 1148-51.
    • (2003) Science , vol.300 , pp. 1148-1151
    • Sharma, S.1    Tenoever, B.R.2    Grandvaux, N.3
  • 95
    • 0038374178 scopus 로고    scopus 로고
    • IKKi/IKKε plays a key role in integrating signals induced by pro-inflammatory stimuli
    • Kravchenko VV, Mathison JC, Schwamborn K, et al. IKKi/IKKε plays a key role in integrating signals induced by pro-inflammatory stimuli. J Biol Chem 2003; 278: 26612-9.
    • (2003) J Biol Chem , vol.278 , pp. 26612-26619
    • Kravchenko, V.V.1    Mathison, J.C.2    Schwamborn, K.3
  • 96
    • 0035950978 scopus 로고    scopus 로고
    • Expression and regulation of inducible IkappaB kinase (IKK-i) in human fibroblastlike synoviocytes
    • Aupperle KR, Yamanishi Y, Bennett BL, et al. Expression and regulation of inducible IkappaB kinase (IKK-i) in human fibroblastlike synoviocytes. Cell Immunol 2001; 214: 54-9.
    • (2001) Cell Immunol , vol.214 , pp. 54-59
    • Aupperle, K.R.1    Yamanishi, Y.2    Bennett, B.L.3
  • 97
    • 11144357258 scopus 로고    scopus 로고
    • ESE-1 is a novel transcriptional mediator of angiopoietin-1 expression in the setting of inflammation
    • Brown C, Gaspar J, Pettit A, et al. ESE-1 is a novel transcriptional mediator of angiopoietin-1 expression in the setting of inflammation. J Biol Chem 2004; 279: 12794-803.
    • (2004) J Biol Chem , vol.279 , pp. 12794-12803
    • Brown, C.1    Gaspar, J.2    Pettit, A.3
  • 98
    • 0037653338 scopus 로고    scopus 로고
    • Responses to the proinflammatory cytokines interleukin-1 and tumor necrosis factor α in cells derived from rheumatoid synovium and other joint tissues involve nuclear factor kB-mediated induction of the Ets transcription factor ESE-1
    • Grall F, Gu X, Tan L, et al. Responses to the proinflammatory cytokines interleukin-1 and tumor necrosis factor α in cells derived from rheumatoid synovium and other joint tissues involve nuclear factor kB-mediated induction of the Ets transcription factor ESE-1. Arthritis Rheum 2003; 48: 1249-60.
    • (2003) Arthritis Rheum , vol.48 , pp. 1249-1260
    • Grall, F.1    Gu, X.2    Tan, L.3
  • 99
    • 0038659368 scopus 로고    scopus 로고
    • NF-kB-dependent lymphocyte hyperadhesiveness to synovial fibroblasts by hypoxia and reoxygenation: Potential role in rheumatoid arthritis
    • Han M, Kim J, Park B, et al. NF-kB-dependent lymphocyte hyperadhesiveness to synovial fibroblasts by hypoxia and reoxygenation: potential role in rheumatoid arthritis. J Leukoc Biol 2003; 73: 525-9.
    • (2003) J Leukoc Biol , vol.73 , pp. 525-529
    • Han, M.1    Kim, J.2    Park, B.3
  • 100
    • 0036901163 scopus 로고    scopus 로고
    • Bcl-3 is an interleukin-1-responsive gene in chondrocytes and synovial fibroblasts that activates transcription of the matrix metalloproteinase 1 gene
    • Elliott S, Coon C, Hays E, et al. Bcl-3 is an interleukin-1-responsive gene in chondrocytes and synovial fibroblasts that activates transcription of the matrix metalloproteinase 1 gene. Arthritis Rheum 2002; 46: 3230-9.
    • (2002) Arthritis Rheum , vol.46 , pp. 3230-3239
    • Elliott, S.1    Coon, C.2    Hays, E.3
  • 101
    • 0033623180 scopus 로고    scopus 로고
    • Integration of the NF-kB and mitogen-activated protein kinase/AP-1 pathways at the collagenase-1 promoter: Divergence of IL-1 and TNF-dependent signal transduction in rabbit primary synovial fibroblasts
    • Barchowsky A, Frleta D, Vincenti MP. Integration of the NF-kB and mitogen-activated protein kinase/AP-1 pathways at the collagenase-1 promoter: divergence of IL-1 and TNF-dependent signal transduction in rabbit primary synovial fibroblasts. Cytokine 2000; 12: 1469-79.
    • (2000) Cytokine , vol.12 , pp. 1469-1479
    • Barchowsky, A.1    Frleta, D.2    Vincenti, M.P.3
  • 102
    • 0033851463 scopus 로고    scopus 로고
    • Interleukin-1 induction of collagenase 3 (Matrix metalloproteinase 13) gene expression in chondrocytes requires p38, c-Jun N-terminal kinase, and nuclear factor kB-differential regulation of collagenase 1 and collagenase 3
    • Mengshol JA, Vincenti MP, Coon CI, Barchowsky A, Brinckerhoff CE. Interleukin-1 induction of collagenase 3 (matrix metalloproteinase 13) gene expression in chondrocytes requires p38, c-Jun N-terminal kinase, and nuclear factor kB-differential regulation of collagenase 1 and collagenase 3. Arthritis Rheum 2000; 43: 801-11.
    • (2000) Arthritis Rheum , vol.43 , pp. 801-811
    • Mengshol, J.A.1    Vincenti, M.P.2    Coon, C.I.3    Barchowsky, A.4    Brinckerhoff, C.E.5
  • 103
    • 0034041595 scopus 로고    scopus 로고
    • Stimulation of 92-kd gelatinase (Matrix metalloproteinase 9) production by interleukin-17 in human monocyte/macrophages-a possible role in rheumatoid arthritis
    • Jovanovic DV, Martel-Pelletier J, Di Battista JA, et al. Stimulation of 92-kd gelatinase (matrix metalloproteinase 9) production by interleukin-17 in human monocyte/macrophages-a possible role in rheumatoid arthritis. Arthritis Rheum 2000; 43: 1134-44.
    • (2000) Arthritis Rheum , vol.43 , pp. 1134-1144
    • Jovanovic, D.V.1    Martel-Pelletier, J.2    Di Battista, J.A.3
  • 104
    • 0031285250 scopus 로고    scopus 로고
    • Activation of the I-kBαkinase complex by MEKK1, a kinase of the JNK pathway
    • Lee FS, Hagler J, Chen ZJJ, Maniatis T. Activation of the I-kBα kinase complex by MEKK1, a kinase of the JNK pathway. Cell 1997; 88: 213-22.
    • (1997) Cell , vol.88 , pp. 213-222
    • Lee, F.S.1    Hagler, J.2    Chen, Z.3    Maniatis, T.4
  • 105
    • 0033829852 scopus 로고    scopus 로고
    • Mitogen-activated kinase kinase kinase 1 regulates T cell receptor-and CD28-mediated signaling events which lead to NF-kB activation
    • Tuosto L, Costanzo A, Guido F, et al. Mitogen-activated kinase kinase kinase 1 regulates T cell receptor-and CD28-mediated signaling events which lead to NF-kB activation. Eur J Immunol 2000; 30: 2445-54.
    • (2000) Eur J Immunol , vol.30 , pp. 2445-2454
    • Tuosto, L.1    Costanzo, A.2    Guido, F.3
  • 106
    • 0033559545 scopus 로고    scopus 로고
    • The Jun kinase cascade is responsible for activating the CD28 response element of the IL-2 promoter: Proof of cross-talk with the IκB kinase cascade
    • Kempiak SJ, Hiura TS, Nel AE. The Jun kinase cascade is responsible for activating the CD28 response element of the IL-2 promoter: proof of cross-talk with the IκB kinase cascade. J Immunol 1999; 162: 3176-87.
    • (1999) J Immunol , vol.162 , pp. 3176-3187
    • Kempiak, S.J.1    Hiura, T.S.2    Nel, A.E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.