Targeting the IL-15 receptor with an antagonist IL-15 mutant/Fcγ2a protein blocks delayed-type hypersensitivity

Journal of Immunology

Volumn 160, Issue 12, 1998, Pages 5742-5748

  Kim, Yon Su ^a,b   Maslinski, Wlodzimierz ^a,b,d   Zheng, Xin Xiao ^a,b   Stevens, A Christopher ^a,b   Li, Xian Chang ^a,b   Tesch, Gregory H ^a,c   Kelley, Vicki R ^a,c   Strom, Terry B ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d INSTITUTE OF RHEUMATOLOGY   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

FC RECEPTOR; INTERLEUKIN 15; INTERLEUKIN RECEPTOR;

ANIMAL CELL; ANTIGEN SPECIFICITY; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL MUTANT; CELL PROLIFERATION; COMPETITIVE INHIBITION; DELAYED HYPERSENSITIVITY; DRUG RECEPTOR BINDING; GENE TARGETING; IMMUNE RESPONSE; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN METABOLISM; TARGET CELL;

ANIMALS; CELL DIVISION; DNA-BINDING PROTEINS; HALF-LIFE; HUMANS; HYPERSENSITIVITY, DELAYED; INTERLEUKIN-15; MICE; MICE, INBRED BALB C; MILK PROTEINS; PHOSPHORYLATION; RECEPTORS, IGG; RECEPTORS, INTERLEUKIN-15; RECEPTORS, INTERLEUKIN-2; RECOMBINANT FUSION PROTEINS; STAT3 TRANSCRIPTION FACTOR; STAT5 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS; TYROSINE;

EID: 0343183719     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Finkelman, F. D., and C. Maliszewski, 1997. Enhancing cytokine effects in vivo. Immunologist 5:10.
2. Bamford, R., A. Grant, J. Burton, C. Peters, G. Kurys, C. Goldman, J. Brennan, E. Roessler, and T. Waldmann. 1994. The interleukin (IL) 2 receptor β chain is shared by IL-2 and a cytokine, provisionally designated IL-T, that stimulates T-cell proliferation and the induction of lymphokine-activated killer cells. Proc. Natl. Acad. Sci. USA 91:4940.
3. Carson, W. E., J. G. Giri, M. J. Lindemann, M. L. Linett, M. Ahdieh, R. Paxton, D. Anderson, J. Eisenmann, K. Grabstein, and M. A. Caligiuri. 1994. Interleukin (IL) 15 is a novel cytokine that activates human natural killer cells via components of the IL-2 receptor. J. Exp. Med. 180:1395.
4. Bamford, R. N., Y. Tagaya, and T. A. Waldman. 1997. Interleukin 15: what it does and how it is controlled. Immunologist 5:52.
5. Giri, J. G., D. M. Anderson, S. Kumaki, L. S. Park, K. H. Grabstein, and D. Cosman. 1995. IL-15, a novel T cell growth factor that shares activities and receptor components with IL-2. J. Leukocyte Biol. 57:763.
6. Grabstein, K. H., J. Eisenman, K. Shanebeck, C. Rauch, S. Srinivasan, V. Fung, C. Beers, J. Richardson, M. A. Schoenborn, M. Ahdieh, L. Johnson. M. R. Alderson, J. D. Watson, D. M. Anderson, and J. G. Giri. 1994, Cloning of a T cell factor that interacts with the β chain of the interleukin-2 receptor. Science 264:965.
7. Wilkinson, P. C., and F. Y. Liew. 1995. Chemoattraction of human blood T lymphocytes by interleukin-15. J. Exp. Med. 1995:1255.
8. Carson, D. A. 1997. Unconventional T-cell activation by IL-15 in rheumatoid arthritis. Nat. Med. 3:148.
9. McInnes, I. B., J. Al-Mugahles, M. Field, B. P. Huang, R. P. Huang, R. Dixon, R. D. Sturrock, P. C. Wilkinson, and F. Y. Liew. 1996. The role of interleukin-15 in T-cell migration and activation in rheumatoid arthritis. Nat. Med. 2:175.
10. McInnes, I. B., B. P. Leung, R. D. Sturrock, M. Field, and F. Y. Liew. 1997. Interleukin-15 mediates T cell-dependent regulation of tumor necrosis factor-α production in rheumatoid arthritis, Nat. Med. 3:189.
11. Kirman, I., and O. H. Nielson. 1996. Increased numbers of interleukin-15-expressing cells in active colitis. Am. J. Gastroenterol. 91:1789.
12. Strehlau, J., M. Pavlakis, M. Lipman, M. Shapiro, L. Vasconcellos, W. Harmon. and T. B. Strom. 1997. Quantitative detection of immune activation transcripts as a diagnostic tool in kidney transplantation. Proc. Natl. Acad. Sci. USA 94:695.
13. Pavlakis, M., J. Strehlau, M. Lipman, M. Shapiro, W. Maslinski, and T. B. Strom. 1996. Intragraft IL-15 transcripts are increased in human renal allograft rejection. Transplantation 62:543.
14. Anderson, D. M., S. Kumaki, M. Ahdieh, J. Bertles, M. Tometsko, A. Loomis, J. Giri, N. G. Copeland, D. J. Gilbert, N. A. Jenkins, V. Valentine, D. N. Shapiro, S. W. Morris, L. S. Park, and D. Cosman. 1995. Functional characterization of the human interleukin-15 receptor α chain and close linkage of IL-15Rα and IL-2Rα genes. J. Biol. Chem. 270:29862.
15. Giri, J. G., M. Ahdieh, J. Eisenman, K. Shanebeck. K. Grabstein, S. Kumaki, A. Namen, L. S. Park, D. Cosman, and D. Anderson. 1994. Utilisation of the β and γ chains of the IL-2 receptor by the novel cytokine IL-15. EMBO J. 13:2822.
16. Giri, J. G., S. Kumaki, M. Ahdieh, D. J. Friend, A. Loomis, K. Shanebeck. R. DuBose, D. Cosman, L. S. Park, and D. M. Anderson. 1995. Identification and cloning of a novel IL-15 binding protein that is structurally related to the a chain of the IL-2 receptor. EMBO J. 14:3654.
17. Nickerson, P., X. X. Zheng, J. Steiger, A. W. Steele, W. Steurer, P. Roy-Chaudhury, W. Muller, and T. B. Strom. 1996. Prolonged islet allograft acceptance in the absence of interleukin 4 expression. Transplant Immunol. 4:81.
18. Landolfi, N. 1991. A chimeric IL-2/Ig molecule possesses the functional activity of both proteins. J. Immunol. 146:915.
19. Zheng, X. X., A. W. Steele, P. W. Nickerson, W. Steurer, J. Steiger, and T. B. Strom. 1995. Administration of noncytolytic IL-10/Fc in murine models of lipopolysaccharide-induced septic shock and allogeneic islet transplantation. J. Immunol. 154:5590.
20. Pettit, D. K., T. P. Bonnert, J. Eisenman, S. Srinivasan, R. Paxton, C. Beers, D. Lynch, B. Miller, J. Yost, K. H. Grabstein, and W. R. Gombotz. 1997. Structure-function studies of interleukin 15 using site-specific mutagenesis, polyethylene glycol conjugation, and homology modeling. J. Biol. Chem. 272:2312.
21. Chae, D.-W., Y. Nosaka, T. B. Strom, and W. Maslinski. 1996. Distribution of IL-15 receptor α-chains on human peripheral blood mononuclear cells and effect of immunosuppressive drugs on receptor expression. J. Immunol. 157:2813.
22. Stevens, A. C., J. Matthews, P. Andres, V. Baffis, X. X. Zheng, D.-W. Chae, J. Smith, T. B. Strom, and W. Maslinski. 1997. Interleukin-15 signals T84 colonic epithelial cells in the absence of the interleukin-2 receptor β-chain. Am. J. Physiol 272:G1201.
23. Johnston, J. A., M. Kawamura, R. A. Kirken, Y.-Q. Chen. T. B. Blake, K. Shibuya, J. R. Ortaldo, D. W. Me Vicar, and J. J. O'Shea. 1994. Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2. Nature 370:151.
24. Lin, J.-X., T.-S. Migone, M. Tsang, M. Friedman, J. A. Weatherbee, L. Zhou, A. Yamauchi, E. T. Bloom, J. Mietz, S. John, and W. J. Leonard. 1995. The role of shared receptor motifs and common Stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15, Immunity 2:331.
25. c receptor-ligand complex. J. Immunol. 156:1339.
26. Quinn, L. S., K. L. Haugk, and K. H. Grabstein. 1995. Interleukin-15: a novel anabolic cytokine for skeletal muscle. Endocrinology 136:3669.
27. Agostini, C. L. Trentin, M. Facco, R. Sancetta, A. Cerutti, C. Tassinari, L. Cimarosto, F. Adami, A. Cipriani, R. Zambello, and G. Semenzato. 1996. Role of IL-15, IL-12, and their receptors in the development of T cell alveolitis in pulmonary sarcoidosis. J. Immunol. 157:910.
28. Zurawski, S. M., and G. Zurawski. 1992. Receptor antagonist and selective agonist derivatives of mouse interleukin-2. EMBO J. 11:3905.
29. Flores-Villanueva, P. O., X. X. Zheng, T. B. Strom, and M. J. Stadecker. 1996. Recombinant IL-10 and IL-10/Fc treatment down-regulate egg antigen-specific delayed hypersensitivity reactions and egg granuloma formation in schistosomiasis. J. Immunol. 156:3315.
30. Bastos, M. G., O. Pankewycz, V. E. Kelley, J. R. Murphy, and T. B. Strom. 1990. Concomitant administration of hapten and IL-2-toxin (DAB486-IL-2) results in specific deletion of antigen-activated T cell clones. J. Immunol. 145:3535.
31. Dieli, F., G. L. Andersen, S. C. Romano, G. Sireci, F. Gervasi, and A. Salerno. 1994. IL-4 is essential for the systemic transfer of delayed hypersensitivity by T cell line. J. Immunol. 152:2698.
32. Cher, D. J., and T. R. Mosmann. 1987. Two types of murine helper T cell clone. II. Delayed-type hypersensitivity is mediated by Th1 clones. J. Immunol. 138: 3688.
33. Li, L., J. F. Elliott, and T. R. Mosmann. 1994. IL-10 inhibits cytokine production, vascular leakage, and swelling during T helper 1 cell-induced delayed-type hypersensitivity. J. Immunol. 153:3967.