-
1
-
-
1942438028
-
Microtubules as a target for anticancer drugs
-
Jordan MA, Wilson L. Microtubules as a target for anticancer drugs. Nat Rev Cancer 2004;4:253-265 •• A review on microtubule and microtubule targeted drugs. (Pubitemid 38525281)
-
(2004)
Nature Reviews Cancer
, vol.4
, Issue.4
, pp. 253-265
-
-
Jordan, M.A.1
Wilson, L.2
-
2
-
-
33947717002
-
Anticancer drugs from nature - Natural products as a unique source of new microtubule-stabilizing agents
-
DOI 10.1039/b515619j
-
Altmann K-H, Gertsch J. Anticancer drugs from nature - natural products as a unique source of new microtubule-stabilizing agents. Nat Prod Rep 2007;24:327-357 •• A recent and comprehensive review on natural products based MSAs and their derivatives. (Pubitemid 46504987)
-
(2007)
Natural Product Reports
, vol.24
, Issue.2
, pp. 327-357
-
-
Altmann, K.-H.1
Gertsch, J.2
-
3
-
-
17844379231
-
A molecular-mechanical model of the microtubule
-
DOI 10.1529/biophysj.104.051789
-
Molodtsov MI, Ermakova EA, Shnol EE, et al. A molecular-mechanical model of the microtubule. Biophys J 2005;88:3167-3179 (Pubitemid 40586570)
-
(2005)
Biophysical Journal
, vol.88
, Issue.5
, pp. 3167-3179
-
-
Molodtsov, M.I.1
Ermakova, E.A.2
Shnol, E.E.3
Grishchuk, E.L.4
McIntosh, J.R.5
Ataullakhanov, F.I.6
-
4
-
-
0035889710
-
Novel molecules that interact with microtubules and have functional activity similar to Taxol
-
DOI 10.1016/S1359-6446(01)02038-4, PII S1359644601020384
-
He L, Orr GA, Horwitz SB. Novel molecules that interact with microtubules and have functional activity similar to Taxol. Drug Discov Today 2001;6:1153-1164 (Pubitemid 32999054)
-
(2001)
Drug Discovery Today
, vol.6
, Issue.22
, pp. 1153-1164
-
-
He, L.1
Orr, G.A.2
Horwitz, S.B.3
-
5
-
-
0035416117
-
Microtubule-stabilizing agents: A growing class of important anticancer drugs
-
DOI 10.1016/S1367-5931(00)00225-8
-
Altmann K-H. Microtubule-stabilizing agents: a growing class of important anticancer drugs. Curr Opin Chem Biol 2001;5:424-431 (Pubitemid 32900515)
-
(2001)
Current Opinion in Chemical Biology
, vol.5
, Issue.4
, pp. 424-431
-
-
Altmann, K.-H.1
-
6
-
-
0141507953
-
Suppression of microtubule dynamics by epothilone
-
Kamath K, Jordan MA. Suppression of microtubule dynamics by epothilone. Cancer Res 2003;63:6026-6031
-
(2003)
Cancer Res
, vol.63
, pp. 6026-6031
-
-
Kamath, K.1
Jordan, M.A.2
-
7
-
-
3142723291
-
Synergistic suppression of microtubule dynamics by discodermolide and paclitaxel in non-small cell lung carcinoma cells
-
DOI 10.1158/0008-5472.CAN-04-0693
-
Honore S, Kamath K, Braguer D, et al. Synergistic suppression of microtubule dynamics by discodermolide and paclitaxel in non-small cell lung carcinoma cells. Cancer Res 2004;64:4957-4964 (Pubitemid 38924543)
-
(2004)
Cancer Research
, vol.64
, Issue.14
, pp. 4957-4964
-
-
Honore, S.1
Kamath, K.2
Braguer, D.3
Horwitz, S.B.4
Wilson, L.5
Briand, C.6
Jordan, M.A.7
-
8
-
-
34249794861
-
Microtubule-associated proteins as targets in cancer chemotherapy
-
DOI 10.1158/1078-0432.CCR-06-3040
-
Bhat KM, Setaluri V. Microtubule-associated proteins as targets in cancer chemotherapy. Clin Cancer Res 2007;13:2849-2854 (Pubitemid 46849557)
-
(2007)
Clinical Cancer Research
, vol.13
, Issue.10
, pp. 2849-2854
-
-
Bhat, K.M.R.1
Setaluri, V.2
-
9
-
-
0030020158
-
Mitotic block induced in HeLa cells by low concentrations of paclitaxel (taxol) results in abnormal mitotic exit and apoptotic cell death
-
Jordan MA, Wendell K, Gardiner S, et al. Mitotic block induced in HeLa cells by low concentrations of paclitaxel (Taxol) results in abnormal mitotic exit and apoptotic cell death. Cancer Res 1996;56:816-825 (Pubitemid 26055472)
-
(1996)
Cancer Research
, vol.56
, Issue.4
, pp. 816-825
-
-
Jordan, M.A.1
Wendell, K.2
Gardiner, S.3
Derry, W.B.4
Copp, H.5
Wilson, L.6
-
10
-
-
0029807822
-
Differential taxol-dependent arrest of transformed and nontransformed cells in the G1 phase of the cell cycle, and specific-related mortality of transformed cells
-
DOI 10.1083/jcb.135.3.689
-
Trielli MO, Andreassen PR, Lacroix FB, et al. Differential taxol-dependent arrest of transformed and nontransformed cells in the G1 phase of the cell cycle, and specific-related mortality of transformed cells. J Cell Biol 1996;135:689-700 (Pubitemid 26372925)
-
(1996)
Journal of Cell Biology
, vol.135
, Issue.3
, pp. 689-700
-
-
Trielli, M.O.1
Andreassen, P.R.2
Lacroix, F.B.3
Margolis, R.L.4
-
11
-
-
0036531790
-
Differential mitotic responses to microtubule-stabilizing and -destabilizing drugs
-
Chen J-GC, Horwitz SB. Differential mitotic responses to microtubule-stabilizing and -destabilizing drugs. Cancer Res 2002;14:1935-1938 (Pubitemid 34408432)
-
(2002)
Cancer Research
, vol.62
, Issue.7
, pp. 1935-1938
-
-
Chen, J.-G.1
Horwitz, S.B.2
-
12
-
-
0345275866
-
Gene Expression and Mitotic Exit Induced by Microtubule-Stabilizing Drugs
-
Chen J-GC, Yang C-PHY, Cammer M, Horwitz SB. Gene expression and mitotic exit induced by microtubule-stabilizing drugs. Cancer Res 2003;15:7891-7899 (Pubitemid 37466724)
-
(2003)
Cancer Research
, vol.63
, Issue.22
, pp. 7891-7899
-
-
Chen, J.-G.1
Yang, C.-P.H.2
Cammer, M.3
Horwitz, S.B.4
-
13
-
-
34548824827
-
Epothilone D, a microtubule-stabilizing compound, inhibits neointimal hyperplasia after rat carotid artery injury by cell cycle arrest via regulation of G1-checkpoint proteins
-
DOI 10.1016/j.vph.2007.06.009, PII S153718910700105X
-
Kim T-J, Lim Y, Kim D-W, et al. Epothilone D, a microtubule-stabilizing compound, inhibits neointimal hyperplasia after rat carotid artery injury by cell cycle arrest via regulation of G1-checkpoint proteins. Vasc Pharmcol 2007;47:229-237 (Pubitemid 47451829)
-
(2007)
Vascular Pharmacology
, vol.47
, Issue.4
, pp. 229-237
-
-
Kim, T.-J.1
Lim, Y.2
Kim, D.-W.3
Kwon, J.-S.4
Son, J.-H.5
Jin, Y.-R.6
Son, D.J.7
Jung, J.-C.8
Avery, M.A.9
Hong, J.T.10
Yun, Y.-P.11
-
14
-
-
0033534641
-
Screening of a library of phage-displayed peptides identifies human Bcl-2 as a Taxol-binding protein
-
DOI 10.1006/jmbi.1998.2303
-
Rodi DJ, Janes RW, Sanganee HJ, et al. Screening of a library of phage-displayed peptides identifies human bcl-2 as a taxol-binding protein. J Mol Biol 1999;285:197-203 (Pubitemid 29034037)
-
(1999)
Journal of Molecular Biology
, vol.285
, Issue.1
, pp. 197-203
-
-
Rodi, D.J.1
Janes, R.W.2
Sanganee, H.J.3
Holton, R.A.4
Wallace, B.A.5
Makowski, L.6
-
15
-
-
0033545932
-
Heat shock protein 90 mediates macrophage activation by Taxol and bacterial lipopolysaccharide
-
DOI 10.1073/pnas.96.10.5645
-
Byrd CA, Bornmann W, Erdjument-Bromage H, et al. Heat shock protein 90 mediates macrophage activation by Taxol and bacterial lipopolysaccharide. Proc Natl Acad Sci USA 1999;96:5645-5650 (Pubitemid 29234672)
-
(1999)
Proceedings of the National Academy of Sciences of the United States of America
, vol.96
, Issue.10
, pp. 5645-5650
-
-
Byrd, C.A.1
Bornmann, W.2
Erdjument-Bromage, H.3
Tempst, P.4
Pavletich, N.5
Rosen, N.6
Nathan, C.F.7
Ding, A.8
-
16
-
-
0033564270
-
Use of a photoactivatable taxol analogue to identify unique cellular targets in murine macrophages: Identification of murine CD18 as a major taxol-binding protein and a role for Mac-1 in taxol-induced gene expression
-
Bhat N, Perera PY, Carboni JM, et al. Use of a photoactivatable taxol analogue to identify unique cellular targets in murine macrophages: identification of murine CD18 as a major taxol-binding protein and a role for Mac-1 in taxol-induced gene expression. J Immunol 1999;162:7335-7342 (Pubitemid 29277709)
-
(1999)
Journal of Immunology
, vol.162
, Issue.12
, pp. 7335-7342
-
-
Bhat, N.1
Perera, P.-Y.2
Carboni, J.M.3
Blanco, J.4
Golenbock, D.T.5
Mayadas, T.N.6
Vogel, S.N.7
-
17
-
-
33845339607
-
Paclitaxel induces calcium oscillations via an inositol 1,4,5-trisphosphate receptor and neuronal calcium sensor 1-dependent mechanism
-
Boehmerle W, Splittgerber U, Lazarus MB, et al. Paclitaxel induces calcium oscillations via an inositol 1,4,5-trisphosphate receptor and neuronal calcium sensor 1-dependent mechanism. Proc Natl Acad Sci USA 2006;103:18356-18361
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 18356-18361
-
-
Boehmerle, W.1
Splittgerber, U.2
Lazarus, M.B.3
-
18
-
-
36849030422
-
Screening of paclitaxel-binding molecules from a library of random peptides displayed on T7 phage particles using paclitaxel-photoimmobilized resin
-
DOI 10.1021/bc700287v
-
Aoki S, Morohashi K, Sunoki T, et al. Screening of paclitaxel-binding molecules from a library of random Peptides displayed on T7 phage particles using paclitaxel-photoimmobilized resin. Bioconjug Chem 2007;18:1981-1986 (Pubitemid 350219999)
-
(2007)
Bioconjugate Chemistry
, vol.18
, Issue.6
, pp. 1981-1986
-
-
Aoki, S.1
Morohashi, K.2
Sunoki, T.3
Kuramochi, K.4
Kobayashi, S.5
Sugawara, F.6
-
19
-
-
55549143335
-
Paclitaxel binding to human and murine MD-2
-
Zimmer SM, Liu J, Clayton JL, et al. Paclitaxel binding to human and murine MD-2. J Biol Chem 2008;283:27916-27926
-
(2008)
J Biol Chem
, vol.283
, pp. 27916-27926
-
-
Zimmer, S.M.1
Liu, J.2
Clayton, J.L.3
-
20
-
-
0034307316
-
Paclitaxel induces release of cytochrome c from mitochondria isolated from human neuroblastoma cells
-
André N, Braguer D, Brasseur G, et al. Paclitaxel induces release of cytochrome c from mitochondria isolated from human neuroblastoma cells. Cancer Res 2000;60:5349-5353 (Pubitemid 30761239)
-
(2000)
Cancer Research
, vol.60
, Issue.19
, pp. 5349-5353
-
-
Andre, N.1
Braguer, D.2
Brasseur, G.3
Goncalves, A.4
Lemesle-Meunier, D.5
Guise, S.6
Jordan, M.A.7
Briand, C.8
-
21
-
-
52949107914
-
Patupilone-induced apoptosis is mediated by mitochondrial reactive oxygen species through Bim relocalization to mitochondria
-
Khawaja NR, Carré M, Kovacic H, et al. Patupilone-induced apoptosis is mediated by mitochondrial reactive oxygen species through Bim relocalization to mitochondria. Mol Pharmacol 2008;74:1072-1083
-
(2008)
Mol Pharmacol
, vol.74
, pp. 1072-1083
-
-
Khawaja, N.R.1
Carré, M.2
Kovacic, H.3
-
22
-
-
0015211527
-
Plant antitumor agents VI. The isolation and structure of taxol a novel anti-leukemic and anti-tumor agent from Taxus brevifolia
-
Wani MC, Taylor HL, Wall ME, et al. Plant antitumor agents VI. The isolation and structure of taxol a novel anti-leukemic and anti-tumor agent from Taxus brevifolia. J Am Chem Soc 1971;93:2325-2327
-
(1971)
J Am Chem Soc
, vol.93
, pp. 2325-2327
-
-
Wani, M.C.1
Taylor, H.L.2
Wall, M.E.3
-
23
-
-
0018387446
-
Promotion of microtubule assembly in vitro by taxol
-
Schiff PB, Fant J, Horwitz SB. Promotion of microtubule assembly in vitro by taxol. Nature 1979;277:665-667 (Pubitemid 9114288)
-
(1979)
Nature
, vol.277
, Issue.5698
, pp. 665-667
-
-
Schiff, P.B.1
Fant, J.2
Horwitz, S.B.3
-
24
-
-
0029063397
-
Structure of tubulin at 6.5Å and location of the taxol-binding site
-
Nogales E, Wolf SG, Khan IA, et al. Structure of tubulin at 6.5Å and location of the taxol-binding site. Nature 1995;375:424-427
-
(1995)
Nature
, vol.375
, pp. 424-427
-
-
Nogales, E.1
Wolf, S.G.2
Khan, I.A.3
-
25
-
-
0033791649
-
Structural insights into microtubule function
-
DOI 10.1146/annurev.biochem.69.1.277
-
Nogales E. Structural insights into microtubule function. Annu Rev Biochem 2000;69:277-302 (Pubitemid 30792211)
-
(2000)
Annual Review of Biochemistry
, vol.69
, pp. 277-302
-
-
Nogales, E.1
-
26
-
-
67649324248
-
Taxane derivatives for targeted therapy of cancer
-
US6191290
-
Safavy A. Taxane derivatives for targeted therapy of cancer. US6191290; 2001
-
(2001)
-
-
Safavy, A.1
-
27
-
-
67649384391
-
Water soluble micelle-forming and biodegradable cyclotriphosphazene-taxol conjugate anticancer agent and preparation method thereof
-
US20070292384
-
Sohn Y-S, Ji D-E, Jun Y-J, Lee H-J. Water soluble micelle-forming and biodegradable cyclotriphosphazene-taxol conjugate anticancer agent and preparation method thereof. US20070292384; 2007
-
(2007)
-
-
Sohn, Y.-S.1
Ji, D.-E.2
Jun, Y.-J.3
Lee, H.-J.4
-
28
-
-
18844462763
-
Oral efficacy and bioavailability of a novel taxane
-
Polizzi D, Pratesi G, Monestiroli S, et al. Oral efficacy and bioavailability of a novel taxane. Clin Cancer Res 2000;6:2070-2074 (Pubitemid 30305107)
-
(2000)
Clinical Cancer Research
, vol.6
, Issue.5
, pp. 2070-2074
-
-
Polizzi, D.1
Pratesi, G.2
Monestiroli, S.3
Tortoreto, M.4
Zunino, F.5
Bombardelli, E.6
Riva, A.7
Morazzoni, P.8
Colombo, T.9
D'Incalci, M.10
Zucchetti, M.11
-
29
-
-
0642349139
-
MAC-321, a novel taxane with greater efficacy than paclitaxel and docetaxel in vitro and in vivo
-
Sampath D, Discafani CM, Loganzo F, et al. MAC-321, a novel taxane with greater efficacy than paclitaxel and docetaxel in vitro and in vivo. Mol Cancer Ther 2003;2:873-884
-
(2003)
Mol Cancer Ther
, vol.2
, pp. 873-884
-
-
Sampath, D.1
Discafani, C.M.2
Loganzo, F.3
-
30
-
-
18444380509
-
Phase I and pharmacokinetics (PK) of DJ-927, an oral taxane, in patients (Pts) with advanced cancers
-
Beeram M, Takinoto CH, Gadgeel S, et al. Phase I and pharmacokinetics (PK) of DJ-927, an oral taxane, in patients (Pts) with advanced cancers. J Clin Oncol 2004;22:2028
-
(2004)
J Clin Oncol
, vol.22
, pp. 2028
-
-
Beeram, M.1
Takinoto, C.H.2
Gadgeel, S.3
-
31
-
-
33644971659
-
A phase I trial of the novel oral taxane BMS-275183 in patients with advanced solid tumors
-
Broker LE, deVos FY, Gall H, et al. A phase I trial of the novel oral taxane BMS-275183 in patients with advanced solid tumors. J Clin Oncol 2004;22:2029
-
(2004)
J Clin Oncol
, vol.22
, pp. 2029
-
-
Broker, L.E.1
DeVos, F.Y.2
Gall, H.3
-
32
-
-
33745202343
-
Preclinical pharmacologic evaluation of MST-997, an orally active taxane with superior in vitro and in vivo efficacy in paclitaxel- And docetaxel-resistant tumor models
-
DOI 10.1158/1078-0432.CCR-05-2349
-
Sampath D, Greenberger LM, Beyer C, et al. Preclinical pharmacologic evaluation of MST-997, and orally active taxane with superior in vitro and in vivo efficacy in paclitaxel- and docetaxel-resistant tumor models. Clin Cancer Res 2006;12:3459-3469 (Pubitemid 43910892)
-
(2006)
Clinical Cancer Research
, vol.12
, Issue.11
, pp. 3459-3469
-
-
Sampath, D.1
Greenberger, L.M.2
Beyer, C.3
Hari, M.4
Liu, H.5
Baxter, M.6
Sharon, Y.7
Rios, C.8
Discafani, C.9
-
34
-
-
41949119102
-
Paclitaxel and docetaxel resistance: Molecular mechanisms and development of new generation taxanes
-
A recent review on SAR studies of taxanes to overcome multi-drug resistance
-
Galletti E, Magnani M, Renzulli ML, Botta M. Paclitaxel and docetaxel resistance: molecular mechanisms and development of new generation taxanes. ChemMedChem 2007;2:920-942 • A recent review on SAR studies of taxanes to overcome multi-drug resistance.
-
(2007)
ChemMedChem
, vol.2
, pp. 920-942
-
-
Galletti, E.1
Magnani, M.2
Renzulli, M.L.3
Botta, M.4
-
35
-
-
0345688612
-
Mechanisms of Taxol resistance related to microtubules
-
DOI 10.1038/sj.onc.1206934, Drug Resistance
-
Orr GA, Verdier-Pinard P, McDaid H, Horwitz SB. Mechanisms of Taxol resistance related to microtubules. Oncogene 2003;22:7280-7295 (Pubitemid 37487160)
-
(2003)
Oncogene
, vol.22
, Issue.47 REV. ISS. 6
, pp. 7280-7295
-
-
Orr, G.A.1
Verdier-Pinard, P.2
McDaid, H.3
Horwitz, S.B.4
-
36
-
-
0033373639
-
Interaction of docetaxel ('Taxotere') with human P-glycoprotein
-
Shirakawa K, Takara K, Tanigawara Y, et al. Interaction of docetaxel ("Taxotere") with human P-glycoprotein. Jpn J Cancer Res 1999;90:1380-1386 (Pubitemid 30032078)
-
(1999)
Japanese Journal of Cancer Research
, vol.90
, Issue.12
, pp. 1380-1386
-
-
Shirakawa, K.1
Takara, K.2
Tanigawara, Y.3
Aoyama, N.4
Kasuga, M.5
Komada, F.6
Sakaeda, T.7
Okumura, K.8
-
38
-
-
44949120890
-
Overcoming tumor drug resistance with high-affinity taxanes: A SAR study of C2-modified 7-acyl-10-deacetyl cephalomannines
-
Yang C-G, Barasoain I, Li X, et al. Overcoming tumor drug resistance with high-affinity taxanes: a SAR study of C2-modified 7-acyl-10-deacetyl cephalomannines. ChemMedChem 2007;2:691-701
-
(2007)
ChemMedChem
, vol.2
, pp. 691-701
-
-
Yang, C.-G.1
Barasoain, I.2
Li, X.3
-
39
-
-
37449017239
-
Looking at drug resistance mechanisms for microtubule interacting drugs: Dose TUBB3 work?
-
Ferlini C, Raspaglio G, Cicchillitti L, et al. Looking at drug resistance mechanisms for microtubule interacting drugs: dose TUBB3 work? Curr Cancer Drug Targets 2007;7:704-712
-
(2007)
Curr Cancer Drug Targets
, vol.7
, pp. 704-712
-
-
Ferlini, C.1
Raspaglio, G.2
Cicchillitti, L.3
-
40
-
-
0030931827
-
Taxol-resistant epithelial ovarian tumors are associated with altered expression of specific β-tubulin isotypes
-
Kavallaris M, Kuo DY-S, Burkhart CA, et al. Taxol-resistant epithelial ovarian tumors are associated with altered expression of specific β-tubulin isotypes. J Clin Invest 1997;100:1282-1293 (Pubitemid 27386315)
-
(1997)
Journal of Clinical Investigation
, vol.100
, Issue.5
, pp. 1282-1293
-
-
Kavallaris, M.1
Kuo, D.Y.-S.2
Burkhart, C.A.3
Regl, D.L.4
Norris, M.D.5
Haber, M.6
Horwitz, S.B.7
-
41
-
-
19944430079
-
Class III β-tubulin overexpression is a prominent mechanism of paclitaxel resistance in ovarian cancer patients
-
Mozzetti S, Ferlini C, Concolino P, et al. Class III β-tubulin overexpression is a prominent mechanism of paclitaxel resistance in ovarian cancer patients. Clin Cancer Res 2005;298:298-305 (Pubitemid 40075808)
-
(2005)
Clinical Cancer Research
, vol.11
, Issue.1
, pp. 298-305
-
-
Mozzetti, S.1
Ferlini, C.2
Concolino, P.3
Filippetti, F.4
Raspaglio, G.5
Prislei, S.6
Gallo, D.7
Martinelli, E.8
Ranelletti, F.O.9
Ferrandina, G.10
Scambia, G.11
-
42
-
-
14544302690
-
Expression of class III β-tubulin in non-small cell lung cancer is correlated with resistance to taxane chemotherapy
-
Dumontet C, Isaac S, Souquet P-J, et al. Expression of class III β-tubulin in non-small cell lung cancer is correlated with resistance to taxane chemotherapy. Bull Cancer 2005;92:E25-30
-
(2005)
Bull Cancer
, vol.92
-
-
Dumontet, C.1
Isaac, S.2
Souquet, P.-J.3
-
43
-
-
30344437279
-
Class III β-tubulin expression in tumor cells predicts response and outcome in patients with non-small cell lung cancer receiving paclitaxel
-
DOI 10.1158/1535-7163.MCT-05-0244
-
Sève P, Mackey J, Isaac S, et al. Class III β-tubulin expression in tumor cells predicts response and outcome in patients with non-small cell lung cancer receiving paclitaxel. Mol Cancer Ther 2005;4:2001-2007 (Pubitemid 43056983)
-
(2005)
Molecular Cancer Therapeutics
, vol.4
, Issue.12
, pp. 2001-2007
-
-
Seve, P.1
Mackey, J.2
Isaac, S.3
Tredan, O.4
Souquet, P.-J.5
Perol, M.6
Lai, R.7
Voloch, A.8
Dumontet, C.9
-
44
-
-
0036290799
-
Increased levels of tyrosinated α-, βIII-, and βIV-tubulin isotypes in paclitaxel-resistant MCF-7 breast cancer cells
-
Banerjee A. Increased levels of tyrosinated α-, βIII-, and βIV-tubulin isotypes in paclitaxel-resistant MCF-7 breast cancer cells. Biochem Biophys Res Commun 2002;293:598-601
-
(2002)
Biochem Biophys Res Commun
, vol.293
, pp. 598-601
-
-
Banerjee, A.1
-
45
-
-
23444443007
-
Alterations of β-tubulin isotypes in breast cancer cells resistant to docetaxel
-
DOI 10.1096/fj.04-3178fje
-
Shalli K, Brown I, Heys SD, Schofield AC. Alterations of β-tubulin isotypes in breast cancer cells resistant to docetaxel. FASEB J 2005;19:1299-1301 (Pubitemid 41113729)
-
(2005)
FASEB Journal
, vol.19
, Issue.10
, pp. 1299-1301
-
-
Shalli, K.1
Brown, I.2
Heys, S.D.3
Schofield, A.C.4
-
46
-
-
33746604292
-
Predictive factors for response to docetaxel in human breast cancers
-
DOI 10.1111/j.1349-7006.2006.00265.x
-
Noguchi S. Predictive factors for response to docetaxel in human breast cancers. Cancer Sci 2006;97:813-820 (Pubitemid 44151259)
-
(2006)
Cancer Science
, vol.97
, Issue.9
, pp. 813-820
-
-
Noguchi, S.1
-
47
-
-
67649347513
-
Tubulin isotype screening in cancer therapy using hemiasterlin analogs
-
US20060148014
-
Agoulnik S, Kuznetsov G, Littlefield BA. Tubulin isotype screening in cancer therapy using hemiasterlin analogs. US20060148014; 2006
-
(2006)
-
-
Agoulnik, S.1
Kuznetsov, G.2
Littlefield, B.A.3
-
48
-
-
67649347513
-
Tubulin isotype screening in cancer therapy using halichondrin B analogs
-
US20060154312
-
Agoulnik S, Kuznetsov G, Littlefield BA. Tubulin isotype screening in cancer therapy using halichondrin B analogs. US20060154312; 2006
-
(2006)
-
-
Agoulnik, S.1
Kuznetsov, G.2
Littlefield, B.A.3
-
49
-
-
16844378550
-
The seco-taxane IDN5390 is able to target class III β-tubulin and to overcome paclitaxel resistance
-
DOI 10.1158/0008-5472.CAN-04-3065
-
Ferlini C, Raspaglio G, Mozzetti S, et al. The seco-taxane IDN5390 is able to target class III β-tubulin and to overcome paclitaxel resistance. Cancer Res 2005;65:2397-405 • Describes a βIII-tubulin-targeting taxane. (Pubitemid 40490151)
-
(2005)
Cancer Research
, vol.65
, Issue.6
, pp. 2397-2405
-
-
Ferlini, C.1
Raspaglio, G.2
Mozzetti, S.3
Cicchillitti, L.4
Filippetti, F.5
Gallo, D.6
Fattorusso, C.7
Campiani, G.8
Scambia, G.9
-
50
-
-
0029049468
-
Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action
-
Bollag DM, McQueney PA, Zhu J, et al. Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action. Cancer Res 1995;55:2325-2333
-
(1995)
Cancer Res
, vol.55
, pp. 2325-2333
-
-
Bollag, D.M.1
McQueney, P.A.2
Zhu, J.3
-
51
-
-
0041629362
-
Microtubule alterations and mutations induced by desoxyepothilone B: Implications for drug-target interactions
-
DOI 10.1016/S1074-5521(03)00141-8
-
Verrills NM, Flemming CL, Liu M, et al. Microtubule alterations and mutations induced by desoxyepothilone B: implications for drug-target interactions. Chem Biol 2003;10:597-607 (Pubitemid 36940936)
-
(2003)
Chemistry and Biology
, vol.10
, Issue.7
, pp. 597-607
-
-
Verrills, N.M.1
Flemming, C.L.2
Liu, M.3
Ivery, M.T.4
Cobon, G.S.5
Norris, M.D.6
Haber, M.7
Kavallaris, M.8
-
52
-
-
3843053396
-
The binding mode of epothilone A on α, β-tubulin by electron crystallography
-
Nettles JH, Li H, Cornett B, et al. The binding mode of epothilone A on α, β-tubulin by electron crystallography. Science 2004;305:866-869
-
(2004)
Science
, vol.305
, pp. 866-869
-
-
Nettles, J.H.1
Li, H.2
Cornett, B.3
-
53
-
-
38949121627
-
Epothilones as lead structures for the synthesis-based discovery of new chemotypes for microtubule stabilization
-
Feyen F, Cachoux F, Gertsch J, et al. Epothilones as lead structures for the synthesis-based discovery of new chemotypes for microtubule stabilization. Acc Chem Res 2008;41:21-31
-
(2008)
Acc Chem Res
, vol.41
, pp. 21-31
-
-
Feyen, F.1
Cachoux, F.2
Gertsch, J.3
-
54
-
-
38449120471
-
Novel tubulin-targeting agents: Anticancer activity and pharmacologic profile of epothilones and related analogues
-
A recent review on Phase I studies of epothilones
-
Fumoleau P, Coudert B, Isambert N, Ferrant E. Novel tubulin-targeting agents: anticancer activity and pharmacologic profile of epothilones and related analogues. Ann Oncol 2007;18(Suppl 5):v9-v15 • A recent review on Phase I studies of epothilones.
-
(2007)
Ann Oncol
, vol.18
, Issue.SUPPL. 5
-
-
Fumoleau, P.1
Coudert, B.2
Isambert, N.3
Ferrant, E.4
-
55
-
-
38449091336
-
Potential clinical applications of epothilones: A review of phase II studies
-
A recent review on Phase II studies of epothilones
-
Larkin JMG, Kaye SB. Potential clinical applications of epothilones: a review of phase II studies. Ann Oncol 2007;18(Suppl 5):v28-34 • A recent review on Phase II studies of epothilones.
-
(2007)
Ann Oncol
, vol.18
, Issue.SUPPL. 5
-
-
Larkin, J.M.G.1
Kaye, S.B.2
-
56
-
-
67649347512
-
Methods of administering epothilone analogs for the treatment of cancer
-
Bristol-Myers Squibb Company. EP1938821
-
Bristol-Myers Squibb Company. Methods of administering epothilone analogs for the treatment of cancer. EP1938821; 2008
-
(2008)
-
-
-
57
-
-
57149135866
-
Preclinical efficacy spectrum and pharmacokinetics of ixabepilone
-
Lee FYF, Smykla R, Johnston K, et al. Preclinical efficacy spectrum and pharmacokinetics of ixabepilone. Cancer Chemother Pharmacol 2009;63:201-212
-
(2009)
Cancer Chemother Pharmacol
, vol.63
, pp. 201-212
-
-
Lee, F.Y.F.1
Smykla, R.2
Johnston, K.3
-
58
-
-
45549107529
-
Epothilones: Clinical update and future directions
-
Williston Park
-
Donovan D, Vahdat LT. Epothilones: clinical update and future directions. Oncology (Williston Park) 2008;22:408-416
-
(2008)
Oncology
, vol.22
, pp. 408-416
-
-
Donovan, D.1
Vahdat, L.T.2
-
59
-
-
34548157209
-
Efficacy and safety of ixabepilone (BMS-247550) in a phase II study of patients with advanced breast cancer resistant to an anthracycline, a taxane, and capecitabine
-
DOI 10.1200/JCO.2006.09.3849
-
Perez EA, Lerzo G, Pivot X, et al. Efficacy and safety of ixabepilone (BMS-247550) in a phase II study of patients with advanced breast cancer resistant to an anthracycline, a taxane, and capecitabine. J Clin Oncol 2007;25:3407-3414 (Pubitemid 47310876)
-
(2007)
Journal of Clinical Oncology
, vol.25
, Issue.23
, pp. 3407-3414
-
-
Perez, E.A.1
Lerzo, G.2
Pivot, X.3
Thomas, E.4
Vahdat, L.5
Bosserman, L.6
Viens, P.7
Cai, C.8
Mullaney, B.9
Peck, R.10
Hortobagyi, G.N.11
-
60
-
-
43549095495
-
Ixabepilone: A novel antineoplastic agent with low susceptibility to multiple tumor resistance mechanisms
-
DOI 10.1634/theoncologist.2007-0167
-
Vahdat L. Ixabepilone: a novel antineoplastic agent with low susceptibility to multiple tumor resistance mechanisms. Oncologist 2008;13:214-221 (Pubitemid 351679896)
-
(2008)
Oncologist
, vol.13
, Issue.3
, pp. 214-221
-
-
Vahdat, L.1
-
61
-
-
45849114756
-
Ixabepilone: A new microtubule-targeting agent for breast cancer
-
Higa GM, Abraham J. Ixabepilone: a new microtubule-targeting agent for breast cancer. Expert Rev Anticancer Ther 2008;8:671-681
-
(2008)
Expert Rev Anticancer Ther
, vol.8
, pp. 671-681
-
-
Higa, G.M.1
Abraham, J.2
-
62
-
-
51849114328
-
Pharmacokinetic profile of the microtubule stabilizer patupilone in tumor-bearing rodents and comparison of anti-cancer activity with other MTS in vitro and in vivo
-
O'Reilly T, Wartmann M, Brueggen J, et al. Pharmacokinetic profile of the microtubule stabilizer patupilone in tumor-bearing rodents and comparison of anti-cancer activity with other MTS in vitro and in vivo. Cancer Chemother Pharmacol 2008;62:1045-1054
-
(2008)
Cancer Chemother Pharmacol
, vol.62
, pp. 1045-1054
-
-
O'Reilly, T.1
Wartmann, M.2
Brueggen, J.3
-
63
-
-
65949105046
-
Sagopilone crosses the blood-brain barrier in vivo to inhibit brain tumor growth and metastases
-
Hoffman J, Fichtmer I, Lemm M, et al. Sagopilone crosses the blood-brain barrier in vivo to inhibit brain tumor growth and metastases. Neuro Oncol 2009;11:158-166
-
(2009)
Neuro Oncol
, vol.11
, pp. 158-166
-
-
Hoffman, J.1
Fichtmer, I.2
Lemm, M.3
-
64
-
-
0025160288
-
Discodermolide: A new bioactive polyhydroxylated lactone from the marine sponge discodermia dissoluta
-
DOI 10.1021/jo00303a029
-
Gunasekera SP, Gunasekera M, Longley RE, Schulte GK. Discodermolide: a new bioactive polyhydroxylated lactone from the marine sponge Discodermia dissoluta. J Org Chem 1990;55:4912-4915 (Pubitemid 20269838)
-
(1990)
Journal of Organic Chemistry
, vol.55
, Issue.16
, pp. 4912-4915
-
-
Gunasekera, S.P.1
Gunasekera, M.2
Longley, R.E.3
-
65
-
-
0025936629
-
Discodermolide-a new, marine-derived immunosuppressive compound. II. in vivo studies
-
Longley RE, Caddigan D, Harmody D, et al. Discodermolide-a new, marine-derived immunosuppressive compound. II. In vivo studies. Transplantation 1991;52:656-661
-
(1991)
Transplantation
, vol.52
, pp. 656-661
-
-
Longley, R.E.1
Caddigan, D.2
Harmody, D.3
-
66
-
-
67649345289
-
Discodermolide compounds, compositions containing same and methods of preparation and use
-
WO9101982
-
Gunasekera M, Gunasekera SP, Longley RE, Burres N. Discodermolide compounds, compositions containing same and methods of preparation and use. WO9101982; 1991
-
(1991)
-
-
Gunasekera, M.1
Gunasekera, S.P.2
Longley, R.E.3
Burres, N.4
-
67
-
-
0030039669
-
Discodermolide, a cytotoxic marine agent that stabilizes microtubules more potently than taxol
-
ter Haar E, Kowalski RJ, Hamel E, et al. Discodermolide, a cytotoxic marine agent that stabilizes microtubules more potently than taxol. Biochemistry 1996;35:243-250
-
(1996)
Biochemistry
, vol.35
, pp. 243-250
-
-
Ter Haar, E.1
Kowalski, R.J.2
Hamel, E.3
-
68
-
-
0030113284
-
(+)-Discodermolide binds to microtubules in stoichiometric ratio to tubulin dimers, blocks taxol binding and results in mitotic arrest
-
Hung DT, Chen J, Schreiber SL. (+)-Discodermolide binds to microtubules in stoichiometric ratio to tubulin dimers, blocks taxol binding and results in mitotic arrest. Chem Biol 1996;3:287-293 (Pubitemid 126663327)
-
(1996)
Chemistry and Biology
, vol.3
, Issue.4
, pp. 287-293
-
-
Hung, D.T.1
Chen, J.2
Schreiber, S.L.3
-
69
-
-
0030761586
-
The microtubule-stabilizing agent discodermolide competitively inhibits the binding of paclitaxel (taxol) to tubulin polymers, enhances tubulin nucleation reactions more potently than paclitaxel, and inhibits the growth of paclitaxel-resistant cells
-
Kowalski RJ, Giannakakou P, Gunasekera SP, et al. The microtubule-stabilizing agent discodermolide competitively inhibits the binding of paclitaxel (Taxol) to tubulin polymers, enhances tubulin nudeation reactions more potently than paclitaxel, and inhibits the growth of paclitaxel-resistant cells. Mol Pharmacol 1997;52:613-622 (Pubitemid 27443983)
-
(1997)
Molecular Pharmacology
, vol.52
, Issue.4
, pp. 613-622
-
-
Kowalski, R.J.1
Giannakakou, P.2
Gunasekera, S.P.3
Longley, R.E.4
Day, B.W.5
Hamel, E.6
-
70
-
-
0034597447
-
The chemistry and biology of discodermolide
-
Kalesse M. The chemistry and biology of discodermolide. ChemBioChem 2000;1:171-175
-
(2000)
ChemBioChem
, vol.1
, pp. 171-175
-
-
Kalesse, M.1
-
71
-
-
0031932291
-
The potent microtubule-stabilizing agent (+)-discodermolide induces apoptosis in human breast carcinoma cells-preliminary comparisons to paclitaxel
-
Balachandran R, ter Haar E, Welsh MJ, et al. The potent microtubule-stabilizing agent (+)-discodermolide induces apoptosis in human breast carcinoma cells-preliminary comparisons to paclitaxel. Anticancer Drugs 1998;9:67-76
-
(1998)
Anticancer Drugs
, vol.9
, pp. 67-76
-
-
Balachandran, R.1
Ter Haar, E.2
Welsh, M.J.3
-
72
-
-
67649384390
-
Discodermolide compounds and pharmaceutical compositions containing them for cancer therapy
-
WO9720835
-
Longley RE, Gunasekera SP, Pomponi S. Discodermolide compounds and pharmaceutical compositions containing them for cancer therapy. WO9720835; 1997
-
(1997)
-
-
Longley, R.E.1
Gunasekera, S.P.2
Pomponi, S.3
-
73
-
-
21744449331
-
The microtubule stabilizing agent discodermolide is a potent inducer of accelerated cell senescence
-
Klein LE, Freeze BS, Smith III AB, Horwitz SB. The microtubule stabilizing agent discodermolide is a potent inducer of accelerated cell senescence. Cell Cycle 2005;4:501-507 (Pubitemid 41359741)
-
(2005)
Cell Cycle
, vol.4
, Issue.3
, pp. 501-507
-
-
Klein, L.E.1
Freeze, B.S.2
Smith III, A.B.3
Horwitz, S.B.4
-
74
-
-
18844469806
-
Taxol and discodermolide represent a synergistic drug combination in human carcinoma cell lines
-
Martello LA, McDaid HM, Regl DL, et al. Taxol and discodermolide represent a synergistic drug combination in human carcinoma cell lines. Clin Cancer Res 2000;6:1978-1987 (Pubitemid 30305097)
-
(2000)
Clinical Cancer Research
, vol.6
, Issue.5
, pp. 1978-1987
-
-
Martello, L.A.1
McDaid, H.M.2
Regl, D.L.3
Yang, C.H.4
Meng, D.5
Pettus, T.R.R.6
Kaufman, M.D.7
Arimoto, H.8
Danishefsky, S.J.9
Smith III, A.B.10
Horwitz, S.B.11
-
75
-
-
78650944001
-
Method for treating neoplasia using combination chemotherapy
-
US20020065234
-
Horwitz SB, McDaid HM, Martello LA. Method for treating neoplasia using combination chemotherapy. US20020065234; 2002
-
(2002)
-
-
Horwitz, S.B.1
McDaid, H.M.2
Martello, L.A.3
-
76
-
-
3142723291
-
Synergistic suppression of microtubule dynamics by discodermolide and paclitaxel in non-small cell lung carcinoma cells
-
DOI 10.1158/0008-5472.CAN-04-0693
-
Honore S, Kamath K, Braguer D, et al. Synergistic suppression of microtubule dynamics by discodermolide and paclitaxel in non-small cell lung carcinoma cells. Cancer Res 2004;64:4957-4964 (Pubitemid 38924543)
-
(2004)
Cancer Research
, vol.64
, Issue.14
, pp. 4957-4964
-
-
Honore, S.1
Kamath, K.2
Braguer, D.3
Horwitz, S.B.4
Wilson, L.5
Briand, C.6
Jordan, M.A.7
-
77
-
-
31544455024
-
Potentiation of taxol efficacy and by discodermolide in ovarian carcinoma xenograft-bearing mice
-
DOI 10.1158/1078-0432.CCR-05-0229
-
Huang GS, Lopez-Barcons L, Freeze BS, et al. Potentiation of taxol efficacy by discodermolide in ovarian carcinoma xenograft-bearing mice. Clin Cancer Res 2006;12:298-304 (Pubitemid 43166207)
-
(2006)
Clinical Cancer Research
, vol.12
, Issue.1
, pp. 298-304
-
-
Huang, G.S.1
Lopez-Barcons, L.2
Freeze, B.S.3
Smith III, A.B.4
Goldberg, G.L.5
Horwitz, S.B.6
McDaid, H.M.7
-
78
-
-
0037900065
-
1,6-Asymmetric induction in boron-mediated aldol reactions: Application to a practical total synthesis of (+)-discodermolide
-
DOI 10.1021/ol0270780
-
Paterson I, Florence GJ. The development of a practical total synthesis of discodermolide, a promising microtubule-stabilizing anticancer agent. Eur J Org Chem 2003;12:2193-2208 (Pubitemid 37140516)
-
(2003)
Organic Letters
, vol.5
, Issue.1
, pp. 35-38
-
-
Paterson, I.1
Delgado, O.2
Florence, G.J.3
Lyothier, I.4
Scott, J.P.5
Sereinig, N.6
-
80
-
-
18644385908
-
Toward understanding how the lactone moiety of discodermolide affects activity
-
DOI 10.1021/ja051185i
-
Shaw SJ, Sundermann KF, Burlingame MA, et al. Toward understanding how the lactone moiety of discodermolide affects activity. J Am Chem Soc 2005;127:6532-6533 (Pubitemid 40664150)
-
(2005)
Journal of the American Chemical Society
, vol.127
, Issue.18
, pp. 6532-6533
-
-
Shaw, S.J.1
Sundermann, K.F.2
Burlingame, M.A.3
Myles, D.C.4
Freeze, B.S.5
Xian, M.6
Brouard, I.7
Smith III, A.B.8
-
81
-
-
34547869791
-
Coumarin-derived discodermolide analogues possessing equivalent antiproliferative activity to the natural product - A further simplification of the lactone region
-
DOI 10.1039/b708884c
-
Shaw SJ, Menzella HG, Myles DC, et al. Coumarin-derived discodermolide analogues possessing equivalent antiproliferative activity to the natural product - a further simplification of the lactone region. Org Biomol Chem 2007;5:2753-2755 (Pubitemid 47258231)
-
(2007)
Organic and Biomolecular Chemistry
, vol.5
, Issue.17
, pp. 2753-2755
-
-
Shaw, S.J.1
Menzella, H.G.2
Myles, D.C.3
Xian, M.4
Smith III, A.B.5
-
82
-
-
13444291392
-
Design, synthesis, and evaluation of carbamate-substituted analogues of (+)-discodermolide
-
Smith III AB, Freeze BS, LaMarche MJ, et al. Design, synthesis, and evaluation of carbamate-substituted analogues of (+)-discodermolide. Org Lett 2005;7:311-314 (Pubitemid 40208696)
-
(2005)
Organic Letters
, vol.7
, Issue.2
, pp. 311-314
-
-
Smith III, A.B.1
Freeze, B.S.2
Lamarche, M.J.3
Hirose, T.4
Brouard, I.5
Rucker, P.V.6
Xian, M.7
Sundermann, K.F.8
Shaw, S.J.9
Burlingame, M.A.10
Horwitz, S.B.11
Myles, D.C.12
-
83
-
-
0034913460
-
Structure-activity relationship studies of discodermolide and its semisynthetic acetylated analogs on microtubule function and cytotoxicity
-
DOI 10.1007/s002800100287
-
Isbrucker RA, Gunasekera SP, Longley RE. Structure-activity relationship studies of discodermolide and its semisynthetic acetylated analogs on microtubule function and cytotoxicity. Cancer Chemother Pharmacol 2001;48:29-36 (Pubitemid 32662433)
-
(2001)
Cancer Chemotherapy and Pharmacology
, vol.48
, Issue.1
, pp. 29-36
-
-
Isbrucker, R.A.1
Gunasekera, S.P.2
Longley, R.E.3
-
84
-
-
0035089418
-
Acetylated analogues of the microtubule-stabilizing agent discodermolide: Preparation and biological activity
-
DOI 10.1021/np000423e
-
Gunasekera SP, Longley RE, Isbrucker RA. Acetylated analogues of the microtubule-stabilizing agent discodermolide: preparation and biological activity. J Nat Prod 2001;64:171-174 (Pubitemid 32198340)
-
(2001)
Journal of Natural Products
, vol.64
, Issue.2
, pp. 171-174
-
-
Gunasekera, S.P.1
Longley, R.E.2
Isbrucker, R.A.3
-
85
-
-
0036853788
-
Five new discodermolide analogues' from the marine sponge Discodermia species
-
DOI 10.1021/np020219m
-
Gunasekera SP, Paul GK, Longley RE, et al. Five new discodermolide analogues from the marine sponge Discodermia species. J Nat Prod 2002;65:1643-1648 (Pubitemid 35386795)
-
(2002)
Journal of Natural Products
, vol.65
, Issue.11
, pp. 1643-1648
-
-
Gunasekera, S.P.1
Paul, G.K.2
Longley, R.E.3
Isbrucker, R.A.4
Pomponi, S.A.5
-
87
-
-
31544473618
-
A phase I pharmacokinetic (PK) trial of XAA296A (Discodermolide) administered every 3 weeks to adult patients with advanced solid malignancies
-
Mita A, Lockhart AC, Chen T-L, et al. A phase I pharmacokinetic (PK) trial of XAA296A (Discodermolide) administered every 3 weeks to adult patients with advanced solid malignancies. J Clin Oncol 2004;22:2025
-
(2004)
J Clin Oncol
, vol.22
, pp. 2025
-
-
Mita, A.1
Lockhart, A.C.2
Chen, T.-L.3
-
89
-
-
0028364041
-
Isolation and structure of the cancer cell growth inhibitor dictyostatin 1
-
Pettit GR, Cichacz ZA, Gao F, et al. Isolation and structure of the cancer cell growth inhibitor dicyostatin 1. J Chem Soc Chem Commun 1994;1994:1111-1112 (Pubitemid 24155638)
-
(1994)
Journal of the Chemical Society - Series Chemical Communications
, Issue.9
, pp. 1111-1112
-
-
Pettit, G.R.1
Cichacz, Z.A.2
Gao, F.3
Boyd, M.R.4
Schmidt, J.M.5
-
90
-
-
67649335100
-
Isolation and structure of dictyostatin 1 and its use as anti-neoplastic agent
-
EP0680958
-
Pettit GR, Cichacz ZA. Isolation and structure of dictyostatin 1 and its use as anti-neoplastic agent. EP0680958; 1995
-
(1995)
-
-
Pettit, G.R.1
Cichacz, Z.A.2
-
91
-
-
0038005594
-
Tubulin polymerizing activity of dictyostatin-1, a polyketide of marine sponge origin
-
DOI 10.1016/S0006-2952(03)00192-8
-
Isbrucker RA, Cummins J, Pomponi SA, et al. Tubulin polymerizing activity of dictyostatin-1, a polyketide of marine sponge origin. Biochem Pharmacol 2003;66:75-82 (Pubitemid 36724901)
-
(2003)
Biochemical Pharmacology
, vol.66
, Issue.1
, pp. 75-82
-
-
Isbrucker, R.A.1
Cummins, J.2
Pomponi, S.A.3
Longley, R.E.4
Wright, A.E.5
-
92
-
-
27744476031
-
Tubulin assembly, taxoid site binding, and cellular effects of the microtubule-stabilizing agent dictyostatin
-
DOI 10.1021/bi050685l
-
Madiraju C, Edler MC, Hamel E, et al. Tubulin assembly, taxoid site binding, and cellular effects of the microtubule-stabilizing agent dictyostatin. Biochemistry 2005;44:15053-15063 (Pubitemid 41612284)
-
(2005)
Biochemistry
, vol.44
, Issue.45
, pp. 15053-15063
-
-
Madiraju, C.1
Edler, M.C.2
Hamel, E.3
Raccor, B.S.4
Balachandran, R.5
Zhu, G.6
Giuliano, K.A.7
Vogt, A.8
Shin, Y.9
Fournier, J.-H.10
Fukui, Y.11
Bruckner, A.M.12
Curran, D.P.13
Day, B.W.14
-
93
-
-
41749125906
-
Development of practical syntheses of the marine anticancer agents discodermolide and dictyostatin
-
Florence GJ, Gardner NM, Paterson I. Development of practical syntheses of the marine anticancer agents discodermolide and dictyostatin. Nat Prod Rep 2008;25:342-375
-
(2008)
Nat Prod Rep
, vol.25
, pp. 342-375
-
-
Florence, G.J.1
Gardner, N.M.2
Paterson, I.3
-
94
-
-
0030984058
-
Eleutherobin, a new cytotoxin that mimics paclitaxel (Taxol) by stabilizing microtubules
-
DOI 10.1021/ja9717828
-
Lindel T, Jensen PR, Fenical W, et al. Eleutherobin, a new cytotoxin class that mimics paclitaxel (Taxol) by stabilizing microtubules. J Am Chem Soc 1997;119:8744-8745 (Pubitemid 27406321)
-
(1997)
Journal of the American Chemical Society
, vol.119
, Issue.37
, pp. 8744-8745
-
-
Lindel, T.1
Jensen, P.R.2
Fenical, W.3
Long, B.H.4
Casazza, A.M.5
Carboni, J.6
Fairchild, C.R.7
-
95
-
-
0032520890
-
Eleutherobin, a novel cytotoxic agent that induces tubulin polymerization, is similar to paclitaxel (taxol®)
-
Long BH, Carboni JM, Wasserman AJ, et al. Eleutherobin, a novel cytotoxic agent that induces tubulin polymerization, is similar to paclitaxel (Taxol®). Cancer Res 1998;58:1111-1115 (Pubitemid 28183193)
-
(1998)
Cancer Research
, vol.58
, Issue.6
, pp. 1111-1115
-
-
Long, B.H.1
Carboni, J.M.2
Wasserman, A.J.3
Cornell, L.A.4
Casazza, A.M.5
Jensen, P.R.6
Lindel, T.7
Fenical, W.8
Fairchild, C.R.9
-
96
-
-
0002551688
-
Sarcodictyins: A new class of marine derivatives with mode of action similar to taxol
-
abstract 30
-
Ciomei M, Albanese C, Pastori W, et al. Sarcodictyins: a new class of marine derivatives with mode of action similar to taxol [abstract 30]. Proc Am Assoc Cancer Res 1997;38:5
-
(1997)
Proc Am Assoc Cancer Res
, vol.38
, pp. 5
-
-
Ciomei, M.1
Albanese, C.2
Pastori, W.3
-
97
-
-
0033609037
-
The coral-derived natural products eleutherobin and sarcodictyins a and B: Effects on the assembly of purified tubulin with and without microtubule-associated proteins and binding at the polymer taxoid site
-
Hamel E, Sackett DL, Vourloumis D, Nicolaou KC. The coral-derived natural products eleutherobin and sarcodictyins A and B: effects on the assembly of purified tubulin with and without microtubule-associated proteins and binding at the polymer taxoid site. Biochemistry 1999;38:5490-5498 (Pubitemid 129514855)
-
(1999)
Biochemistry
, vol.38
, Issue.17
, pp. 5490-5498
-
-
Hamel, E.1
Sackett, D.L.2
Vourloumis, D.3
Nicolaou, K.C.4
-
98
-
-
67649368876
-
Sarcodictyin and eleutherobin useful for stabilizing microtubules
-
WO9921862
-
Nicolaou KC, Vandelft F, Hosokawa S, et al. Sarcodictyin and eleutherobin useful for stabilizing microtubules. WO9921862; 1999
-
(1999)
-
-
Nicolaou, K.C.1
Vandelft, F.2
Hosokawa, S.3
-
100
-
-
67649345290
-
Terpenoidic derivatives useful as antitumor agents
-
US5869514
-
Battistini C, Ciomei M, Pietra F, et al. Terpenoidic derivatives useful as antitumor agents. US5869514; 1999
-
(1999)
-
-
Battistini, C.1
Ciomei, M.2
Pietra, F.3
-
101
-
-
67649356522
-
Simplified sarcondictyin derivatives as anti-tumor agents
-
US20050038112
-
Mongelli N, Menichincheri M, Ciomei M, et al. Simplified sarcondictyin derivatives as anti-tumor agents. US20050038112; 2005
-
(2005)
-
-
Mongelli, N.1
Menichincheri, M.2
Ciomei, M.3
-
102
-
-
0033083045
-
Laulimalide and isolaulimalide, new paclitaxel-like microtubule- Stabilizing agents
-
Mooberry SL, Tien G, Hernandez AH, et al. Laulimalide and isolaulimalide, new paclitaxel-like microtubule-stubilizing agents. Cancer Res 1999;59:653-660 (Pubitemid 29076064)
-
(1999)
Cancer Research
, vol.59
, Issue.3
, pp. 653-660
-
-
Mooberry, S.L.1
Tien, G.2
Hernandez, A.H.3
Plubrukarn, A.4
Davidson, B.S.5
-
103
-
-
0023710155
-
Laulimalides: New potent cytotoxic macrolides from a marine sponge and a nudibranch predator
-
DOI 10.1021/jo00250a053
-
Corley DG, Herb R, Moore RE, et al. Laulimalide. New potent cytotoxic macrolides from a marine sponge and a nudibranch predator. J Org Chem 1988;53:3644-3646 (Pubitemid 18182797)
-
(1988)
Journal of Organic Chemistry
, vol.53
, Issue.15
, pp. 3644-3646
-
-
Corley, D.G.1
Herb, R.2
Moore, R.E.3
Scheuer, P.J.4
Paul, V.J.5
-
104
-
-
67649332759
-
Laulimalide microtubule stabilizing agents
-
US20020198256
-
Mooberry SL, Davidson BS. Laulimalide microtubule stabilizing agents. US20020198256; 2002
-
(2002)
-
-
Mooberry, S.L.1
Davidson, B.S.2
-
105
-
-
18444400213
-
The microtubule stabilizing agent laulimalide does not bind in the taxoid site, kills cells resistant to paclitaxel and epothilones, and may not require its epoxide moiety for activity
-
DOI 10.1021/bi020211b
-
Pryor DE, O'Brate A, Bilcer G, et al. The microtubule stabilizing agent laulimalide does not bind in the taxoid site, kills cells resistant to paclitaxel and epothilones, and may not require its epoxide moiety for activity. Biochemistry 2002;41:9109-9115 (Pubitemid 34787268)
-
(2002)
Biochemistry
, vol.41
, Issue.29
, pp. 9109-9115
-
-
Pryor, D.E.1
O'Brate, A.2
Bilcer, G.3
Diaz, J.F.4
Wang, Y.5
Wang, Y.6
Kabaki, M.7
Jung, M.K.8
Andreu, J.M.9
Ghosh, A.K.10
Giannakakou, P.11
Hamel, E.12
-
106
-
-
4444315009
-
Computational comparison of microtubule-stabilising agents laulimalide and peloruside with taxol and colchicine
-
DOI 10.1016/j.bmcl.2004.07.053, PII S0960894X04009540
-
Pineda O, Farràs J, Maccari L, et al. Computational comparison of microtubule-stabilising agents laulimalide and peloruside with taxol and colchicine. Bioorg Med Chem Lett 2004;14:4825-4829 (Pubitemid 39165575)
-
(2004)
Bioorganic and Medicinal Chemistry Letters
, vol.14
, Issue.19
, pp. 4825-4829
-
-
Pineda, O.1
Farras, J.2
Maccari, L.3
Manetti, F.4
Botta, M.5
Vilarrasa, J.6
-
107
-
-
3042584537
-
Laulimalide and paclitaxel: A comparison of their effects on tubulin assembly and their synergistic action when present simultaneously
-
DOI 10.1124/mol.66.1.113
-
Gapud EJ, Bai R, Ghosh AK, Hamel E. Laulimalide and paclitaxel: a comparison of their effects on tubulin assembly and their synergistic action when present simultaneously. Mol Pharmacol 2004;66:113-121 (Pubitemid 38822093)
-
(2004)
Molecular Pharmacology
, vol.66
, Issue.1
, pp. 113-121
-
-
Gapud, E.J.1
Bai, R.2
Ghosh, A.K.3
Hamel, E.4
-
108
-
-
33748460813
-
Laulimalide and synthetic laulimalide analogues are synergistic with paclitaxel and 2-methoxyestradiol
-
DOI 10.1021/mp060016h
-
Clark EA, Hills PM, Davidson BS, et al. Laulimalide and synthetic laulimalide analogues are synergistic with paclitaxel and 2-methoxyestradiol. Mol Pharm 2006;3:457-467 (Pubitemid 44351929)
-
(2006)
Molecular Pharmaceutics
, vol.3
, Issue.4
, pp. 457-467
-
-
Clark, E.A.1
Hills, P.M.2
Davidson, B.S.3
Wender, P.A.4
Mooberry, S.L.5
-
109
-
-
33645103854
-
The microtubule binding drug laulimalide inhibits vascular endothelial growth factor-induced human endothelial cell migration and is synergistic when combined with docetaxel (Taxotere)
-
Lu H, Murtagh J, Schwartz EL. The microtubule binding drug laulimalide inhibits vascular endothelial growth factor-induced human endothelial cell migration and is synergistic when combined with docetaxel (Taxotere). Mol Pharmacol 2006;69:1207-1215
-
(2006)
Mol Pharmacol
, vol.69
, pp. 1207-1215
-
-
Lu, H.1
Murtagh, J.2
Schwartz, E.L.3
-
110
-
-
0141508044
-
Microtubule-stabilizing marine metabolite laulimalide and its derivatives: Synthetic approaches and antitumor activity
-
Mulzer J, Öhler E. Microtubule-stabilizing marine metabolite laulimalide and its derivatives: synthetic approaches and antitumor activity. Chem Rev 2003;103:3753-3786
-
(2003)
Chem Rev
, vol.103
, pp. 3753-3786
-
-
Mulzer, J.1
Öhler, E.2
-
111
-
-
34249308550
-
In vitro and in vivo anticancer activities of synthetic (-)-laulimalide, a marine natural product microtubule stabilizing agent
-
Liu J, Towle MJ, Cheng H, et al. In vitro and in vivo anticancer activities of synthetic (-)-laulimalide, a marine natural product microtubule stabilizing agent. Anticancer Res 2007;27:1509-1518
-
(2007)
Anticancer Res
, vol.27
, pp. 1509-1518
-
-
Liu, J.1
Towle, M.J.2
Cheng, H.3
-
112
-
-
0034723214
-
Peloruside A: A potent cytotoxic macrolide isolated from the New Zealand marine sponge Mycale sp
-
DOI 10.1021/jo991296y
-
West LM, Northcote PT, Battershill CN. Peloruside A: a potent cytotoxic macrolide isolated from the New Zealand marine sponge Mycale sp. J Org Chem 2000;65:445-449 (Pubitemid 30061125)
-
(2000)
Journal of Organic Chemistry
, vol.65
, Issue.2
, pp. 445-449
-
-
West, L.M.1
Northcote, P.T.2
Battershill, C.N.3
-
113
-
-
0037096807
-
Peloruside A, a novel antimitotic agent with paclitaxel-like microtubule-stabilizing activity
-
Hood KA, West LM, Rouwé B, et al. Peloruside A, a novel antimitotic agent with paclitaxel-like microtubule-stabilizing activity. Cancer Res 2002;62:3356-3360 (Pubitemid 34651377)
-
(2002)
Cancer Research
, vol.62
, Issue.12
, pp. 3356-3360
-
-
Hood, K.A.1
West, L.M.2
Rouwe, B.3
Northcote, P.T.4
Berridge, M.V.5
Wakefield, St.J.6
Miller, J.H.7
-
114
-
-
3442894416
-
Peloruside a does not bind to the taxoid site on β-tubulin and retains its activity in multidrug-resistant cell lines
-
DOI 10.1158/0008-5472.CAN-04-0771
-
Gaitanos TN, Buey RM, Díaz JF, et al. Peloruside A does not bind to the taxoid site on β-tubulin and retains its activity in multidrug-resistant cell lines. Cancer Res 2004;64:5063-5067 (Pubitemid 39006519)
-
(2004)
Cancer Research
, vol.64
, Issue.15
, pp. 5063-5067
-
-
Gaitanos, T.N.1
Buey, R.M.2
Fernando Diaz, J.3
Northcote, P.T.4
Teesdale-Spittle, P.5
Andreu, J.M.6
Miller, J.H.7
-
115
-
-
33751163059
-
Synergistic effects of peloruside a and laulimalide with taxoid site drugs, but not with each other, on tubulin assembly
-
DOI 10.1124/mol.106.027847
-
Hamel E, Day BW, Miller JH, et al. Synergistic effects of peloruside A and laulimalide with taxoid site drugs, but not with each other, on tubulin assembly. Mol Pharmacol 2006;70:1555-1564 (Pubitemid 44776415)
-
(2006)
Molecular Pharmacology
, vol.70
, Issue.5
, pp. 1555-1564
-
-
Hamel, E.1
Day, B.W.2
Miller, J.H.3
Jung, M.K.4
Northcote, P.T.5
Ghosh, A.K.6
Curran, D.P.7
Cushman, M.8
Nicolaou, K.C.9
Paterson, I.10
Sorensen, E.J.11
-
116
-
-
34247391586
-
Peloruside a synergizes with other microtubule stabilizing agents in cultured cancer cell lines
-
DOI 10.1021/mp060101p
-
Wilmes A, Bargh K, Kelly C, et al. Peloruside A synergizes with other microtubule stabilizing agents in cultured cancer cell lines. Mol Pharm 2007;4:269-280 (Pubitemid 46640603)
-
(2007)
Molecular Pharmaceutics
, vol.4
, Issue.2
, pp. 269-280
-
-
Wilmes, A.1
Bargh, K.2
Kelly, C.3
Northcote, P.T.4
Miller, J.H.5
-
117
-
-
42649104801
-
A unique mode of microtubule stabilization induced by peloruside A
-
Huzil JT, Chik JK, Slysz GW, et al. A unique mode of microtubule stabilization induced by peloruside A. J Mol Biol 2008;378:1016-1030
-
(2008)
J Mol Biol
, vol.378
, pp. 1016-1030
-
-
Huzil, J.T.1
Chik, J.K.2
Slysz, G.W.3
-
118
-
-
0034009228
-
A new antimitotic substance, FR182877: I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities
-
Tokyo
-
Sato B, Muramatsu H, Miyauchi M, et al. A new antimitotic substance, FR182877: I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities. J Antibiot (Tokyo) 2000;53:123-130
-
(2000)
J Antibiot
, vol.53
, pp. 123-130
-
-
Sato, B.1
Muramatsu, H.2
Miyauchi, M.3
-
119
-
-
0034050286
-
A new antimitotic substance, FR182877. II. the mechanism of action
-
Sato B, Nakajima H, Hori Y, et al. A new antimitotic substance, FR182877: II. The mechanism of action. J Antibiot 2000;53:204-206 (Pubitemid 30135881)
-
(2000)
Journal of Antibiotics
, vol.53
, Issue.2
, pp. 204-206
-
-
Sato, B.1
Nakajima, H.2
Hori, Y.3
Hino, M.4
Hashimoto, S.5
Terano, H.6
-
120
-
-
23944524786
-
Cyclostreptin (FR182877), an antitumor tubulin-polymerizing agent deficient in enhancing tubulin assembly despite its high affinity for the taxoid site
-
DOI 10.1021/bi050660m
-
Edler MC, Buey RM, Gussio R, et al. Cyclostreptin (FR182877), an antitumor tubulin-polymerizing agent deficient in enhancing tubulin assembly despite its high affinity for the taxoid site. Biochemistry 2005;44:11525-11528 (Pubitemid 41209088)
-
(2005)
Biochemistry
, vol.44
, Issue.34
, pp. 11525-11538
-
-
Edler, M.C.1
Buey, R.M.2
Gussio, R.3
Marcus, A.I.4
Vanderwal, C.D.5
Sorensen, E.J.6
Diaz, J.F.7
Giannakakou, P.8
Hamel, E.9
-
121
-
-
33846374429
-
Cyclostreptin binds covalently to microtubule pores and lumenal taxoid binding sites
-
DOI 10.1038/nchembio853, PII NCHEMBIO853
-
Buey RM, Calvo E, Barasoain I, et al. Cyclostreptin binds covalently to microtubule pores and luminal taxoid binding sites. Nat Chem Biol 2007;3:117-125 (Pubitemid 46134999)
-
(2007)
Nature Chemical Biology
, vol.3
, Issue.2
, pp. 117-125
-
-
Buey, R.M.1
Calvo, E.2
Barasoain, I.3
Pineda, O.4
Edler, M.C.5
Matesanz, R.6
Cerezo, G.7
Vanderwal, C.D.8
Day, B.W.9
Sorensen, E.J.10
Lopez, J.A.11
Andreu, J.M.12
Hamel, E.13
Diaz, J.F.14
-
123
-
-
33751204460
-
The tubulin-bound conformation of discodermolide derived by NMR studies in solution supports a common pharmacophore model for epothilone and discodermolide
-
DOI 10.1002/anie.200602793
-
Sánchez-Pedregal VM, Kubicek K, Meiler J, et al. The tubulin-bound conformation of discodermolide derived by NMR studies in solution supports a common pharmacophore model for epothilone and discodermolide. Angew Chem Int Ed Engl 2006;45:7388-7394 (Pubitemid 44786965)
-
(2006)
Angewandte Chemie - International Edition
, vol.45
, Issue.44
, pp. 7388-7394
-
-
Sanchez-Pedregal, V.M.1
Kubicek, K.2
Meiler, J.3
Lyothier, I.4
Paterson, I.5
Carlomagno, T.6
-
124
-
-
0033551046
-
A common pharmacophore for cytotoxic natural products that stabilize microtubules
-
DOI 10.1073/pnas.96.8.4256
-
Ojima I, Chakravarty S, Inoue T, et al. A common pharmacophore for cytotoxic natural products that stabilize microtubules. Proc Natl Acad Sci USA 1999;96:4256-4261 • Describes the common pharmacophore of five MSAs. (Pubitemid 29190323)
-
(1999)
Proceedings of the National Academy of Sciences of the United States of America
, vol.96
, Issue.8
, pp. 4256-4261
-
-
Ojima, I.1
Chakravarty, S.2
Inoue, T.3
Lin, S.4
He, L.5
Horwitz, S.B.6
Kuduk, S.D.7
Danishefsky, S.J.8
-
125
-
-
12944277104
-
A common pharmacophore for epothilone and taxanes: Molecular basis for drug resistance conferred by tubulin mutations in human cancer cells
-
DOI 10.1073/pnas.040546297
-
Giannakakou P, Gussio R, Nogales E, et al. A common pharmacophore for epothilone and taxanes: molecular basis for drug resistance conferred by tubulin mutations in human cancer cells. Proc Natl Acad Sci USA 2000;97:2904-2909 (Pubitemid 30159270)
-
(2000)
Proceedings of the National Academy of Sciences of the United States of America
, vol.97
, Issue.6
, pp. 2904-2909
-
-
Giannakakou, P.1
Gussio, R.2
Nogales, E.3
Downing, K.H.4
Zaharevitz, D.5
Bollbuck, B.6
Poy, G.7
Sackett, D.8
Nicolaou, K.C.9
Fojo, T.10
-
126
-
-
3042836538
-
The bioactive Taxol conformation on β-tubulin: Experimental evidence from highly active constrained analogs
-
DOI 10.1073/pnas.0403459101
-
Ganesh T, Guza RC, Bane S, et al. The bioactive taxol conformation on β-tubulin: Experimental evidence from highly active constrained analogs. Proc Natl Acad Sci USA 2004;101:10006-10011 (Pubitemid 38891186)
-
(2004)
Proceedings of the National Academy of Sciences of the United States of America
, vol.101
, Issue.27
, pp. 10006-10011
-
-
Ganesh, T.1
Guza, R.C.2
Bane, S.3
Ravindra, R.4
Shanker, N.5
Lakdawala, A.S.6
Snyder, J.P.7
Kingston, D.G.I.8
-
127
-
-
15744400734
-
Use of the tubulin bound paclitaxel conformation for structure-based rational drug design
-
DOI 10.1016/j.chembiol.2005.01.004
-
Geney R, Sun L, Pera P, et al. Use of the tubulin bound paclitaxel conformation for structure-based rational drug design. Chem Biol 2005;12:339-348 (Pubitemid 40406281)
-
(2005)
Chemistry and Biology
, vol.12
, Issue.3
, pp. 339-348
-
-
Geney, R.1
Sun, L.2
Pera, P.3
Bernacki, R.J.4
Xia, S.5
Horwitz, S.B.6
Simmerling, C.L.7
Ojima, I.8
-
128
-
-
67649302696
-
Microtubule stabilizing compounds
-
US20030203929
-
Ghosh AK. Microtubule stabilizing compounds. US20030203929; 2003
-
(2003)
-
-
Ghosh, A.K.1
-
129
-
-
33645937652
-
Microtubule stabilizing agents: Their molecular signaling consequences and the potential for enhancement by drug combination
-
Bergstralh DT, Ting JP-Y. Microtubule stabilizing agents: their molecular signaling consequences and the potential for enhancement by drug combination. Cancer Treat Rev 2006;32:166-179
-
(2006)
Cancer Treat Rev
, vol.32
, pp. 166-179
-
-
Bergstralh, D.T.1
Ting, J.P.-Y.2
-
130
-
-
0031728267
-
Multidrug resistance: Clinical relevance in solid tumours and strategies for circumvention
-
Kaye SB. Multidrug resistance: clinical relevance in solid tumours and strategies for circumvention. Curr Opin Oncol 1998;1:S15-9 (Pubitemid 28482336)
-
(1998)
Current Opinion in Oncology
, vol.10
, Issue.SUPPL. 1
-
-
Kaye, S.B.1
-
131
-
-
0032927941
-
Cancer multidrug resistance
-
DOI 10.1038/5289
-
Persidis A. Cancer multidrug resistance. Nat Biotechnol 1999;17:94-95 (Pubitemid 29037219)
-
(1999)
Nature Biotechnology
, vol.17
, Issue.1
, pp. 94-95
-
-
Persidis, A.1
-
132
-
-
0034496578
-
Dose P-glycoprotein play a role in anticancer drug pharmacokinetics?
-
Sparreboom A, Nooter K. Dose P-glycoprotein play a role in anticancer drug pharmacokinetics? Drug Resist Updat 2000;3:357-363
-
(2000)
Drug Resist Updat
, vol.3
, pp. 357-363
-
-
Sparreboom, A.1
Nooter, K.2
|