Five new discodermolide analogues' from the marine sponge Discodermia species

Journal of Natural Products

Volumn 65, Issue 11, 2002, Pages 1643-1648

  Gunasekera, Sarath P ^a   Paul, Gopal K ^a   Longley, Ross E ^a   Isbrucker, Richard A ^a   Pomponi, Shirley A ^a  

^a FLORIDA ATLANTIC UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

19 AMINOCARBONYLDISCODERMOLIDE; 2 DISCODERMOLIDE; 2 METHYLDISCODERMOLIDE; 5 HYDROXYMETHYLDISCODERMOLATE; 9(13) CYCLODISCODERMOLIDE; DISCODERMOLIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CANCER CELL CULTURE; CARIBBEAN ISLANDS; CONTROLLED STUDY; CYTOTOXICITY; DISCODERMIA; DRUG ACTIVITY; DRUG ISOLATION; DRUG POTENCY; HUMAN; HUMAN CELL; NONHUMAN; SPONGE (PORIFERA); STRUCTURE ACTIVITY RELATION;

ADENOCARCINOMA; ANIMALS; CARIBBEAN REGION; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; LACTONES; LEUKEMIA P388; MICE; MOLECULAR STRUCTURE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PORIFERA; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

ANIMALIA; DISCODERMIA; INVERTEBRATA; MURINAE; PORIFERA;

EID: 0036853788     PISSN: 01633864     EISSN: None     Source Type: Journal    
DOI: 10.1021/np020219m     Document Type: Article

References (34)

1. Gunasekera, S. P.; Gunasekera, M.; Longley, R. E.; Schulte, G. K. J. Org. Chem. 1990, 55, 4912-4915 (correction: 1991, 56, 1346).
2. Longley, R. E.; Gunasekera, S. P.; Faherty, D.; McLane, J.; Dumont, F. Ann. N. Y. Acad. Sci. 1993, 696, 94-107.
3. Longley, R. E.; Caddigan, D.; Harmody, D.; Gunasekera, M.; Gunasekera, S. P. Transplantation 1991, 52, 650-656.
4. Longley, R. E.; Caddigan, D.; Harmody, D.; Gunasekera, M.; Gunasekera, S. P. Transplantation 1991, 52, 656-661.
5. ter Haar, E.; Kowalski, R. J.; Hamel, E.; Lin, C. M.; Longley, R. E.; Gunasekera, S. P.; Rosenkranz, H. S.; Day, B. W. Biochemistry 1996, 35, 243-250.
6. Hung, G. T.; Chen, J.; Schreiber, S. L. Chem. Biol. 1996, 3, 287-293.
7. Kowalski, R. J.; Giannakakou, P.; Gunasekera, S. P.; Longley, R. E.; Day, B. W.; Hamel, E. Mol. Pharmacol. 1997, 52, 613-622.
8. Balachandran, R.; ter Haar, E.; Welsh, M. J.; Grant, S. G.; Day, B. W. Anticancer Drugs 1998, 6, 67-76.
9. Balachandran, R.; Grant, S. G.; Welsh, M. J.; Day, B. W. Breast J. 1998, 4, 409-419.
10. Nerenberg, J. B.; Hung, D. T.; Somers, P. K.; Schreiber, S. L J. Am. Chem. Soc. 1993, 115, 12621-12622.
11. Hung, D. T.; Nerenberg, J. B.; Schreiber, S. L J. Am. Chem. Soc. 1996, 118, 11054-11080.
12. Paterson, I.; Florence, G. J.; Gerlach, K.; Scott, J. P. Angew. Chem. 2000, 39, 377-380.
13. Smith, A. B., III; Qui, Y.; Jones, D. R.; Kobayashi, K. J. Am. Chem. Soc. 1995, 117, 12011-12012.
14. Marshall, J. A.; Johns, B. A. J. Org. Chem. 1998, 63, 7885-7892.
15. Harried, S. S.; Yang, G.; Strawn, M. A.; Myles, D. C. J. Org. Chem. 1997, 62, 6098-6099.
16. Clark, D. L.; Heathcock, C. H. J. Org. Chem. 1993, 58, 5878-5879.
17. Paterson, I.; Wren, S. P. J. Chem. Soc., Chem. Commun. 1993, 1790-1792.
18. Golec, J. M. C.; Jones, S. D. Tetrahedron Lett. 1993, 34, 8159-8162.
19. Evans, P. L.; Golec, J. M. C.; Gillespie, R. J. Tetrahedron Lett. 1993, 34, 8163-8166.
20. Golec, J. M. C.; Gillespie, R. J. Tetrahedron Lett. 1993, 34, 8167-8168.
21. Yang, G.; Myles, D. C. Tetrahedron Lett. 1994, 35, 1313-1316.
22. Yang, G.; Myles, D. C. Tetrahedron Lett. 1994, 35, 2503-2504.
23. Paterson, I.; Schlapbach, A. Synlett 1995, 5, 498-500.
24. Miyazawa, M.; Oonuma, K.; Maruyama, M.; Miyashita, M. Chem Lett. 1997, 1191-1192.
25. Marshall, J. A.; Zhi-Hui, L.; Johns, B. A. J. Org. Chem. 1998, 63, 817-823.
26. Evans, D. A.; Halstead, D. P.; Allison B. D. Tetrahedron Lett. 1999, 40, 4461-4462.
27. Filla, S. A.; Song, J. J.; Chen, L.; Masamune, S. Tetrahedron Lett. 1999, 40, 5449-5453.
28. Misske, A. M.; Hoffmann, H. M. R. Tetrahedron 1999, 55, 4315-4324.
29. Smith, A. B., III; Kaufman, M. D.; Beachamp, T. J.; LaMarche, M. J.; Arimoyo, H. J. Org. Lett. 2000, 2, 1983-1983.
30. Paterson, I.; Florence, G. J.; Gerlach, K.; Scott, J. P.; Sereinig, N. J. Am Chem. Soc. 2001, 123, 9535-9544.
31. Gunasekera, S. P.; Longley, R. E.; Isbrucker, R. A. J. Nat. Prod. 2001, 64, 171-174.
32. Isbrucker, R. I.; Gunasekera, S. P.; Longley, R. E. Cancer Chemother. Pharmacol. 2001, 48, 29-36.
33. Smith, A. B., III; LaMarche, M. J.; Falcone-Hindley, M. Org. Lett. 2001, 3, 695-698.
34. Gunasekera S. P.; Longley, R E.; Isbrucker, R. A.; Paul, G.; Pomponi, S. A.; Wright, A. E. Serial number 09/796,175, U.S. Patent filed on February 28, 2001.