Structure-activity relationship studies of discodermolide and its semisynthetic acetylated analogs on microtubule function and cytotoxicity

Cancer Chemotherapy and Pharmacology

Volumn 48, Issue 1, 2001, Pages 29-36

  Isbrucker, R A ^a   Gunasekera, S P ^a   Longley, R E ^a  

^a FLORIDA ATLANTIC UNIVERSITY   (United States)

Author keywords

Discodermolide; Paclitaxel; Structure activity relationship; Tubulin

Indexed keywords

ANTIMITOTIC AGENT; CARBON; DISCODERMOLIDE; DRUG ANALOG; HYDROXYL GROUP; PACLITAXEL; TUBULIN;

ACETYLATION; ARTICLE; CELL CYCLE; CELL CYCLE G2 PHASE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG CYTOTOXICITY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LUNG ADENOCARCINOMA; MICROTUBULE; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN INTERACTION; STRUCTURE ACTIVITY RELATION; TUMOR CELL;

ACETYLATION; ALKANES; ANIMALS; ANTINEOPLASTIC AGENTS; CARBAMATES; CATTLE; LACTONES; MICROTUBULES; PYRONES; STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN;

EID: 0034913460     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002800100287     Document Type: Article

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