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Volumn 9, Issue 1, 1998, Pages 67-76

The potent microtubule-stabilizing agent (+)-discodermolide induces apoptosis in human breast carcinoma cells - Preliminary comparisons to paclitaxel

Author keywords

Apoptosis; Discodermolide; Flow cytometry; Hoechst 33342; Paclitaxel; Pulsed field gel electrophoresis

Indexed keywords

DISCODERMOLIDE; DNA FRAGMENT; DOCETAXEL; HOE 33342; PACLITAXEL; TUBULIN; UNCLASSIFIED DRUG;

EID: 0031932291     PISSN: 09594973     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001813-199801000-00008     Document Type: Article
Times cited : (63)

References (28)
  • 1
    • 0027968083 scopus 로고
    • Paclitaxel. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in the treatment of cancer
    • Spencer CM, Faulds D. Paclitaxel. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in the treatment of cancer. Drugs 1994; 48: 794-847.
    • (1994) Drugs , vol.48 , pp. 794-847
    • Spencer, C.M.1    Faulds, D.2
  • 2
    • 0029563137 scopus 로고
    • Docetaxel (Taxotere): An effective agent in the management of second-line breast cancer
    • van Oosterom AT. Docetaxel (Taxotere): an effective agent in the management of second-line breast cancer. Sem Oncol 1995; 22: 22-8.
    • (1995) Sem Oncol , vol.22 , pp. 22-28
    • Van Oosterom, A.T.1
  • 3
    • 0025160288 scopus 로고
    • Discodermolide - A new bioactive polyhydroxylated lactone from the marine sponge Discodermia dissoluta
    • correction: J Org Chem 1991; 56: 1346
    • Gunasekera SP, Gunasekera M, Longley RE, Schulte GK. Discodermolide - a new bioactive polyhydroxylated lactone from the marine sponge Discodermia dissoluta. J Org Chem 1990; 55: 4912-5 (correction: J Org Chem 1991; 56: 1346).
    • (1990) J Org Chem , vol.55 , pp. 4912-4915
    • Gunasekera, S.P.1    Gunasekera, M.2    Longley, R.E.3    Schulte, G.K.4
  • 4
    • 0030039669 scopus 로고    scopus 로고
    • Discodermolide, a cytotoxic marine agent that stabilizes microtubules more potently than taxol
    • Ter Haar E, Kowalski RJ, Hamel E, et al. Discodermolide, a cytotoxic marine agent that stabilizes microtubules more potently than taxol. Biochemistry 1996; 35: 423-30.
    • (1996) Biochemistry , vol.35 , pp. 423-430
    • Ter Haar, E.1    Kowalski, R.J.2    Hamel, E.3
  • 5
    • 0030761586 scopus 로고    scopus 로고
    • The rnicrotubule-stabilizing agent discodermolide competitively inhibits the binding of paclitaxel (Taxol®) to tubulin polymers, enhances tubulin nucleation reactions more potently than paclitaxel, and inhibits the growth of paclitaxel-resistant cells
    • Kowalski RJ, Giannakakou P, Gunasekera SP, Longley RE, Day BW, Hamel E. The rnicrotubule-stabilizing agent discodermolide competitively inhibits the binding of paclitaxel (Taxol®) to tubulin polymers, enhances tubulin nucleation reactions more potently than paclitaxel, and inhibits the growth of paclitaxel-resistant cells. Mol Pharmacol 1997; 52: 613-22.
    • (1997) Mol Pharmacol , vol.52 , pp. 613-622
    • Kowalski, R.J.1    Giannakakou, P.2    Gunasekera, S.P.3    Longley, R.E.4    Day, B.W.5    Hamel, E.6
  • 6
    • 0029965342 scopus 로고    scopus 로고
    • Direct tubulin polymerization perturbation contributes significantly to the induction of micronuclei in vivo
    • Ter Haar E, Day BW, Rosenkranz HS. Direct tubulin polymerization perturbation contributes significantly to the induction of micronuclei in vivo. Mutat Res 1996; 350: 331-7.
    • (1996) Mutat Res , vol.350 , pp. 331-337
    • Ter Haar, E.1    Day, B.W.2    Rosenkranz, H.S.3
  • 7
    • 0030272619 scopus 로고    scopus 로고
    • Computational and molecular modeling evaluation of the structural basis for tubulin polymerization inhibition by colchicine site agents
    • Ter Haar E, Rosenkranz HS, Hamel E, Day BW. Computational and molecular modeling evaluation of the structural basis for tubulin polymerization inhibition by colchicine site agents. Bioorg Med Chem 1996; 4: 1659-71.
    • (1996) Bioorg Med Chem , vol.4 , pp. 1659-1671
    • Ter Haar, E.1    Rosenkranz, H.S.2    Hamel, E.3    Day, B.W.4
  • 8
    • 0029049468 scopus 로고
    • Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action
    • Bollag DM, McQueney PA, Zhu J, et al. Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action. Cancer Res 1995; 55: 2325-33.
    • (1995) Cancer Res , vol.55 , pp. 2325-2333
    • Bollag, D.M.1    McQueney, P.A.2    Zhu, J.3
  • 9
    • 0025942924 scopus 로고
    • Discodermolide - A new, marine-derived immunosuppressive compound. I. in vitro studies
    • correction: Transplantation 1993; 55: 236
    • Longley RE, Caddigan D, Harmody D, Gunasekera M, Gunasekera SP. Discodermolide - a new, marine-derived immunosuppressive compound. I. In vitro studies. Transplantation 1991; 52: 650-6. (correction: Transplantation 1993; 55: 236)
    • (1991) Transplantation , vol.52 , pp. 650-656
    • Longley, R.E.1    Caddigan, D.2    Harmody, D.3    Gunasekera, M.4    Gunasekera, S.P.5
  • 12
    • 0028505014 scopus 로고
    • Distinct binding and cellular properties of synthetic (+)- and (-)-discodermolides
    • Hung DT, Nerenberg JB, Schreiber SL. Distinct binding and cellular properties of synthetic (+)- and (-)-discodermolides. Chem Biol 1994; 1: 67-71.
    • (1994) Chem Biol , vol.1 , pp. 67-71
    • Hung, D.T.1    Nerenberg, J.B.2    Schreiber, S.L.3
  • 13
    • 0030020158 scopus 로고    scopus 로고
    • Mitotic block induced in HeLa cells by low concentrations of paclitaxel (Taxol) results in abnormal mitotic exit and apoptotic cell death
    • Jordan MA, Wendell K, Gardiner S, Derry WB, Copp H, Wilson L. Mitotic block induced in HeLa cells by low concentrations of paclitaxel (Taxol) results in abnormal mitotic exit and apoptotic cell death. Cancer Res 1996; 56: 816-25.
    • (1996) Cancer Res , vol.56 , pp. 816-825
    • Jordan, M.A.1    Wendell, K.2    Gardiner, S.3    Derry, W.B.4    Copp, H.5    Wilson, L.6
  • 14
    • 0028070358 scopus 로고
    • 1 phase by interference with spindle formation without affecting other microtubule functions during anaphase and telophase
    • 1 phase by interference with spindle formation without affecting other microtubule functions during anaphase and telophase. Cancer Res 1994; 54: 4355-61.
    • (1994) Cancer Res , vol.54 , pp. 4355-4361
    • Long, B.H.1    Fairchild, C.R.2
  • 15
    • 0030113284 scopus 로고    scopus 로고
    • (+)-Discodermolide binds to microtubules in stoichiometric ratio to tubulin dimers, blocks taxol binding and results in mitotic arrest
    • Hung DT, Chen J, Schreiber SL. (+)-Discodermolide binds to microtubules in stoichiometric ratio to tubulin dimers, blocks taxol binding and results in mitotic arrest. Chem Biol 1996; 3: 287-93.
    • (1996) Chem Biol , vol.3 , pp. 287-293
    • Hung, D.T.1    Chen, J.2    Schreiber, S.L.3
  • 16
  • 17
    • 0029860912 scopus 로고    scopus 로고
    • Synthesis of discodermolides useful for investigating microtubule binding and stabilization
    • Hung DT, Nerenberg JB, Scheiber SL. Synthesis of discodermolides useful for investigating microtubule binding and stabilization. J Am Chem Soc 1996; 118: 11054-80.
    • (1996) J Am Chem Soc , vol.118 , pp. 11054-11080
    • Hung, D.T.1    Nerenberg, J.B.2    Scheiber, S.L.3
  • 18
    • 0029980263 scopus 로고    scopus 로고
    • Cytostatic and cytotoxic action of the antitumor agent Z-1,1-dichloro-2,3-diphenylcyclopropane in three human breast cancer cell lines
    • Ter Haar E, Day BW. Cytostatic and cytotoxic action of the antitumor agent Z-1,1-dichloro-2,3-diphenylcyclopropane in three human breast cancer cell lines. Anticancer Res 1996; 16: 1107-15.
    • (1996) Anticancer Res , vol.16 , pp. 1107-1115
    • Ter Haar, E.1    Day, B.W.2
  • 19
    • 0026073718 scopus 로고
    • Mouse micronucleus tests with known and suspect spindle poisons: Results from two laboratories
    • Adler ID, Kliesch U, van Hummelen P, Kirsch-Volders M. Mouse micronucleus tests with known and suspect spindle poisons: results from two laboratories. Mutagenesis 1991; 6: 47-53.
    • (1991) Mutagenesis , vol.6 , pp. 47-53
    • Adler, I.D.1    Kliesch, U.2    Van Hummelen, P.3    Kirsch-Volders, M.4
  • 20
    • 0027972061 scopus 로고
    • Differential induction of etoposide-mediated apoptosis in human leukemia HL-60 and K562 cells
    • Ritke MK, Rusnak JM, Lazo JS, et al. Differential induction of etoposide-mediated apoptosis in human leukemia HL-60 and K562 cells. Mol Pharmacol 1994; 46: 605-11.
    • (1994) Mol Pharmacol , vol.46 , pp. 605-611
    • Ritke, M.K.1    Rusnak, J.M.2    Lazo, J.S.3
  • 21
    • 0026492817 scopus 로고
    • Features of apoptotic cells applicable for gel electrophoresis and flow cytometry
    • Darzynkiewicz Z, Bruno S, Del Bino G, et al. Features of apoptotic cells applicable for gel electrophoresis and flow cytometry. Cytometry 1992; 13: 795-808.
    • (1992) Cytometry , vol.13 , pp. 795-808
    • Darzynkiewicz, Z.1    Bruno, S.2    Del Bino, G.3
  • 22
    • 0027217084 scopus 로고
    • Apoptotic cell death in epithelial cells: Cleavage of DNA to 300 and/or 50 kb fragments prior to or in the absence of inter-nucleosomal fragmentation
    • Oberhammer F, Wilson JW, Dive C, et al. Apoptotic cell death in epithelial cells: cleavage of DNA to 300 and/or 50 kb fragments prior to or in the absence of inter-nucleosomal fragmentation. EMBO J 1993; 12: 3679-84.
    • (1993) EMBO J , vol.12 , pp. 3679-3684
    • Oberhammer, F.1    Wilson, J.W.2    Dive, C.3
  • 25
    • 0029653416 scopus 로고
    • 2+-dependent endonuclease activation is an early event in VP-16-induced apoptosis of human breast cancer MCF7 cells in vitro
    • 2+-dependent endonuclease activation is an early event in VP-16-induced apoptosis of human breast cancer MCF7 cells in vitro. Biochim Biophys Acta 1995; 1266: 135-42.
    • (1995) Biochim Biophys Acta , vol.1266 , pp. 135-142
    • Sokolova, I.A.1    Cowan, K.H.2    Schneider, E.3
  • 26
    • 0029303048 scopus 로고
    • Effects of tamoxifen on growth and apoptosis of estrogen-dependent and -independent human breast cancer cells
    • Perry RR, Kang Y, Greaves B. Effects of tamoxifen on growth and apoptosis of estrogen-dependent and -independent human breast cancer cells. Ann Surg Oncol 1995; 2: 238-45.
    • (1995) Ann Surg Oncol , vol.2 , pp. 238-245
    • Perry, R.R.1    Kang, Y.2    Greaves, B.3
  • 27
    • 0029081697 scopus 로고
    • Induction of programmed cell death in human breast cancer cells by an unsymmetrically alkylated polyamine analogue
    • -McCloskey DE, Casero RA Jr, Woster PM, Davidson NE. Induction of programmed cell death in human breast cancer cells by an unsymmetrically alkylated polyamine analogue. Cancer Res 1995; 55: 3233-6.
    • (1995) Cancer Res , vol.55 , pp. 3233-3236
    • McCloskey, D.E.1    Casero Jr., R.A.2    Woster, P.M.3    Davidson, N.E.4
  • 28
    • 0029048177 scopus 로고
    • MCF-7 human mammary adenocarcinoma cell death in vitro in response to hormone withdrawal and DNA damage
    • Wilson JW, Wakeling AE, Morris ID, Hickman JA, Dive C. MCF-7 human mammary adenocarcinoma cell death in vitro in response to hormone withdrawal and DNA damage. Int J Cancer 1995; 61: 502-8.
    • (1995) Int J Cancer , vol.61 , pp. 502-508
    • Wilson, J.W.1    Wakeling, A.E.2    Morris, I.D.3    Hickman, J.A.4    Dive, C.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.