메뉴 건너뛰기




Volumn 14, Issue 2, 2009, Pages 273-297

Emerging drug therapies in Huntington's disease

Author keywords

Cell based therapies; Cognitive; Dopamine; Environmental influences; GABA; Glutamate; Huntington's disease; Motor; Neuroprotective; Neuropsychiatric; Pharmacology

Indexed keywords

ACR 16; AMANTADINE; AMISULPRIDE; ANTINEOPLASTIC ANTIBIOTIC; APOMORPHINE; BACLOFEN; BN 82451; BUTYRIC ACID; CANNABINOID; CLONAZEPAM; DIAZEPAM; DONEPEZIL; FLUOXETINE; HALOPERIDOL; ICOSAPENTAENOIC ACID ETHYL ESTER; KETAMINE; MEMANTINE; METHENAMINE; MILACEMIDE; MINOCYCLINE; MIRTAZAPINE; MITHRAMYCIN A; MONOAMINE OXIDASE INHIBITOR; N (7 HYDROXY 2,2,4,6 TETRAMETHYL 1 INDANYL) 4 (3 METHOXYPHENYL) 1 PIPERAZINEACETAMIDE; OLANZAPINE; QUETIAPINE; RAPAMYCIN; RISPERIDONE; RIVASTIGMINE; SULPIRIDE; TETRABENAZINE; TREHALOSE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 67649304952     PISSN: 14728214     EISSN: None     Source Type: Journal    
DOI: 10.1517/14728210902918299     Document Type: Review
Times cited : (26)

References (200)
  • 4
    • 41849133159 scopus 로고    scopus 로고
    • Cerebral cortex and the clinical expression of Huntington's disease: Complexity and heterogeneity
    • Rosas HD, Salat DH, Lee SY, et al. Cerebral cortex and the clinical expression of Huntington's disease: complexity and heterogeneity. Brain 2008;131:1057-1068
    • (2008) Brain , vol.131 , pp. 1057-1068
    • Rosas, H.D.1    Salat, D.H.2    Lee, S.Y.3
  • 7
  • 9
    • 45149107487 scopus 로고    scopus 로고
    • Mechanisms of neurodegeneration in Huntington's disease
    • DOI 10.1111/j.1460-9568.2008.06310.x
    • Gil JM, Rego AC. Mechanisms of neurodegeneration in Huntington's disease. Eur J Neurosci 2008;27:2803-2820 (Pubitemid 351832229)
    • (2008) European Journal of Neuroscience , vol.27 , Issue.11 , pp. 2803-2820
    • Gil, J.M.1    Rego, A.C.2
  • 10
    • 15944413899 scopus 로고    scopus 로고
    • The Paradigm of Huntington's Disease: Therapeutic Opportunities in Neurodegeneration
    • DOI 10.1602/neurorx.1.1.128, PII S154553430670013X
    • Leegwater-Kim J, Cha JH. The paradigm of Huntington's disease: therapeutic opportunities in neurodegeneration. NeuroRx 2004;1:128-138 (Pubitemid 46589346)
    • (2004) NeuroRx , vol.1 , Issue.1 , pp. 128-138
    • Leegwater-Kim, J.1    Cha, J.-H.J.2
  • 11
    • 0022876328 scopus 로고
    • Huntington's disease: Pathogenesis and management
    • Martin JB, Gusella JF. Huntington's disease. Pathogenesis and management. N Engl J Med 1986;315:1267-1276 (Pubitemid 17049686)
    • (1986) New England Journal of Medicine , vol.315 , Issue.20 , pp. 1267-1276
    • Martin, J.B.1    Gusella, J.F.2
  • 12
    • 0026651654 scopus 로고
    • Huntington disease in Finland: A molecular and genealogical study
    • Ikonen E, Ignatius J, Norio R, et al. Huntington disease in Finland: a molecular and genealogical study. Hum Genet 1992;89:275-280
    • (1992) Hum Genet , vol.89 , pp. 275-280
    • Ikonen, E.1    Ignatius, J.2    Norio, R.3
  • 14
    • 33847683050 scopus 로고    scopus 로고
    • Predictive testing for Huntington's disease
    • DOI 10.1016/j.brainresbull.2006.10.023, PII S0361923006003297
    • Tibben A. Predictive testing for Huntington's disease. Brain Res Bull 2007;72:165-171 (Pubitemid 46367464)
    • (2007) Brain Research Bulletin , vol.72 , Issue.2-3 SPEC. ISS , pp. 165-171
    • Tibben, A.1
  • 15
    • 53049084348 scopus 로고    scopus 로고
    • The current clinical management of Huntington's disease
    • Phillips W, Shannon KM, Barker RA. The current clinical management of Huntington's disease. Mov Disord 2008;23:1491-1504
    • (2008) Mov Disord , vol.23 , pp. 1491-1504
    • Phillips, W.1    Shannon, K.M.2    Barker, R.A.3
  • 16
    • 33847694688 scopus 로고    scopus 로고
    • Autopsy-proven Huntington's disease with 29 trinucleotide repeats
    • DOI 10.1002/mds.21195
    • Kenney C, Powell S, Jankovic J. Autopsy-proven Huntington's disease with 29 trinucleotide repeats. Mov Disord 2007;22:127-130 (Pubitemid 46382686)
    • (2007) Movement Disorders , vol.22 , Issue.1 , pp. 127-130
    • Kenney, C.1    Powell, S.2    Jankovic, J.3
  • 19
    • 1842471357 scopus 로고    scopus 로고
    • Experimental basis for the putative role of GluR6/kainate glutamate receptor subunit in Huntington's disease natural history
    • DOI 10.1016/j.nbd.2003.12.010, PII S0969996103002869
    • Diguet E, Fernagut PO, Normand E, et al. Experimental basis for the putative role of GluR6/kainate glutamate receptor subunit in Huntington's disease natural history. Neurobiol Dis 2004;15:667-675 (Pubitemid 38429981)
    • (2004) Neurobiology of Disease , vol.15 , Issue.3 , pp. 667-675
    • Diguet, E.1    Fernagut, P.-O.2    Normand, E.3    Centelles, L.4    Mulle, C.5    Tison, F.6
  • 21
    • 0028099258 scopus 로고
    • RNA editing of the glutamate receptor subunits GluR2 and GluR6 in human brain tissue
    • Paschen W, Hedreen JC, Ross CA. RNA editing of the glutamate receptor subunits GluR2 and GluR6 in human brain tissue. J Neurochem 1994;63:1596-1602 (Pubitemid 24326199)
    • (1994) Journal of Neurochemistry , vol.63 , Issue.5 , pp. 1596-1602
    • Paschen, W.1    Hedreen, J.C.2    Ross, C.A.3
  • 23
    • 0037851144 scopus 로고    scopus 로고
    • Clinical neurology of Huntington's disease
    • Bates GP, Harper P, Jones L, editors, Oxford: New York Oxford University Press (UK)
    • Kremer B. Clinical neurology of Huntington's disease. In: Bates GP, Harper P, Jones L, editors, Huntington's Disease. Oxford Monographs On Medical Genetics. Oxford: New York Oxford University Press (UK); 2002, volume 1
    • (2002) Huntington's Disease. Oxford Monographs on Medical Genetics , vol.1
    • Kremer, B.1
  • 25
    • 41349100027 scopus 로고    scopus 로고
    • The metabolic profile of early Huntington's disease - A combined human and transgenic mouse study
    • Goodman AO, Murgatroyd PR, Medina-Gomez G, et al. The metabolic profile of early Huntington's disease - a combined human and transgenic mouse study. Exp Neurol 2008;210:691-698
    • (2008) Exp Neurol , vol.210 , pp. 691-698
    • Goodman, A.O.1    Murgatroyd, P.R.2    Medina-Gomez, G.3
  • 27
    • 57049161397 scopus 로고    scopus 로고
    • Ten-year rate of longitudinal change in neurocognitive and motor function in prediagnosis Huntington disease
    • Solomon AC, Stout JC, Weaver M, et al. Ten-year rate of longitudinal change in neurocognitive and motor function in prediagnosis Huntington disease. Mov Disord 2008;23:1830-1836
    • (2008) Mov Disord , vol.23 , pp. 1830-1836
    • Solomon, A.C.1    Stout, J.C.2    Weaver, M.3
  • 32
    • 85009332113 scopus 로고    scopus 로고
    • Unified Huntington's disease rating scale: Reliability and consistency
    • DOI 10.1002/mds.870110204
    • Unified Huntington's Disease Rating Scale: reliability and consistency. Huntington Study Group. Mov Disord 1996;11:136-142 (Pubitemid 26082779)
    • (1996) Movement Disorders , vol.11 , Issue.2 , pp. 136-142
    • Kieburtz, K.1
  • 33
    • 36949023982 scopus 로고    scopus 로고
    • The differential diagnosis of chorea
    • DOI 10.1136/pn.2007.134585
    • Wild EJ, Tabrizi SJ. The differential diagnosis of chorea. Pract Neurol 2007;7:360-373 (Pubitemid 350237712)
    • (2007) Practical Neurology , vol.7 , Issue.6 , pp. 360-373
    • Wild, E.J.1    Tabrizi, S.J.2
  • 36
    • 41249096422 scopus 로고    scopus 로고
    • Symptomatic treatment of Huntington disease
    • Adam OR, Jankovic J. Symptomatic treatment of Huntington disease. Neurotherapeutics 2008;5:181-197
    • (2008) Neurotherapeutics , vol.5 , pp. 181-197
    • Adam, O.R.1    Jankovic, J.2
  • 37
    • 57049139342 scopus 로고    scopus 로고
    • A Europe-wide assessment of current medication choices in Huntington's disease
    • Priller J, Ecker D, Landwehrmeyer B, Craufurd D. A Europe-wide assessment of current medication choices in Huntington's disease. Mov Disord 2008;23:1788
    • (2008) Mov Disord , vol.23 , pp. 1788
    • Priller, J.1    Ecker, D.2    Landwehrmeyer, B.3    Craufurd, D.4
  • 39
    • 52049085768 scopus 로고    scopus 로고
    • Pathophysiology of Huntington's disease: From huntingtin functions to potential treatments
    • Roze E, Saudou F, Caboche J. Pathophysiology of Huntington's disease: from huntingtin functions to potential treatments. Curr Opin Neurol 2008;21:497-503
    • (2008) Curr Opin Neurol , vol.21 , pp. 497-503
    • Roze, E.1    Saudou, F.2    Caboche, J.3
  • 40
    • 0025975251 scopus 로고
    • Neuroleptic drug-induced extrapyramidal syndromes and tardive dyskinesia
    • Casey DE. Neuroleptic drug-induced extrapyramidal syndromes and tardive dyskinesia. Schizophr Res 1991;4:109-120
    • (1991) Schizophr Res , vol.4 , pp. 109-120
    • Casey, D.E.1
  • 42
    • 33846427359 scopus 로고    scopus 로고
    • EPS profiles: The atypical antipsychotics - Are not all the same
    • DOI 10.1097/00131746-200701000-00003, PII 0013174620070100000003
    • Weiden PJ. EPS profiles: the atypical antipsychotics are not all the same. J Psychiatr Pract 2007;13:13-24 (Pubitemid 46148428)
    • (2007) Journal of Psychiatric Practice , vol.13 , Issue.1 , pp. 13-24
    • Weiden, P.J.1
  • 43
    • 0021966828 scopus 로고
    • The gait abnormality of Huntington's disease
    • Koller WC, Trimble J. The gait abnormality of Huntington's disease. Neurology 1985;35:1450-1454 (Pubitemid 15242419)
    • (1985) Neurology , vol.35 , Issue.10 , pp. 1450-1454
    • Koller, W.C.1    Trimble, J.2
  • 44
    • 0024741260 scopus 로고
    • Huntington's disease: Tetrabenazine versus haloperidol in the control of involuntary movements
    • Gimenez-Roldan S, Mateo D. Huntington disease: tetrabenazine compared to haloperidol in the reduction of involuntary movements. Neurologia 1989;4:282-287 (Pubitemid 19278289)
    • (1989) Neurologia , vol.4 , Issue.8 , pp. 282-287
    • Giminez-Roldan, S.1    Mateo, D.2
  • 45
    • 0023868584 scopus 로고
    • Serum haloperidol concentration and choreiform movements in Huntington's disease
    • Barr AN, Fischer JH, Koller WC, et al. Serum haloperidol concentration and choreiform movements in Huntington's disease. Neurology 1988;38:84-88 (Pubitemid 18028098)
    • (1988) Neurology , vol.38 , Issue.1 , pp. 84-88
    • Barr, A.N.1    Fischer, J.H.2    Koller, W.C.3    Spunt, A.L.4    Singhal, A.5
  • 46
    • 0019027714 scopus 로고
    • Clinical evaluation of amantadine and haloperidol in Huntington's chorea
    • Saran BM, Klein MS, Benay EM. Clinical evaluation of amantadine and haloperidol in Huntington's chorea. J Clin Psychiatry 1980;41:221
    • (1980) J Clin Psychiatry , vol.41 , pp. 221
    • Saran, B.M.1    Klein, M.S.2    Benay, E.M.3
  • 47
    • 0016799879 scopus 로고
    • A double blind trial of lithium carbonate and haloperidol in Huntington's chorea
    • Leonard DP, Kidson MA, Brown JG, et al. A double blind trial of lithium carbonate and haloperidol in Huntington's chorea. Aust NZ J Psychiatry 1975;9:115-118
    • (1975) Aust NZ J Psychiatry , vol.9 , pp. 115-118
    • Leonard, D.P.1    Kidson, M.A.2    Brown, J.G.3
  • 48
    • 0021175970 scopus 로고
    • A double blind trial of sulpiride in Huntington's disease and tardive dyskinesia
    • Quinn N, Marsden CD. A double blind trial of sulpiride in Huntington's disease and tardive dyskinesia. J Neurol Neurosurg Psychiatry 1984;47:844-847 (Pubitemid 14059377)
    • (1984) Journal of Neurology Neurosurgery and Psychiatry , vol.47 , Issue.8 , pp. 844-847
    • Quinn, N.1    Marsden, C.D.2
  • 49
    • 33745759912 scopus 로고    scopus 로고
    • Pharmacological management of Huntington's disease: An evidence-based review
    • Bonelli RM, Wenning GK. Pharmacological management of Huntington's disease: an evidence-based review. Curr Pharm Des 2006;12:2701-2720
    • (2006) Curr Pharm des , vol.12 , pp. 2701-2720
    • Bonelli, R.M.1    Wenning, G.K.2
  • 51
    • 0036276160 scopus 로고    scopus 로고
    • Olanzapine in Huntington's disease
    • DOI 10.1034/j.1600-0404.2002.01197.x
    • Paleacu D, Anca M, Giladi N. Olanzapine in Huntington's disease. Acta Neurol Scand 2002;105:441-444 (Pubitemid 34620570)
    • (2002) Acta Neurologica Scandinavica , vol.105 , Issue.6 , pp. 441-444
    • Paleacu, D.1    Anca, M.2    Giladi, N.3
  • 53
    • 0034727062 scopus 로고    scopus 로고
    • Improvement of Huntington's disease with olanzapine and valproate [7]
    • DOI 10.1056/NEJM200009283431316
    • Grove VE Jr, Quintanilla J, DeVaney GT. Improvement of Huntington's disease with olanzapine and valproate. N Engl J Med 2000;343:973-974 (Pubitemid 30727816)
    • (2000) New England Journal of Medicine , vol.343 , Issue.13 , pp. 973-974
    • Grove Jr., V.E.1    Quintanilla, J.2    Devaney, G.T.3
  • 54
    • 0036321441 scopus 로고    scopus 로고
    • Rapid onset of tardive dyskinesia in huntington disease with olanzapine [3]
    • DOI 10.1097/00004714-200208000-00020
    • Benazzi F. Rapid onset of tardive dyskinesia in Huntington disease with olanzapine. J Clin Psychopharmacol 2002;22:438-439 (Pubitemid 34810339)
    • (2002) Journal of Clinical Psychopharmacology , vol.22 , Issue.4 , pp. 438-439
    • Benazzi, F.1
  • 55
    • 0029056324 scopus 로고
    • Acute challenge with apomorphine in Huntington's disease: A double-blind study
    • Albanese A, Cassetta E, Carretta D, et al. Acute challenge with apomorphine in Huntington's disease: a double-blind study. Clin Neuropharmacol 1995;18:427-434
    • (1995) Clin Neuropharmacol , vol.18 , pp. 427-434
    • Albanese, A.1    Cassetta, E.2    Carretta, D.3
  • 56
    • 0018100179 scopus 로고
    • Apomorphine hydrochloride-induced improvement in Huntington's chorea. Stimulation of dopamine receptor
    • Corsini GU, Onali P, Masala C, et al. Apomorphine hydrochloride-induced improvement in Huntington's chorea: stimulation of dopamine receptor. Arch Neurol 1978;35:27-30 (Pubitemid 8267695)
    • (1978) Archives of Neurology , vol.35 , Issue.1 , pp. 27-30
    • Corsini, G.U.1    Onali, P.2    Masala, C.3
  • 57
    • 38549166606 scopus 로고    scopus 로고
    • Short-term continuous infusion of apomorphine hydrochloride for treatment of Huntington's chorea: A double blind, randomized cross-over trial
    • DOI 10.1002/mds.21718
    • Vitale C, Marconi S, Di Maio L, et al. Short-term continuous infusion of apomorphine hydrochloride for treatment of Huntington's chorea: a double blind, randomized cross-over trial. Mov Disord 2007;22:2359-2364 (Pubitemid 351155981)
    • (2007) Movement Disorders , vol.22 , Issue.16 , pp. 2359-2364
    • Vitale, C.1    Marconi, S.2    Di Maio, L.3    De Michele, G.4    Longo, K.5    Bonavita, V.6    Barone, P.7
  • 59
    • 0019254352 scopus 로고
    • Seven cases of Huntington's disease in childhood and levodopa induced improvement in the hypokinetic-rigid form
    • DOI 10.1016/0303-8467(80)90017-7
    • Jongen PJ, Renier WO, Gabreels FJ. Seven cases of Huntington's disease in childhood and levodopa induced improvement in the hypokinetic-rigid form. Clin Neurol Neurosurg 1980;82:251-261 (Pubitemid 11100926)
    • (1980) Clinical Neurology and Neurosurgery , vol.82 , Issue.4 , pp. 251-261
    • Jongen, P.J.H.1    Renier, W.O.2    Gabreels, F.J.M.3
  • 60
    • 0016158978 scopus 로고
    • Huntington's chorea: The rigid form (Westphal variant) treated with levodopa
    • Low PA, Allsop JL, Halmagyi GM. Huntington's chorea: the rigid form (Westphal variant) treated with levodopa. Med J Aust 1974;1:393-394
    • (1974) Med J Aust , vol.1 , pp. 393-394
    • Low, P.A.1    Allsop, J.L.2    Halmagyi, G.M.3
  • 62
    • 0023833860 scopus 로고
    • Tetrabenazine therapy of dystonia, chorea, tics, and other dyskinesias
    • Jankovic J, Orman J. Tetrabenazine therapy of dystonia, chorea, tics, and other dyskinesias. Neurology 1988;38:391-394 (Pubitemid 18083674)
    • (1988) Neurology , vol.38 , Issue.3 , pp. 391-394
    • Jankovic, J.1    Orman, J.2
  • 63
    • 33645798913 scopus 로고    scopus 로고
    • Tetrabenazine as antichorea therapy in Huntington disease: A randomized controlled trial
    • DOI 10.1212/01.wnl.0000198586.85250.13, PII 0000611420060214000016
    • Tetrabenazine as antichorea therapy in Huntington disease: a randomized controlled trial. Neurology 2006;66:366-372 (Pubitemid 43739938)
    • (2006) Neurology , vol.66 , Issue.3 , pp. 366-372
    • Marshall, F.J.1
  • 65
    • 61449249292 scopus 로고    scopus 로고
    • Treatment of the symptoms of Huntington's disease: Preliminary results comparing aripiprazole and tetrabenazine
    • Brusa L, Orlacchio A, Moschella V, et al. Treatment of the symptoms of Huntington's disease: preliminary results comparing aripiprazole and tetrabenazine. Mov Disord 2009;24:126-129
    • (2009) Mov Disord , vol.24 , pp. 126-129
    • Brusa, L.1    Orlacchio, A.2    Moschella, V.3
  • 66
    • 0031029072 scopus 로고    scopus 로고
    • Long-term effects of tetrabenazine in hyperkinetic movement disorders
    • Jankovic J, Beach J. Long-term effects of tetrabenazine in hyperkinetic movement disorders. Neurology 1997;48:358-362 (Pubitemid 27087603)
    • (1997) Neurology , vol.48 , Issue.2 , pp. 358-362
    • Jankovic, J.1    Beach, J.2
  • 67
    • 33847731495 scopus 로고    scopus 로고
    • Long-term tolerability of tetrabenazine in the treatment of hyperkinetic movement disorders
    • DOI 10.1002/mds.21222
    • Kenney C, Hunter C, Jankovic J. Long-term tolerability of tetrabenazine in the treatment of hyperkinetic movement disorders. Mov Disord 2007;22:193-197 (Pubitemid 46374760)
    • (2007) Movement Disorders , vol.22 , Issue.2 , pp. 193-197
    • Kenney, C.1    Hunter, C.2    Jankovic, J.3
  • 68
    • 59849086625 scopus 로고    scopus 로고
    • The long-term effect of tetrabenazine in the management of Huntington disease
    • Fasano A, Cadeddu F, Guidubaldi A, et al. The long-term effect of tetrabenazine in the management of Huntington disease. Clin Neuropharmacol 2008;31:313-318
    • (2008) Clin Neuropharmacol , vol.31 , pp. 313-318
    • Fasano, A.1    Cadeddu, F.2    Guidubaldi, A.3
  • 69
    • 0020086179 scopus 로고
    • Treatment of hyperkinetic movement disorders with tetrabenazine: A double-blind crossover study
    • Jankovic J. Treatment of hyperkinetic movement disorders with tetrabenazine: a double-blind crossover study. Ann Neurol 1982;11:41-47 (Pubitemid 12209517)
    • (1982) Annals of Neurology , vol.11 , Issue.1 , pp. 41-47
    • Jankovic, J.1
  • 73
    • 0037056392 scopus 로고    scopus 로고
    • Huntington's disease: A randomized, controlled trial using the NMDA-antagonist amantadine
    • Verhagen Metman L, Morris MJ, Farmer C, et al. Huntington's disease: a randomized, controlled trial using the NMDA-antagonist amantadine. Neurology 2002;59:694-699
    • (2002) Neurology , vol.59 , pp. 694-699
    • Verhagen Metman, L.1    Morris, M.J.2    Farmer, C.3
  • 74
    • 0038375825 scopus 로고    scopus 로고
    • A randomized trial of amantadine in Huntington disease
    • DOI 10.1001/archneur.60.7.996
    • O'Suilleabhain P, Dewey RB Jr. A randomized trial of amantadine in Huntington disease. Arch Neurol 2003;60:996-998 (Pubitemid 36858360)
    • (2003) Archives of Neurology , vol.60 , Issue.7 , pp. 996-998
    • O'Suilleabhain, P.1    Dewey Jr., R.B.2
  • 75
    • 0023231127 scopus 로고
    • Adverse behavioral effects of amantadine therapy in Huntington's disease
    • DOI 10.1097/00007611-198710000-00032
    • Stewart JT. Adverse behavioral effects of amantadine therapy in Huntington's disease. South Med J 1987;80:1324-1325 (Pubitemid 17160804)
    • (1987) Southern Medical Journal , vol.80 , Issue.10 , pp. 1324-1325
    • Stewart, J.T.1
  • 77
    • 34548814154 scopus 로고    scopus 로고
    • A pilot study of the clinical efficacy and safety of memantine for Huntington's disease
    • DOI 10.1016/j.parkreldis.2006.08.005, PII S135380200600215X
    • Ondo WG, Mejia NI, Hunter CB. A pilot study of the clinical efficacy and safety of memantine for Huntington's disease. Parkinsonism Relat Disord 2007;13:453-454 (Pubitemid 47446371)
    • (2007) Parkinsonism and Related Disorders , vol.13 , Issue.7 , pp. 453-454
    • Ondo, W.G.1    Mejia, N.I.2    Hunter, C.B.3
  • 80
    • 0017867094 scopus 로고
    • Huntington's disease: Treatment with muscimol, a GABA-mimetic drug
    • Shoulson I, Goldblatt D, Charlton M, Joynt RJ. Huntington's disease: treatment with muscimol, a GABA-mimetic drug. Ann Neurol 1978;4:279-284 (Pubitemid 8389826)
    • (1978) Annals of Neurology , vol.4 , Issue.3 , pp. 279-284
    • Shoulson, I.1    Goldblatt, D.2    Charlton, M.3    Joynt, R.J.4
  • 81
    • 0018976229 scopus 로고
    • Failure of aminooxyacetic acid therapy in Huntington disease
    • Perry TL, Wright JM, Hansen S, et al. Failure of aminooxyacetic acid therapy in Huntington disease. Neurology 1980;30:772-775 (Pubitemid 10033677)
    • (1980) Neurology , vol.30 , Issue.7 , pp. 772-775
    • Perry, T.L.1    Wright, J.M.2    Hansen, S.3
  • 82
    • 0023229288 scopus 로고
    • Isoniazid-induced alteration of CSF neurotransmitter amino acids in Huntington's disease
    • DOI 10.1016/0006-8993(87)90364-7
    • Manyam BV, Ferraro TN, Hare TA. Isoniazid-induced alteration of CSF neurotransmitter amino acids in Huntington's disease. Brain Res 1987;408:125-130 (Pubitemid 17068422)
    • (1987) Brain Research , vol.408 , Issue.1-2 , pp. 125-130
    • Manyam, B.V.1    Ferraro, T.N.2    Hare, T.A.3
  • 83
    • 0015790690 scopus 로고
    • Baclofen and lithium in Huntington's chorea
    • Anden NE, Dalen P, Johansson B. Baclofen and lithium in Huntington's chorea. Lancet 1973;2:93
    • (1973) Lancet , vol.2 , pp. 93
    • Anden, N.E.1    Dalen, P.2    Johansson, B.3
  • 84
    • 0017145183 scopus 로고
    • Lioresal in Huntington's disease
    • Paulson GW. Lioresal in Huntington's disease. Dis Nerv Syst 1976;37:465-467
    • (1976) Dis Nerv Syst , vol.37 , pp. 465-467
    • Paulson, G.W.1
  • 86
    • 67649351118 scopus 로고    scopus 로고
    • Neurochemistry of Huntington's disease
    • Bates GP, Harper P, Jones L, editors, Oxford: New York Oxford University Press (UK)
    • Yohrling G, Cha JH. Neurochemistry of Huntington's disease. In: Bates GP, Harper P, Jones L, editors, Huntington's disease. Oxford Monographs On Medical Genetics. Oxford: New York Oxford University Press (UK); 2002, volume 1
    • (2002) Huntington's Disease. Oxford Monographs on Medical Genetics , vol.1
    • Yohrling, G.1    Cha, J.H.2
  • 87
    • 0018376370 scopus 로고
    • Alterations in the benzodiazepine receptor of Huntington's diseased human brain
    • DOI 10.1016/0006-8993(79)90060-X
    • Reisine TD, Wastek GJ, Speth RC, et al. Alterations in the benzodiazepine receptor of Huntington's diseased human brain. Brain Res 1979;165:183-187 (Pubitemid 9126616)
    • (1979) Brain Research , vol.165 , Issue.1 , pp. 183-187
    • Reisine, T.D.1    Wastek, G.J.2    Speth, R.C.3
  • 88
    • 0017252399 scopus 로고
    • Clonazepam in the treatment of choreiform activity
    • Peiris JB, Boralessa H, Lionel ND. Clonazepam in the treatment of choreiform activity. Med J Aust 1976;1:225-227
    • (1976) Med J Aust , vol.1 , pp. 225-227
    • Peiris, J.B.1    Boralessa, H.2    Lionel, N.D.3
  • 89
    • 0023673267 scopus 로고
    • Treatment of Huntington's disease with clonazepam
    • Stewart JT. Treatment of Huntington's disease with clonazepam. South Med J 1988;81:102
    • (1988) South Med J , vol.81 , pp. 102
    • Stewart, J.T.1
  • 90
    • 0014345503 scopus 로고
    • A quantitative evaluation of the effect of diazepam in Huntington's chorea
    • Farrell DF, Hofmann WW. A quantitative evaluation of the effect of diazepam in Huntington's chorea. Arch Phys Med Rehabil 1968;49:586-591
    • (1968) Arch Phys Med Rehabil , vol.49 , pp. 586-591
    • Farrell, D.F.1    Hofmann, W.W.2
  • 91
    • 33846815309 scopus 로고    scopus 로고
    • Two years' follow-up of rivastigmine treatment in Huntington disease
    • DOI 10.1097/01.wnf.0000240945.44370.f0, PII 0000282620070100000007
    • de Tommaso M, Difruscolo O, Sciruicchio V, et al. Two years' follow-up of rivastigmine treatment in Huntington disease. Clin Neuropharmacol 2007;30:43-46 (Pubitemid 46204317)
    • (2007) Clinical Neuropharmacology , vol.30 , Issue.1 , pp. 43-46
    • De Tommaso, M.1    Difruscolo, O.2    Sciruicchio, V.3    Specchio, N.4    Livrea, P.5
  • 92
    • 33749861388 scopus 로고    scopus 로고
    • Effect of donepezil on motor and cognitive function in Huntington disease
    • DOI 10.1212/01.wnl.0000238106.10423.00, PII 0000611420061010000034
    • Cubo E, Shannon KM, Tracy D, et al. Effect of donepezil on motor and cognitive function in Huntington disease. Neurology 2006;67:1268-1271 (Pubitemid 44563842)
    • (2006) Neurology , vol.67 , Issue.7 , pp. 1268-1271
    • Cubo, E.1    Shannon, K.M.2    Tracy, D.3    Jaglin, J.A.4    Bernard, B.A.5    Wuu, J.6    Leurgans, S.E.7
  • 93
    • 44449146417 scopus 로고    scopus 로고
    • Patient and caregiver quality of life in Huntington's disease
    • Ready RE, Mathews M, Leserman A, Paulsen JS. Patient and caregiver quality of life in Huntington's disease. Mov Disord 2008;23:721-726
    • (2008) Mov Disord , vol.23 , pp. 721-726
    • Ready, R.E.1    Mathews, M.2    Leserman, A.3    Paulsen, J.S.4
  • 95
    • 0037372769 scopus 로고    scopus 로고
    • Mirtazapine in suicidal Huntington's disease [1]
    • Bonelli RM. Mirtazapine in suicidal Huntington's disease. Ann Pharmacother 2003;37:452 (Pubitemid 36249652)
    • (2003) Annals of Pharmacotherapy , vol.37 , Issue.3 , pp. 452
    • Bonelli, R.M.1
  • 96
    • 0029900003 scopus 로고    scopus 로고
    • L-deprenyl augmentation of fluoxetine in a patient with Huntington's disease
    • Patel SV, Tariot PN, Asnis J. L-Deprenyl augmentation of fluoxetine in a patient with Huntington's disease. Ann Clin Psychiatry 1996;8:23-26 (Pubitemid 26193734)
    • (1996) Annals of Clinical Psychiatry , vol.8 , Issue.1 , pp. 23-26
    • Patel, S.V.1    Tariot, P.N.2    Asnis, J.3
  • 97
    • 0022975046 scopus 로고
    • Treatment of depression in Huntington's disease with monoamine oxidase inhibitors
    • Ford MF. Treatment of depression in Huntington's disease with monoamine oxidase inhibitors. Br J Psychiatry 1986;149:654-656 (Pubitemid 17170943)
    • (1986) British Journal of Psychiatry , vol.149 , Issue.NOV , pp. 654-656
    • Ford, M.F.1
  • 98
    • 0016911040 scopus 로고
    • Haloperidol, reserpine, l-dopa and amantidine in the treatment of Huntington chorea
    • author's transl
    • Candelise L. Haloperidol, reserpine, l-dopa and amantidine in the treatment of Huntington chorea (author's transl). Riv Patol Nerv Ment 1976;96:54-62
    • (1976) Riv Patol Nerv Ment , vol.96 , pp. 54-62
    • Candelise, L.1
  • 100
    • 29544445190 scopus 로고    scopus 로고
    • Quetiapine in the treatment of behavioral disturbances in patients with Huntington's disease
    • DOI 10.1176/appi.psy.47.1.70
    • Alpay M, Koroshetz WJ. Quetiapine in the treatment of behavioral disturbances in patients with Huntington's disease. Psychosomatics 2006;47:70-72 (Pubitemid 43017124)
    • (2006) Psychosomatics , vol.47 , Issue.1 , pp. 70-72
    • Alpay, M.1    Koroshetz, W.J.2
  • 101
    • 0036669789 scopus 로고    scopus 로고
    • From cannabis to cannabinergics: New therapeutic opportunities
    • DOI 10.1016/S0163-7258(02)00250-4, PII S0163725802002504
    • Goutopoulos A, Makriyannis A. From cannabis to cannabinergics: new therapeutic opportunities. Pharmacol Ther 2002;95:103-117 (Pubitemid 35232129)
    • (2002) Pharmacology and Therapeutics , vol.95 , Issue.2 , pp. 103-117
    • Goutopoulos, A.1    Makriyannis, A.2
  • 102
    • 33750837262 scopus 로고    scopus 로고
    • Nabilone could treat chorea and irritability in Huntington's disease [3]
    • DOI 10.1176/appi.neuropsych.18.4.553
    • Curtis A, Rickards H. Nabilone could treat chorea and irritability in Huntington's disease. J Neuropsychiatry Clin Neurosci 2006;18:553-554 (Pubitemid 44713898)
    • (2006) Journal of Neuropsychiatry and Clinical Neurosciences , vol.18 , Issue.4 , pp. 553-554
    • Curtis, A.1    Rickards, H.2
  • 103
    • 39149099116 scopus 로고    scopus 로고
    • Behavioural problems in Huntington's disease using the Problem Behaviours Assessment
    • DOI 10.1016/j.genhosppsych.2007.11.005, PII S0163834307002265
    • Kingma EM, van Duijn E, Timman R, et al. Behavioural problems in Huntington's disease using the problem behaviours assessment. Gen Hosp Psychiatry 2008;30:155-161 (Pubitemid 351255558)
    • (2008) General Hospital Psychiatry , vol.30 , Issue.2 , pp. 155-161
    • Kingma, E.M.1    Van Duijn, E.2    Timman, R.3    Van Der Mast, R.C.4    Roos, R.A.C.5
  • 105
    • 0031780369 scopus 로고    scopus 로고
    • Awareness of involuntary movements in Huntington disease
    • DOI 10.1001/archneur.55.6.801
    • Snowden JS, Craufurd D, Griffiths HL, Neary D. Awareness of involuntary movements in Huntington disease. Arch Neurol 1998;55:801-805 (Pubitemid 28265696)
    • (1998) Archives of Neurology , vol.55 , Issue.6 , pp. 801-805
    • Snowden, J.S.1    Craufurd, D.2    Griffiths, H.L.3    Neary, D.4
  • 106
    • 67651176147 scopus 로고    scopus 로고
    • Health-related quality of life in Huntington's disease: Which factors matter most?
    • Ho AK, Gilbert AS, Mason SL, et al. Goodman AO, Barker RA: Health-related quality of life in Huntington's disease: which factors matter most? Mov Disord 2008;24(4):572-576
    • (2008) Mov Disord , vol.24 , Issue.4 , pp. 572-576
    • Ho, A.K.1    Gilbert, A.S.2    Mason, S.L.3    Goodman, A.O.4    Barker, R.A.5
  • 107
    • 0029055717 scopus 로고
    • Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes
    • Nasir J, Floresco SB, O'Kusky JR, et al. Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes. Cell 1995;81:811-823
    • (1995) Cell , vol.81 , pp. 811-823
    • Nasir, J.1    Floresco, S.B.2    O'Kusky, J.R.3
  • 109
    • 0032832305 scopus 로고    scopus 로고
    • Sequence-specific cleavage of Huntingtin mRNA by catalytic DNA
    • DOI 10.1002/1531-8249(199909)46:3<366::AID-ANA12>3.0.CO;2-D
    • Yen L, Strittmatter SM, Kalb RG. Sequence-specific cleavage of Huntingtin mRNA by catalytic DNA. Ann Neurol 1999;46:366-373 (Pubitemid 29416274)
    • (1999) Annals of Neurology , vol.46 , Issue.3 , pp. 366-373
    • Yen, L.1    Strittmatter, S.M.2    Kalb, R.G.3
  • 118
    • 33645733075 scopus 로고    scopus 로고
    • Minocycline or iNOS inhibition block 3-nitrotyrosine increases and blood-brain barrier leakiness in amyloid beta-peptide-injected rat hippocampus
    • Ryu JK, McLarnon JG. Minocycline or iNOS inhibition block 3-nitrotyrosine increases and blood-brain barrier leakiness in amyloid beta-peptide-injected rat hippocampus. Exp Neurol 2006;198:552-557
    • (2006) Exp Neurol , vol.198 , pp. 552-557
    • Ryu, J.K.1    McLarnon, J.G.2
  • 120
    • 3543092682 scopus 로고    scopus 로고
    • Minocycline safety and tolerability in Huntington disease
    • Minocycline safety and tolerability in Huntington disease. Neurology 2004;63:547-549 (Pubitemid 39031391)
    • (2004) Neurology , vol.63 , Issue.3 , pp. 547-549
    • Cudkowicz, M.1
  • 121
    • 12244265476 scopus 로고    scopus 로고
    • Minocycline for Huntington's disease: An open label study
    • Bonelli RM, Heuberger C, Reisecker F. Minocycline for Huntington's disease: an open label study. Neurology 2003;60:883-884 (Pubitemid 36297384)
    • (2003) Neurology , vol.60 , Issue.5 , pp. 883-884
    • Bonelli, R.M.1    Heuberger, C.2    Reisecker, F.3
  • 122
    • 4444233214 scopus 로고    scopus 로고
    • Minocycline in Huntington's disease: A pilot study
    • DOI 10.1002/mds.20018
    • Thomas M, Ashizawa T, Jankovic J. Minocycline in Huntington's disease: a pilot study. Mov Disord 2004;19:692-695 (Pubitemid 39173025)
    • (2004) Movement Disorders , vol.19 , Issue.6 , pp. 692-695
    • Thomas, M.1    Ashizawa, T.2    Jankovic, J.3
  • 124
    • 1642618292 scopus 로고    scopus 로고
    • Sweet relief for Huntington disease
    • DOI 10.1038/nm0204-123
    • Katsuno M, Adachi H, Sobue G. Sweet relief for Huntington disease. Nat Med 2004;10:123-124 (Pubitemid 38524873)
    • (2004) Nature Medicine , vol.10 , Issue.2 , pp. 123-124
    • Katsuno, M.1    Adachi, H.2    Sobue, G.3
  • 125
    • 1342325378 scopus 로고    scopus 로고
    • Novel Nuclear Shuttle Proteins, HDBP1 and HDBP2, Bind to Neuronal Cell-specific cis-Regulatory Element in the Promoter for the Human Huntington's Disease Gene
    • DOI 10.1074/jbc.M310726200
    • Tanaka K, Shouguchi-Miyata J, Miyamoto N, Ikeda JE. Novel nuclear shuttle proteins, HDBP1 and HDBP2, bind to neuronal cell-specific cis-regulatory element in the promoter for the human Huntington's disease gene. J Biol Chem 2004;279:7275-7286 (Pubitemid 38248877)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.8 , pp. 7275-7286
    • Tanaka, K.1    Shouguchi-Miyata, J.2    Miyamoto, N.3    Ikeda, J.-E.4
  • 127
    • 33749040671 scopus 로고    scopus 로고
    • Role of autophagy in the clearance of mutant huntingtin: A step towards therapy?
    • Ravikumar B, Rubinsztein DC. Role of autophagy in the clearance of mutant huntingtin: a step towards therapy? Mol Aspects Med 2006;27:520-527
    • (2006) Mol Aspects Med , vol.27 , pp. 520-527
    • Ravikumar, B.1    Rubinsztein, D.C.2
  • 128
    • 1242338962 scopus 로고    scopus 로고
    • Amelioration of behavioral deficits in a rat model of Huntington's disease by an excitotoxic lesion to the globus pallidus
    • DOI 10.1016/S0014-4886(03)00312-1
    • Ayalon L, Doron R, Weiner I, Joel D. Amelioration of behavioral deficits in a rat model of Huntington's disease by an excitotoxic lesion to the globus pallidus. Exp Neurol 2004;186:46-58 (Pubitemid 38229904)
    • (2004) Experimental Neurology , vol.186 , Issue.1 , pp. 46-58
    • Ayalon, L.1    Doron, R.2    Weiner, I.3    Joel, D.4
  • 129
    • 29044433626 scopus 로고    scopus 로고
    • B receptors at glutamatergic synapses in the rat striatum
    • DOI 10.1016/j.neuroscience.2005.07.013, PII S0306452205007621
    • Lacey CJ, Boyes J, Gerlach O, et al. GABA(B) receptors at glutamatergic synapses in the rat striatum. Neuroscience 2005;136:1083-1095 (Pubitemid 41790522)
    • (2005) Neuroscience , vol.136 , Issue.4 , pp. 1083-1095
    • Lacey, C.J.1    Boyes, J.2    Gerlach, O.3    Chen, L.4    Magill, P.J.5    Bolam, J.P.6
  • 130
    • 0025274408 scopus 로고
    • Synaptic and intrinsic control of membrane excitability of neostriatal neurons. I. An in vivo analysis
    • Calabresi P, Mercuri NB, Stefani A, Bernardi G. Synaptic and intrinsic control of membrane excitability of neostriatal neurons. I. An in vivo analysis. J Neurophysiol 1990;63:651-662
    • (1990) J Neurophysiol , vol.63 , pp. 651-662
    • Calabresi, P.1    Mercuri, N.B.2    Stefani, A.3    Bernardi, G.4
  • 131
    • 20444367602 scopus 로고    scopus 로고
    • Abnormal sensitivity to cannabinoid receptor stimulation might contribute to altered gamma-aminobutyric acid transmission in the striatum of R6/2 huntington's disease mice
    • DOI 10.1016/j.biopsych.2005.03.008, PII S0006322305002702
    • Centonze D, Rossi S, Prosperetti C, et al. Abnormal sensitivity to cannabinoid receptor stimulation might contribute to altered gamma-aminobutyric acid transmission in the striatum of R6/2 Huntington's disease mice. Biol Psychiatry 2005;57:1583-1589 (Pubitemid 40805389)
    • (2005) Biological Psychiatry , vol.57 , Issue.12 , pp. 1583-1589
    • Centonze, D.1    Rossi, S.2    Prosperetti, C.3    Tscherter, A.4    Bernardi, G.5    Maccarrone, M.6    Calabresi, P.7
  • 132
    • 33846462480 scopus 로고    scopus 로고
    • Stem cell transplantation for Huntington's disease
    • DOI 10.1016/j.expneurol.2006.11.007, PII S0014488606006157
    • Dunnett SB, Rosser AE. Stem cell transplantation for Huntington's disease. Exp Neurol 2007;203:279-292 (Pubitemid 46149598)
    • (2007) Experimental Neurology , vol.203 , Issue.2 , pp. 279-292
    • Dunnett, S.B.1    Rosser, A.E.2
  • 134
    • 0031887047 scopus 로고    scopus 로고
    • Safety of intrastriatal neurotransplantation for Huntington's disease patients
    • DOI 10.1006/exnr.1997.6685
    • Kopyov OV, Jacques S, Lieberman A, et al. Safety of intrastriatal neurotransplantation for Huntington's disease patients. Exp Neurol 1998;149:97-108 (Pubitemid 28091019)
    • (1998) Experimental Neurology , vol.149 , Issue.1 , pp. 97-108
    • Kopyov, O.V.1    Jacques, S.2    Lieberman, A.3    Duma, C.M.4    Eagle, K.S.5
  • 136
    • 0034627143 scopus 로고    scopus 로고
    • Motor and cognitive improvements in patients with Huntington's disease after neural transplantation
    • Bachoud-Levi AC, Remy P, Nguyen JP, et al. Motor and cognitive improvements in patients with Huntington's disease after neural transplantation. Lancet 2000;356:1975-1979
    • (2000) Lancet , vol.356 , pp. 1975-1979
    • Bachoud-Levi, A.C.1    Remy, P.2    Nguyen, J.P.3
  • 137
    • 33644967927 scopus 로고    scopus 로고
    • Effect of fetal neural transplants in patients with Huntington's disease 6 years after surgery: A long-term follow-up study
    • Bachoud-Levi AC, Gaura V, Brugieres P, et al. Effect of fetal neural transplants in patients with Huntington's disease 6 years after surgery: a long-term follow-up study. Lancet Neurol 2006;5:303-309
    • (2006) Lancet Neurol , vol.5 , pp. 303-309
    • Bachoud-Levi, A.C.1    Gaura, V.2    Brugieres, P.3
  • 139
    • 0042527172 scopus 로고    scopus 로고
    • Autologous adult bone marrow stem cell transplantation in an animal model of huntington's disease: Behavioral and morphological outcomes
    • DOI 10.1080/00207450390207759
    • Lescaudron L, Unni D, Dunbar GL. Autologous adult bone marrow stem cell transplantation in an animal model of huntington's disease: behavioral and morphological outcomes. Int J Neurosci 2003;113:945-956 (Pubitemid 36975650)
    • (2003) International Journal of Neuroscience , vol.113 , Issue.7 , pp. 945-956
    • Lescaudron, L.1    Unni, D.2    Dunbar, G.L.3
  • 140
    • 34250659732 scopus 로고    scopus 로고
    • Huntington's disease: Pathological mechanisms and therapeutic strategies
    • Ramaswamy S, Shannon KM, Kordower JH. Huntington's disease: pathological mechanisms and therapeutic strategies. Cell Transplant 2007;16:301-312 (Pubitemid 47300233)
    • (2007) Cell Transplantation , vol.16 , Issue.3 , pp. 301-312
    • Ramaswamy, S.1    Shannon, K.M.2    Kordower, J.H.3
  • 141
    • 0030911441 scopus 로고    scopus 로고
    • Cellular delivery of human CNTF prevents motor and cognitive dysfunction in a rodent model of Huntington's disease
    • DOI 10.1016/S0963-6897(97)00035-3, PII S0963689797000353
    • Emerich DF, Cain CK, Greco C, et al. Cellular delivery of human CNTF prevents motor and cognitive dysfunction in a rodent model of Huntington's disease. Cell Transplant 1997;6:249-266 (Pubitemid 27225176)
    • (1997) Cell Transplantation , vol.6 , Issue.3 , pp. 249-266
    • Emerich, D.F.1    Cain, C.K.2    Greco, C.3    Saydoff, J.A.4    Hu, Z.Y.5    Liu, H.6    Lindner, M.D.7
  • 145
    • 1542350108 scopus 로고    scopus 로고
    • Genetic and environmental factors in the pathogenesis of Huntington's disease
    • DOI 10.1007/s10048-003-0169-5
    • van Dellen A, Hannan AJ. Genetic and environmental factors in the pathogenesis of Huntington's disease. Neurogenetics 2004;5:9-17 (Pubitemid 38297468)
    • (2004) Neurogenetics , vol.5 , Issue.1 , pp. 9-17
    • Van Dellen, A.1    Hannan, A.J.2
  • 147
    • 33645452859 scopus 로고    scopus 로고
    • Neurogenesis in the R6/1 transgenic mouse model of Huntington's disease: Effects of environmental enrichment
    • Lazic SE, Grote HE, Blakemore C, et al. Neurogenesis in the R6/1 transgenic mouse model of Huntington's disease: effects of environmental enrichment. Eur J Neurosci 2006;23:1829-1838
    • (2006) Eur J Neurosci , vol.23 , pp. 1829-1838
    • Lazic, S.E.1    Grote, H.E.2    Blakemore, C.3
  • 148
    • 1542286877 scopus 로고    scopus 로고
    • Environmental Enrichment Rescues Protein Deficits in a Mouse Model of Huntington's Disease, Indicating a Possible Disease Mechanism
    • DOI 10.1523/JNEUROSCI.1658-03.2004
    • Spires TL, Grote HE, Varshney NK, et al. Environmental enrichment rescues protein deficits in a mouse model of Huntington's disease, indicating a possible disease mechanism. J Neurosci 2004;24:2270-2276 (Pubitemid 38314558)
    • (2004) Journal of Neuroscience , vol.24 , Issue.9 , pp. 2270-2276
    • Spires, T.L.1    Grote, H.E.2    Varshney, N.K.3    Cordery, P.M.4    Van Dellen, A.5    Blakemore, C.6    Hannan, A.J.7
  • 149
    • 0032957382 scopus 로고    scopus 로고
    • Environmental enrichment inhibits spontaneous apoptosis, prevents seizures and is neuroprotective
    • DOI 10.1038/7449
    • Young D, Lawlor PA, Leone P, et al. Environmental enrichment inhibits spontaneous apoptosis, prevents seizures and is neuroprotective. Nat Med 1999;5:448-453 (Pubitemid 29180587)
    • (1999) Nature Medicine , vol.5 , Issue.4 , pp. 448-453
    • Young, D.1    Lawlor, P.A.2    Leone, P.3    Dragunow, M.4    During, M.J.5
  • 150
    • 0032052003 scopus 로고    scopus 로고
    • Huntingtin protein colocalizes with lesions of neurodegenerative diseases: An investigation in Huntington's, Alzheimer's, and Pick's diseases
    • Singhrao SK, Thomas P, Wood JD, et al. Huntingtin protein colocalizes with lesions of neurodegenerative diseases: an investigation in Huntington's, Alzheimer's, and Pick's diseases. Exp Neurol 1998;150:213-222
    • (1998) Exp Neurol , vol.150 , pp. 213-222
    • Singhrao, S.K.1    Thomas, P.2    Wood, J.D.3
  • 151
    • 41749124167 scopus 로고    scopus 로고
    • Brain reserve and the prevention of dementia
    • Valenzuela MJ. Brain reserve and the prevention of dementia. Curr Opin Psychiatry 2008;21:296-302
    • (2008) Curr Opin Psychiatry , vol.21 , pp. 296-302
    • Valenzuela, M.J.1
  • 152
    • 0033457954 scopus 로고    scopus 로고
    • Differential clinical and motor control function in a pair of monozygotic twins with Huntington's disease
    • DOI 10.1002/1531-8257(199903)14:2<320::AID-MDS1018>3.0.CO;2-Z
    • Georgiou N, Bradshaw JL, Chiu E, et al. Differential clinical and motor control function in a pair of monozygotic twins with Huntington's disease. Mov Disord 1999;14:320-325 (Pubitemid 30011851)
    • (1999) Movement Disorders , vol.14 , Issue.2 , pp. 320-325
    • Georgiou, N.1    Bradshaw, J.L.2    Chiu, E.3    Tudor, A.4    O'Gorman, L.5    Phillips, J.G.6
  • 153
    • 67649328593 scopus 로고    scopus 로고
    • Lifestyle activity and age of onset in Huntington's disease
    • St Pete Beach, Florida, Huntington's Study Group
    • Churchyard A. Lifestyle activity and age of onset in Huntington's disease. In: Huntington Disease Clinical Research Symposium. St Pete Beach, Florida, Huntington's Study Group: 2008
    • (2008) Huntington Disease Clinical Research Symposium
    • Churchyard, A.1
  • 155
    • 18844447024 scopus 로고    scopus 로고
    • Translating Therapies for Huntington's Disease from Genetic Animal Models to Clinical Trials
    • DOI 10.1602/neurorx.1.3.298, PII S1545534306700463, Evidence-Based Neurotherapeutics:A Spectrum of Evidence
    • Hersch SM, Ferrante RJ. Translating therapies for Huntington's disease from genetic animal models to clinical trials. NeuroRx 2004;1:298-306 (Pubitemid 46589358)
    • (2004) NeuroRx , vol.1 , Issue.3 , pp. 298-306
    • Hersch, S.M.1    Ferrante, R.J.2
  • 157
    • 0028978527 scopus 로고
    • Expression of beta-galactosidase under the control of the human c-myc promoter in transgenic mice is inhibited by mithramycin
    • Jones DE Jr, Cui DM, Miller DM. Expression of beta-galactosidase under the control of the human c-myc promoter in transgenic mice is inhibited by mithramycin. Oncogene 1995;10:2323-2330
    • (1995) Oncogene , vol.10 , pp. 2323-2330
    • Jones Jr., D.E.1    Cui, D.M.2    Miller, D.M.3
  • 159
    • 36248970599 scopus 로고    scopus 로고
    • Sodium phenylbutyrate in Huntington's disease: A dose-finding study
    • DOI 10.1002/mds.21632
    • Hogarth P, Lovrecic L, Krainc D. Sodium phenylbutyrate in Huntington's disease: a dose-finding study. Mov Disord 2007;22:1962-1964 (Pubitemid 350134213)
    • (2007) Movement Disorders , vol.22 , Issue.13 , pp. 1962-1964
    • Hogarth, P.1    Lovrecic, L.2    Krainc, D.3
  • 161
    • 0034799214 scopus 로고    scopus 로고
    • A bile acid protects against motor and cognitive deficits and reduces striatal degeneration in the 3-nitropropionic acid model of Huntington's disease
    • DOI 10.1006/exnr.2001.7755
    • Keene CD, Rodrigues CM, Eich T, et al. A bile acid protects against motor and cognitive deficits and reduces striatal degeneration in the 3-nitropropionic acid model of Huntington's disease. Exp Neurol 2001;171:351-360 (Pubitemid 32955297)
    • (2001) Experimental Neurology , vol.171 , Issue.2 , pp. 351-360
    • Keene, C.D.1    Rodrigues, C.M.P.2    Eich, T.3    Linehan-Stieers, C.4    Abt, A.5    Kren, B.T.6    Steer, C.J.7    Low, W.C.8
  • 162
    • 0042666901 scopus 로고    scopus 로고
    • Chronic lithium chloride treatment has variable effects on motor behaviour and survival of mice transgenic for the Huntington's disease mutation
    • DOI 10.1016/S0361-9230(03)00141-2
    • Wood NI, Morton AJ. Chronic lithium chloride treatment has variable effects on motor behaviour and survival of mice transgenic for the Huntington's disease mutation. Brain Res Bull 2003;61:375-383 (Pubitemid 36945468)
    • (2003) Brain Research Bulletin , vol.61 , Issue.4 , pp. 375-383
    • Wood, N.I.1    Morton, A.J.2
  • 163
    • 0015965527 scopus 로고
    • Treatment of Huntington's chorea with lithium carbonate. A double-blind trial
    • Aminoff MJ, Marshall J. Treatment of Huntington's chorea with lithium carbonate. A double-blind trial. Lancet 1974;1:107-109
    • (1974) Lancet , vol.1 , pp. 107-109
    • Aminoff, M.J.1    Marshall, J.2
  • 164
    • 0017738763 scopus 로고
    • Lithium treatment of Huntington's chorea. A placebo-controlled clinical trial
    • Vestergaard P, Baastrup PC, Petersson H. Lithium treatment of Huntington's chorea. A placebo-controlled clinical trial. Acta Psychiatr Scand 1977;56:183-188
    • (1977) Acta Psychiatr Scand , vol.56 , pp. 183-188
    • Vestergaard, P.1    Baastrup, P.C.2    Petersson, H.3
  • 166
    • 0036172346 scopus 로고    scopus 로고
    • Prolonged survival and decreased abnormal movements in transgenic model of Huntington disease, with administration of the transglutaminase inhibitor cystamine
    • DOI 10.1038/nm0202-143
    • Karpuj MV, Becher MW, Springer JE, et al. Prolonged survival and decreased abnormal movements in transgenic model of Huntington disease, with administration of the transglutaminase inhibitor cystamine. Nat Med 2002;8:143-149 (Pubitemid 34155125)
    • (2002) Nature Medicine , vol.8 , Issue.2 , pp. 143-149
    • Karpuj, M.V.1    Becher, M.W.2    Springer, J.E.3    Chabas, D.4    Youssef, S.5    Pedotti, R.6    Mitchell, D.7    Steinman, L.8
  • 168
    • 5444229092 scopus 로고    scopus 로고
    • Cystamine increases L-cysteine levels in Huntington's disease transgenic mouse brain and in a PC12 model of polyglutamine aggregation
    • DOI 10.1111/j.1471-4159.2004.02726.x
    • Fox JH, Barber DS, Singh B, et al. Cystamine increases L-cysteine levels in Huntington's disease transgenic mouse brain and in a PC12 model of polyglutamine aggregation. J Neurochem 2004;91:413-422 (Pubitemid 39363440)
    • (2004) Journal of Neurochemistry , vol.91 , Issue.2 , pp. 413-422
    • Fox, J.H.1    Barber, D.S.2    Singh, B.3    Zucker, B.4    Swindell, M.K.5    Norflus, F.6    Buzescu7
  • 169
    • 0022536654 scopus 로고
    • Huntington's disease: Effect of cysteamine, a somatostatin-depleting agent
    • Shults C, Steardo L, Barone P, et al. Huntington's disease: effect of cysteamine, a somatostatin-depleting agent. Neurology 1986;36:1099-1102 (Pubitemid 16038591)
    • (1986) Neurology , vol.36 , Issue.8 , pp. 1099-1102
    • Shults, C.1    Steardo, L.2    Barone, P.3
  • 170
    • 33646248382 scopus 로고    scopus 로고
    • CYTE-I-HD: Phase I dose finding and tolerability study of cysteamine (Cystagon) in Huntington's disease
    • Dubinsky R, Gray C. CYTE-I-HD: phase I dose finding and tolerability study of cysteamine (Cystagon) in Huntington's disease. Mov Disord 2006;21:530-533
    • (2006) Mov Disord , vol.21 , pp. 530-533
    • Dubinsky, R.1    Gray, C.2
  • 171
    • 0037126988 scopus 로고    scopus 로고
    • Essential fatty acids given from conception prevent topographies of motor deficit in a transgenic model of Huntington's disease
    • DOI 10.1016/S0306-4522(01)00409-2, PII S0306452201004092
    • Clifford JJ, Drago J, Natoli AL, et al. Essential fatty acids given from conception prevent topographies of motor deficit in a transgenic model of Huntington's disease. Neuroscience 2002;109:81-88 (Pubitemid 34088148)
    • (2002) Neuroscience , vol.109 , Issue.1 , pp. 81-88
    • Clifford, J.J.1    Drago, J.2    Natoli, A.L.3    Wong, J.Y.F.4    Kinsella, A.5    Waddington, J.L.6    Vaddadi, K.S.7
  • 172
    • 0037148140 scopus 로고    scopus 로고
    • A randomised, placebo-controlled, double blind study of treatment of Huntington's disease with unsaturated fatty acids
    • Vaddadi KS, Soosai E, Chiu E, Dingjan P. A randomised, placebo-controlled, double blind study of treatment of Huntington's disease with unsaturated fatty acids. Neuroreport 2002;13:29-33 (Pubitemid 34102022)
    • (2002) NeuroReport , vol.13 , Issue.1 , pp. 29-33
    • Vaddadi, K.S.1    Soosai, E.2    Chiu, E.3    Dingjan, P.4
  • 174
    • 54449085055 scopus 로고    scopus 로고
    • Reduction in cerebral atrophy associated with ethyl-eicosapentaenoic acid treatment in patients with Huntington's disease
    • Puri BK, Bydder GM, Manku MS, et al. Reduction in cerebral atrophy associated with ethyl-eicosapentaenoic acid treatment in patients with Huntington's disease. J Int Med Res 2008;36:896-905
    • (2008) J Int Med Res , vol.36 , pp. 896-905
    • Puri, B.K.1    Bydder, G.M.2    Manku, M.S.3
  • 176
    • 61449249687 scopus 로고    scopus 로고
    • Randomized Controlled Trial of Ethyl-Eicosapentaenoic Acid in Huntington disease: The TREND-HD Study
    • Randomized Controlled Trial of Ethyl-Eicosapentaenoic Acid in Huntington disease: The TREND-HD Study. Arch Neurol 2008;65:1582-1589
    • (2008) Arch Neurol , vol.65 , pp. 1582-1589
  • 179
    • 0345600893 scopus 로고    scopus 로고
    • Dosage effects of riluzole in Huntington's disease: A multicenter placebo-controlled study
    • Dosage effects of riluzole in Huntington's disease: a multicenter placebo-controlled study. Neurology 2003;61:1551-1556 (Pubitemid 37505578)
    • (2003) Neurology , vol.61 , Issue.11 , pp. 1551-1556
    • Marshall, F.J.1
  • 182
    • 85009226418 scopus 로고    scopus 로고
    • 10 and remacemide in Huntington's disease
    • A randomized, placebo-controlled trial of coenzyme Q10 and remacemide in Huntington's disease. Neurology 2001;57:397-404 (Pubitemid 32757583)
    • (2001) Neurology , vol.57 , Issue.3 , pp. 397-404
    • Kieburtz, K.1
  • 183
    • 0037971143 scopus 로고    scopus 로고
    • Increased survival and neuroprotective effects of BN82451 in a transgenic mouse model of Huntington's disease
    • DOI 10.1046/j.1471-4159.2003.t01-1-01868.x
    • Klivenyi P, Ferrante RJ, Gardian G, et al. Increased survival and neuroprotective effects of BN82451 in a transgenic mouse model of Huntington's disease. J Neurochem 2003;86:267-272 (Pubitemid 36753867)
    • (2003) Journal of Neurochemistry , vol.86 , Issue.1 , pp. 267-272
    • Klivenyi, P.1    Ferrante, R.J.2    Gardian, G.3    Browne, S.4    Chabrier, P.-E.5    Beal, M.F.6
  • 184
    • 0344625374 scopus 로고    scopus 로고
    • Safety and tolerability of the free-radical scavenger OPC-14117 in Huntington's disease
    • Safety and tolerability of the free-radical scavenger OPC-14117 in Huntington's disease. The Huntington Study Group. Neurology 1998;50:1366-1373 (Pubitemid 28240353)
    • (1998) Neurology , vol.50 , Issue.5 , pp. 1366-1373
    • Marshall, F.J.1
  • 185
    • 47149108940 scopus 로고    scopus 로고
    • Effect of dimebon on cognition, activities of daily living, behaviour, and global function in patients with mild-to-moderate Alzheimer's disease: A randomised, double-blind, placebo-controlled study
    • DOI 10.1016/S0140-6736(08)61074-0, PII S0140673608610740
    • Doody RS, Gavrilova SI, Sano M, et al. Effect of dimebon on cognition, activities of daily living, behaviour, and global function in patients with mild-to-moderate Alzheimer's disease: a randomised, double-blind, placebo-controlled study. Lancet 2008;372:207-215 (Pubitemid 351978110)
    • (2008) The Lancet , vol.372 , Issue.9634 , pp. 207-215
    • Doody, R.S.1    Gavrilova, S.I.2    Sano, M.3    Thomas, R.G.4    Aisen, P.S.5    Bachurin, S.O.6    Seely, L.7    Hung, D.8
  • 186
    • 67649323801 scopus 로고    scopus 로고
    • Available from
    • Available from: https://www.euro-hd.net
  • 190
    • 0035960544 scopus 로고    scopus 로고
    • Coenzyme Q10 and remacemide hydrochloride ameliorate motor deficits in a Huntington's disease transgenic mouse model
    • DOI 10.1016/S0304-3940(01)02326-6, PII S0304394001023266
    • Schilling G, Coonfield ML, Ross CA, Borchelt DR. Coenzyme Q10 and remacemide hydrochloride ameliorate motor deficits in a Huntington's disease transgenic mouse model. Neurosci Lett 2001;315:149-153 (Pubitemid 33079072)
    • (2001) Neuroscience Letters , vol.315 , Issue.3 , pp. 149-153
    • Schilling, G.1    Coonfield, M.L.2    Ross, C.A.3    Borchelt, D.R.4
  • 194
    • 0034955984 scopus 로고    scopus 로고
    • Dichloroacetate exerts therapeutic effects in transgenic mouse models of Huntington's disease
    • Andreassen OA, Ferrante RJ, Huang HM, et al. Dichloroacetate exerts therapeutic effects in transgenic mouse models of Huntington's disease. Ann Neurol 2001;50:112-117
    • (2001) Ann Neurol , vol.50 , pp. 112-117
    • Andreassen, O.A.1    Ferrante, R.J.2    Huang, H.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.