A controlled trial of remacemide hydrochloride in Huntington's disease

Movement Disorders

Volumn 11, Issue 3, 1996, Pages 273-277

  Kieburtz, Karl ^a   Feigin, Andrew ^a   McDermott, Michael ^a   Como, Peter ^a   Abwender, David ^a   Zimmerman, Carol ^a   Hickey, Charlyne ^a   Orme, Constance ^a   Claude, Kathy ^a   Sotack, Jennie ^a   Greenamyre, J Timothy ^a   Dunn, Cynthia ^b   Shoulson, Ira ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^b Fisons Pharmaceuticals   (United States)

Author keywords

Clinical trial; Glutamate receptor blocker; Huntington's disease

Indexed keywords

N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PLACEBO; REMACEMIDE;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG TOLERABILITY; FEMALE; HUMAN; HUNTINGTON CHOREA; MALE; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME;

ACETAMIDES; ADULT; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; FEMALE; HUMANS; HUNTINGTON DISEASE; MALE; MIDDLE AGED; NEUROLOGIC EXAMINATION; NEUROPROTECTIVE AGENTS; NEUROPSYCHOLOGICAL TESTS; RECEPTORS, N-METHYL-D-ASPARTATE; TREATMENT OUTCOME;

EID: 9244263519     PISSN: 08853185     EISSN: None     Source Type: Journal    
DOI: 10.1002/mds.870110310     Document Type: Article

References (23)

1. Huntington's Disease Collaborative Research Group. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. Cell 1993;72:271-283.
2. Greenamyre JT, Shoulson I. Huntington's disease. In: Calne DB, ed. Neurodegenerative diseases. Philadelphia: WB Saunders, 1994:685-704.
3. Reiner A, Albin R, Anderson KD, et al. Differential loss of striatal projection neurons in Huntington's disease. Proc Natl Acad Sci USA 1988;85:5733-5737.
4. Coyle JT, Schwarz R. Lesion of striatal neurons with kainic acid provides a model of Huntington's disease. Nature 1976; 263:244-246.
5. Albin RL, Young AB, Penney JB, et al. Abnormalities of striatal projection neurons and N-methyl-D-aspartate receptors in presymptomatic Huntington's disease. N Engl J Med 1990;322:1292-1298.
6. Young AB, Greenamyre JT, Hollingsworth Z, et al. NMDA receptor losses in putamen from patients with Huntington's disease. Science 1988;241:981-983.
7. Beal MF, Kowall NW, Ferrante RJ, et al. Quinolinic acid striatal lesions in primates as a model of Huntington's disease. Ann Neurol 1989;26:137.
8. Rothman S, Olney J. Excitotoxicity and the NMDA receptor. Trends Neurosci 1987;10:299-302.
9. Albin RL, Young AB, Penney JB. The functional anatomy of basal ganglia disorders. Trends Neurosci 1989;12:366-375.
10. DeLong M. Primate models of movement disorders of basal ganglia origin. Trends Neurosci 1990;13:281-285.
11. Muir RT, Palmer GL. Remacemide. Epilepsy Res Suppl 1991;3:147-152.
12. Palmer GC, Murray RJ, Wilson TCM, et al. Biological profile of the metabolites and potential metabolites of the anti-convulsant remacemide. Epilepsy Res 1992;12:9-20.
13. Shoulson I, Fahn S. Huntington's disease: clinical care and evaluation. Neurology 1979;29:1-3.
14. Shoulson I, Odoroff C, Oakes D, et al. A controlled clinical trial of baclofen in early Huntington's disease. Ann Neurol 1989;25:252-259.
15. Folstein MF, Folstein SE, McHugh PR. "Mini-Mental State": a practical guide for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975;12:189-198.
16. Reitan RM, Wolfson D. The Halstead-Reitan Neuropsychological Test Battery. Tucson: Neuropsychology Press, 1985.
17. Smith A. Symbol Digit Modalities test manual. Los Angeles: Western Psychological Services, 1982.
18. Stroop JR. Studies of interference in serial verbal reactions. J Exp Psychol 1935;18:643-662.
19. Brandt J. The Hopkins Verbal Learning Test: development of a new memory test with six equivalent forms. Clin Neuropsychol 1991;5:126-142.
20. Beck AT, Ward CH, Mendelson M, Mack J, Erbaugh JK. An inventory for measuring depression. Arch Gen Psychiatry 1961;14:561-571.
21. Agresti A, Categorical data analysis. New York: Wiley, 1990.
22. Miller RG Jr. Simultaneous statistical inference. 2nd ed. New York: Springer-Verlag, 1981.
23. Koek W, Woods JH, Winger JD. MK-801, a proposed non-competitive antagonist of excitatory amino acid neurotransmission, produces phencyclidine-like behavioral effects in pigeons, rats, and rhesus monkeys. J Pharmacol Exp Ther 1988;245:969-974.