Huntingtin protein colocalizes with lesions of neurodegenerative diseases: An investigation in Huntington's, Alzheimer's, and Pick's diseases

Experimental Neurology

Volumn 150, Issue 2, 1998, Pages 213-222

  Singhrao, S K ^a   Thomas, P ^a   Wood, J D ^a   MacMillan, J C ^a   Neal, J W ^a   Harper, P S ^a   Jones, A L ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID; HUNTINGTIN; POLYCLONAL ANTIBODY; TRINUCLEOTIDE;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; CAUDATE NUCLEUS; CELL INCLUSION; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; HUNTINGTON CHOREA; IMMUNOCYTOCHEMISTRY; NERVE DEGENERATION; NEURITE; NEUROFIBRILLARY TANGLE; NEUROFILAMENT; PICK PRESENILE DEMENTIA; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PUTAMEN;

EID: 0032052003     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.1998.6778     Document Type: Article

References (52)

1. Albin R. A. Widespread expression of the human and rat Huntingtons disease gene in brain and non-neural tissues. Nature Genet. 5:1993;259-265.
2. Allsop D., Landon M., Kidd M., Lowe J. S., Reynolds G. P., Gardner A. Monoclonal antibodies raised against a subsequence of cerebrovascular amyloid in Alzheimer's disease. Neurosci. Lett. 68:1986;252-256.
3. Braak H., Braak E. Neuropathological staging of Alzheimer-related changes. Acta Neuropath. 82:1991;239-259.
4. Constantinidis J., Richard J., Tissot R. Pick's disease. Histological and clinical correlations. Eur. Neurol. 11:1974;208-217.
5. Cross, R. B. Demonstration of neurofibrillary tangles in paraffin sections 1982. A quick and simple method using Palmgrens method, Med. Lab. Sci. 39, 67, 69.
6. Davies S. W., Turmaine M., Cozens B. A., DiFiglia M., Sharp A. H., Ross C. A., Scherzinger E., Wanker E. E., Mangiarini L., Bates G. P. Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation. Cell. 90:1997.
7. DiFiglia M., Sapp E., Chase K. O., Davies S. W., Bates G. P., Vonsattel J-P, Aronin N. Aggregation of Huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain. Science. 277:1997;1990-1993.
8. Dickson D. W., Kress Y., Crowe A., Yen S-H. Monoclonal antibodies to Alzheimer neurofibrillary tangles. 2. Demonstration of a common antigenic determinant between ANT and neurofibrillary degeneration in progressive supranuclear palsy. Am. J. Pathol. 120:1985;292-303.
9. Ferrante R. J., Kowall N., Beal M. F., Richardson Jr E. P., Bird E., Martin J. B. Selective sparing of a class of striatal neurons in Huntingtons disease. Science. 230:1985;561-563.
10. Ferrante R. J, Kowall N., Beal M. F., Richardson E. P. jr, Bird E., Martin J. B. Morphologic and histochemical characteristics of a spared subset of striatal neurons in Huntingtons disease. J. Neuropath. Exp. Neurol. 46:1987;12-27.
11. Ferrante R. J., Gutekunst C-A., Perisichetti F., McNeill S., Kowall N., Gusella J. F., McDonald M. E., Beal M. F., Hersch S. M. Heterogeneous topographic and cellular distribution of huntingtin expression in the normal human neostriatum. J. Neurosci. 17:1997;3052-3063.
12. Gutekunst C-A., Levy A. I., Heilman C. J., Whaley W. L., Yi H., Nash N. R., Rees H. D., Maden J. J., Hersch S. M. Identification and localisation of huntingtin in brain and human lymphoblastoid cell lines with anti-fusion protien antibodies. Proc. Natl. Acad. Sci. USA. 92:1995;8710-8714.
13. Harper P. S. Huntington's Disease. 1996;W. B. Saunders, London.
14. Hedreen J., Folstein S. E. Early loss of striosomes neurons in Huntingtons disease. J Neuropath. Exp. Neurol. 54:1995;105-120.
15. Huntington G. On chorea. Med Surg Rep. 26:1972;317-321.
16. Cell. 72:1993;971-983.
17. Iwatsubo T., Odaka A., Suzuki N., Mizusawa H., Nukina N., Ihara Y. Visualization of Aβ42(43) and Aβ40 in senile plaques with end specific Ab monoclonals: Evidence that an initially deposited species is Aβ 42 (43). Neuron. 13:1994;45-53.
18. Jackson M., Gentleman S., Lennox G., Ward L., Gray T., Morrel K., Lowe J. The cortical neuritic pathology of Huntingtons disease. Neuropath. Appl. Neurobiol. 21:1995;18-26.
19. Joachim C. L., Morris J. H., Kosik K. S., Selkoe D. J. Tau antisera recognise neurofibrillary tangles in a range of neurodegenerative disorders. Ann. Neurol. 1987;514-520.
20. Kalchman M. A., Graham R. K., Xia G., Koide H. B., Hodgson J. G., Graham K. C., Goldberg Y. P., Gietz R. D., Pickarl C. M., Hayden M. R. Huntingtin is ubiquinated and interacts with specific ubiquitin conjugating enzyme. J. Biol. Chem. 271:1996;19385-19394.
21. Kato S., Nakamura H., Otomo E. Reappraisal of neurofibrillary tangles: Immunohistochemical, ultrastructural, and immunoelectron microscopical studies. Acta. Neuropathol. 77:1989;258-266.
22. Kato S., Nakamura H. Presence of two different fibril subtypes in the Pick body: An immunoelectron microscopic study. Acta Neuropathol. (Berlin). 81:1990;125-129.
23. Kawaguchi Y., Okamoto T., Taniwaki H., Aizawa M., Inoue M., Katayama S., Kawakami A., Nakamura S., Nishimura M., Akiguchi I. CAG expansions in a novel gene for Machado-Joseph disease at chromosome 14q32.1. Nature Genet. 8:1995;221-228.
24. Koide R., Ikeuchi T., Onodera O., Tanaka H., Igarashi S., Endo K., Takahashi H., Kondo R., Ishikawa A., Hayashi T., Saito M., Tomoda A., Miike T., Naito H., Ikuta F., Tsuji S. Unstable expansion of CAG repeat in hereditary dentatorubralpallidoluysian atrophy (DRPLA). Nature Genet. 6:1994;9-13.
25. Kosinski C., Cha Jang-Ho, Young A. B., Persichetti F., MacDonald M., Gusella J. F., Penny J. B., Standaert D. G. Huntingtin immunoreactivity in the rat neostriatum: Differential accumulation in projection and inter neurons. Exp. Neurol. 144:1997;289-247.
26. La Spada A. R., Wilson E. M., Lubahn D. B., Harding A. E., Fischbeck K. H. Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy. Nature. 352:1991;77-79.
27. Landwerhrmeyer G. B., McNeil S. M., Dure L. S., Ge P., Aizawa H., Huang Q., Ambrose C. M., Duyao M. P., Bird E. D., Bonilla E., de Young M., Avila-Gonzales A. J., Wexler N., DiFiglia M., Gusella J. F., Mc Donald M. E., Penny J. B., Young A. B., Vonsattel J-P. Huntingtons Disease Gene; Regional and cellular expression in brain of normal and affected individuals. Ann Neurol. 37:1995;218-230.
28. Love S., Saitoh T., Quijada S., Cole G. M., Terry R. D. Alz-50, ubiquitin and tau immunoreactivity of neurofibrillary tangles , Pick bodies and Lewy bodies. J. Neuropath. Exp. Neurol. 47:1988;1-8.
29. Love S., Burrola P., Terry R. D., Wiley C. A. Immunoelectron microscopy of Alzheimer and Pick brain tissue labelled with the monoclonal antibody Alz-50. J. Neuropathol. Appl. Neurobiol. 15:1989;223-231.
30. Masliah E., Terry R. D., Mallory M. Diffuse plaques do not accentuate synapse loss in Alzheimers disease. Am. J. Pathol. 137:1990;1293-1297.
31. Nagafuchi S., Yanagisawa H., Sato K., Shirayama T., Ohsaki E., Bundo M., Takeda T., Tadokoro K., Kondo I., Murayama N., Tanaka Y., Kikushima H., Umino K., Kurosawa H., Furukawa T., Nihei K., Inoue T., Sano A., Komure O., Takahashi M., Yoshizawa T., Kanazawa I., Yamada M. Dentatorubral and pallidoluysian atrophy expansion of an unstable CAG trinucleotide on chromosome 12p. Nature Genet. 6:1994;14-18.
32. Orr H. T. Expansion of an unstable trinucleotide CAG repeat in spinocerebellar ataxia type 1. Nature Genet. 4:1993;221-226.
33. Paulson H. L., Perez M. K., Trottier Y., Trojanowski J. Q., Subramony S. H., Das S. S., Vig P., Mandel J-L., Fischbeck K. H., Pittman R. N. Intranuclear inclusions of expanded polyglutamine protein in spinocerebellar ataxia type 3. Neuron. 19:1997;333-344.
34. Perry G., Selkoe D. J., Block B. R., Stewart D., Autilio-Gambetti L., Gambetti P. Electron microscopic localisation of Alzheimer neurofibrillary tangle components recognised by an antiserum to paired helical filaments. J. Neuropathol. Exp. Neurol. 45:1986;161-168.
35. Perutz M. F. Glutamine repeats as polar zippers; their role in inherited neurodegenerative diseases. Mol. Med. 1:1995;718-721.
36. Roizin L., Stellar S., Liu J. C. Neuronal nuclear-cytoplasmic changes in Huntington's chorea: Electron microscope investigations. Adv. Neurol. 23:1979;95-122.
37. Rubinsztein D. C., Leggo J., Coles R., Almqvist E., Biancalana V., Cassiman J-J, Chotai K., Connarty M., Craufurd D., Curtis A., Curtis D., Dvidson M. J., Differ A-M, Dode C., Dodge A., Frontali M., Ranen N. G., Stine O. C., Sherr M., Abbott M. H., Franz M. L., Graham C. A., Harper P. S., Hedreen J. C., Jackson A., Kaplan J-C., Losekoot M., MacMillan J. C., Morrison P., Trottier Y., Novelletto A., Simpson S. A., Theilmann J., Whittaker J. L., Folstein S. E., Ross C. A., Hayden M. R. Phenotypic characterization of individuals with 30-40 CAG repeats in the Huntington disease (HD) gene reveals HD cases with 36 repeats and apparently normal elderly individuals with 36-39 repeats. Am. J. Hum. Genet. 59:1996;16-22.
38. Sahnek Z., Lasek J. Inhibition of proteolysis blocks anterograde-retrograde conversion of axonally transported vesicles. Brain Res. 460:1988;199-203.
39. Scherzinger E., Lurz R., Turmaine M., Mangiarini L., Hollenbach B., Hasenbank R., Bates G. P., Davies S. W., Lehrach H., Wanker E. E. Huntingtin- encoded polyglutamine expansions form amyloid-like aggregates in vitro and in vivo. Cell. 90:1997;549-558.
40. Sharp A. H., Loev S. J., Schilling G., Li S. H., Li X. J., Bao J., Wagster M. V., Kotzuk J. A., Steiner J. P., Lo A. Widespread expression of Huntington's disease gene (IT-15) protein product. Neuron. 14:1995;1065-1074.
41. Singhrao S. K., Neal J. W., Gasque P., Morgan B. P., Newman G. R. Role of complement in the aetiology of Pick's disease? J. Neuropath. Exp. Neurol. 55:1996;578-593.
42. Snell R. G., MacMillian J. C., Cheadle J. P., Fenton I., Lazarou L. P., Davis P., MacDonald M. E., Gusella J. F., Harper P. S., Shaw D. J. Relationship between trinucleotide repeat expansion and phenotypic variation in Huntingtons disease. Nature Genet. 4:1993;393-397.
43. Sotrel A., Paskevich P. A., Kierly M. P. HM. P. Morphometric analysis of the prefrontal cortex in Huntington's disease. Neurology. 41:1991;1117-1123.
44. Strong T. V., Tangle D. A., Valdes J. M., Elmer L. W., Boehm K., Swaroop M., Kaatz K. W., Collins F. S, Albin R. A. Widespread expression of the human and rat Huntingtons disease gene in brain and non-neural tissues. Nature Genet. 5:1993;259-265.
45. Trottier Y., Lutz Y., Stevanin G., Imbert G., Devys D., Cancel G., Sandou F., Weber C., David G., Tora L., Agid Y., Brice A., Mandel J-L. Polyglutamine expansion as a pathological epitope in Huntington's disease and four dominant cerebellar ataxias. Nature. 378:1995.
46. Tukamoto T., Nukina N., Ide K., Kanazawa I. Huntington's disease gene product, huntingtin, associates with microtubules in vitro. J. Mol. Br. Res. 1997.
47. Vonsattel J-P., Myers R. H., Stevens T. J., Ferrante R. J., Bird E. D., Richardson jr E. P. Neuropathologic characterisation of Huntingtons disease. J. Neuropath. Exp. Neurol. 44:1985;559-577.
48. Wellington C., Brinkman J. R., Kusky O., Hayden M. R. Towards understanding the molecular pathology of Huntingtons disease. Brain Pathol. 7:1997;979-1002.
49. Wolozin B. L., Pruchnicki A., Dickson D. W., Davies P. A neuronal antigen in the brains of Alzheimer patients. Science. 232:1986;648-650.
50. Wood J. D., MacMillan J. C., Harper P. S., Lowenstein P. R., Jones A. L. Partial characterisation of murine huntingtin apparent variations in the subcellular localisation of huntingtin in human, mouse and rat brain. Hum. Mol. Genet. 54:1996;481-487.
51. Yankner B. New clues to Alzheimers disease: Unravelling the roles of amyloid and tau. Nature Med. 2:1996;850-852.
52. Yashara O. Picks disease immunohistochemistry : New alterations and Alzheimers disease comparisons. Acta Neuropathol. 89:1995;322-330.