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Volumn 93, Issue 1, 2005, Pages 145-155

Multiple pathways of apolipoprotein E signaling in primary neurons

Author keywords

secretase; ApoE; Disabled kinase; Lipoproteins; Receptors

Indexed keywords

APOLIPOPROTEIN E; CALCIUM CHANNEL BLOCKING AGENT; DIZOCILPINE; GAMMA SECRETASE; GAMMA SECRETASE INHIBITOR; GUANINE NUCLEOTIDE BINDING PROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; PERTUSSIS TOXIN; PROTEIN; PROTEIN DAB1; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

EID: 16244405249     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2004.03007.x     Document Type: Article
Times cited : (104)

References (47)
  • 1
    • 0344197741 scopus 로고    scopus 로고
    • Regulation of protein tyrosine kinase signaling by substrate degradation during brain development
    • Arnaud L., Ballif B. A., Forster E. and Cooper J. A. (2003) Regulation of protein tyrosine kinase signaling by substrate degradation during brain development. Mol. Cell Biol. 23, 9293-9302.
    • (2003) Mol. Cell Biol. , vol.23 , pp. 9293-9302
    • Arnaud, L.1    Ballif, B.A.2    Forster, E.3    Cooper, J.A.4
  • 2
    • 0034633703 scopus 로고    scopus 로고
    • The endocytic receptor protein LRP also mediates neuronal calcium signaling via N-methyl-D-aspartate receptors
    • Bacskai B. J., Xia M. Q., Strickland D. K., Rebeck G. W. and Hyman B. T. (2000) The endocytic receptor protein LRP also mediates neuronal calcium signaling via N-methyl-D-aspartate receptors. Proc. Natl Acad. Sci. USA 97, 11 551-11 556.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97
    • Bacskai, B.J.1    Xia, M.Q.2    Strickland, D.K.3    Rebeck, G.W.4    Hyman, B.T.5
  • 3
    • 0345317906 scopus 로고    scopus 로고
    • Tyrosine phosphorylation of Disabled-1 is essential for Reelin-stimulated activation of Akt and Src family kinases
    • Ballif B. A., Arnaud L. and Cooper J. A. (2003) Tyrosine phosphorylation of Disabled-1 is essential for Reelin-stimulated activation of Akt and Src family kinases. Mol. Brain Res. 117, 152-159.
    • (2003) Mol. Brain Res. , vol.117 , pp. 152-159
    • Ballif, B.A.1    Arnaud, L.2    Cooper, J.A.3
  • 4
    • 0345894331 scopus 로고    scopus 로고
    • Reelin-mediated signaling locally regulates protein kinase B/Akt and glycogen synthase kinase 3β
    • Beffert U., Morfini G., Bock H. H., Reyna H., Brady S. T. and Herz J. (2002) Reelin-mediated signaling locally regulates protein kinase B/Akt and glycogen synthase kinase 3β. J. Biol. Chem. 277, 49 958-49 964.
    • (2002) J. Biol. Chem. , vol.277
    • Beffert, U.1    Morfini, G.2    Bock, H.H.3    Reyna, H.4    Brady, S.T.5    Herz, J.6
  • 5
    • 1542409285 scopus 로고    scopus 로고
    • Fuctions of lipoprotein receptors in neurons
    • Beffert U., Stolt P. C. and Herz J. (2004) Fuctions of lipoprotein receptors in neurons. J. Lipid Res. 45, 403-409.
    • (2004) J. Lipid Res. , vol.45 , pp. 403-409
    • Beffert, U.1    Stolt, P.C.2    Herz, J.3
  • 6
    • 0037430909 scopus 로고    scopus 로고
    • Binding of purified Reelin to ApoER2 and VLDLR mediates tyrosine phosphorylation of Disabled-1
    • Benhayon D., Magdaleno S. and Curran T. (2003) Binding of purified Reelin to ApoER2 and VLDLR mediates tyrosine phosphorylation of Disabled-1. Mol. Brain Res. 112, 33-45.
    • (2003) Mol. Brain Res. , vol.112 , pp. 33-45
    • Benhayon, D.1    Magdaleno, S.2    Curran, T.3
  • 7
    • 0037425581 scopus 로고    scopus 로고
    • Reelin activates Src family tyrosine kinases in neurons
    • Bock H. H. and Herz J. (2003) Reelin activates Src family tyrosine kinases in neurons. Curr. Biol. 13, 18-26.
    • (2003) Curr. Biol. , vol.13 , pp. 18-26
    • Bock, H.H.1    Herz, J.2
  • 8
    • 0141755223 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase interacts with the adaptor protein Dab1 in response to Reelin signaling and is required for normal cortical lamination
    • Bock H. H., Jossin Y., Liu P., Forster E., May P., Goffinet A. M. and Herz J. (2003) Phosphatidylinositol 3-kinase interacts with the adaptor protein Dab1 in response to Reelin signaling and is required for normal cortical lamination. J. Biol. Chem. 278, 38 772-38 779.
    • (2003) J. Biol. Chem. , vol.278
    • Bock, H.H.1    Jossin, Y.2    Liu, P.3    Forster, E.4    May, P.5    Goffinet, A.M.6    Herz, J.7
  • 12
    • 0029866177 scopus 로고    scopus 로고
    • The interaction between apolipoprotein E and Alzheimer's amyloid beta-peptide is dependent on beta-peptide conformation
    • Golabek A. A., Soto C., Vogel T. and Wisniewski T. (1996) The interaction between apolipoprotein E and Alzheimer's amyloid beta-peptide is dependent on beta-peptide conformation. J. Biol. Chem. 271, 10 602-10 606.
    • (1996) J. Biol. Chem. , vol.271
    • Golabek, A.A.1    Soto, C.2    Vogel, T.3    Wisniewski, T.4
  • 13
    • 0034682827 scopus 로고    scopus 로고
    • Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction
    • Gotthard M., Trommsdorf M., Nevitt M. F., Shelton J., Richardson J. A., Stockinger W., Nimpf J. and Herz J. (2000) Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction. J. Biol. Chem. 275, 25 616-25 624.
    • (2000) J. Biol. Chem. , vol.275
    • Gotthard, M.1    Trommsdorf, M.2    Nevitt, M.F.3    Shelton, J.4    Richardson, J.A.5    Stockinger, W.6    Nimpf, J.7    Herz, J.8
  • 14
    • 0034668838 scopus 로고    scopus 로고
    • Neuronal apoptosis by apolipoprotein E4 through low-density lipoprotein receptor-related protein and heterotrimeric GTPases
    • Hashimoto Y., Jiang H., Niikura T., Ito Y., Hagiwara A., Umezawa K., Abe Y., Murayama Y. and Nishimoto I. (2000) Neuronal apoptosis by apolipoprotein E4 through low-density lipoprotein receptor-related protein and heterotrimeric GTPases. J. Neurosci. 20, 8401-8409.
    • (2000) J. Neurosci. , vol.20 , pp. 8401-8409
    • Hashimoto, Y.1    Jiang, H.2    Niikura, T.3    Ito, Y.4    Hagiwara, A.5    Umezawa, K.6    Abe, Y.7    Murayama, Y.8    Nishimoto, I.9
  • 15
    • 20244361899 scopus 로고    scopus 로고
    • Involvement of c-Jun N-terminal kinase in amyloid precursor protein-mediated neuronal cell death
    • Hashimoto Y., Tsuji O., Niikura T. et al. (2003) Involvement of c-Jun N-terminal kinase in amyloid precursor protein-mediated neuronal cell death. J. Neurochem. 84, 864-877.
    • (2003) J. Neurochem. , vol.84 , pp. 864-877
    • Hashimoto, Y.1    Tsuji, O.2    Niikura, T.3
  • 16
    • 0034305790 scopus 로고    scopus 로고
    • Apolipoprotein E receptors: Linking brain development and Alzheimer's disease
    • Herz J. and Beffert U. (2000) Apolipoprotein E receptors: linking brain development and Alzheimer's disease. Nat. Rev. Neurosci. 1, 51-58.
    • (2000) Nat. Rev. Neurosci. , vol.1 , pp. 51-58
    • Herz, J.1    Beffert, U.2
  • 17
    • 0033213319 scopus 로고    scopus 로고
    • Direct binding of Reelin to VLDL receptor and ApoE receptor 2 induces tyrosine phosphorylation of disabled-1 and modulates Tau phosphorylation
    • Hiesberger T., Trommsdorff M., Howell B. W., Groffinet A., Mumby M. C., Cooper J. A. and Herz J. (1999) Direct binding of Reelin to VLDL receptor and ApoE receptor 2 induces tyrosine phosphorylation of disabled-1 and modulates Tau phosphorylation. Neuron. 24, 481-489.
    • (1999) Neuron , vol.24 , pp. 481-489
    • Hiesberger, T.1    Trommsdorff, M.2    Howell, B.W.3    Groffinet, A.4    Mumby, M.C.5    Cooper, J.A.6    Herz, J.7
  • 18
    • 0033559054 scopus 로고    scopus 로고
    • Reelin-induced tyrosine phophorylation of disabled 1 during neuronal positioning
    • Howell B. W., Herrick T. M. and Cooper J. A. (1999) Reelin-induced tyrosine phophorylation of disabled 1 during neuronal positioning. Genes Dev. 13, 643-648.
    • (1999) Genes Dev. , vol.13 , pp. 643-648
    • Howell, B.W.1    Herrick, T.M.2    Cooper, J.A.3
  • 19
    • 0032054723 scopus 로고    scopus 로고
    • Signal transduction by the c-Jun N-terminal kinase (JNK) - From inflammation to development
    • Ip Y. T. and Davis R. J. (1998) Signal transduction by the c-Jun N-terminal kinase (JNK) - from inflammation to development. Curr. Opin. Cell Biol. 10, 205-219.
    • (1998) Curr. Opin. Cell Biol. , vol.10 , pp. 205-219
    • Ip, Y.T.1    Davis, R.J.2
  • 20
    • 2942557122 scopus 로고    scopus 로고
    • Gamma-secretase: Proteasome of the membrane?
    • Kopan R. and Ilagan M. X. (2004) Gamma-secretase: proteasome of the membrane? Nat. Rev. Mol. Cell Biol. 5, 499-504.
    • (2004) Nat. Rev. Mol. Cell Biol. , vol.5 , pp. 499-504
    • Kopan, R.1    Ilagan, M.X.2
  • 21
    • 0033118607 scopus 로고    scopus 로고
    • The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development
    • Kuan C. Y., Yang D. D., Samanta Roy D. R., Davis R. J., Rakic P. and Flavell R. A. (1999) The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development. Neuron. 22, 667-676.
    • (1999) Neuron , vol.22 , pp. 667-676
    • Kuan, C.Y.1    Yang, D.D.2    Samanta Roy, D.R.3    Davis, R.J.4    Rakic, P.5    Flavell, R.A.6
  • 24
    • 0042093508 scopus 로고    scopus 로고
    • ApoE4 impairs hippocampal plasticity isoform-specifically and blocks the environmental stimulation of synaptogenesis and memory
    • Levi O., Jongen-Relo A. L., Feldon J., Roses A. D. and Michaelson D. M. (2003) ApoE4 impairs hippocampal plasticity isoform-specifically and blocks the environmental stimulation of synaptogenesis and memory. Neurobiol. Dis. 13, 273-282.
    • (2003) Neurobiol. Dis. , vol.13 , pp. 273-282
    • Levi, O.1    Jongen-Relo, A.L.2    Feldon, J.3    Roses, A.D.4    Michaelson, D.M.5
  • 25
    • 0035947646 scopus 로고    scopus 로고
    • Differential functions of members of the low density lipoprotein receptor family suggested by their distinct endocytosis rates
    • Li Y., Lu W., Marzolo M. P. and Bu G. (2001) Differential functions of members of the low density lipoprotein receptor family suggested by their distinct endocytosis rates. J. Biol. Chem. 276, 18 000-18 006.
    • (2001) J. Biol. Chem. , vol.276
    • Li, Y.1    Lu, W.2    Marzolo, M.P.3    Bu, G.4
  • 27
    • 0037166319 scopus 로고    scopus 로고
    • Proteolytic processing of low density lipoprotein receptor-related protein mediates regulated release of its intracellular domain
    • May P., Reddy Y. K. and Herz J. (2002) Proteolytic processing of low density lipoprotein receptor-related protein mediates regulated release of its intracellular domain. J. Biol. Chem. 277, 18 736-18 743.
    • (2002) J. Biol. Chem. , vol.277
    • May, P.1    Reddy, Y.K.2    Herz, J.3
  • 28
    • 0141733204 scopus 로고    scopus 로고
    • Differential glycosylation regulates processing of lipoprotein receptors by gamma-secretase
    • May P., Bock H. H., Nimpf J. and Herz J. (2003) Differential glycosylation regulates processing of lipoprotein receptors by gamma-secretase. J. Biol. Chem. 278, 37 386-37 392.
    • (2003) J. Biol. Chem. , vol.278
    • May, P.1    Bock, H.H.2    Nimpf, J.3    Herz, J.4
  • 29
    • 0031030661 scopus 로고    scopus 로고
    • The low-density lipoprotein receptor-related protein, a multifunctional apolipoprotein E receptor, modulates hippocampal neunte development
    • Narita M., Bu G., Holtzman D. M. and Schwartz A. L. (1997) The low-density lipoprotein receptor-related protein, a multifunctional apolipoprotein E receptor, modulates hippocampal neunte development. J. Neurochem. 68, 587-595.
    • (1997) J. Neurochem. , vol.68 , pp. 587-595
    • Narita, M.1    Bu, G.2    Holtzman, D.M.3    Schwartz, A.L.4
  • 30
    • 0037154858 scopus 로고    scopus 로고
    • Apolipoprotein E4 inhibits, and apolipoprotein E3 promotes neurite outgrowth in cultured adult mouse cortical neurons through the low-density lipoprotein receptor-related protein
    • Nathan B. P., Jiang Y., Wong G. K., Shen F., Brewer G. J. and Struble R. G. (2002) Apolipoprotein E4 inhibits, and apolipoprotein E3 promotes neurite outgrowth in cultured adult mouse cortical neurons through the low-density lipoprotein receptor-related protein. Brain Res. 928, 96-105.
    • (2002) Brain Res. , vol.928 , pp. 96-105
    • Nathan, B.P.1    Jiang, Y.2    Wong, G.K.3    Shen, F.4    Brewer, G.J.5    Struble, R.G.6
  • 31
    • 0035793539 scopus 로고    scopus 로고
    • Apolipoprotein E4 stimulates cAMP response element-binding protein transcriptional activity through the extracellular signal-regulated kinase pathway
    • Ohkubo N., Mitsuda N., Tamatani M., Yamaguchi A., Lee Y. D., Ogihara T., Vitek M. P. and Tohyama M. (2001) Apolipoprotein E4 stimulates cAMP response element-binding protein transcriptional activity through the extracellular signal-regulated kinase pathway. J. Biol. Chem. 276, 3046-3053.
    • (2001) J. Biol. Chem. , vol.276 , pp. 3046-3053
    • Ohkubo, N.1    Mitsuda, N.2    Tamatani, M.3    Yamaguchi, A.4    Lee, Y.D.5    Ogihara, T.6    Vitek, M.P.7    Tohyama, M.8
  • 32
    • 12244279939 scopus 로고    scopus 로고
    • Dp-regulation of mitogen-activated protein kinases ERK1/2 and MEK1/2 is associated with the progression of neurofibrillary degeneration in Alzheimer's disease
    • Pei J. J., Braak H., An W. L., Winblad B., Cowburn R. F., Iqbal K. and Grundke-Iqbal I. (2002) Dp-regulation of mitogen-activated protein kinases ERK1/2 and MEK1/2 is associated with the progression of neurofibrillary degeneration in Alzheimer's disease. Brain Res. Mol. Brain Res. 109, 45-55.
    • (2002) Brain Res. Mol. Brain Res. , vol.109 , pp. 45-55
    • Pei, J.J.1    Braak, H.2    An, W.L.3    Winblad, B.4    Cowburn, R.F.5    Iqbal, K.6    Grundke-Iqbal, I.7
  • 33
    • 0025826774 scopus 로고
    • Astrocytic apolipoprotein E mRNA and GFAP mRNA in hippocampus after entorhinal cortex lesioning
    • Poirier J., Hess M., May P. C. and Finch C. E. (1991) Astrocytic apolipoprotein E mRNA and GFAP mRNA in hippocampus after entorhinal cortex lesioning. Brain Res. Mol. Brain Res. 11, 97-106.
    • (1991) Brain Res. Mol. Brain Res. , vol.11 , pp. 97-106
    • Poirier, J.1    Hess, M.2    May, P.C.3    Finch, C.E.4
  • 34
    • 0032557518 scopus 로고    scopus 로고
    • Effects of the amyloid protein precursor of Alzheimer's disease and other ligands of the LDL receptor-related protein on neurite outgrowth from sympathetic neurons in culture
    • Postuma R. B., Martins R. N., Cappai R., Beyreuther K., Masters C. L., Strickland D. K., Mok S. S. and Small D. H. (1998) Effects of the amyloid protein precursor of Alzheimer's disease and other ligands of the LDL receptor-related protein on neurite outgrowth from sympathetic neurons in culture. FEBS Lett. 428, 13-16.
    • (1998) FEBS Lett. , vol.428 , pp. 13-16
    • Postuma, R.B.1    Martins, R.N.2    Cappai, R.3    Beyreuther, K.4    Masters, C.L.5    Strickland, D.K.6    Mok, S.S.7    Small, D.H.8
  • 35
    • 0032589297 scopus 로고    scopus 로고
    • Alpha2-macroglobulin enhances the clearance of endogenous soluble beta-amyloid peptide via low-density lipoprotein receptor-related protein in cortical neurons
    • Qiu Z., Strickland D. K., Hyman B. T. and Rebeck G. W. (1999) Alpha2-macroglobulin enhances the clearance of endogenous soluble beta-amyloid peptide via low-density lipoprotein receptor-related protein in cortical neurons. J. Neurochem. 73, 1393-1398.
    • (1999) J. Neurochem. , vol.73 , pp. 1393-1398
    • Qiu, Z.1    Strickland, D.K.2    Hyman, B.T.3    Rebeck, G.W.4
  • 36
    • 0037177803 scopus 로고    scopus 로고
    • Alpha 2-macroglobulin exposure reduces calcium responses to N-methyl-D-aspartate via low density lipoprotein receptor-related protein in cultured hippocampal neurons
    • Qiu Z., Strickland D. K., Hyman B. T. and Rebeck G. W. (2002) Alpha 2-macroglobulin exposure reduces calcium responses to N-methyl-D-aspartate via low density lipoprotein receptor-related protein in cultured hippocampal neurons. J. Biol. Chem. 277, 14 458-14 466.
    • (2002) J. Biol. Chem. , vol.277
    • Qiu, Z.1    Strickland, D.K.2    Hyman, B.T.3    Rebeck, G.W.4
  • 37
    • 0242570611 scopus 로고    scopus 로고
    • ApoE isoforms affect neuronal N-methyl-D-aspartate calcium responses and toxicity via receptor-mediated processes
    • Qiu Z., Crutcher K. A., Hyman B. T. and Rebeck G. W. (2003) ApoE isoforms affect neuronal N-methyl-D-aspartate calcium responses and toxicity via receptor-mediated processes. Neuroscience. 122. 291-303.
    • (2003) Neuroscience , vol.122 , pp. 291-303
    • Qiu, Z.1    Crutcher, K.A.2    Hyman, B.T.3    Rebeck, G.W.4
  • 38
    • 4544297239 scopus 로고    scopus 로고
    • Apolipoprotein E receptors mediate neurite outgrowth through activation of p44/42 mitogen-activated protein kinase in primary neurons
    • Qiu Z., Hyman B. T. and Rebeck G. W. (2004) Apolipoprotein E receptors mediate neurite outgrowth through activation of p44/42 mitogen-activated protein kinase in primary neurons. J. Biol. Chem. 279, 34 948-34 956.
    • (2004) J. Biol. Chem. , vol.279
    • Qiu, Z.1    Hyman, B.T.2    Rebeck, G.W.3
  • 40
    • 9144264158 scopus 로고    scopus 로고
    • Receptor clustering is involved in Reelin signaling
    • Strasser V., Fasching D., Hauser C. et al. (2004) Receptor clustering is involved in Reelin signaling. Mol. Cell Biol. 24, 1378-1386.
    • (2004) Mol. Cell Biol. , vol.24 , pp. 1378-1386
    • Strasser, V.1    Fasching, D.2    Hauser, C.3
  • 43
    • 0028269666 scopus 로고
    • Hypothesis: Microtubule instability and paired helical filament formation in Alzheimer disease brain are related to apolipoprotein E genotype
    • Strittmatter W. J., Weisgraber K. H., Goedert M. et al. (1994) Hypothesis: microtubule instability and paired helical filament formation in Alzheimer disease brain are related to apolipoprotein E genotype. Exp. Neurol. 125, 163-171.
    • (1994) Exp. Neurol. , vol.125 , pp. 163-171
    • Strittmatter, W.J.1    Weisgraber, K.H.2    Goedert, M.3
  • 44
    • 0033567074 scopus 로고    scopus 로고
    • Truncated apolipoprotein E (ApoE) causes increased intraceullar calcium and may mediate ApoE neurotoxicity
    • Tolar M., Keller J. N., Chan S., Mattson M. P., Marques M. A. and Crutcher K. A. (1999) Truncated apolipoprotein E (ApoE) causes increased intraceullar calcium and may mediate ApoE neurotoxicity. J. Neurosci. 19, 7100-7110.
    • (1999) J. Neurosci. , vol.19 , pp. 7100-7110
    • Tolar, M.1    Keller, J.N.2    Chan, S.3    Mattson, M.P.4    Marques, M.A.5    Crutcher, K.A.6
  • 45
    • 0032509346 scopus 로고    scopus 로고
    • Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein
    • Trommsdorff M., Borg J. P., Margolis B. and Herz J. (1998) Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein. J. Biol. Chem. 273, 33 556-33 560.
    • (1998) J. Biol. Chem. , vol.273
    • Trommsdorff, M.1    Borg, J.P.2    Margolis, B.3    Herz, J.4
  • 47
    • 0028880006 scopus 로고
    • Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
    • Xia Z., Dickens M., Raingeaud J., Davis R. J. and Greenberg M. E. (1995) Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science. 270, 1326-1331.
    • (1995) Science , vol.270 , pp. 1326-1331
    • Xia, Z.1    Dickens, M.2    Raingeaud, J.3    Davis, R.J.4    Greenberg, M.E.5


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