Receptor-associated protein: A specialized chaperone and antagonist for members of the LDL receptor gene family

Current Opinion in Lipidology

Volumn 9, Issue 2, 1998, Pages 149-155

  Bu, Guojun ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHAPERONE; LIPOPROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR;

BIOCHEMISTRY; CYTOLOGY; DISULFIDE BOND; ENDOPLASMIC RETICULUM; HUMAN; LIGAND BINDING; LIPOPROTEIN METABOLISM; MOLECULAR GENETICS; MULTIGENE FAMILY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN PROTEIN INTERACTION; RECEPTOR GENE; REVIEW;

HUMANS; LIGANDS; MOLECULAR CHAPERONES; PROTEIN BINDING; PROTEIN FOLDING; RECEPTORS, LDL;

EID: 0031923160     PISSN: 09579672     EISSN: None     Source Type: Journal    
DOI: 10.1097/00041433-199804000-00012     Document Type: Review

References (39)

1. Herz J, Willnow TE. Functions of the LDL receptor gene family. Ann NY Acad Sci 1994; 737:14-19.
2. Krieger M, Herz J. Structures and functions of multiligand lipoprotein receptors: macrophage scavenger receptors and LDL receptor-related protein (LRP). Ann Rev Biochem 1994; 63:601-637.
3. Strickland DK, Ashcom JD, Williams S, Battey F, Behre E, McTigue K. et al. Primary structure of alpha 2-macroglobulin receptor-associated protein. Human homologue of a Heymann nephritis antigen. J Biol Chem 1991; 266:13364-13369.
4. Bu G, Maksymovitch EA, Geuze H, Schwartz AL. Subcellular localization and endocytic function of low density lipoprotein receptor-related protein in human glioblastoma cells. J Biol Chem 1994; 269:29874-29882.
5. Bu G, Geuze HJ, Strous GJ, Schwartz AL. 39kDa receptor-associated protein is an ER resident protein and molecular chaperone for LDL receptor-related protein. EMBO J 1995; 14:2269-2280.
6. Obermoeller LM, Warshawsky I, Wardell MR, Bu GJ. Differential functions of triplicated repeats suggest two independent roles for the receptor-associated protein as a molecular chaperone. J Biol Chem 1997; 272:10761-10768.
7. Willnow TE, Rohlmann A, Horton J, Otani H, Braun JR, Hammer RE, et al. RAP. a specialized chaperone, prevents ligand-induced Er retention and degradation of LDL receptor-related endocytic receptors. EMBO J 1996; 15:2632-2639.
8. Bu GJ, Rennke S. Receptor-associated protein is a folding chaperone for low density lipoprotein receptor-related protein. J Biol Chem 1996; 271:22218-22224.
9. Ashcom JD, Tiller SE, Dickerson K, Cravens JL, Argraves WS, Strickland DK. The human alpha 2-macroglobulin receptor: identification of a 420-kD cell surface glycoprotein specific for the activated conformation ot alpha 2-macroglobulin. J Cell Biol 1990; 110:1041-1048.
10. Petersen CM, Ellgaard L, Nykjaer A, Vilhardt F, Vorum H, Thogersen HC, et al. The receptor-associated protein (RAP) binds calmodulin and is phosphorylated by calmodulin-dependent kinase II. EMBO J 1996; 15:4165-4173.
11. Zheng G, Bachinsky DR, Stamenkovic I, Strickland DK, Brown D, Andres G, et al. Organ distribution in rats of two members of the low-density lipoprotein receptor gene family, gp330 and LRP/alpa 2MR, and the receptor-associated protein (RAP). J Histochem Cytochem 1994; 42:531-542.
12. Bu G, Maksymovitch EA, Nerbonne JM, Schwartz AL. Expression and function of the low density lipoprotein receptor-related protein (LRP) in mammalian central neurons. J Biol Chem 1994; 269:18521-18528.
13. Furukawa T, Ozawa M, Huang RP, Muramatsu T. A heparin binding protein whose expression increases during differentiation of embryonal carcinoma cells to parietal endoderm cells: cDNA cloning and sequence analysis. J Biochem 1990; 108:297-302.
14. Pietromonaco S, Kerjaschki D, Binder S, Ullrich R, Farquhar MG. Molecular cloning of a cDNA encoding a major pathogenic domain of the Heymann nephritis antigen gp330. Proc Natl Acad USA 1990; 87:1811-1815.
15. Warshawsky I, Bu G, Schwartz AL. Identification of domains on the 39-kDa protein that inhibit the binding of ligands to the low density lipoprotein receptor-related protein. J Biol Chem 1993; 268:22046-22054.
16. Warshawsky I, Bu G, Schwartz AL. Binding analysis of amino-terminal and carboxyl-terminal regions of the 39-kDa protein to the low density lipoprotein receptor-related protein. J Biol Chem 1994; 269:3325-3330.
17. Warshawsky I, Bu G, Schwartz AL. Sites within the 39-kDa protein important for regulating ligand binding to the low-density lipoprotein receptor-related protein. Biochemistry 1995; 34:3404-3415.
18. Ellgaard L, Holtet TL, Nielsen PR, Etzerodt M, Gliemann J, Thogersen HC. Dissection of the domain architecture of the alpha(2)macroglobulin-receptor-associated protein. Euro J Biochem 1997; 244:544-551.
19. Hiesberger T, Hodits R, Ullrich R, Exner M, Kerjaschki D, Schneider WJ, et al. Receptor-associated protein and members of the low density lipoprotein receptor family share a common epitope. An extended model for the development of passive Heymann nephritis. J Biol Chem 1996; 271:28792-28797.
20. 2-macroglobulin receptor-associated protein. Proc Natl Acad Sci USA 1997; 94:7521-7525.
21. Herz J, Goldstein JL, Strickland DK, Ho YK, Brown MS. 39-kDa protein modulates binding of ligands to low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor. J Biol Chem 1991; 266: 21232-21238.
22. Moestrup SK, Gliemann J. Analysis of ligand recognition by the purified alpha 2-macroglobulin receptor (low-density lipoprotein receptor-related protein). Evidence that high affinity of alpha 2-macroglobulin-proteinase complex is achieved by binding to adjacent receptors. J Biol Chem 1991; 266:14011-14017.
23. Bu G, Williams S, Strickland DK, Schwartz AL. Low-density lipoprotein receptor-related protein/alpha 2-mcroglobulin receptor is an hepatic receptor for tissue-type plasminogen activator. Proc Natl Acad Sci USA 1992; 89:7427-7431.
24. Orth K, Madison EL, Gething MJ, Sambrook JF, Herz J. Complexes of tissue-type plasminogen activator and its serpin inhibitor plasminogen-activator inhibitor type 1 are internalized by means of the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor. Proc Natl Acad Sci USA 1992; 89:7422-7426.
25. Williams SE, Ashcom JD, Argraves WS, Strickland DK, A novel mechanism for controlling the activity of alpha 2-macroglobulin receptor/low-density lipoprotein receptor-related protein. Multiple regulatory sites for 39-kDa receptor-associated protein. J Biol Chem 1992; 267:9035-9040.
26. Nykjaer A. Petersen CM, Moller B, Jensen PH, Moestrup SK, Holtet TL, et al. Purified alpha 2-macroglobulin receptor/LDL receptor-related protein binds urokinase.plasminogen activator inhibitor type-1 complex. Evidence that the alpha 2-macroglobulin receptor mediates cellular degradation of urokinase receptor-bound complexes. J Biol Chem 1992; 267,14535-14546.
27. Iadonato SP, Bu G, Maksymovitch EA, Schwartz AL. Interaction of a 39-kDa protein with the low density-lipoprotein-receptor-related protein (LRP) on rat hepatoma cells. Biochem J 1993; 296:867-875.
28. Kounnas MZ, Argraves WS, Strickland DK. The 39-kDa receptor-associated protein interacts with two members of the low density lipoprotein receptor family, alpha 2-macroglobulin receptor and glycoprotein 330. J Biol Chem 1992; 267:21162-21166.
29. Battey FD, Gafvels ME, FitzGerald DJ, Argraves WS, Chappell DA, Strauss JF, et al. The 39-kDa receptor-associated protein regulates ligand binding by the very low density lipoprotein receptor. J Biol Chem 1994; 269:23268-23273.
30. Medh JD, Fry GL, Bowsen SL, Pladet MW, Strickland DK, Chappell DA. The 39-kDa receptor-associated protein modulates lipoprotein catabolism by binding to LDL receptors. J Biol Chem 1995; 270:536-540.
31. Horn IR, Vandenberg BMM, Vandermeijden PZ, Pannekoek H, Vanzonneveld AJ. Molecular analysis of ligand binding to the second cluster of complement-type repeats of the low-density lipoprotein receptor-related protein-evidence for an allosteric component in receptor-associated protein-mediated inhibition of ligand binding. J Biol Chem 1997; 272:13608-13613.
32. Warshawsky I, Bu G, Schwartz AL. 39-kD protein inhibits tissue-type plasminogen activator clearance in vivo. J Clin Invest 1993; 92:937-944.
33. Willnow TE, Sheng Z, Ishibashi S, Herz J. Inhibition of hepatic chylomicron remnant uptake by gene transfer of a receptor antagonist. Science 1994; 264:1471-1474.
34. Narita M, Bu G, Herz J, Schwartz AL. Two receptor systems are involved in the plasma clearance of tissue-type plasminogen activator (t-PA) in vivo. J Clin Invest 1995;96:1164-1168.
35. Orlando RA, Kerjaschki D, Kurihara H, Biemesderfer D, Farquhar MG. gp330 associates with a 44-kDa protein in the rat kidney to form the Heymann nephritis antigenic complex. Proc Natl Acad Sci USA 1992; 89:6698-6702.
36. Bu GJ, Rennke S, Geuze HJ. Erd2 Proteins Mediate Er Retention Of the Hnel Signal Of Lrps Receptor-Associated Protein (RAP). J Cell Sci 1997; 110:65-73.
37. Pelham HR. Sorting and retrieval between the endoplasmic reticulum and Golgi apparatus. Curr Opin Cell Biol 1995; 7:530-535.
38. Willnow TE, Armstrong SA, Hammer RE, Herz J. Functional expression of low density lipoprotein receptor-related protein is controlled by receptor-associated protein in vivo. Proc Natl Acad Sci U S A 1995; 92:4537-4541.
39. Sant AJ, Miller J. MHC class II antigen processing: biology of invariant chain. Curr Opin Immunol 1994; 6:57-63.