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Volumn 24, Issue 10, 2004, Pages 2527-2534

Neuron-Specific Apolipoprotein E4 Proteolysis Is Associated with Increased Tau Phosphorylation in Brains of Transgenic Mice

Author keywords

Alzheimer's disease; Apolipoprotein E; Excitotoxin; Proteolysis; Tau phosphorylation; Transgenic mice

Indexed keywords

AMYLOID; APOLIPOPROTEIN E3; APOLIPOPROTEIN E4; EXCITOTOXIN; GLIAL FIBRILLARY ACIDIC PROTEIN; ISOPROTEIN; KAINIC ACID; NEURON SPECIFIC ENOLASE; TAU PROTEIN;

EID: 12144290271     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4315-03.2004     Document Type: Article
Times cited : (337)

References (69)
  • 1
    • 0037385034 scopus 로고    scopus 로고
    • Increased expression of neuronal apolipoprotein E in human brain with cerebral infarction
    • Aoki K, Uchihara T, Sanjo N, Nakamura A, Ikeda K, Tsuchiya K, Wakayama Y (2003) Increased expression of neuronal apolipoprotein E in human brain with cerebral infarction. Stroke 34:875-880.
    • (2003) Stroke , vol.34 , pp. 875-880
    • Aoki, K.1    Uchihara, T.2    Sanjo, N.3    Nakamura, A.4    Ikeda, K.5    Tsuchiya, K.6    Wakayama, Y.7
  • 3
    • 0029912740 scopus 로고    scopus 로고
    • Expression of apolipoprotein E in normal and diverse neurodegenerative disease brain
    • Bao F, Arai H, Matsushita S, Higuchi S, Sasaki H (1996) Expression of apolipoprotein E in normal and diverse neurodegenerative disease brain. NeuroReport 7:1733-1739.
    • (1996) NeuroReport , vol.7 , pp. 1733-1739
    • Bao, F.1    Arai, H.2    Matsushita, S.3    Higuchi, S.4    Sasaki, H.5
  • 4
    • 0030009670 scopus 로고    scopus 로고
    • Apolipoprotein E, plaques, tangles and cholinergic dysfunction in Alzheimer's disease
    • Beffert U, Poirier J (1996) Apolipoprotein E, plaques, tangles and cholinergic dysfunction in Alzheimer's disease. Ann NY Acad Sci 777:166-174.
    • (1996) Ann NY Acad Sci , vol.777 , pp. 166-174
    • Beffert, U.1    Poirier, J.2
  • 6
    • 0022350033 scopus 로고
    • Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system
    • Boyles JK, Pitas RE, Wilson E, Mahley RW, Taylor JM (1985) Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system. J Clin Invest 76:1501-1513.
    • (1985) J Clin Invest , vol.76 , pp. 1501-1513
    • Boyles, J.K.1    Pitas, R.E.2    Wilson, E.3    Mahley, R.W.4    Taylor, J.M.5
  • 8
    • 0034055035 scopus 로고    scopus 로고
    • Dominant negative effects of apolipoprotein E4 revealed in transgenic models of neurodegenerative disease
    • Buttini M, Akeefe H, Lin C, Mahley RW, Pitas RE, Wyss-Coray T, Mucke L (2000) Dominant negative effects of apolipoprotein E4 revealed in transgenic models of neurodegenerative disease. Neuroscience 97:207-210.
    • (2000) Neuroscience , vol.97 , pp. 207-210
    • Buttini, M.1    Akeefe, H.2    Lin, C.3    Mahley, R.W.4    Pitas, R.E.5    Wyss-Coray, T.6    Mucke, L.7
  • 9
    • 0037115049 scopus 로고    scopus 로고
    • Modulation of Alzheimer-like synaptic and cholinergic deficits in transgenic mice by human apolipoprotein E depends on isoform, aging, and overexpression of amyloid β peptides but not on plaque formation
    • Buttini M, Yu G-Q, Shockley K, Huang Y, Jones B, Masliah E, Mallory M, Yeo T, Longo FM, Mucke L (2002) Modulation of Alzheimer-like synaptic and cholinergic deficits in transgenic mice by human apolipoprotein E depends on isoform, aging, and overexpression of amyloid β peptides but not on plaque formation. J Neurosci 22:10539-10548.
    • (2002) J Neurosci , vol.22 , pp. 10539-10548
    • Buttini, M.1    Yu, G.-Q.2    Shockley, K.3    Huang, Y.4    Jones, B.5    Masliah, E.6    Mallory, M.7    Yeo, T.8    Longo, F.M.9    Mucke, L.10
  • 10
    • 0030836345 scopus 로고    scopus 로고
    • Increased neuronal endocytosis and protease delivery to early endosomes in sporadic Alzheimer's disease: Neuropathologic evidence for a mechanism of increased β-amyloidogenesis
    • Cataldo AM, Barnett JL, Pieroni C, Nixon RA (1997) Increased neuronal endocytosis and protease delivery to early endosomes in sporadic Alzheimer's disease: neuropathologic evidence for a mechanism of increased β-amyloidogenesis. J Neurosci 17:6142-6151.
    • (1997) J Neurosci , vol.17 , pp. 6142-6151
    • Cataldo, A.M.1    Barnett, J.L.2    Pieroni, C.3    Nixon, R.A.4
  • 11
    • 0033869715 scopus 로고    scopus 로고
    • Endocytic pathway abnormalities precede amyloid β deposition in sporadic Alzheimer's disease and Down syndrome: Differential effects of APOE genotype and presenilin mutations
    • Cataldo AM, Peterhoff CM, Troncoso JC, Gomez-Isla T, Hyman BT, Nixon RA (2000) Endocytic pathway abnormalities precede amyloid β deposition in sporadic Alzheimer's disease and Down syndrome: differential effects of APOE genotype and presenilin mutations. Am J Pathol 157:277-286.
    • (2000) Am J Pathol , vol.157 , pp. 277-286
    • Cataldo, A.M.1    Peterhoff, C.M.2    Troncoso, J.C.3    Gomez-Isla, T.4    Hyman, B.T.5    Nixon, R.A.6
  • 13
    • 0027413656 scopus 로고
    • Tau protein and paired helical filaments of Alzheimer's disease
    • Crowther RA (1993) Tau protein and paired helical filaments of Alzheimer's disease. Curr Opin Struct Biol 3:202-206.
    • (1993) Curr Opin Struct Biol , vol.3 , pp. 202-206
    • Crowther, R.A.1
  • 14
    • 0035068579 scopus 로고    scopus 로고
    • Synthesis and processing of apolipoprotein E in human brain cultures
    • Dekroon RM, Armati PJ (2001) Synthesis and processing of apolipoprotein E in human brain cultures. Glia 33:298-305.
    • (2001) Glia , vol.33 , pp. 298-305
    • Dekroon, R.M.1    Armati, P.J.2
  • 15
    • 0025951302 scopus 로고
    • Neuropathological changes in scrapie and Alzheimer's disease are associated with increased expression of apolipoprotein E and cathepsin D in astrocytes
    • Diedrich JF, Minnigan H, Carp RI, Whitaker JN, Race R, Frey II W, Haase AT (1991) Neuropathological changes in scrapie and Alzheimer's disease are associated with increased expression of apolipoprotein E and cathepsin D in astrocytes. J Virol 65:4759-4768.
    • (1991) J Virol , vol.65 , pp. 4759-4768
    • Diedrich, J.F.1    Minnigan, H.2    Carp, R.I.3    Whitaker, J.N.4    Race, R.5    Frey II, W.6    Haase, A.T.7
  • 18
    • 0033673563 scopus 로고    scopus 로고
    • Synthesis and regulation of apolipoprotein E during the differentiation of human neuronal precursor NT2/D1 cells into postmitotic neurons
    • Ferreira S, Dupire M-J, Delacourte A, Najib J, Caillet-Boudin M-L (2000) Synthesis and regulation of apolipoprotein E during the differentiation of human neuronal precursor NT2/D1 cells into postmitotic neurons. Exp Neurol 166:415-421.
    • (2000) Exp Neurol , vol.166 , pp. 415-421
    • Ferreira, S.1    Dupire, M.-J.2    Delacourte, A.3    Najib, J.4    Caillet-Boudin, M.-L.5
  • 19
    • 0042733013 scopus 로고    scopus 로고
    • Rab5-stimulated upregulation of the endocytic pathway increases intracellular β-cleaved amyloid precursor protein carboxyl-terminal fragment levels and Aβ production
    • Grbovic OM, Mathews PM, Jiang Y, Schmidt SD, Dinakar R, Summers-Terio NB, Ceresa BP, Nixon RA, Cataldo AM (2003) Rab5-stimulated upregulation of the endocytic pathway increases intracellular β-cleaved amyloid precursor protein carboxyl-terminal fragment levels and Aβ production. J Biol Chem 278:31261-31268.
    • (2003) J Biol Chem , vol.278 , pp. 31261-31268
    • Grbovic, O.M.1    Mathews, P.M.2    Jiang, Y.3    Schmidt, S.D.4    Dinakar, R.5    Summers-Terio, N.B.6    Ceresa, B.P.7    Nixon, R.A.8    Cataldo, A.M.9
  • 23
    • 0034870449 scopus 로고    scopus 로고
    • Behavioral phenotyping of GFAP-apoE3 and -apoE4 transgenic mice: apoE4 mice show profound working memory impairments in the absence of Alzheimer's-like neuropathology
    • Hartman RE, Wozniak DF, Nardi A, Olney JW, Sartorius L, Holtzman DM (2001) Behavioral phenotyping of GFAP-apoE3 and -apoE4 transgenic mice: apoE4 mice show profound working memory impairments in the absence of Alzheimer's-like neuropathology. Exp Neurol 170:326-344.
    • (2001) Exp Neurol , vol.170 , pp. 326-344
    • Hartman, R.E.1    Wozniak, D.F.2    Nardi, A.3    Olney, J.W.4    Sartorius, L.5    Holtzman, D.M.6
  • 24
    • 0042023711 scopus 로고    scopus 로고
    • Alzheimer disease in the US population: Prevalence estimates using the 2000 census
    • Hebert LE, Scherr PA, Bienias JL, Bennett DA, Evans DA (2003) Alzheimer disease in the US population: prevalence estimates using the 2000 census. Arch Neurol 60:1119-1122.
    • (2003) Arch Neurol , vol.60 , pp. 1119-1122
    • Hebert, L.E.1    Scherr, P.A.2    Bienias, J.L.3    Bennett, D.A.4    Evans, D.A.5
  • 25
    • 0034305790 scopus 로고    scopus 로고
    • Apolipoprotein E receptors: Linking brain development and Alzheimer's disease
    • Herz J, Beffert U (2000) Apolipoprotein E receptors: linking brain development and Alzheimer's disease. Nat Rev Neurosci 1:51-58.
    • (2000) Nat Rev Neurosci , vol.1 , pp. 51-58
    • Herz, J.1    Beffert, U.2
  • 27
    • 0004473175 scopus 로고    scopus 로고
    • Apolipoprotein E and human disease
    • (Barter PJ, Rye K-A, eds). Amsterdam: Harwood
    • Huang Y, Mahley RW (1999). Apolipoprotein E and human disease. In: Plasma lipids and their role in disease (Barter PJ, Rye K-A, eds), pp 257-284. Amsterdam: Harwood.
    • (1999) Plasma Lipids and Their Role in Disease , pp. 257-284
    • Huang, Y.1    Mahley, R.W.2
  • 29
    • 0035902514 scopus 로고    scopus 로고
    • Apolipoprotein E fragments present in Alzheimer's disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons
    • Huang Y, Liu XQ, Wyss-Coray T, Brecht WJ, Sanan DA, Mahley RW (2001) Apolipoprotein E fragments present in Alzheimer's disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons. Proc Natl Acad Sci USA 98:8838-8843.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 8838-8843
    • Huang, Y.1    Liu, X.Q.2    Wyss-Coray, T.3    Brecht, W.J.4    Sanan, D.A.5    Mahley, R.W.6
  • 31
    • 0037077284 scopus 로고    scopus 로고
    • Apolipoprotein E4 potentiates amyloid β peptide-induced lysosomal leakage and apoptosis in neuronal cells
    • Ji Z-S, Miranda RD, Newhouse YM, Weisgraber KH, Huang Y, Mahley RW (2002) Apolipoprotein E4 potentiates amyloid β peptide-induced lysosomal leakage and apoptosis in neuronal cells. J Biol Chem 277:21821-21828.
    • (2002) J Biol Chem , vol.277 , pp. 21821-21828
    • Ji, Z.-S.1    Miranda, R.D.2    Newhouse, Y.M.3    Weisgraber, K.H.4    Huang, Y.5    Mahley, R.W.6
  • 35
    • 0028173205 scopus 로고
    • 1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer β-protein into filaments
    • 1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer β-protein into filaments. Nature 372:92-94.
    • (1994) Nature , vol.372 , pp. 92-94
    • Ma, J.1    Yee, A.2    Brewer Jr., H.B.3    Das, S.4    Potter, H.5
  • 36
    • 0032839621 scopus 로고    scopus 로고
    • Apolipoprotein E: From atherosclerosis to Alzheimer's disease and beyond
    • Mahley R, Huang Y (1999) Apolipoprotein E: from atherosclerosis to Alzheimer's disease and beyond. Curr Opin Lipidol 10:207-217.
    • (1999) Curr Opin Lipidol , vol.10 , pp. 207-217
    • Mahley, R.1    Huang, Y.2
  • 37
    • 2542430827 scopus 로고    scopus 로고
    • Apolipoprotein E: Structure and function in lipid metabolism and neurobiology
    • (Rosenberg RN, Prusiner SB, DiMauro S, Barchi RL, Nestler EJ, eds). Philadelphia: Butterworth Heinemann
    • Mahley R, Huang Y (2000) Apolipoprotein E: structure and function in lipid metabolism and neurobiology. In: The molecular and genetic basis of neurologic and psychiatric disease, Ed 3 (Rosenberg RN, Prusiner SB, DiMauro S, Barchi RL, Nestler EJ, eds), pp 565-573. Philadelphia: Butterworth Heinemann.
    • (2000) The Molecular and Genetic Basis of Neurologic and Psychiatric Disease, Ed 3 , pp. 565-573
    • Mahley, R.1    Huang, Y.2
  • 39
    • 0029995278 scopus 로고    scopus 로고
    • Neurons of the human frontal cortex display apolipoprotein E immunoreactivity: Implications for Alzheimer's disease
    • Metzger RE, LaDu MJ, Pan JB, Getz GS, Frail DE, Falduto MT (1996) Neurons of the human frontal cortex display apolipoprotein E immunoreactivity: implications for Alzheimer's disease. J Neuropathol Exp Neurol 55:372-380.
    • (1996) J Neuropathol Exp Neurol , vol.55 , pp. 372-380
    • Metzger, R.E.1    LaDu, M.J.2    Pan, J.B.3    Getz, G.S.4    Frail, D.E.5    Falduto, M.T.6
  • 40
    • 0029765553 scopus 로고    scopus 로고
    • Apolipoprotein E allele-specific antioxidant activity and effects on cytotoxicity by oxidative insults and β-amyloid peptides
    • Miyata M, Smith JD (1996) Apolipoprotein E allele-specific antioxidant activity and effects on cytotoxicity by oxidative insults and β-amyloid peptides. Nat Genet 14:55-61.
    • (1996) Nat Genet , vol.14 , pp. 55-61
    • Miyata, M.1    Smith, J.D.2
  • 41
    • 0036454496 scopus 로고    scopus 로고
    • Selective vulnerability of corticocortical and hippocampal circuits in aging and Alzheimer's disease
    • Morrison JH, Hof PR (2002) Selective vulnerability of corticocortical and hippocampal circuits in aging and Alzheimer's disease. Prog Brain Res 136:467-486.
    • (2002) Prog Brain Res , vol.136 , pp. 467-486
    • Morrison, J.H.1    Hof, P.R.2
  • 42
    • 0025971426 scopus 로고
    • Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease
    • Namba Y, Tomonaga M, Kawasaki H, Otomo E, Ikeda K (1991) Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease. Brain Res 541:163-166.
    • (1991) Brain Res , vol.541 , pp. 163-166
    • Namba, Y.1    Tomonaga, M.2    Kawasaki, H.3    Otomo, E.4    Ikeda, K.5
  • 44
    • 0029157112 scopus 로고
    • The inhibitory effect of apolipoprotein E4 on neurite outgrowth is associated with microtubule depolymerization
    • Nathan BP, Chang K-C, Bellosta S, Brisch E, Ge N, Mahley RW, Pitas RE (1995) The inhibitory effect of apolipoprotein E4 on neurite outgrowth is associated with microtubule depolymerization. J Biol Chem 270:19791-19799.
    • (1995) J Biol Chem , vol.270 , pp. 19791-19799
    • Nathan, B.P.1    Chang, K.-C.2    Bellosta, S.3    Brisch, E.4    Ge, N.5    Mahley, R.W.6    Pitas, R.E.7
  • 45
    • 0025826774 scopus 로고
    • Astrocytic apolipoprotein E mRNA and GFAP mRNA in hippocampus after entorhinal cortex lesioning
    • Poirier J, Hess M, May PC, Finch CE (1991) Astrocytic apolipoprotein E mRNA and GFAP mRNA in hippocampus after entorhinal cortex lesioning. Mol Brain Res 11:97-106.
    • (1991) Mol Brain Res , vol.11 , pp. 97-106
    • Poirier, J.1    Hess, M.2    May, P.C.3    Finch, C.E.4
  • 46
    • 0032168460 scopus 로고    scopus 로고
    • Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: Increased susceptibility of females
    • Raber J, Wong D, Buttini M, Orth M, Bellosta S, Pitas RE, Mahley RW, Mucke L (1998) Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: increased susceptibility of females. Proc Natl Acad Sci USA 95:10914-10919.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 10914-10919
    • Raber, J.1    Wong, D.2    Buttini, M.3    Orth, M.4    Bellosta, S.5    Pitas, R.E.6    Mahley, R.W.7    Mucke, L.8
  • 48
    • 0037096337 scopus 로고    scopus 로고
    • Androgens protect against apolipoprotein E4-induced cognitive deficits
    • Raber J, Bongers G, LeFevour A, Buttini M, Mucke L (2002) Androgens protect against apolipoprotein E4-induced cognitive deficits. J Neurosci 22:5204-5209.
    • (2002) J Neurosci , vol.22 , pp. 5204-5209
    • Raber, J.1    Bongers, G.2    LeFevour, A.3    Buttini, M.4    Mucke, L.5
  • 50
    • 0001087846 scopus 로고
    • The Alzheimer diseases
    • Roses AD (1994) The Alzheimer diseases. Curr Neurol 14:111-141.
    • (1994) Curr Neurol , vol.14 , pp. 111-141
    • Roses, A.D.1
  • 51
    • 0030005627 scopus 로고    scopus 로고
    • Apolipoprotein E alleles as risk factors in Alzheimer's disease
    • Roses AD (1996) Apolipoprotein E alleles as risk factors in Alzheimer's disease. Annu Rev Med 47:387-400.
    • (1996) Annu Rev Med , vol.47 , pp. 387-400
    • Roses, A.D.1
  • 53
    • 0030887853 scopus 로고    scopus 로고
    • Genetic determinants of susceptibility to excitotoxic cell death: Implications for gene targeting approaches
    • Schauwecker PE, Steward O (1997) Genetic determinants of susceptibility to excitotoxic cell death: implications for gene targeting approaches. Proc Natl Acad Sci USA 94:4103-4108.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 4103-4108
    • Schauwecker, P.E.1    Steward, O.2
  • 54
    • 0025753852 scopus 로고
    • The molecular pathology of Alzheimer's disease
    • Selkoe DJ (1991) The molecular pathology of Alzheimer's disease. Neuron 6:487-498.
    • (1991) Neuron , vol.6 , pp. 487-498
    • Selkoe, D.J.1
  • 55
    • 0028281583 scopus 로고
    • Lipoprotein(a): Physiologic function, association with atherosclerosis, and effects of lipid-lowering drug therapy
    • Spinler SA, Cziraky MJ (1994) Lipoprotein(a): physiologic function, association with atherosclerosis, and effects of lipid-lowering drug therapy. Ann Pharmacother 28:343-351.
    • (1994) Ann Pharmacother , vol.28 , pp. 343-351
    • Spinler, S.A.1    Cziraky, M.J.2
  • 60
    • 0035950188 scopus 로고    scopus 로고
    • New frontiers in Alzheimer's disease genetics
    • Tanzi RE, Bertram L (2001) New frontiers in Alzheimer's disease genetics. Neuron 32:181-184.
    • (2001) Neuron , vol.32 , pp. 181-184
    • Tanzi, R.E.1    Bertram, L.2
  • 61
    • 0033889344 scopus 로고    scopus 로고
    • Expression of human apolipoprotein E4 in neurons causes hyperphosphorylation of protein tau in the brains of transgenic mice
    • Tesseur I, Van Dorpe J, Spittaels K, Van den Haute C, Moechars D, Van Leuven F (2000a) Expression of human apolipoprotein E4 in neurons causes hyperphosphorylation of protein tau in the brains of transgenic mice. Am J Pathol 156:951-964.
    • (2000) Am J Pathol , vol.156 , pp. 951-964
    • Tesseur, I.1    Van Dorpe, J.2    Spittaels, K.3    Van Den Haute, C.4    Moechars, D.5    Van Leuven, F.6
  • 62
    • 0033694470 scopus 로고    scopus 로고
    • Prominent axonopathy and disruption of axonal transport in transgenic mice expressing human apolipoprotein E4 in neurons of brain and spinal cord
    • Tesseur I, Van Dorpe J, Bruynseels K, Bronfman F, Sciot R, Van Lommel A, Van Leuven F (2000b) Prominent axonopathy and disruption of axonal transport in transgenic mice expressing human apolipoprotein E4 in neurons of brain and spinal cord. Am J Pathol 157:1495-1510.
    • (2000) Am J Pathol , vol.157 , pp. 1495-1510
    • Tesseur, I.1    Van Dorpe, J.2    Bruynseels, K.3    Bronfman, F.4    Sciot, R.5    Van Lommel, A.6    Van Leuven, F.7
  • 63
    • 0030804828 scopus 로고    scopus 로고
    • Neurotoxicity of the 22 kDa thrombin-cleavage fragment of apolipoprotein E and related synthetic peptides is receptor-mediated
    • Tolar M, Marques MA, Harmony JAK, Crutcher KA (1997) Neurotoxicity of the 22 kDa thrombin-cleavage fragment of apolipoprotein E and related synthetic peptides is receptor-mediated. J Neurosci 17:5678-5686.
    • (1997) J Neurosci , vol.17 , pp. 5678-5686
    • Tolar, M.1    Marques, M.A.2    Harmony, J.A.K.3    Crutcher, K.A.4
  • 64
    • 0033567074 scopus 로고    scopus 로고
    • Truncated apolipoprotein E (apoE) causes increased intracellular calcium and may mediate apoE neurotoxicity
    • Tolar M, Keller JN, Chan S, Mattson MP, Marques MA, Crutcher KA (1999) Truncated apolipoprotein E (apoE) causes increased intracellular calcium and may mediate apoE neurotoxicity. J Neurosci 19:7100-7110.
    • (1999) J Neurosci , vol.19 , pp. 7100-7110
    • Tolar, M.1    Keller, J.N.2    Chan, S.3    Mattson, M.P.4    Marques, M.A.5    Crutcher, K.A.6
  • 65
    • 0026542786 scopus 로고
    • Apolipoprotein E: A pathological chaperone protein in patients with cerebral and systemic amyloid
    • Wisniewski T, Frangione B (1992) Apolipoprotein E: a pathological chaperone protein in patients with cerebral and systemic amyloid. Neurosci Lett 135:235-238.
    • (1992) Neurosci Lett , vol.135 , pp. 235-238
    • Wisniewski, T.1    Frangione, B.2
  • 66
    • 0027970307 scopus 로고
    • Acceleration of Alzheimer's fibril formation by apolipoprotein E in vitro
    • Wisniewski T, Castaño EM, Golabek A, Vogel T, Frangione B (1994) Acceleration of Alzheimer's fibril formation by apolipoprotein E in vitro. Am J Pathol 145:1030-1035.
    • (1994) Am J Pathol , vol.145 , pp. 1030-1035
    • Wisniewski, T.1    Castaño, E.M.2    Golabek, A.3    Vogel, T.4    Frangione, B.5


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