Dendritic spine loss in the hippocampus of young PDAPP and Tg2576 mice and its prevention by the ApoE2 genotype

Neurobiology of Disease

Volumn 13, Issue 3, 2003, Pages 246-253

  Lanz, T A ^a   Carter, D B ^a   Merchant, K M ^a  

^a PFIZER INC   (United States)

Author keywords

Alzheimer's disease; Amyloid; apoE; CA1; Dendrite; Hippocampus; PDAPP; Synapse; Tg2576

Indexed keywords

AMYLOID; APOLIPOPROTEIN E2;

AGE DISTRIBUTION; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DENDRITIC SPINE; DENSITY; GENE OVEREXPRESSION; GENOTYPE; HIPPOCAMPUS; HUMAN; MALE; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; STAINING; TRANSGENE; TRANSGENIC MOUSE;

EID: 0043095312     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-9961(03)00079-2     Document Type: Article

References (38)

1. Arendash G.W., King D.L., Gordon M.N., Morgan D., Hatcher J.M., Hope C.E., Diamond D.M. Progressive, age-related behavioral impairments in transgenic mice carrying both mutant amyloid precursor protein and presenilin-1 transgenes. Brain Res. 891:2001;42-53.
2. Arendt T. Disturbance of neuronal plasticity is a critical pathogenetic event in Alzheimer's disease. Int. J. Dev. Neurosci. 19:2001;231-245.
3. Arendt T., Bruckner M.K., Gertz H.J., Marcova L. Cortical distribution of neurofibrillary tangles in Alzheimer's disease matches the pattern of neurons that retain their capacity of plastic remodelling in the adult brain. Neuroscience. 83:1998;991-1002.
4. Avila-Costa M.R., Colin-Barenque L., Fortoul T.I., Machado-Salas P., Espinosa-Villanueva J., Rugerio-Vargas C., Rivas-Arancibia S. Memory deterioration in an oxidative stress model and its correlation with cytological changes on rat hippocampus CA1. Neurosci. Lett. 270:1999;107-109.
5. Baloyannis S.J., Manolidis S.L., Manolidis L.S. The acoustic cortex in Alzheimer's disease. Acta Otolaryngol. Suppl. 494:1992;1-13.
6. Bowman B.H., Jansen L., Yang F. Discovery of a brain promoter from the human transferring gene and its utilization for development of transgenic mice that express human apolipoprotein E alleles. Proc. Natl. Acad. Sci. USA. 92:1995;12115-12119.
7. Brendza R.P., O'Brien C., Simmons K., McKeel D.W., Bales K.R., Paul S.M., Olney J.W., Sanes J.R., Holtzman D.M. PDAPP; YFP double transgenic mice a tool to study amyloid-beta associated changes in axonal, dendritic, and synaptic structures . J. Comp. Neurol. 456:2003;375-383.
8. Calhoun M.E., Wiederhold K.H., Abramowski D., Phinney A.L., Probst A., Sturchler-Pierrat C., Staufenbiel M., Sommer B., Jucker M. Neuron loss in APP transgenic mice. Nature. 395:1998;755-756.
9. Chapman P.F., Falinska A.M., Knevett S.G., Ramsay M.F. Genes, models and Alzheimer's disease. Trends Genet. 17:2001;254-261.
10. Cheng H.W., Rafols J.A., Goshgarian H.G., Anavi Y., Tong J., McNeill T.H. Differential spine loss and regrowth of striatal neurons following multiple forms of deafferentation a Golgi study . Exp. Neurol. 147:1997;287-298.
11. Davidsson P., Blennow K. Neurochemical dissection of synaptic pathology in Alzheimer's disease. Int. Psychogeriatr. 10:1998;11-23.
12. de Ruiter J.P., Uylings H.B. Morphometric and dendritic analysis of fascia dentata granule cells in human aging and senile dementia. Brain Res. 402:1987;217-229.
13. V717F transgenic mice. Neurobiol. Dis. 7:2000;71-85.
14. Einstein G., Buranosky R., Crain B.J. Dendritic pathology of granule cells in Alzheimer's disease is unrelated to neuritic plaques. J. Neurosci. 14:1994;5077-5088.
15. Fagan A.M., Watson M., Parsadanian M., Bales K.B., Paul S.M., Holtzman D.M. Human and murine ApoE markedly alters Aβ metabolism before and after plaque formation in a mouse model of Alzheimer's disease. Neurobiol. Dis. 9:2002;305-318.
16. Ferrer I., Guionnet N., Cruz-Sanchez F., Tunon T. Neuronal alterations in patients with dementia a Golgi study on biopsy samples . Neurosci. Lett. 114:1990;11-16.
17. Games D., Adams D., Alessandri R., et al. Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein. Nature. 373:1995;523-527.
18. Gould E., Woolley C.S., Frankfurt M., McEwen B.S. Gonadal steroids regulate dendritic spine density in hippocampal pyramidal cells in adulthood. J. Neurosci. 10:1990;1286-1291.
19. Hsia A.Y., Masliah E., McConlogue L., Yu G.Q., Tatsuno G., Hu K., Kholodenko D., Malenka R.C., Nicoll R.A., Mucke L. Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models. Proc. Natl. Acad. Sci. USA. 96:1999;3228-3233.
20. Hsiao K., Chapman P., Nilsen S., Eckman C., Harigaya Y., Younkin S., Yang F., Cole G. Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice. Science. 274:1996;99-102.
21. Irizarry M.C., McNamara M., Fedorchak K., Hsiao K., Hyman B.T. APPSw transgenic mice develop age-related A beta deposits and neuropil abnormalities, but no neuronal loss in CA1. J. Neuropathol. Exp. Neurol. 56:1997;965-973.
22. Janus C., Westaway D. Transgenic mouse models of Alzheimer's disease. Physiol. Behav. 73:2001;873-886.
23. Ji, Y., Gong, Y., Gan, W., Holtzman, D.W., Wisniewski, T., 2002. Apolipoprotein E modulates spine density and morphology independent of dendrite structure in apolipoprotein E transgenic mice. 2002 Abstract Viewer/Itinerary Planner. Program No. 883.5. Society for Neuroscience, Washington, OC. Online.
24. Kawarabayashi T., Younkin L.H., Saido T.C., Shoji M., Ashe K.H., Younkin S.G. Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease. J. Neurosci. 21:2001;372-381.
25. Larson J., Lynch G., Games D., Seubert P. Alterations in synaptic transmission and long-term potentiation in hippocampal slices from young and aged PDAPP mice. Brain Res. 840:1999;23-35.
26. Leuba G. Aging of dendrites in the cerebral cortex of the mouse. Neuropathol. Appl. Neurobiol. 9:1983;467-475.
27. Megias M., Emri Z.S., Freund T.F., Gulyás A.I. Total number and distribution of inhibitory and excitatory synapses on hippocampal CA1 pyramidal cells. Neuroscience. 102:2001;527-540.
28. Moechars D., Dewachter I., Lorent K., Reverse D., Baekelandt V., Naidu A., Tesseur I., Spittaels K., Haute C.V., Checler F., Godaux E., Cordell B., Van Leuven F. Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain. J. Biol. Chem. 274:1999;6483-6492.
29. Mucke L., Masliah E., Yu G.Q., Mallory M., Rockenstein E.M., Tatsuno G., Hu K., Kholodenko D., Johnson-Wood K., McConlogue L. High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice synaptotoxicity without plaque formation . J. Neurosci. 20:2000;4050-4058.
30. Mullan M., Crawford F., Axelman K., Houlden H., Lilius L., Winblad B., Lannfelt L. A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid. Nat. Genet. 1:1992;345-347.
31. Murrell J., Farlow M., Ghetti B., Benson M.D. A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease. Science. 254:1991;97-99.
32. Parnavelas J.G., Lynch G., Brecha N., Cotman C.W., Globus A. Spine loss and regrowth in hippocampus following deafferentation. Nature. 248:1974;71-73.
33. Probst A., Basler V., Bron B., Ulrich J. Neuritic plaques in senile dementia of Alzheimer type a Golgi analysis in the hippocampal region . Brain Res. 268:1983;249-254.
34. Redwine J.M., Kosofsky B., Jacobs R.E., Games D., Reilly J.F., Morrison J.H., Young W.G., Bloom F.E. Dentate gyrus volume is reduced before onset of plaque formation in PDAPP mice a magnetic resonance microscopy and stereologic analysis . Proc. Natl. Acad. Sci. USA. 100:2003;1381-1386.
35. Stephenson D., Rash K., Smalstig B., Roberts E., Johnstone E., Sharp J., Panetta J., Little S., Kramer R., Clemens J. Cytosolic phospholipase A2 is induced in reactive glia following different forms of neurodegeneration. Glia. 27:1999;110-128.
36. Takeuchi A., Irizarry M.C., Duff K., Saido T.C., Hsiao Ashe K., Hasegawa M., Mann D.M., Hyman B.T., Iwatsubo T. Age-related amyloid beta deposition in transgenic mice overexpressing both Alzheimer mutant presenilin 1 and amyloid beta precursor protein Swedish mutant is not associated with global neuronal loss. Am. J. Pathol. 157:2000;331-339.
37. Uylings H.B.M., de Brabander J.M. Neuronal changes in normal human aging and Alzheimer's disease. Brain Cognit. 49:2002;268-276.
38. Van Hoesen G.W., Hyman B.T. Hippocampal formation anatomy and the patterns of pathology in Alzheimer's disease . Prog. Brain Res. 83:1990;445-457.