The Air noncoding RNA epigenetically silences transcription by targeting G9a to chromatin

Science

Volumn 322, Issue 5908, 2008, Pages 1717-1720

  Nagano, Takashi ^a,b   Mitchell, Jennifer A ^a   Sanz, Lionel A ^c   Pauler, Florian M ^d   Ferguson Smith, Anne C ^e   Feil, Robert ^c   Fraser, Peter ^a  

^a BABRAHAM INSTITUTE   (United Kingdom)

^b UNIVERSITY OF FUKUI   (Japan)

^c INSTITUT DE GÉNÉTIQUE MOLÉCULAIRE DE MONTPELLIER   (France)

^d ERICH SCHMID INSTITUTE OF MATERIALS SCIENCE   (Austria)

^e UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AIR NONCODING RNA; HISTONE ACETYLTRANSFERASE; ORGANIC CATION TRANSPORTER 2; ORGANIC CATION TRANSPORTER 3; PLACENTA PROTEIN; PROTEIN IGF2R; UNCLASSIFIED DRUG; UNTRANSLATED RNA;

ALLELE; GENE EXPRESSION; PROTEIN; RNA;

ALLELE; ANIMAL TISSUE; ARTICLE; CHROMATIN; CONTROLLED STUDY; EPIGENETICS; GENE INTERACTION; GENE SILENCING; GENE TARGETING; GENETIC TRANSCRIPTION; METHYLATION; MOLECULAR INTERACTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN;

ALLELES; ANIMALS; CHROMATIN; EPIGENESIS, GENETIC; FEMALE; GENOMIC IMPRINTING; HISTONE-LYSINE N-METHYLTRANSFERASE; HISTONES; IN SITU HYBRIDIZATION, FLUORESCENCE; MALE; METHYLATION; MICE; MICE, INBRED BALB C; MYOCARDIUM; ORGANIC CATION TRANSPORT PROTEINS; PLACENTA; PREGNANCY; PROMOTER REGIONS, GENETIC; RNA INTERFERENCE; RNA, UNTRANSLATED; TRANSCRIPTION, GENETIC;

EID: 56549111129     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1163802     Document Type: Article

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21. We thank A. Segonds-Pichon for statistics, G. Kelsey and W. Reik for critical reading, D. Barlow and members of the Fraser lab for discussions. P.F. is a Senior Fellow of the Medical Research Council, UK. This work was supported by the Biotechnology and Biological Sciences Research Council, UK, and by the Agence National de la Recherche and Institut National de Cancer, France. The authors declare that they have no competing financial interests.