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Volumn 6, Issue 8, 2005, Pages 648-654

Silence of the genes - Mechanisms of long-term repression

Author keywords

[No Author keywords available]

Indexed keywords

CIS ACTING ELEMENT; DNA; DNA METHYLTRANSFERASE 1; FRAGILE X MENTAL RETARDATION PROTEIN; HISTONE DEACETYLASE; HISTONE H3; HISTONE H4; HISTONE LYSINE METHYLTRANSFERASE; OCTAMER TRANSCRIPTION FACTOR 4; PROTEIN ZFP1A1; RAG2 PROTEIN; RNA; RNA POLYMERASE; TATA BINDING PROTEIN; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN;

EID: 22944489197     PISSN: 14710056     EISSN: None     Source Type: Journal    
DOI: 10.1038/nrg1639     Document Type: Review
Times cited : (77)

References (101)
  • 1
    • 0027959928 scopus 로고
    • Oct-4 transcription factor is differentially expressed in the mouse embryo during establishment of the first two extraembryonic cell lineages involved in implantation
    • Palmieri, S. L., Peter, W., Hess, H. & Scholer, H. R. Oct-4 transcription factor is differentially expressed in the mouse embryo during establishment of the first two extraembryonic cell lineages involved in implantation. Dev. Biol. 166, 259-267 (1994).
    • (1994) Dev. Biol. , vol.166 , pp. 259-267
    • Palmieri, S.L.1    Peter, W.2    Hess, H.3    Scholer, H.R.4
  • 2
    • 0028940587 scopus 로고
    • Gene number, noise reduction and biological complexity
    • Bird, A. P. Gene number, noise reduction and biological complexity. Trends Genet. 11, 94-100 (1995).
    • (1995) Trends Genet. , vol.11 , pp. 94-100
    • Bird, A.P.1
  • 3
    • 10644237968 scopus 로고    scopus 로고
    • RNAi-mediated pathways in the nucleus
    • Matzke, M. A. & Birchler, J. A. RNAi-mediated pathways in the nucleus. Nature Rev. Genet. 6, 24-35 (2005).
    • (2005) Nature Rev. Genet. , vol.6 , pp. 24-35
    • Matzke, M.A.1    Birchler, J.A.2
  • 4
    • 0029796093 scopus 로고    scopus 로고
    • Identification of potential target genes for the neuron-restrictive silencer factor
    • Schoenherr, C. J., Paquette, A. J. & Anderson, D. J. Identification of potential target genes for the neuron-restrictive silencer factor. Proc. Natl Acad. Sci. USA 93, 9881-9886 (1996).
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , pp. 9881-9886
    • Schoenherr, C.J.1    Paquette, A.J.2    Anderson, D.J.3
  • 5
    • 0031694917 scopus 로고    scopus 로고
    • NRSF/REST is required in vivo for repression of multiple neuronal target genes during embryogenesis
    • Chen, Z. F., Paquette, A. J. & Anderson, D. J. NRSF/REST is required in vivo for repression of multiple neuronal target genes during embryogenesis. Nature Genet. 20, 136-142 (1998).
    • (1998) Nature Genet. , vol.20 , pp. 136-142
    • Chen, Z.F.1    Paquette, A.J.2    Anderson, D.J.3
  • 6
    • 0028968802 scopus 로고
    • The neuron-restrictive silencer factor (NRSF): A coordinate repressor of multiple neuron-specific genes
    • Schoenherr, C. J. & Anderson, D. J. The neuron-restrictive silencer factor (NRSF): a coordinate repressor of multiple neuron-specific genes. Science 267, 1360-1363 (1995).
    • (1995) Science , vol.267 , pp. 1360-1363
    • Schoenherr, C.J.1    Anderson, D.J.2
  • 7
    • 2342475666 scopus 로고    scopus 로고
    • Polycomb complexes and silencing mechanisms
    • Lund, A. H. & van Lohuizen, M. Polycomb complexes and silencing mechanisms. Curr. Opin. Cell. Biol. 16, 239-246 (2004).
    • (2004) Curr. Opin. Cell. Biol. , vol.16 , pp. 239-246
    • Lund, A.H.1    Van Lohuizen, M.2
  • 8
    • 0026740497 scopus 로고
    • Developmental pattern of gene-specific DNA methylation in the mouse embryo and germline
    • Kafri, T. et al. Developmental pattern of gene-specific DNA methylation in the mouse embryo and germline. Genes Dev. 6, 705-714 (1992).
    • (1992) Genes Dev. , vol.6 , pp. 705-714
    • Kafri, T.1
  • 9
    • 0023119242 scopus 로고
    • Temporal and regional changes in DNA methylation in the embryonic, extraembryonic and germ cell lineages during mouse embryo development
    • Monk, M., Boubelik, M. & Lehnert, S. Temporal and regional changes in DNA methylation in the embryonic, extraembryonic and germ cell lineages during mouse embryo development. Development 99, 371-382 (1987).
    • (1987) Development , vol.99 , pp. 371-382
    • Monk, M.1    Boubelik, M.2    Lehnert, S.3
  • 11
    • 0025869047 scopus 로고
    • Demethylation of CpG islands in embryonic cells
    • Frank, D. et al. Demethylation of CpG islands in embryonic cells. Nature 351, 239-241 (1991).
    • (1991) Nature , vol.351 , pp. 239-241
    • Frank, D.1
  • 12
    • 0028104109 scopus 로고
    • Sp1 elements protect a CpG island from de novo methylation
    • Brandeis, M. et al. Sp1 elements protect a CpG island from de novo methylation. Nature 371, 435-438 (1994).
    • (1994) Nature , vol.371 , pp. 435-438
    • Brandeis, M.1
  • 13
    • 0032992224 scopus 로고    scopus 로고
    • DNA methylation represses transcription in vivo
    • Siegfried, Z. et al. DNA methylation represses transcription in vivo. Nature Genet. 22, 203-206 (1999).
    • (1999) Nature Genet. , vol.22 , pp. 203-206
    • Siegfried, Z.1
  • 14
    • 0027960055 scopus 로고
    • Sp1 sites in the mouse Aprt gene promoter are required to prevent methylation of the CpG island
    • Macleod, D., Charlton, J., Mullins, J. & Bird, A. P. Sp1 sites in the mouse Aprt gene promoter are required to prevent methylation of the CpG island. Genes Dev. 8, 2282-2292 (1994).
    • (1994) Genes Dev. , vol.8 , pp. 2282-2292
    • Macleod, D.1    Charlton, J.2    Mullins, J.3    Bird, A.P.4
  • 15
    • 0020486108 scopus 로고
    • Substrate and sequence specificity of a eukaryotic DNA methylase
    • Gruenbaum, Y., Cedar, H. & Razin, A. Substrate and sequence specificity of a eukaryotic DNA methylase. Nature 292, 620-622 (1982).
    • (1982) Nature , vol.292 , pp. 620-622
    • Gruenbaum, Y.1    Cedar, H.2    Razin, A.3
  • 16
    • 0018120376 scopus 로고
    • Eucaryotic DNA: Organization of the genome for replication
    • Hand, R. Eucaryotic DNA: Organization of the genome for replication. Cell 15, 317-325 (1978).
    • (1978) Cell , vol.15 , pp. 317-325
    • Hand, R.1
  • 18
    • 0021362841 scopus 로고
    • Replication timing of genes and middle repetitive sequences
    • Goldman, M. A., Holmquist, G. P., Caston, L. A. & Nag, A. Replication timing of genes and middle repetitive sequences. Science 224, 686-692 (1984).
    • (1984) Science , vol.224 , pp. 686-692
    • Goldman, M.A.1    Holmquist, G.P.2    Caston, L.A.3    Nag, A.4
  • 19
    • 0036613754 scopus 로고    scopus 로고
    • Clustering of housekeeping genes provides a unified model of gene order in the human genome
    • Lercher, M. J., Urrutia, A. O. & Hurst, L. D. Clustering of housekeeping genes provides a unified model of gene order in the human genome. Nature Genet. 31, 180-183 (2002).
    • (2002) Nature Genet. , vol.31 , pp. 180-183
    • Lercher, M.J.1    Urrutia, A.O.2    Hurst, L.D.3
  • 20
    • 0025218485 scopus 로고
    • Multiple origins of replication in the dihydrofolate reductase amplicons of a methotrexate-resistant chinese hamster cell line
    • Ma, C., Leu, T. H. & Hamlin, J. L. Multiple origins of replication in the dihydrofolate reductase amplicons of a methotrexate-resistant chinese hamster cell line. Mol. Cell. Biol. 10, 1338-1346 (1990).
    • (1990) Mol. Cell. Biol. , vol.10 , pp. 1338-1346
    • Ma, C.1    Leu, T.H.2    Hamlin, J.L.3
  • 21
    • 0026511908 scopus 로고
    • Delineation of DNA replication time zones by fluorescence in situ hybridization
    • Selig, S., Okumura, K., Ward, D. C. & Cedar, H. Delineation of DNA replication time zones by fluorescence in situ hybridization. EMBO J. 11, 1217-1225 (1992).
    • (1992) EMBO J. , vol.11 , pp. 1217-1225
    • Selig, S.1    Okumura, K.2    Ward, D.C.3    Cedar, H.4
  • 22
    • 17944382111 scopus 로고    scopus 로고
    • Developmental regulation of DNA replication timing at the human β-globin locus
    • Simon, I. et al. Developmental regulation of DNA replication timing at the human β-globin locus. EMBO J. 20, 6150-6157 (2001).
    • (2001) EMBO J. , vol.20 , pp. 6150-6157
    • Simon, I.1
  • 23
    • 0343953085 scopus 로고    scopus 로고
    • Long-distance control of origin choice and replication timing in the human β-globin locus are independent of the locus control region
    • Cimbora, D. M. et al. Long-distance control of origin choice and replication timing in the human β-globin locus are independent of the locus control region. Mol. Cell. Biol. 20, 5581-5591 (2000).
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 5581-5591
    • Cimbora, D.M.1
  • 24
    • 0013887376 scopus 로고
    • Autoradiography of chromosomal DNA fibers from Chinese hamster cells
    • Huberman, J. A. & Riggs, A. D. Autoradiography of chromosomal DNA fibers from Chinese hamster cells. Proc. Natl Acad. Sci. USA 55, 599-606 (1966).
    • (1966) Proc. Natl Acad. Sci. USA , vol.55 , pp. 599-606
    • Huberman, J.A.1    Riggs, A.D.2
  • 25
    • 0020327977 scopus 로고
    • Assembly of transcriptionally active 5S RNA gene chromatin in vitro
    • Gottesfeld, J. & Bloomer, L. S. Assembly of transcriptionally active 5S RNA gene chromatin in vitro. Cell 28, 781-791 (1982).
    • (1982) Cell , vol.28 , pp. 781-791
    • Gottesfeld, J.1    Bloomer, L.S.2
  • 26
    • 0018732098 scopus 로고
    • Assembly of an active chromatin structure during replication
    • Weintraub, H. Assembly of an active chromatin structure during replication. Nucleic Acids Res. 7, 781-792 (1979).
    • (1979) Nucleic Acids Res. , vol.7 , pp. 781-792
    • Weintraub, H.1
  • 27
    • 0037078986 scopus 로고    scopus 로고
    • The establishment of transcriptional competence in early and late S-phase
    • Zhang, J., Feng, X., Hashimshony, T., Keshet, I. & Cedar, H. The establishment of transcriptional competence in early and late S-phase. Nature 420, 198-202 (2002).
    • (2002) Nature , vol.420 , pp. 198-202
    • Zhang, J.1    Feng, X.2    Hashimshony, T.3    Keshet, I.4    Cedar, H.5
  • 28
    • 0035839136 scopus 로고    scopus 로고
    • Translating the histone code
    • Jenuwein, T. & Allis, C. D. Translating the histone code. Science 293, 1074-1080 (2001).
    • (2001) Science , vol.293 , pp. 1074-1080
    • Jenuwein, T.1    Allis, C.D.2
  • 29
    • 0034791301 scopus 로고    scopus 로고
    • Common themes in mechanisms of gene silencing
    • Moazed, D. Common themes in mechanisms of gene silencing. Mol. Cell 8, 489-498 (2001).
    • (2001) Mol. Cell , vol.8 , pp. 489-498
    • Moazed, D.1
  • 30
    • 0032574977 scopus 로고    scopus 로고
    • Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex
    • Nan, X. et al. Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex. Nature 393, 386-389 (1998).
    • (1998) Nature , vol.393 , pp. 386-389
    • Nan, X.1
  • 31
    • 0031837109 scopus 로고    scopus 로고
    • Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription
    • Jones, P. L. et al. Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription. Nature Genet. 19, 187-191 (1998).
    • (1998) Nature Genet. , vol.19 , pp. 187-191
    • Jones, P.L.1
  • 33
    • 0036338205 scopus 로고    scopus 로고
    • Histone H3 lysine 9 methylation is an epigenetic imprint of facultative heterochromatin
    • Peters, A. H. et al. Histone H3 lysine 9 methylation is an epigenetic imprint of facultative heterochromatin. Nature Genet. 30, 77-80 (2002).
    • (2002) Nature Genet. , vol.30 , pp. 77-80
    • Peters, A.H.1
  • 34
    • 0347955358 scopus 로고    scopus 로고
    • Histone methyltransferases direct different degrees of methylation to define distinct chromatin domains
    • Rice, J. C. et al. Histone methyltransferases direct different degrees of methylation to define distinct chromatin domains. Mol. Cell 12, 1591-1598 (2003).
    • (2003) Mol. Cell , vol.12 , pp. 1591-1598
    • Rice, J.C.1
  • 35
    • 0034632829 scopus 로고    scopus 로고
    • Regulation of chromatin structure by site-specific histone H3 methyltransferases
    • Rea, S. et al. Regulation of chromatin structure by site-specific histone H3 methyltransferases. Nature 406, 593-599 (2000).
    • (2000) Nature , vol.406 , pp. 593-599
    • Rea, S.1
  • 36
    • 0035282573 scopus 로고    scopus 로고
    • Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins
    • Lachner, M., O'Carroll, D., Rea, S., Mechtler, K. & Jenuwein, T. Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins. Nature 410, 116-120 (2001).
    • (2001) Nature , vol.410 , pp. 116-120
    • Lachner, M.1    O'Carroll, D.2    Rea, S.3    Mechtler, K.4    Jenuwein, T.5
  • 37
    • 0035282458 scopus 로고    scopus 로고
    • Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain
    • Bannister, A. J. et al. Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain. Nature 410, 120-124 (2001).
    • (2001) Nature , vol.410 , pp. 120-124
    • Bannister, A.J.1
  • 38
    • 4344685735 scopus 로고    scopus 로고
    • Methyl-CpG binding protein MBD1 couples histone H3 methylation at lysine 9 by SETDB1 to DNA replication and chromatin assembly
    • Sarraf, S. A. & Stancheva, I. Methyl-CpG binding protein MBD1 couples histone H3 methylation at lysine 9 by SETDB1 to DNA replication and chromatin assembly. Mol. Cell 15, 595-605 (2004).
    • (2004) Mol. Cell , vol.15 , pp. 595-605
    • Sarraf, S.A.1    Stancheva, I.2
  • 39
    • 2942631126 scopus 로고    scopus 로고
    • Localized domains of g9a-mediated histone methylation are required for silencing of neuronal genes
    • Roopra, A., Qazi, R., Schoenike, B., Daley, T. J. & Morrison, J. F. Localized domains of g9a-mediated histone methylation are required for silencing of neuronal genes. Mol. Cell 14, 727-738 (2004).
    • (2004) Mol. Cell , vol.14 , pp. 727-738
    • Roopra, A.1    Qazi, R.2    Schoenike, B.3    Daley, T.J.4    Morrison, J.F.5
  • 40
    • 0037444227 scopus 로고    scopus 로고
    • Asynchronous replication timing of imprinted loci is independent of DNA methylation, but consistent with differential subnuclear localization
    • Gribnau, J., Hochedlinger, K., Hata, K., Li, E. & Jaenisch, R. Asynchronous replication timing of imprinted loci is independent of DNA methylation, but consistent with differential subnuclear localization. Genes Dev. 17, 759-773 (2003).
    • (2003) Genes Dev. , vol.17 , pp. 759-773
    • Gribnau, J.1    Hochedlinger, K.2    Hata, K.3    Li, E.4    Jaenisch, R.5
  • 41
    • 0022540321 scopus 로고
    • CpG-rich islands and the function of DNA methylation
    • Bird, A. P. CpG-rich islands and the function of DNA methylation. Nature 321, 209-213 (1986).
    • (1986) Nature , vol.321 , pp. 209-213
    • Bird, A.P.1
  • 42
    • 0022000776 scopus 로고
    • A fraction of the mouse genome that is derived from islands of nonmethylated CpG-rich DNA
    • Bird, A. P., Taggart, M., Frommer, M., Miller, O. J. & Macleod, D. A fraction of the mouse genome that is derived from islands of nonmethylated CpG-rich DNA. Cell 40, 91-99 (1985).
    • (1985) Cell , vol.40 , pp. 91-99
    • Bird, A.P.1    Taggart, M.2    Frommer, M.3    Miller, O.J.4    Macleod, D.5
  • 43
    • 0035158704 scopus 로고    scopus 로고
    • Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation
    • Jackson-Grusby, L. et al. Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation. Nature Genet. 27, 31-39 (2001).
    • (2001) Nature Genet. , vol.27 , pp. 31-39
    • Jackson-Grusby, L.1
  • 44
    • 0037072943 scopus 로고    scopus 로고
    • A unique developmental pattern of Oct-3/4 DNA methylation is controlled by a cis-demodification element
    • Gidekel, S. & Bergman, Y. A unique developmental pattern of Oct-3/4 DNA methylation is controlled by a cis-demodification element. J. Biol. Chem. 277, 34521-34530 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 34521-34530
    • Gidekel, S.1    Bergman, Y.2
  • 45
    • 2342481623 scopus 로고    scopus 로고
    • Recent advances in X-chromosome inactivation
    • Heard, E. Recent advances in X-chromosome inactivation. Curr. Opin. Cell Biol. 16, 247-255 (2004).
    • (2004) Curr. Opin. Cell Biol. , vol.16 , pp. 247-255
    • Heard, E.1
  • 46
    • 10744230544 scopus 로고    scopus 로고
    • Suv39h-mediated histone H3 lysine 9 methylation directs DNA methylation to major satellite repeats at pericentric heterochromatin
    • Lehnertz, B. et al. Suv39h-mediated histone H3 lysine 9 methylation directs DNA methylation to major satellite repeats at pericentric heterochromatin. Curr. Biol. 13, 1192-1200 (2003).
    • (2003) Curr. Biol. , vol.13 , pp. 1192-1200
    • Lehnertz, B.1
  • 47
    • 0036591890 scopus 로고    scopus 로고
    • Replication timing and transcriptional control: Beyond cause and effect
    • Gilbert, D. M. Replication timing and transcriptional control: beyond cause and effect. Curr. Opin. Cell Biol. 14, 377-383 (2002).
    • (2002) Curr. Opin. Cell Biol. , vol.14 , pp. 377-383
    • Gilbert, D.M.1
  • 48
    • 0019856177 scopus 로고
    • Transcriptional regulation of immunoglobulin V genes
    • Mather, E. L. & Perry, R. P. Transcriptional regulation of immunoglobulin V genes. Nucleic Acids Res. 9, 6855-6867 (1981).
    • (1981) Nucleic Acids Res. , vol.9 , pp. 6855-6867
    • Mather, E.L.1    Perry, R.P.2
  • 49
    • 0033849663 scopus 로고    scopus 로고
    • Targeting of Ikaros to pericentromeric heterochromatin by direct DNA binding
    • Cobb, B. S. et al. Targeting of Ikaros to pericentromeric heterochromatin by direct DNA binding. Genes Dev. 14, 2146-2160 (2000).
    • (2000) Genes Dev. , vol.14 , pp. 2146-2160
    • Cobb, B.S.1
  • 50
    • 0033306577 scopus 로고    scopus 로고
    • Transcriptional repression by REST: Recruitment of Sin3A and histone deacetylase to neuronal genes
    • Huang, Y., Myers, S. J. & Dingledine, R. Transcriptional repression by REST: recruitment of Sin3A and histone deacetylase to neuronal genes. Nature Neurosci. 2, 867-872 (1999).
    • (1999) Nature Neurosci. , vol.2 , pp. 867-872
    • Huang, Y.1    Myers, S.J.2    Dingledine, R.3
  • 51
    • 0034817393 scopus 로고    scopus 로고
    • Widespread collaboration of Isw2 and Sin3-Rpd3 chromatin remodeling complexes in transcriptional repression
    • Fazzio, T. G. et al. Widespread collaboration of Isw2 and Sin3-Rpd3 chromatin remodeling complexes in transcriptional repression. Mol. Cell. Biol. 21, 6450-6460 (2001).
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 6450-6460
    • Fazzio, T.G.1
  • 52
    • 3042762340 scopus 로고    scopus 로고
    • Cyclin a repression in quiescent cells is associated with chromatin remodeling of its promoter and requires Brahma/SNF2α
    • Coisy, M. et al. Cyclin A repression in quiescent cells is associated with chromatin remodeling of its promoter and requires Brahma/SNF2α. Mol. Cell 15, 43-56 (2004).
    • (2004) Mol. Cell , vol.15 , pp. 43-56
    • Coisy, M.1
  • 53
    • 0038521256 scopus 로고    scopus 로고
    • P53 represses RNA polymerase III transcription by targeting TBP and inhibiting promoter occupancy by TFIIIB
    • Crighton, D. et al. p53 represses RNA polymerase III transcription by targeting TBP and inhibiting promoter occupancy by TFIIIB. EMBO J. 22, 2810-2820 (2003).
    • (2003) EMBO J. , vol.22 , pp. 2810-2820
    • Crighton, D.1
  • 54
    • 0027535235 scopus 로고
    • Effects of DNA methylation on DNA-binding proteins and gene expression
    • Tate, P. H. & Bird, A. P. Effects of DNA methylation on DNA-binding proteins and gene expression. Curr. Opin. Genet. Dev. 3, 226-231 (1993).
    • (1993) Curr. Opin. Genet. Dev. , vol.3 , pp. 226-231
    • Tate, P.H.1    Bird, A.P.2
  • 55
    • 0038243168 scopus 로고    scopus 로고
    • The role of DNA methylation in setting up chromatin structure during development
    • Hashimshony, T., Zhang, J., Keshet, I., Bustin, M. & Cedar, H. The role of DNA methylation in setting up chromatin structure during development. Nature Genet. 34, 187-192 (2003).
    • (2003) Nature Genet. , vol.34 , pp. 187-192
    • Hashimshony, T.1    Zhang, J.2    Keshet, I.3    Bustin, M.4    Cedar, H.5
  • 56
    • 0022545498 scopus 로고
    • DNA methylation affects the formation of active chromatin
    • Keshet, I., Lieman-Hurwitz, J. & Cedar, H. DNA methylation affects the formation of active chromatin. Cell 44, 535-543 (1986).
    • (1986) Cell , vol.44 , pp. 535-543
    • Keshet, I.1    Lieman-Hurwitz, J.2    Cedar, H.3
  • 57
    • 0015806627 scopus 로고
    • The synthesis of globin RNA from duck reticulocyte chromatin in vitro
    • Axel, R., Cedar, H. & Felsenfeld, G. The synthesis of globin RNA from duck reticulocyte chromatin in vitro. Proc. Natl Acad. Sci. USA 70, 2029-2032 (1973).
    • (1973) Proc. Natl Acad. Sci. USA , vol.70 , pp. 2029-2032
    • Axel, R.1    Cedar, H.2    Felsenfeld, G.3
  • 58
    • 0015781821 scopus 로고
    • Transcription of chromatin in vitro
    • Cedar, H. & Felsenfeld, G. Transcription of chromatin in vitro. J. Mol. Biol. 77, 237-254 (1973).
    • (1973) J. Mol. Biol. , vol.77 , pp. 237-254
    • Cedar, H.1    Felsenfeld, G.2
  • 59
    • 0017142124 scopus 로고
    • Chromosomal subunits in active genes have an altered conformation
    • Weintraub, H. & Groudine, M. Chromosomal subunits in active genes have an altered conformation. Science 193, 848-856 (1976).
    • (1976) Science , vol.193 , pp. 848-856
    • Weintraub, H.1    Groudine, M.2
  • 60
    • 0019128626 scopus 로고
    • Nuclease sensitivity of active chromatin
    • Gazit, B. & Cedar, H. Nuclease sensitivity of active chromatin. Nucleic Acids Res. 8, 5143-5155 (1980).
    • (1980) Nucleic Acids Res. , vol.8 , pp. 5143-5155
    • Gazit, B.1    Cedar, H.2
  • 61
    • 0025301095 scopus 로고
    • RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination
    • Oettinger, M. A., Schatz, D. G., Gorka, C. & Baltimore, D. RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination. Science 248, 1517-1523 (1990).
    • (1990) Science , vol.248 , pp. 1517-1523
    • Oettinger, M.A.1    Schatz, D.G.2    Gorka, C.3    Baltimore, D.4
  • 62
    • 0019510628 scopus 로고
    • Reactivation of an inactive human X chromosome: Evidence for X inactivation by DNA methylation
    • Mohandas, T., Sparker, R. S. & Shapiro, L. J. Reactivation of an inactive human X chromosome: Evidence for X inactivation by DNA methylation. Science 211, 393-396 (1981).
    • (1981) Science , vol.211 , pp. 393-396
    • Mohandas, T.1    Sparker, R.S.2    Shapiro, L.J.3
  • 64
    • 0023408235 scopus 로고
    • DNA methylation stabilizes X chromosome inactivation in eutherians but not in marsupials: Evidence for multistep maintenance of mammalian X dosage compensation
    • Kaslow, D. C. & Migeon, B. R. DNA methylation stabilizes X chromosome inactivation in eutherians but not in marsupials: evidence for multistep maintenance of mammalian X dosage compensation. Proc. Natl Acad. Sci. USA. 84, 6210-6214 (1987).
    • (1987) Proc. Natl Acad. Sci. USA. , vol.84 , pp. 6210-6214
    • Kaslow, D.C.1    Migeon, B.R.2
  • 65
    • 0034840431 scopus 로고    scopus 로고
    • Chromatin goes global
    • Berger, S. L. & Felsenfeld, G. Chromatin goes global. Mol. Cell 8, 263-268 (2001).
    • (2001) Mol. Cell , vol.8 , pp. 263-268
    • Berger, S.L.1    Felsenfeld, G.2
  • 66
    • 0030006070 scopus 로고    scopus 로고
    • Clonal selection and learning in the antibody system
    • Rajewsky, K. Clonal selection and learning in the antibody system. Nature 381, 751-758 (1996).
    • (1996) Nature , vol.381 , pp. 751-758
    • Rajewsky, K.1
  • 67
    • 5044220453 scopus 로고    scopus 로고
    • A step-wise epigenetic process controls immunoglobulin allelic exclusion
    • Bergman, Y. & Cedar, H. A step-wise epigenetic process controls immunoglobulin allelic exclusion. Nature Rev. Immunol. 4, 753-61 (2004).
    • (2004) Nature Rev. Immunol. , vol.4 , pp. 753-761
    • Bergman, Y.1    Cedar, H.2
  • 68
    • 3242878307 scopus 로고    scopus 로고
    • Monoallelic gene expression: A repertoire of recurrent themes
    • Goldmit, M. & Bergman, Y. Monoallelic gene expression: A repertoire of recurrent themes. Immunol. Rev. 200, 197-214 (2004).
    • (2004) Immunol. Rev. , vol.200 , pp. 197-214
    • Goldmit, M.1    Bergman, Y.2
  • 69
    • 0037023361 scopus 로고    scopus 로고
    • Subnuclear compartmentalization of immunoglobulin loci during lymphocyte development
    • Kosak, S. T. et al. Subnuclear compartmentalization of immunoglobulin loci during lymphocyte development. Science 296, 158-162 (2002).
    • (2002) Science , vol.296 , pp. 158-162
    • Kosak, S.T.1
  • 70
    • 0345268756 scopus 로고    scopus 로고
    • Biallelic germline transcription at the κ-immunoglobulin locus
    • Singh, N., Bergman, Y., Cedar, H. & Chess, A. Biallelic germline transcription at the κ-immunoglobulin locus. J. Exp. Med. 197, 743-750 (2003).
    • (2003) J. Exp. Med. , vol.197 , pp. 743-750
    • Singh, N.1    Bergman, Y.2    Cedar, H.3    Chess, A.4
  • 71
    • 0035829551 scopus 로고    scopus 로고
    • Asynchronous replication and allelic exclusion in the immune system
    • Mostoslavsky, R. et al. Asynchronous replication and allelic exclusion in the immune system. Nature 414, 221-225 (2001).
    • (2001) Nature , vol.414 , pp. 221-225
    • Mostoslavsky, R.1
  • 72
    • 0032526136 scopus 로고    scopus 로고
    • κ-chain monoallelic demethylation and the establishment of allelic exclusion
    • Mostoslavsky, R. et al. κ-chain monoallelic demethylation and the establishment of allelic exclusion. Genes Dev. 12, 1801-1811 (1998).
    • (1998) Genes Dev. , vol.12 , pp. 1801-1811
    • Mostoslavsky, R.1
  • 73
    • 0033638506 scopus 로고    scopus 로고
    • Histone acetylation and hSWI/SNF remodeling act in concert to stimulate V(D)J cleavage of nucleosomal DNA
    • Kwon, J., Morshead, K. B., Guyon, J. R., Kingston, R. E. & Oettinger, M. A. Histone acetylation and hSWI/SNF remodeling act in concert to stimulate V(D)J cleavage of nucleosomal DNA. Mol. Cell 6, 1037-1048 (2000).
    • (2000) Mol. Cell , vol.6 , pp. 1037-1048
    • Kwon, J.1    Morshead, K.B.2    Guyon, J.R.3    Kingston, R.E.4    Oettinger, M.A.5
  • 74
    • 0025828597 scopus 로고
    • A strain-specific modifier on mouse chromosome 4 controls the methylation of independent transgene loci
    • Engler, P. et al. A strain-specific modifier on mouse chromosome 4 controls the methylation of independent transgene loci. Cell 65, 1-20 (1991).
    • (1991) Cell , vol.65 , pp. 1-20
    • Engler, P.1
  • 75
    • 0026507505 scopus 로고
    • CpG methylated minichromosomes become inaccessible for V(D)J recombination after undergoing replication
    • Hsieh, C. L. & Lieber, M. R. CpG methylated minichromosomes become inaccessible for V(D)J recombination after undergoing replication. EMBO J. 11, 315-325 (1992).
    • (1992) EMBO J. , vol.11 , pp. 315-325
    • Hsieh, C.L.1    Lieber, M.R.2
  • 76
    • 0034682539 scopus 로고    scopus 로고
    • V(D)J recombination is not activated by demethylation of the κ-locus
    • Cherry, S. R., Beard, C., Jaenisch, R. & Baltimore, D. V(D)J recombination is not activated by demethylation of the κ-locus. Proc. Natl Acad. Sci. USA 97, 8467-8472 (2000).
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , pp. 8467-8472
    • Cherry, S.R.1    Beard, C.2    Jaenisch, R.3    Baltimore, D.4
  • 77
    • 0038610946 scopus 로고    scopus 로고
    • A multistep mechanism for the activation of rearrangement in the immune system
    • Ji, Y., Zhang, J., Lee, A. I., Cedar, H. & Bergman, Y. A multistep mechanism for the activation of rearrangement in the immune system. Proc. Natl Acad. Sci. USA 100, 7557-7562 (2003).
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 7557-7562
    • Ji, Y.1    Zhang, J.2    Lee, A.I.3    Cedar, H.4    Bergman, Y.5
  • 78
    • 0035931753 scopus 로고    scopus 로고
    • Nuclear position leaves its mark on replication timing
    • Gilbert, D. M. Nuclear position leaves its mark on replication timing. J. Cell Biol. 152, F11-F15 (2001).
    • (2001) J. Cell Biol. , vol.152
    • Gilbert, D.M.1
  • 79
    • 0035939669 scopus 로고    scopus 로고
    • The replication timing program of the Chinese hamster β-globin locus is established coincident with its repositioning near peripheral heterochromatin in early G1 phase
    • Li, F. et al. The replication timing program of the Chinese hamster β-globin locus is established coincident with its repositioning near peripheral heterochromatin in early G1 phase. J. Cell Biol. 154, 283-292 (2001).
    • (2001) J. Cell Biol. , vol.154 , pp. 283-292
    • Li, F.1
  • 80
    • 0024345780 scopus 로고
    • Activation and repression of a β-globin gene in cell hybrids is accompanied by a shift in its temporal regulation
    • Dhar, V., Skoultchi, A. I. & Schildkraut, C. L. Activation and repression of a β-globin gene in cell hybrids is accompanied by a shift in its temporal regulation. Mol. Cell. Biol. 9, 3524-3532 (1989).
    • (1989) Mol. Cell. Biol. , vol.9 , pp. 3524-3532
    • Dhar, V.1    Skoultchi, A.I.2    Schildkraut, C.L.3
  • 81
    • 0022450433 scopus 로고
    • A developmentally stable chromatin structure in the human β-globin gene cluster
    • Forrester, W. C., Thompson, C., Elder, J. T. & Groudine, M. A developmentally stable chromatin structure in the human β-globin gene cluster. Proc. Natl Acad. Sci. USA 83, 1359-1363 (1986).
    • (1986) Proc. Natl Acad. Sci. USA , vol.83 , pp. 1359-1363
    • Forrester, W.C.1    Thompson, C.2    Elder, J.T.3    Groudine, M.4
  • 83
    • 0020624202 scopus 로고
    • DNA methylation and the regulation of the globin gene expression
    • Busslinger, M., Hurst, J. & Flavell, R. A. DNA methylation and the regulation of the globin gene expression. Cell 34, 197-206 (1983).
    • (1983) Cell , vol.34 , pp. 197-206
    • Busslinger, M.1    Hurst, J.2    Flavell, R.A.3
  • 84
    • 3242811226 scopus 로고    scopus 로고
    • How mammalian transcriptional repressors work
    • Thiel, G., Lietz, M. & Hohl, M. How mammalian transcriptional repressors work. Eur. J. Biochem. 271, 2855-2862 (2004).
    • (2004) Eur. J. Biochem. , vol.271 , pp. 2855-2862
    • Thiel, G.1    Lietz, M.2    Hohl, M.3
  • 85
    • 0031437119 scopus 로고    scopus 로고
    • Association of transcriptionally silent genes with Ikaros complexes at centromeric heterochromatin
    • Brown, K. E. et al. Association of transcriptionally silent genes with Ikaros complexes at centromeric heterochromatin. Cell 91, 845-854 (1997).
    • (1997) Cell , vol.91 , pp. 845-854
    • Brown, K.E.1
  • 86
    • 15144358621 scopus 로고    scopus 로고
    • Helios, a T cell-restricted Ikaros family member that quantitatively associates with Ikaros at centromeric heterochromatin
    • Hahm, K. et al. Helios, a T cell-restricted Ikaros family member that quantitatively associates with Ikaros at centromeric heterochromatin. Genes Dev. 12, 782-796 (1998).
    • (1998) Genes Dev. , vol.12 , pp. 782-796
    • Hahm, K.1
  • 87
    • 18744405062 scopus 로고    scopus 로고
    • Corepressor-dependent silencing of chromosomal regions encoding neuronal genes
    • Lunyak, V. V. et al. Corepressor-dependent silencing of chromosomal regions encoding neuronal genes. Science 298, 1747-1752 (2002).
    • (2002) Science , vol.298 , pp. 1747-1752
    • Lunyak, V.V.1
  • 88
    • 9444244427 scopus 로고    scopus 로고
    • Chromatin compaction by a polycomb group protein complex
    • Francis, N. J., Kingston, R. E. & Woodcock, C. L. Chromatin compaction by a polycomb group protein complex. Science 306, 1574-1577 (2004).
    • (2004) Science , vol.306 , pp. 1574-1577
    • Francis, N.J.1    Kingston, R.E.2    Woodcock, C.L.3
  • 89
    • 0141753136 scopus 로고    scopus 로고
    • Regulation of V(D)J recombination by nucleosome positioning at recombination signal sequences
    • Baumann, M., Mamais, A., McBlane, F., Xiao, H. & Boyes, J. Regulation of V(D)J recombination by nucleosome positioning at recombination signal sequences. EMBO J. 22, 5197-5207 (2003).
    • (2003) EMBO J. , vol.22 , pp. 5197-5207
    • Baumann, M.1    Mamais, A.2    McBlane, F.3    Xiao, H.4    Boyes, J.5
  • 90
    • 4344609697 scopus 로고    scopus 로고
    • Occupancy and synergistic activation of the FMR1 promoter by Nrf-1 and Sp1 in vivo
    • Smith, K. T., Coffee, B. & Reines, D. Occupancy and synergistic activation of the FMR1 promoter by Nrf-1 and Sp1 in vivo. Hum. Mol. Genet. 13, 1611-1621 (2004).
    • (2004) Hum. Mol. Genet. , vol.13 , pp. 1611-1621
    • Smith, K.T.1    Coffee, B.2    Reines, D.3
  • 91
    • 16944366733 scopus 로고    scopus 로고
    • Variable FMR1 gene methylation of large expansions leads to variable phenotype in three males from one fragile X family
    • de Vries, B. B. et al. Variable FMR1 gene methylation of large expansions leads to variable phenotype in three males from one fragile X family. J. Med. Genet. 33, 1007-1010 (1996).
    • (1996) J. Med. Genet. , vol.33 , pp. 1007-1010
    • De Vries, B.B.1
  • 92
    • 0028305242 scopus 로고    scopus 로고
    • No mental retardation in a man with 40% abnormal methylation at the FMR-1 locus and transmission of sperm cell mutations as premutations
    • Rousseau, F., Robb, L. J., Rouillard, P. & Der Kaloustian, V. M. No mental retardation in a man with 40% abnormal methylation at the FMR-1 locus and transmission of sperm cell mutations as premutations. Hum. Mol. Genet. 3, 927-930 (2000).
    • (2000) Hum. Mol. Genet. , vol.3 , pp. 927-930
    • Rousseau, F.1    Robb, L.J.2    Rouillard, P.3    Der Kaloustian, V.M.4
  • 93
    • 0028857169 scopus 로고    scopus 로고
    • Normal phenotype in two brothers with a full FMR1 mutation
    • Smeets, H. J. et al. Normal phenotype in two brothers with a full FMR1 mutation. Hum. Mol. Genet. 4, 2103-2108 (2000).
    • (2000) Hum. Mol. Genet. , vol.4 , pp. 2103-2108
    • Smeets, H.J.1
  • 94
    • 0036591664 scopus 로고    scopus 로고
    • Advances in understanding of fragile X pathogenesis and FMRP function, and in identification of X linked mental retardation genes
    • Bardoni, B. & Mandel, J. L. Advances in understanding of fragile X pathogenesis and FMRP function, and in identification of X linked mental retardation genes. Curr. Opin. Genet. Dev. 12, 284-293 (2002).
    • (2002) Curr. Opin. Genet. Dev. , vol.12 , pp. 284-293
    • Bardoni, B.1    Mandel, J.L.2
  • 95
    • 0033601073 scopus 로고    scopus 로고
    • Methylation-induced repression - Belts, braces, and chromatin
    • Bird, A. P. & Wolffe, A. P. Methylation-induced repression - belts, braces, and chromatin. Cell 99, 451-454 (1999).
    • (1999) Cell , vol.99 , pp. 451-454
    • Bird, A.P.1    Wolffe, A.P.2
  • 97
    • 0011923583 scopus 로고
    • Distribution of 5-methylcytosine in chromatin
    • Razin, A. & Cedar, H. Distribution of 5-methylcytosine in chromatin. Proc. Natl Acad. Sci. USA 74, 2725-2728 (1977).
    • (1977) Proc. Natl Acad. Sci. USA , vol.74 , pp. 2725-2728
    • Razin, A.1    Cedar, H.2
  • 98
    • 0019417156 scopus 로고
    • Sequence specificity of methylation in higher plant DNA
    • Gruenbaum, Y., Naveh-Many, T., Cedar, H. & Razin, A. Sequence specificity of methylation in higher plant DNA. Nature 292, 860-862 (1981).
    • (1981) Nature , vol.292 , pp. 860-862
    • Gruenbaum, Y.1    Naveh-Many, T.2    Cedar, H.3    Razin, A.4
  • 99
    • 0019875880 scopus 로고
    • Methylation of CpG sequences in eukaryotic DNA
    • Gruenbaum, Y., Stein, R., Cedar, H. & Razin, A. Methylation of CpG sequences in eukaryotic DNA. FEBS Lett. 123, 67-71 (1981).
    • (1981) FEBS Lett. , vol.123 , pp. 67-71
    • Gruenbaum, Y.1    Stein, R.2    Cedar, H.3    Razin, A.4
  • 100
    • 0033945861 scopus 로고    scopus 로고
    • DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci
    • Rountree, M. R., Bachman, K. E. & Baylin, S. B. DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci. Nature Genet. 25, 269-277 (2000).
    • (2000) Nature Genet. , vol.25 , pp. 269-277
    • Rountree, M.R.1    Bachman, K.E.2    Baylin, S.B.3
  • 101
    • 0021203243 scopus 로고
    • Mapping of DNase I sensitive regions on mitotic chromosomes
    • Kerem, B. S., Goitein, R., Diamond, G., Cedar, H. & Marcus, M. Mapping of DNase I sensitive regions on mitotic chromosomes. Cell 38, 493-499 (1984).
    • (1984) Cell , vol.38 , pp. 493-499
    • Kerem, B.S.1    Goitein, R.2    Diamond, G.3    Cedar, H.4    Marcus, M.5


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