Serotonin in affective control

Annual Review of Neuroscience

Volumn 32, Issue , 2009, Pages 95-126

  Dayan, Peter ^a   Huys, Quentin J M ^a,b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

Behavior; Computational model; Dopamine; Opponency; Punishment; Reward

Indexed keywords

ACETYLCHOLINE; DOPAMINE; NORADRENALIN; SEROTONIN; SEROTONIN 1A RECEPTOR; SEROTONIN 1B RECEPTOR;

ANIMAL BEHAVIOR; APPETITE; AVOIDANCE BEHAVIOR; BEHAVIOR; BRAIN FUNCTION; CENTRAL NERVOUS SYSTEM; DOPAMINERGIC SYSTEM; FEEDING BEHAVIOR; INFORMATION PROCESSING; INVERTEBRATE; LEARNING; MAMMAL; NEUROMODULATION; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; PUNISHMENT; REINFORCEMENT; REVIEW; REWARD; SEROTONINERGIC SYSTEM;

AFFECT; ANIMALS; AVOIDANCE LEARNING; BRAIN; EMOTIONS; HUMANS; INVERTEBRATES; MAMMALS; MOTIVATION; REWARD; SEROTONIN;

EID: 67349100969     PISSN: 0147006X     EISSN: 15454126     Source Type: Book Series    
DOI: 10.1146/annurev.neuro.051508.135607     Document Type: Review

References (279)

1. Aghajanian GK, Vandermaelen CP. 1982. Intracellular identification of central noradrenergic and serotonergic neurons by a new double labeling procedure. J. Neurosci. 2(12):1786-92
2. Alex KD, Pehek EA. 2007. Pharmacologic mechanisms of serotonergic regulation of dopamine neurotransmission. Pharmacol. Ther. 113(2):296-320
3. Allers K, Sharp T. 2003. Neurochemical and anatomical identification of fast- and slow-firing neurones in the rat dorsal raphe nucleus using juxtacellular labeling methods in vivo. Neuroscience 122(1):193-204
4. Amat J, Baratta MV, Paul E, Bland ST, Watkins LR, Maier SF. 2005. Medial prefrontal cortex determines how stressor controllability affects behavior and dorsal raphe nucleus. Nat. Neurosci. 8(3):365-71
5. Ansorge MS, Zhou M, Lira A, Hen R, Gingrich JA. 2004. Early-life blockade of the 5-HT transporter alters emotional behavior in adult mice. Science 306(5697):879-81
6. Apicella P. 2002. Tonically active neurons in the primate striatum and their role in the processing of information about motivationally relevant events. Eur. J. Neurosci. 16(11):2017-26
7. Arora S, Anubhuti. 2006. Role of neuropeptides in appetite regulation and obesity - a review. Neuropeptides 40(6):375-401
8. Artigas F. 1993. 5-HT and antidepressants: new views from microdialysis studies. Trends Pharmacol. Sci. 14(7):262
9. Aston-Jones G, Cohen JD. 2005. An integrative theory of locus coeruleus-norepinephrine function: adaptive gain and optimal performance. Annu. Rev. Neurosci. 28:403-50
10. Azmitia EC. 2001. Modern views on an ancient chemical: serotonin effects on cell proliferation, maturation, and apoptosis. Brain Res. Bull. 56(5):413-24
11. Azmitia EC, Segal M. 1978. An autoradiographic analysis of the differential ascending projections of the dorsal and median raphe nuclei in the rat. J. Comp. Neurol. 179(3):641-67
12. Balleine BW. 2005. Neural bases of food-seeking: affect, arousal and reward in corticostriatolimbic circuits. Physiol. Behav. 86(5):717-30
13. Balon R. 2006. SSRI-associated sexual dysfunction. Am. J. Psychiatry 163(9):1504-9; quiz 1664
14. Bandler R, Shipley MT. 1994. Columnar organization in the midbrain periaqueductal gray: modules for emotional expression? Trends Neurosci. 17(9):379-89
15. Barto A. 1995. Adaptive critics and the basal ganglia. In Models of Information Processing in the Basal Ganglia, ed. J Houk, J Davis, D Beiser, pp. 215-32. Cambridge, MA: MIT Press
16. Bayer HM, Glimcher PW. 2005. Midbrain dopamine neurons encode a quantitative reward prediction error signal. Neuron 47(1):129-41
17. Bechtholt AJ, Hill TE, Lucki I. 2007. Anxiolytic effect of serotonin depletion in the novelty-induced hypophagia test. Psychopharmacology (Berl.) 190(4):531-40
18. Behbehani MM, Fields HL. 1979. Evidence that an excitatory connection between the periaqueductal gray and nucleus raphe magnus mediates stimulation produced analgesia. Brain Res. 170(1):85-93
19. Beninger R, Mason S, Phillips A, Fibiger H. 1980. The use of extinction to investigate the nature of neurolepticinduced avoidance deficits. Psychopharmacology 69(1):11-18
20. Berridge KC. 2004. Motivation concepts in behavioral neuroscience. Physiol. Behav. 81:179-209
21. Berridge KC. 2007. The debate over dopamine's role in reward: the case for incentive salience. Psychopharmacology (Berl.) 191(3):391-431
22. Bertsekas DP. 2007. Dynamic Programming and Optimal Control. Belmont, MA: Athena Sci. 2 vols.
23. Bevengut M, Clarac F. 1982. Contrôle de la posture du Crabe Carcinus maenas par des amines biogènes. C. R. Acad. Sci. Paris 295:23-28
24. Beyer CE, Cremers TIFH. 2008. Do selective serotonin reuptake inhibitors acutely increase frontal cortex levels of serotonin? Eur. J. Pharmacol. 580(3):350-54
25. Bicker G, Menzel R. 1989. Chemical codes for the control of behavior in arthropods. Nature 337(6202):33-39
26. Blanchard DC, Blanchard RJ. 1988. Ethoexperimental approaches to the biology of emotion. Annu. Rev. Psychol. 39:43-68
27. Bland ST, Hargrave D, Pepin JL, Amat J, Watkins LR, Maier SF. 2003. Stressor controllability modulates stress-induced dopamine and serotonin efflux and morphine-induced serotonin efflux in the medial prefrontal cortex. Neuropsychopharmacology 28(9):1589-96
28. Blier P, de Montigny C. 1999. Serotonin and drug-induced therapeutic responses in major depression, obsessive-compulsive and panic disorders. Neuropsychopharmacology 21(2 Suppl.):91S-98S
29. Bolles RC. 1970. Species-specific defense reactions and avoidance learning. Psychol. Rev. 77:32-48
30. Bouret S, Sara SJ. 2005. Network reset: a simplified overarching theory of locus coeruleus noradrenaline function. Trends Neurosci. 28(11):574-82
31. Breland K, Breland M. 1961. The misbehavior of organisms. Am. Psychol. 16:681-84
32. Brembs B. 2003. Operant conditioning in invertebrates. Curr. Opin. Neurobiol. 13(6):710-17
33. Brembs B, Heisenberg M. 2000. The operant and the classical in conditioned orientation of Drosophila melanogaster at the flight simulator. Learn. Mem. 7(2):104-15
34. Brembs B, Lorenzetti FD, Reyes FD, Baxter DA, Byrne JH. 2002. Operant reward learning in Aplysia: neuronal correlates and mechanisms. Science 296(5573):1706-9
35. Brodie B, Shore P. 1957. A concept for a role of serotonin and norepinephrine as chemical mediators in the brain. Ann. N. Y. Acad. Sci. 66(3):631-42
36. Brown P, Molliver ME. 2000. Dual serotonin (5-HT) projections to the nucleus accumbens core and shell: relation of the 5-HT transporter to amphetamine-induced neurotoxicity. J. Neurosci. 20(5):1952-63
37. Brown PL, Jenkins HM. 1968. Auto-shaping of the pigeon's key-peck. J. Exp. Anal. Behav. 11(1):1-8
38. Bunin MA, Wightman RM. 1999. Paracrine neurotransmission in the CNS: involvement of 5-HT. Trends Neurosci. 22(9):377-82
39. Burghardt NS, Bush DEA, McEwen BS, LeDoux JE. 2007. Acute selective serotonin reuptake inhibitors increase conditioned fear expression: blockade with a 5-HT(2C) receptor antagonist. Biol. Psychiatry 62(10):1111-18
40. Burghardt NS, Sullivan GM, McEwen BS, Gorman JM, LeDoux JE. 2004. The selective serotonin reuptake inhibitor citalopram increases fear after acute treatment but reduces fear with chronic treatment: a comparison with tianeptine. Biol. Psychiatry 55(12):1171-78
41. Buznikov GA, Lambert HW, Lauder JM. 2001. Serotonin and serotonin-like substances as regulators of early embryogenesis and morphogenesis. Cell Tissue Res. 305(2):177-86
42. Byrne JH, Kandel ER. 1996. Presynaptic facilitation revisited: state and time dependence. J. Neurosci. 16(2):425-35
43. Cabib S, Puglisi-Allegra S. 1996. Stress, depression and the mesolimbic dopamine system. Psychopharmacology 128(4):331-42
44. Cameron DL, Williams JT. 1995. Opposing roles for dopamine and serotonin at presynaptic receptors in the ventral tegmental area. Clin. Exp. Pharmacol. Physiol. 22(11):841-45
45. Carter CJ, Pycock CJ. 1978. Differential effects of central serotonin manipulation on hyperactive and stereotyped behavior. Life Sci. 23(9):953-60
46. Cervo L, Mocaër E, Bertaglia A, Samanin R. 2000. Roles of 5-HT(1A) receptors in the dorsal raphe and dorsal hippocampus in anxiety assessed by the behavioral effects of 8-oh-dpat and s 15535 in a modified Geller-Seifter conflict model. Neuropharmacology 39(6):1037-43
47. Chamberlain SR, Müller U, Blackwell AD, Clark L, Robbins TW, Sahakian BJ. 2006. Neurochemical modulation of response inhibition and probabilistic learning in humans. Science 311:861-63
48. Chase DL, Koelle MR. 2007. Biogenic amine neurotransmitters in C. elegans. WormBook pp. 1-15
49. Clark L, Roiser JP, Cools R, Rubinsztein DC, Sahakian BJ, Robbins TW. 2005. Stop signal response inhibition is not modulated by tryptophan depletion or the serotonin transporter polymorphism in healthy volunteers: implications for the 5-HT theory of impulsivity. Psychopharmacology 182(4):570-78
50. Clarke HF, Walker SC, Dalley JW, Robbins TW, Roberts AC. 2007. Cognitive inflexibility after prefrontal serotonin depletion is behaviorally and neurochemically specific. Cereb. Cortex 17(1):18-27
51. Cohen JD, Blum KI. 2002. Reward and decision. Neuron 36(2):193-98
52. Cools R, Calder AJ, Lawrence AD, Clark L, Bullmore E, Robbins TW. 2005. Individual differences in threat sensitivity predict serotonergic modulation of amygdala response to fearful faces. Psychopharmacology (Berl.) 180(4):670-79
53. Cools R, Roberts AC, Robbins TW. 2008. Serotoninergic regulation of emotional and behavioural control processes. Trends Cogn. Sci. 12(1):31-40
54. Cools R, Robinson OJ, Sahakian B. 2008. Acute tryptophan depletion in healthy volunteers enhances punishment prediction but does not affect reward prediction. Neuropsychopharmacology. 33(9):2291-99
55. Cooper JR, Bloom FE, Roth RH. 2002. The Biochemical Basis of Neuropharmacology. New York: Oxford Univ. Press. 8th ed.
56. Crespi L. 1942. Quantitative variation of incentive and performance in the white rat. Am. J. Psychol. 55:467-517
57. Crockett MJ, Clark L, Tabibnia G, Lieberman MD, Robbins TW. 2008. Serotonin modulates behavioral reactions to unfairness. Science 320(5884):1739
58. Cryan JF, Mombereau C, Vassout A. 2005. The tail suspension test as a model for assessing antidepressant activity: review of pharmacological and genetic studies in mice. Neurosci. Biobehav. Rev. 29(4-5):571-625
59. Dahlström A, Fuxe K. 1964. Evidence for the existence of monoamine-containing neurons in the central nervous system. I. Demonstration of monoamines in the cell bodies of brain stem neurons. Acta Physiol. Scand. Suppl. 232(Suppl.):1-55
60. D'Ardenne K, McClure SM, Nystrom LE, Cohen JD. 2008. Bold responses reflecting dopaminergic signals in the human ventral tegmental area. Science 319(5867):1264-67
61. Daw ND, Kakade S, Dayan P. 2002. Opponent interactions between serotonin and dopamine. Neural Netw. 15:603-16
62. Daw ND, Niv Y, Dayan P. 2005. Uncertainty-based competition between prefrontal and dorsolateral striatal systems for behavioral control. Nat. Neurosci. 8(12):1704-11
63. Dayan P, Huys QJM. 2008. Serotonin, inhibition, and negative mood. PLoS Comput. Biol. 4(2):e4
64. Dayan P, Niv Y, Seymour B, Daw ND. 2006. The misbehavior of value and the discipline of the will. Neural Netw. 19(8):1153-60
65. Dayan P, Yu AJ. 2006. Phasic norepinephrine: a neural interrupt signal for unexpected events. Network 17(4):335-50
66. de Almeida RMM, Ferrari PF, Parmigiani S, Miczek KA. 2005. Escalated aggressive behavior: dopamine, serotonin and GABA. Eur. J. Pharmacol. 526(1-3):51-64
67. Deakin JFW. 1983. Roles of brain serotonergic neurons in escape, avoidance and other behaviors. J. Psychopharmacol. 43:563-77
68. Deakin JFW, Graeff FG. 1991. 5-HT and mechanisms of defense. J. Psychopharmacol. 5:305-16
69. Dekeyne A, Brocco M, Adhumeau A, Gobert A, Millan MJ. 2000. The selective serotonin (5-HT)1A receptor ligand, s15535, displays anxiolytic-like effects in the social interaction and vogel models and suppresses dialysate levels of 5-HT in the dorsal hippocampus of freely-moving rats: a comparison with other anxiolytic agents. Psychopharmacology (Berl.) 152(1):55-66
70. Delgado PL. 2000. Depression: the case for a monoamine deficiency. J. Clin. Psychiatry 61(Suppl. 6):7-11
71. Depue R, Spoont M. 1986. Conceptualizing a serotonin trait. A behavioral dimension of constraint. Ann. N.Y. Acad. Sci. 487:47-62
72. Dias R, Robbins TW, Roberts AC. 1996. Dissociation in prefrontal cortex of affective and attentional shifts. Nature 380:69-72
73. Dickinson A. 1980. Contemporary Animal Learning Theory. Cambridge, UK: Cambridge Univ. Press
74. Dickinson A, Balleine B. 2002. The role of learning in the operation of motivational systems. In Stevens' Handbook of Experimental Psychology, Vol. 3, ed. R Gallistel, pp. 497-534. New York:Wiley
75. Dickinson A, Dearing MF. 1979. Appetitive-aversive interactions and inhibitory processes. In Mechanisms of Learning and Motivation, ed. A Dickinson, RA Boakes. pp. 203-31. Hillsdale, NJ: Erlbaum
76. Dickinson A, Pearce J. 1977. Inhibitory interactions between appetitive and aversive stimuli. Psychol. Bull. 84:690-711
77. Doya K. 2002. Metalearning and neuromodulation. Neural Netw. 15(4-6):495-506
78. Dulawa SC, Hen R. 2005. Recent advances in animal models of chronic antidepressant effects: the noveltyinduced hypophagia test. Neurosci. Biobehav. Rev. 29(4-5):771-83
79. Edwards DH, Kravitz EA. 1997. Serotonin, social status and aggression. Curr. Opin. Neurobiol. 7(6):812-19
80. Estes W. 1943. Discriminative conditioning. I. A discriminative property of conditioned anticipation. J. Exp. Psychol. 32:150-55
81. Everitt BJ, Robbins TW. 1997. Central cholinergic systems and cognition. Annu. Rev. Psychol. 48:649-84
82. Everitt BJ, Robbins TW. 2005. Neural systems of reinforcement for drug addiction: from actions to habits to compulsion. Nat. Neurosci. 8(11):1481-89
83. Evers EAT, Tillie DE, Van Der Veen FM, Lieben CK, Jolles J, et al. 2005. Effects of a novel method of acute tryptophan depletion on plasma tryptophan and cognitive performance in healthy volunteers. Psychopharmacology (Berl.) 178(1):92-99
84. Fadda F. 2000. Tryptophan-free diets: a physiological tool to study brain serotonin function. News Physiol. Sci. 15:260-64
85. Flamm RE, Harris-Warrick RM. 1986a. Aminergic modulation in lobster stomatogastric ganglion. I. Effects on motor pattern and activity of neurons within the pyloric circuit. J. Neurophysiol. 55(5):847-65
86. Flamm RE, Harris-Warrick RM. 1986b. Aminergic modulation in lobster stomatogastric ganglion. II. Target neurons of dopamine, octopamine, and serotonin within the pyloric circuit. J. Neurophysiol. 55(5):866-81
87. Fletcher PJ. 1991. Dopamine receptor blockade in nucleus accumbens or caudate nucleus differentially affects feeding induced by 8-OH-DPAT injected into dorsal or median raphe. Brain Res. 552(2):181-89
88. Fletcher PJ. 1996. Injection of 5-HT into the nucleus accumbens reduces the effects of d-amphetamine on responding for conditioned reward. Psychopharmacology (Berl.) 126(1):62-69
89. Fletcher PJ, Azampanah A, Korth KM. 2002. Activation of 5-HT(1B) receptors in the nucleus accumbens reduces self-administration of amphetamine on a progressive ratio schedule. Pharmacol. Biochem. Behav. 71(4):717-21
90. Fletcher PJ, Korth KM. 1999. Activation of 5-HT1B receptors in the nucleus accumbens reduces amphetamine-induced enhancement of responding for conditioned reward. Psychopharmacology 142(2):165-74
91. Fletcher PJ, Korth KM, Chambers JW. 1999. Selective destruction of brain serotonin neurons by 5,7-dihydroxytryptamine increases responding for a conditioned reward. Psychopharmacology (Berl.) 147(3):291-99
92. Frank MJ, Seeberger LC, O'Reilly RC. 2004. By carrot or by stick: cognitive reinforcement learning in parkinsonism. Science 306(5703):1940-43
93. Friston KJ, Tononi G, Reeke GN, Sporns O, Edelman GM. 1994. Value-dependent selection in the brain: simulation in a synthetic neural model. Neuroscience 59(2):229-43
94. Ganesan R, Pearce JM. 1988. Effect of changing the unconditioned stimulus on appetitive blocking. J. Exp. Psychol. Anim. Behav. Process. 14(3):280-91
95. Gasser PJ, Lowry CA, Orchinik M. 2006. Corticosterone-sensitive monoamine transport in the rat dorsomedial hypothalamus: potential role for organic cation transporter 3 in stress-induced modulation of monoaminergic neurotransmission. J. Neurosci. 26(34):8758-66
96. Geller I, Seifter J. 1960. The effects of meprobamate, barbiturates, d-amphetamine and promazine on experimentally induced conflict in the rat. Psychopharmacology 1(6):482-92
97. Getting PA. 1989. Emerging principles governing the operation of neural networks. Annu. Rev. Neurosci. 12:185-204
98. Getting PA, Dekin MS. 1985. Mechanisms of pattern generation underlying swimming in tritonia. iv. Gating of central pattern generator. J. Neurophysiol. 53(2):466-80
99. Gillette R. 2006. Evolution and function in serotonergic systems. Int. Comp. Biol. 46(6):838-46
100. Gordon JA, Hen R. 2004. Genetic approaches to the study of anxiety. Annu. Rev. Neurosci. 27:193-222
101. Goto Y, Otani S, Grace AA. 2007. The yin and yang of dopamine release: a new perspective. Neuropharmacology 53(5):583-87
102. Gradinaru V, Thompson KR, Zhang F, Mogri M, Kay K, et al. 2007. Targeting and readout strategies for fast optical neural control in vitro and in vivo. J. Neurosci. 27(52):14231-38
103. Graeff FG. 2002. On serotonin and experimental anxiety. Psychopharmacology (Berl.) 163(3-4):467-76
104. Graeff FG. 2004. Serotonin, the periaqueductal gray and panic. Neurosci. Biobehav. Rev. 28(3):239-59
105. Graeff FG, Schoenfeld RI. 1970. Tryptaminergic mechanisms in punished and nonpunished behavior. J. Pharmacol. Exp. Ther. 173(2):277-83
106. Graeff FG, Viana MB, Mora PO. 1996. Opposed regulation by dorsal raphe nucleus 5-HT pathways of two types of fear in the elevated t-maze. Pharmacol. Biochem. Behav. 53(1):171-77
107. Grahn RE, Will MJ, Hammack SE, Maswood S, McQueen MB, et al. 1999. Activation of serotonin-immunoreactive cells in the dorsal raphe nucleus in rats exposed to an uncontrollable stressor. Brain Res. 826(1):35-43
108. Gray JA. 1991. Problems in the Behavioural Sciences, Vol. 5: The Psychology of Fear and Stress. Cambridge, UK: Cambridge Univ. Press. 2 ed.
109. Gray JA, McNaughton N. 2003. The Neuropsychology of Anxiety. Oxford, UK: Oxford Univ. Press. 2nd ed.
110. Griebel G. 1995. 5-Hydroxytryptamine-interacting drugs in animal models of anxiety disorders: more than 30 years of research. Pharmacol. Ther. 65:319-95
111. Griebel G, Moreau JL, Jenck F, Misslin R, Martin JR. 1994. Acute and chronic treatment with 5-HT reuptake inhibitors differentially modulate emotional responses in anxiety models in rodents. Psychopharmacology (Berl.) 113(3-4):463-70
112. Grossberg S. 1984. Some normal and abnormal behavioral syndromes due to transmitter gating of opponent processes. Biol. Psychiatry 19(7):1075-118
113. Hajós M, Allers K, Jennings K, Sharp T, Charette G, Sik A, Kocsis B. 2007. Neurochemical identification of stereotypic burst-firing neurons in the rat dorsal raphe nucleus using juxtacellular labeling methods. Eur. J. Neurosci. 25(1):119-26
114. Halford JCG, Harrold JA, Lawton CL, Blundell JE. 2005. Serotonin (5-HT) drugs: effects on appetite expression and use for the treatment of obesity. Curr. Drug Targets 6(2):201-13
115. Hammer M. 1993. An identified neuron mediates the unconditioned stimulus in associative olfactory learning in honeybees. Nature 366(6450):59-63
116. Hariri AR, Mattay VS, Tessitore A, Kolachana B, Fera F, et al. 2002. Serotonin transporter genetic variation and the response of the human amygdala. Science 297(5580):400-3
117. Harmer CJ. 2008. Serotonin and emotional processing: Does it help explain antidepressant drug action? Neuropharmacology 55(6):1023-28
118. Harris-Warrick RM, Marder E. 1991. Modulation of neural networks for behavior. Annu. Rev. Neurosci. 14:39-57
119. Hashimoto S, Inoue T, Koyama T. 1996. Serotonin reuptake inhibitors reduce conditioned fear stress-induced freezing behavior in rats. Psychopharmacology (Berl.) 123(2):182-86
120. Hasselmo ME. 1995. Neuromodulation and cortical function: modeling the physiological basis of behavior. Behav. Brain Res. 67(1):1-27
121. Hattox A, Li Y, Keller A. 2003. Serotonin regulates rhythmic whisking. Neuron 39(2):343-52
122. Hawkins RD. 1984. A cellular mechanism of classical conditioning in Aplysia. J. Exp. Biol. 112:113-28
123. Heinrich R, Cromarty SI, Hörner M, Edwards DH, Kravitz EA. 1999. Autoinhibition of serotonin cells: an intrinsic regulatory mechanism sensitive to the pattern of usage of the cells. Proc. Natl. Acad. Sci. USA 96(5):2473-78
124. Helluy S, Holmes J. 1990. Serotonin, octopamine, and the clinging behavior induced by the parasite Polymorphus paradoxus (Acanthocephala) in Gammarus lacustris (Crustacea). Can. J. Zool. 68(6):1214-20
125. Herrnstein RJ, Sidman M. 1958. Avoidance conditioning as a factor in the effects of unavoidable shocks on food-reinforced behavior. J. Comp. Physiol. Psychol. 51(3):380-85
126. Heym J, Trulson ME, Jacobs BL. 1982. Raphe unit activity in freely moving cats: effects of phasic auditory and visual stimuli. Brain Res. 232(1):29-39
127. Higgins GA, Fletcher PJ. 2003. Serotonin and drug reward: focus on 5-HT2C receptors. Eur. J. Pharmacol. 480(1-3):151-62
128. Hinz R, Bhagwagar Z, Cowen PJ, Cunningham VJ, Grasby PM. 2007. Validation of a tracer kinetic model for the quantification of 5-HT(2A) receptors in human brain with [(11)C]MDL 100907. J. Cereb. Blood Flow Metab. 27(1):161-72
129. Hirsch S, Bolles R. 1980. On the ability of prey to recognize predators. Z. Tierpsychol. 54:71-84
130. Holland P. 1997. Brain mechanisms for changes in processing of conditioned stimuli in Pavlovian conditioning: implications for behavior theory. Anim. Learn. Behav. 25(4):373-99
131. Horvitz HR, Chalfie M, Trent C, Sulston JE, Evans PD. 1982. Serotonin and octopamine in the nematode Caenorhabditis elegans. Science 216(4549):1012-14
132. Horvitz JC. 2000. Mesolimbocortical and nigrostriatal dopamine responses to salient nonreward events. Neuroscience 96(4):651-56
133. Howell S, Westergaard G, Hoos B, Chavanne TJ, Shoaf SE, et al. 2007. Serotonergic influences on life-history outcomes in free-ranging male rhesus macaques. Am. J. Primatol. 69(8):851-65
134. Hoyer D, Clarke DE, Fozard JR, Hartig PR, Martin GR, et al. 1994. International union of pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol. Rev. 46(2):157-203
135. Hoyer D, Hannon JP, Martin GR. 2002. Molecular, pharmacological and functional diversity of 5-HT receptors. Pharmacol. Biochem. Behav. 71(4):533-54
136. Huys QJM. 2007. Reinforcers and control. Towards a computational etiology of depression. PhD thesis, Gatsby Comp. Neurosci. Unit, Univ. Coll. London http://www.gatsby.ucl.ac.uk/~qhuys/pub/Huys07.pdf
137. Inoue T, Hashimoto S, Tsuchiya K, Izumi T, Ohmori T, Koyama T. 1996. Effect of citalopram, a selective serotonin reuptake inhibitor, on the acquisition of conditioned freezing. Eur. J. Pharmacol. 311(1):1-6
138. Jacobs BL, Azmitia EC. 1992. Structure and function of the brain serotonin system. Physiol. Rev. 72(1):165-229
139. Jacobs BL, Fornal CA. 1993. 5-HT and motor control: a hypothesis. Trends Neurosci. 16(9):346-52
140. Jacobs BL, Fornal CA. 1997. Serotonin and motor activity. Curr. Opin. Neurobiol. 7:820-25
141. Jacobs BL, Fornal CA. 1999. Activity of serotonergic neurons in behaving animals. Neuropsychopharmacology 21(2 Suppl.):9S-15
142. Jacobs BL, Martín-Cora FJ, Fornal CA. 2002. Activity of medullary serotonergic neurons in freely moving animals. Brain Res. Brain Res. Rev. 40(1-3):45-52
143. Jensen P, Farago AF, Awatramani RB, Scott MM, Deneris ES, Dymecki SM. 2008. Redefining the serotonergic system by genetic lineage. Nat. Neurosci. 11(4):417-19
144. Jing J, Gillette R. 1999. Central pattern generator for escape swimming in the notaspid sea slug Pleurobranchaea californica. J. Neurophysiol. 81(2):654-67
145. Jing J, Gillette R. 2000. Escape swim network interneurons have diverse roles in behavioral switching and putative arousal in Pleurobranchaea. J. Neurophysiol. 83(3):1346-55
146. Jing J, Gillette R. 2003. Directional avoidance turns encoded by single interneurons and sustained by multi-functional serotonergic cells. J. Neurosci. 23(7):3039-51
147. Joel D, Niv Y, Ruppin E. 2002. Actor-critic models of the basal ganglia: new anatomical and computational perspectives. Neural. Netw. 15(4-6):535-47
148. Judge SJ, Gartside SE. 2006. Firing of 5-HT neurones in the dorsal and median raphe nucleus in vitro shows differential alpha1-adrenoceptor and 5-HT1A receptor modulation. Neurochem. Int. 48(2):100-7
149. Julius D. 1998. Serotonin receptor knockouts: a moody subject. Proc. Natl. Acad. Sci. USA 95(26):15153-54
150. Kapur S, Remington G. 1996. Serotonin-dopamine interaction and its relevance to schizophrenia. Am. J. Psychiatry 153(4):466-76
151. Kawaguchi Y. 1997. Neostriatal cell subtypes and their functional roles. Neurosci. Res. 27(1):1-8
152. Keay KA, Bandler R. 2001. Parallel circuits mediating distinct emotional coping reactions to different types of stress. Neurosci. Biobehav. Rev. 25(7-8):669-78
153. Kennett GA, Wood MD, Bright F, Trail B, Riley G, et al. 1997. SB 242084, a selective and brain penetrant 5-HT2C receptor antagonist. Neuropharmacology 36(4-5):609-20
154. Killcross S, Coutureau E. 2003. Coordination of actions and habits in the medial prefrontal cortex of rats. Cereb. Cortex 13(4):400-8
155. Kirby LG, Chou-Green JM, Davis K, Lucki I. 1997. The effects of different stressors on extracellular 5-hydroxytryptamine and 5-hydroxyindoleacetic acid. Brain Res. 760(1-2):218-30
156. Klopf A, Weaver S, Morgan J. 1993. A hierarchical network of control systems that learn: modeling nervous system function during classical and instrumental conditioning. Adaptive Behav. 1(3):263-319
157. Kosofsky BE, Molliver ME. 1987. The serotoninergic innervation of cerebral cortex: different classes of axon terminals arise from dorsal and median raphe nuclei. Synapse 1(2):153-68
158. Kravitz EA. 2000. Serotonin and aggression: insights gained from a lobster model system and speculations on the role of amine neurons in a complex behavior. J. Comp. Physiol. A 186(3):221-38
159. Lacroix L, Broersen LM, Feldon J, Weiner I. 2000. Effects of local infusions of dopaminergic drugs into the medial prefrontal cortex of rats on latent inhibition, prepulse inhibition and amphetamine induced activity. Behav. Brain Res. 107(1-2):111-21
160. Lammel S, Hetzel A, Häckel O, Jones I, Liss B, Roeper J. 2008. Unique properties of mesoprefrontal neurons within a dual mesocorticolimbic dopamine system. Neuron 57(5):760-73
161. Lechin F, Van Der Dijs B, Hernández-Adrián G. 2006. Dorsal raphe vs median raphe serotonergic antagonism. Anatomical, physiological, behavioral, neuroendocrinological, neuropharmacological and clinical evidences: relevance for neuropharmacological therapy. Prog. Neuropsychopharmacol. Biol. Psychiatry 30(4):565-85
162. Linnoila M, Virkkunen M, Scheinin M, Nuutila A, Rimon R, Goodwin FK. 1983. Low cerebrospinal fluid 5-hydroxyindoleacetic acid concentration differentiates impulsive from nonimpulsive violent behavior. Life Sci. 33(26):2609-14
163. Lira A, Zhou M, Castanon N, Ansorge MS, Gordon JA, et al. 2003. Altered depression-related behaviors and functional changes in the dorsal raphe nucleus of serotonin transporter-deficient mice. Biol. Psychiatry 54(10):960-71
164. Lovibond PF. 1983. Facilitation of instrumental behavior by a Pavlovian appetitive conditioned stimulus. J. Exp. Psychol. Anim. Behav. Process. 9(3):225-47
165. Lowry CA. 2002. Functional subsets of serotonergic neurones: implications for control of the hypothalamicpituitary-adrenal axis. J. Neuroendocrinol. 14(11):911-23
166. Lowry CA, Johnson PL, Hay-Schmidt A, Mikkelsen J, Shekhar A. 2005. Modulation of anxiety circuits by serotonergic systems. Stress 8(4):233-46
167. Luciana M, Collins PF, Depue RA. 1998. Opposing roles for dopamine and serotonin in the modulation of human spatial working memory functions. Cereb. Cortex 8(3):218-26
168. Lucki I. 1998. The spectrum of behaviors influenced by serotonin. Biol. Psychiatry 44(3):151-62
169. Ma PM, Beltz BS, Kravitz EA. 1992. Serotonin-containing neurons in lobsters: their role as gain-setters in postural control mechanisms. J. Neurophysiol. 68(1):36-54
170. Mackintosh NJ. 1983. Conditioning and Associative Learning. Oxford, UK: Oxford Univ. Press
171. Maier SF, Watkins LR. 2005. Stressor controllability and learned helplessness: the roles of the dorsal raphe nucleus, serotonin, and corticotropin-releasing factor. Neurosci. Biobehav. Rev. 29(4-5):829-41
172. Mansari ME, Blier P. 2006. Mechanisms of action of current and potential pharmacotherapies of obsessivecompulsive disorder. Prog. Neuropsychopharmacol. Biol. Psychiatry 30(3):362-73
173. Marder E, Thirumalai V. 2002. Cellular, synaptic and network effects of neuromodulation. Neural. Netw. 15(4-6):479-93
174. Marr D. 1982. Vision. New York: Freeman
175. Marrocco RT, Lane RF, McClurkin JW, Blaha CD, Alkire MF. 1987. Release of cortical catecholamines by visual stimulation requires activity in thalamocortical afferents of monkey and cat. J. Neurosci. 7(9):2756-67
176. Marsh DM, Dougherty DM, Moeller FG, Swann AC, Spiga R. 2002. Laboratory-measured aggressive behavior of women: acute tryptophan depletion and augmentation. Neuropsychopharmacology 26(5):660-71
177. McClure SM, Daw ND, Montague PR. 2003. A computational substrate for incentive salience. TINS 26:423-28
178. McNaughton N, Corr PJ. 2004. A two-dimensional neuropsychology of defense: fear/anxiety and defensive distance. Neurosci. Biobehav. Rev. 28(3):285-305
179. McQuade R, Sharp T. 1997. Functional mapping of dorsal and median raphe 5-hydroxytryptamine pathways in forebrain of the rat using microdialysis. J. Neurochem. 69(2):791-96
180. Meyer-Lindenberg A, Zink CF. 2007. Imaging genetics for neuropsychiatric disorders. Child Adolesc. Psychiatr. Clin. N. Am. 16(3):581-97
181. Miczek KA, de Almeida RMM, Kravitz EA, Rissman EF, de Boer SF, Raine A. 2007. Neurobiology of escalated aggression and violence. J. Neurosci. 27(44):11803-6
182. Millan MJ. 2002. Descending control of pain. Prog. Neurobiol. 66(6):355-474
183. Millan MJ, Seguin L, Honoré P, Girardon S, Bervoets K. 1996. Pro- and antinociceptive actions of serotonin (5-HT)1A agonists and antagonists in rodents: relationship to algesiometric paradigm. Behav. Brain Res. 73(1-2):69-77
184. Mobbs D, Petrovic P, Marchant JL, Hassabis D, Weiskopf N, et al. 2007. When fear is near: threat imminence elicits prefrontal-periaqueductal gray shifts in humans. Science 317(5841):1079-83
185. Mobini S, Chiang TJ, Al-Ruwaitea AS, Ho MY, Bradshaw CM, Szabadi E. 2000a. Effect of central 5-hydroxytryptamine depletion on intertemporal choice: a quantitative analysis. Psychopharmacology 149(3):313-18
186. Mobini S, Chiang TJ, Ho MY, Bradshaw CM, Szabadi E. 2000b. Effects of central 5-hydroxytryptamine depletion on sensitivity to delayed and probabilistic reinforcement. Psychopharmacology 152(4):390-97
187. Moeller FG, Dougherty DM, Swann AC, Collins D, Davis CM, Cherek DR. 1996. Tryptophan depletion and aggressive responding in healthy males. Psychopharmacology (Berl.) 126(2):97-103
188. Moffitt TE, Brammer GL, Caspi A, Fawcett JP, Raleigh M, et al. 1998. Whole blood serotonin relates to violence in an epidemiological study. Biol. Psychiatry 43(6):446-57
189. Mogil JS, Sternberg WF, Balian H, Liebeskind JC, Sadowski B. 1996. Opioid and nonopioid swim stressinduced analgesia: a parametric analysis in mice. Physiol. Behav. 59(1):123-32
190. Montague PR, Dayan P, Person C, Sejnowski TJ. 1995. Bee foraging in uncertain environments using predictive Hebbian learning. Nature 377(6551):725-28
191. Montague PR, Dayan P, Sejnowski TJ. 1996. A framework for mesencephalic dopamine systems based on predictive Hebbian learning. J. Neurosci. 16(5):1936-47
192. Montague PR, Hyman SE, Cohen JD. 2004. Computational roles for dopamine in behavioural control. Nature 431(7010):760-67
193. Morris G, Nevet A, Arkadir D, Vaadia E, Bergman H. 2006. Midbrain dopamine neurons encode decisions for future action. Nat. Neurosci. 9(8):1057-63
194. Moutoussis M, Bentall RP, Williams J, Dayan P. 2008. A temporal difference account of avoidance learning. Network. 19(2):137-60
195. Mowrer O. 1947. On the dual nature of learning: a reinterpretation of conditioning and problem-solving. Harv. Educ. Rev. 17(2):102-50
196. Murschall A, Hauber W. 2006. Inactivation of the ventral tegmental area abolished the general excitatory influence of Pavlovian cues on instrumental performance. Learn. Mem. 13(2):123-26
197. Nakamura K, Matsumoto M, Hikosaka O. 2008. Reward-dependent modulation of neuronal activity in the primate dorsal raphe nucleus. J. Neurosci. 28(20):5331-43
198. Nargeot R, Baxter DA, Patterson GW, Byrne JH. 1999. Dopaminergic synapses mediate neuronal changes in an analogue of operant conditioning. J. Neurophysiol. 81(4):1983-87
199. Nashold BS. 1974. Central pain: its origins and treatment. Clin. Neurosurg. 21:311-22
200. Niv Y, Daw ND, Joel D, Dayan P. 2007. Tonic dopamine: opportunity costs and the control of response vigor. Psychopharmacology (Berl.) 191(3):507-20
201. Nutt DJ. 2006. The role of dopamine and norepinephrine in depression and antidepressant treatment. J. Clin. Psychiatry 67(Suppl. 6):3-8
202. Nuttley WM, Atkinson-Leadbeater KP, Kooy DVD. 2002. Serotonin mediates food-odor associative learning in the nematode Caenorhabditis elegans. Proc. Natl. Acad. Sci. USA 99(19):12449-54
203. O'Doherty J, Dayan P, Schultz J, Deichmann R, Friston K, Dolan RJ. 2004. Dissociable roles of ventral and dorsal striatum in instrumental conditioning. Science 304(5669):452-54
204. Oliveras JL, Redjemi F, Guilbaud G, Besson JM. 1975. Analgesia induced by electrical stimulation of the inferior centralis nucleus of the raphe in the cat. Pain 1(2):139-45
205. Pang R, Turndorf H, Quartermain D. 1996. Pavlovian fear conditioning in mice anesthetized with halothane. Physiol. Behav. 59(4-5):873-75
206. Panksepp J. 1991. The serotonergic puzzle-box of anxiety. J. Psychopharmacol. 5(4):336
207. Panksepp J. 1998. Affective Neuroscience. New York: Oxford Univ. Press
208. Panksepp JB, Huber R. 2002. Chronic alterations in serotonin function: dynamic neurochemical properties in agonistic behavior of the crayfish, Orconectes rusticus. J. Neurobiol. 50(4):276-90
209. Paton JJ, Belova MA, Morrison SE, Salzman CD. 2006. The primate amygdala represents the positive and negative value of visual stimuli during learning. Nature 439(7078):865-70
210. Pessiglione M, Seymour B, Flandin G, Dolan RJ, Frith CD. 2006. Dopamine-dependent prediction errors underpin reward-seeking behavior in humans. Nature 442(7106):1042-45
211. Peyron C, Petit JM, Rampon C, Jouvet M, Luppi PH. 1997. Forebrain afferents to the rat dorsal raphe nucleus demonstrated by retrograde and anterograde tracing methods. Neuroscience 82(2):443-68
212. Pezawas L, Meyer-Lindenberg A, Drabant EM, Verchinski BA, Munoz KE, et al. 2005. 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression. Nat. Neurosci. 8(6):828-34
213. Phillips PEM, Stuber GD, Heien MLAV, Wightman RM, Carelli RM. 2003. Subsecond dopamine release promotes cocaine seeking. Nature 422(6932):614-18
214. Pisani A, Bonsi P, Picconi B, Tolu M, Giacomini P, Scarnati E. 2001. Role of tonically-active neurons in the control of striatal function: cellular mechanisms and behavioral correlates. Prog. Neuropsychopharmacol. Biol. Psychiatry 25(1):211-30
215. Puterman ML. 2005. Markov Decision Processes: Discrete Stochastic Dynamic Programming (Wiley Series in Probability and Statistics). New York: Wiley-Interscience
216. Raleigh MJ, McGuire MT. 1991. Bidirectional relationships between tryptophan and social behavior in vervet monkeys. Adv. Exp. Med. Biol. 294:289-98
217. Raleigh MJ, McGuire MT, Brammer GL, Pollack DB, Yuwiler A. 1991. Serotonergic mechanisms promote dominance acquisition in adult male vervet monkeys. Brain Res. 559(2):181-90
218. Rangel A, Camerer C, Montague P. 2008. A framework for studying the neurobiology of value-based decision making. Nat. Rev. Neurosci. 9(7):545-56
219. Rattray M, Michael GJ, Lee J, Wotherspoon G, Bendotti C, Priestley JV. 1999. Intraregional variation in expression of serotonin transporter messenger RNA by 5-hydroxytryptamine neurons. Neuroscience 88(1):169-83
220. Redgrave P. 1978. Modulation of intracranial self-stimulation behavior by local perfusions of dopamine, noradrenaline and serotonin within the caudate nucleus and nucleus accumbens. Brain Res. 155(2):277-95
221. Rex A, Voigt JP, Voits M, Fink H. 1998. Pharmacological evaluation of a modified open-field test sensitive to anxiolytic drugs. Pharmacol. Biochem. Behav. 59(3):677-83
222. Reynolds SM, Berridge KC. 2001. Fear and feeding in the nucleus accumbens shell: rostrocaudal segregation of GABA-elicited defensive behavior versus eating behavior. J. Neurosci. 21(9):3261-70
223. Reynolds SM, Berridge KC. 2002. Positive and negative motivation in nucleus accumbens shell: bivalent rostrocaudal gradients for GABA-elicited eating, taste "liking"/quot;disliking" reactions, place preference/avoidance, and fear. J. Neurosci. 22(16):7308-20
224. Richter DW, Manzke T, Wilken B, Ponimaskin E. 2003. Serotonin receptors: guardians of stable breathing. Trends Mol. Med. 9(12):542-48
225. Roberts AC, Glanzman DL. 2003. Learning in Aplysia: looking at synaptic plasticity from both sides. Trends Neurosci. 26(12):662-70
226. Robinson DL, Venton BJ, Heien MLAV, Wightman RM. 2003. Detecting subsecond dopamine release with fast-scan cyclic voltammetry in vivo. Clin. Chem. 49(10):1763-73
227. Rocha BA, Scearce-Levie K, Lucas JJ, Hiroi N, Castanon N, et al. 1998. Increased vulnerability to cocaine in mice lacking the serotonin-1b receptor. Nature 393(6681):175-78
228. Roesch MR, Calu DJ, Schoenbaum G. 2007. Dopamine neurons encode the better option in rats deciding between differently delayed or sized rewards. Nat. Neurosci. 10(12):1615-24
229. Roiser JP, Müller U, Clark L, Sahakian BJ. 2007. The effects of acute tryptophan depletion and serotonin transporter polymorphism on emotional processing in memory and attention. Int. J. Neuropsychopharmacol. 10(4):449-61
230. Rosenkranz JA, Grace AA. 2002. Dopamine-mediated modulation of odour-evoked amygdala potentials during Pavlovian conditioning. Nature 417(6886):282-87
231. Salamone JD, Correa M. 2002. Motivational views of reinforcement: implications for understanding the behavioral functions of nucleus accumbens dopamine. Behav. Brain Res. 137(1-2):3-25
232. Sarter M, Hasselmo ME, Bruno JP, Givens B. 2005. Unraveling the attentional functions of cortical cholinergic inputs: interactions between signal-driven and cognitive modulation of signal detection. Brain Res. Brain Res. Rev. 48(1):98-111
233. Satoh T, Nakai S, Sato T, Kimura M. 2003. Correlated coding of motivation and outcome of decision by dopamine neurons. J. Neurosci. 23(30):9913-23
234. Sawynok J, Esser MJ, Reid AR. 2001. Antidepressants as analgesics: an overview of central and peripheral mechanisms of action. J. Psychiatry Neurosci. 26(1):21-29
235. Schmajuk N, Zanutto B. 1997. Escape, avoidance, and imitation: a neural network approach. Adaptive Behav. 6(1):63-129
236. Schultz W, Dayan P, Montague PR. 1997. Aneural substrate of prediction and reward. Science 275(5306):1593-99
237. Schweighofer N, Bertin M, Shishida K, Okamoto Y, Tanaka SC, et al. 2008. Low-serotonin levels increase delayed reward discounting in humans. J. Neurosci. 28(17):4528-32
238. Schweimer J, Brierley D, Ungless M. 2008. Phasic nociceptive responses in dorsal raphe serotonin neurons. Fundam. Clin. Pharmacol. 22:119
239. Simansky KJ. 1996. Serotonergic control of the organization of feeding and satiety. Behav. Brain Res. 73(1-2):37-42
240. Siwicki KK, Beltz BS, Kravitz EA. 1987. Proctolin in identified serotonergic, dopaminergic, and cholinergic neurons in the lobster, Homarus americanus. J. Neurosci. 7(2):522-32
241. Smith AJ, Li M, Becker S, Kapur S. 2007. Linking animal models of psychosis to computational models of dopamine function. Neuropsychopharmacology 32(1):54-66
242. Smith KA, Fairburn CG, Cowen PJ. 1997. Relapse of depression after rapid depletion of tryptophan. Lancet 249:915-19
243. Solomon RL, Corbit JD. 1974. An opponent-process theory of motivation. I. Temporal dynamics of affect. Psychol. Rev. 81(2):119-45
244. Sombati S, Hoyle G. 1984. Generation of specific behaviors in a locust by local release into neuropil of the natural neuromodulator octopamine. J. Neurobiol. 15(6):481-506
245. Sommer C. 2004. Serotonin in pain and analgesia: actions in the periphery. Mol. Neurobiol. 30(2):117-25
246. Soubrié P. 1986. Reconciling the role of central serotonin neurons in human and animal behavior. Behav. Brain Sci. 9:319-64
247. Stevens DA, Fechter LD, Resnick O. 1969. The effects of p-chlorophenylalanine, a depletor of brain serotonin, on behavior: II. Retardation of passive avoidance learning. Life Sci. 8(8):379-85
248. Suri RE, Schultz W. 1999. A neural network model with dopamine-like reinforcement signal that learns a spatial delayed response task. Neuroscience 91(3):871-90
249. Sutton RS, Barto AG. 1998. Reinforcement Learning: An Introduction. Cambridge, MA: MIT Press
250. Takase LF, Nogueira MI, Baratta M, Bland ST, Watkins LR, et al. 2004. Inescapable shock activates serotonergic neurons in all raphe nuclei of rat. Behav. Brain Res. 153(1):233-39
251. Takase LF, Nogueira MI, Bland ST, Baratta M, Watkins LR, et al. 2005. Effect of number of tailshocks on learned helplessness and activation of serotonergic and noradrenergic neurons in the rat. Behav. Brain Res. 162(2):299-306
252. Tanaka SC, Doya K, Okada G, Ueda K, Okamoto Y, Yamawaki S. 2004. Prediction of immediate and future rewards differentially recruits cortico-basal ganglia loops. Nat. Neurosci. 7(8):887-93
253. Tanaka SC, Schweighofer N, Asahi S, Shishida K, Okamoto Y, et al. 2007. Serotonin differentially regulates short- and long-term prediction of rewards in the ventral and dorsal striatum. PLoS ONE 2(12):e1333
254. Taylor JR, Robbins TW. 1984. Enhanced behavioural control by conditioned reinforcers following microinjections of d-amphetamine into the nucleus accumbens. Psychopharmacology (Berl.) 84(3):405-12
255. Tecott LH. 2007. Serotonin and the orchestration of energy balance. Cell Metab. 6(5):352-61
256. Tenen SS. 1968. Antagonism of the analgesic effect of morphine and other drugs by p-chlorophenylalanine, a serotonin depletor. Psychopharmacologia 12(4):278-85
257. Thiébot MH, Martin P, Puech AJ. 1992. Animal behavioural studies in the evaluation of antidepressant drugs. Br. J. Psychiatry Suppl. Feb.(15):44-50
258. Trudeau L-E, Gutiérrez R. 2007. On cotransmission and neurotransmitter phenotype plasticity. Mol. Interv. 7(3):138-46
259. Tye NC, Everitt BJ, Iversen SD. 1977. 5-hydroxytryptamine and punishment. Nature 268(5622):741-43
260. Ungless MA, Magill PJ, Bolam JP. 2004. Uniform inhibition of dopamine neurons in the ventral tegmental area by aversive stimuli. Science 303(5666):2040-42
261. Walletschek H, Raab A. 1982. Spontaneous activity of dorsal raphe neurons during defensive and offensive encounters in the tree-shrew. Physiol. Behav. 28(4):697-705
262. Walz B, Baumann O, Krach C, Baumann A, Blenau W. 2006. The aminergic control of cockroach salivary glands. Arch. Insect. Biochem. Physiol. 62(3):141-52
263. Weiger WA. 1997. Serotonergic modulation of behavior: a phylogenetic overview. Biol. Rev. Camb. Philos. Soc. 72(1):61-95
264. Weiss JM. 1968. Effects of coping responses on stress. J. Comp. Physiol. Psychol. 65(2):251-60
265. Weisstaub NV, Zhou M, Lira A, Lambe E, González-Maeso J, et al. 2006. Cortical 5-HT2A receptor signaling modulates anxiety-like behaviors in mice. Science 313(5786):536-40
266. Wickens J. 1990. Striatal dopamine in motor activation and reward-mediated learning: steps towards a unifying model. J. Neural. Transm. Gen. Sect. 80(1):9-31
267. Williams DR, Williams H. 1969. Auto-maintenance in the pigeon: sustained pecking despite contingent nonreinforcement. J. Exp. Anal. Behav. 12(4):511-20
268. Williams GV, Goldman-Rakic PS. 1995. Modulation of memory fields by dopamine d1 receptors in prefrontal cortex. Nature 376(6541):572-75
269. Williams J, Dayan P. 2005. Dopamine, learning, and impulsivity: a biological account of attentiondeficit/hyperactivity disorder. J. Child Adolesc. Psychopharmacol. 15(2):160-79; discussion 157-59
270. Wise CD, Berger BD, Stein L. 1972. Benzodiazepines: anxiety-reducing activity by reduction of serotonin turnover in the brain. Science 177(4044):180-83
271. Wogar MA, Bradshaw CM, Szabadi E. 1993. Effect of lesions of the ascending 5-hydroxytryptaminergic pathways on choice between delayed reinforcers. Psychopharmacology (Berl.) 111(2):239-43
272. Wood RM, Rilling JK, Sanfey AG, Bhagwagar Z, Rogers RD. 2006. Effects of tryptophan depletion on the performance of an iterated prisoner's dilemma game in healthy adults. Neuropsychopharmacology 31:1075-84
273. Yu AJ, Dayan P. 2002. Acetylcholine in cortical inference. Neural. Netw. 15(4-6):719-30
274. Yu AJ, Dayan P. 2005. Uncertainty, neuromodulation, and attention. Neuron 46(4):681-92
275. Zhang Y, Lu H, Bargmann CI. 2005. Pathogenic bacteria induce aversive olfactory learning in Caenorhabditis elegans. Nature 438(7065):179-84
276. Zhao Z-Q, Chiechio S, Sun Y-G, Zhang K-H, Zhao C-S, et al. 2007. Mice lacking central serotonergic neurons show enhanced inflammatory pain and an impaired analgesic response to antidepressant drugs. J. Neurosci. 27(22):6045-53
277. Zhou C, Rao Y, Rao Y. 2008. A subset of octopaminergic neurons are important for drosophila aggression. Nat. Neurosci. 11:1059-67
278. Zhou F-M, Liang Y, Salas R, Zhang L, Biasi MD, Dani JA. 2005. Corelease of dopamine and serotonin from striatal dopamine terminals. Neuron 46(1):65-74
279. Zoli M, Jansson A, Syková E, Agnati LF, Fuxe K. 1999. Volume transmission in the CNS and its relevance for neuropsychopharmacology. Trends Pharmacol. Sci. 20(4):142-50