SE 242084, a selective and brain penetrant 5-HT(2C) receptor antagonist

Neuropharmacology

Volumn 36, Issue 4-5, 1997, Pages 609-620

  Kennett, G A ^a   Wood, M D ^a   Bright, F ^a   Trail, B ^a   Riley, G ^a   Holland, V ^a   Avenell, K Y ^a   Stean, T ^a   Upton, N ^a   Bromidge, S ^a   Forbes, I T ^a   Brown, A M ^a   Middlemiss, D N ^a   Blackburn, T P ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

5 HT(2C) receptor; Anxiety; Feeding; SB 242084; Seizures

Indexed keywords

(3 CHLOROPHENYL)PIPERAZINE; 2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 6 CHLORO 5 METHYL 1 [[2 [(2 METHYL 3 PYRIDYL)OXY] 5 PYRIDYL]CARBAMOYL]INDOLINE; 8 AMINO 7 CHLORO 1,4 BENZODIOXAN 5 CARBOXYLIC ACID 1 BUTYL 4 PIPERIDINYLMETHYL ESTER; 8 AMINO 7 IODO 1,4 BENZODIOXAN 5 CARBOXYLIC ACID 1 BUTYL 4 PIPERIDINYLMETHYL ESTER; ADRENERGIC RECEPTOR; BUSPIRONE; DOPAMINE RECEPTOR; EMONAPRIDE; IODOSULPRIDE; LYSERGIDE; MESULERGINE; METITEPINE; MIANSERIN; PHENTOLAMINE; PRAZOSIN; RADIOLIGAND; SEROTONIN; SEROTONIN 1C RECEPTOR; SEROTONIN 2 ANTAGONIST; SEROTONIN 2A RECEPTOR; SEROTONIN 2B RECEPTOR; SEROTONIN 2C ANTAGONIST; UNCLASSIFIED DRUG; 1-(3-CHLOROPHENYL)PIPERAZINE; AMINOPYRIDINE DERIVATIVE; INDOLE DERIVATIVE; PHOSPHATIDYLINOSITOL; PIPERAZINE DERIVATIVE; SEROTONIN AGONIST; SEROTONIN ANTAGONIST; SEROTONIN RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANXIETY; ARTICLE; BEHAVIOR; CONFLICT; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG PENETRATION; DRUG SELECTIVITY; ELECTRIC SHOCK; FOOD INTAKE; GENE EXPRESSION; HUMAN; HUMAN CELL; HYDROLYSIS; HYPOPHAGIA; INTRAPERITONEAL DRUG ADMINISTRATION; LOCOMOTION; MALE; MOLECULAR CLONING; NEUROBLASTOMA CELL; NONHUMAN; ORAL DRUG ADMINISTRATION; PHOSPHOINOSITIDE METABOLISM; PRIORITY JOURNAL; PUNISHMENT; RAT; RECEPTOR AFFINITY; RECEPTOR BINDING; SEIZURE SUSCEPTIBILITY; SEIZURE THRESHOLD; SOCIAL INTERACTION; TRANQUILIZING ACTIVITY; ANIMAL; BRAIN; CELL CULTURE; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; FEEDING BEHAVIOR; METABOLISM; MOTOR ACTIVITY; PSYCHOLOGICAL ASPECT; SOCIAL BEHAVIOR; SPRAGUE DAWLEY RAT;

AMINOPYRIDINES; ANIMALS; ANXIETY; BRAIN; CONFLICT (PSYCHOLOGY); ELECTROSHOCK; FEEDING BEHAVIOR; HUMANS; INDOLES; MALE; MOTOR ACTIVITY; PHOSPHATIDYLINOSITOLS; PIPERAZINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, SEROTONIN; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS; SOCIAL BEHAVIOR; TUMOR CELLS, CULTURED;

EID: 0030610867     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(97)00038-5     Document Type: Article

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