Serotonin and the Orchestration of Energy Balance

Cell Metabolism

Volumn 6, Issue 5, 2007, Pages 352-361

  Tecott, Laurence H ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

(3 CHLOROPHENYL)PIPERAZINE; DEXFENFLURAMINE; FENFLURAMINE; FLUOXETINE; SEROTONIN; SEROTONIN 1B ANTAGONIST; SEROTONIN 1B RECEPTOR; SEROTONIN 1P RECEPTOR; SEROTONIN 2C RECEPTOR; SEROTONIN 4 RECEPTOR;

ANOREXIA; BRAIN STEM RESPONSE; DRUG EFFECT; DRUG MECHANISM; ENERGY BALANCE; FEEDBACK SYSTEM; FEEDING BEHAVIOR; FOOD INTAKE; GASTROINTESTINAL MOTILITY; GENE MUTATION; HOMEOSTASIS; HUMAN; HYPERINSULINEMIA; HYPOTHALAMUS; METABOLIC DISORDER; METABOLIC RATE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PATHOPHYSIOLOGY; PHYLOGENY; PHYSICAL ACTIVITY; PRADER WILLI SYNDROME; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; REGULATORY MECHANISM; REVIEW; SATIETY; SEROTONINERGIC NERVE CELL; SEROTONINERGIC SYSTEM; SEROTONINERGIC TRANSMISSION; SIGNAL TRANSDUCTION; SYNAPTIC TRANSMISSION; TASTE BUD; TASTE PREFERENCE; WEIGHT GAIN;

ANIMALS; CENTRAL NERVOUS SYSTEM; ENERGY METABOLISM; GASTROINTESTINAL TRACT; HUMANS; MODELS, BIOLOGICAL; SEROTONIN;

INVERTEBRATA; MAMMALIA; VERTEBRATA;

EID: 35548988366     PISSN: 15504131     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cmet.2007.09.012     Document Type: Review

References (101)

1. Avery L., and Horvitz H.R. Effects of starvation and neuroactive drugs on feeding in Caenorhabditis elegans. J. Exp. Zool. 253 (1990) 263-270
2. Baxter G., Kennett G., Blaney F., and Blackburn T. 5-HT2 receptor subtypes: a family re-united?. Trends Pharmacol. Sci. 16 (1995) 105-110
3. Blundell J.E., and Leshem M.B. The effect of 5-hydroxytryptophan on food intake and on the anorexic and action of amphetamine and fenfluramine. J. Pharm. Pharmacol. 27 (1975) 31-37
4. Bouwknecht J.A., van der Gugten J., Hijzen T.H., Maes R.A., Hen R., and Olivier B. Male and female 5-HT(1B) receptor knockout mice have higher body weights than wildtypes. Physiol. Behav. 74 (2001) 507-516
5. Bruinvels A.T., Palacios J.M., and Hoyer D. 5-hydroxytryptamine1 recognition sites in rat brain: heterogeneity of non-5-hydroxytryptamine1A/1C binding sites revealed by quantitative receptor autoradiography. Neuroscience 53 (1993) 465-473
6. Bruinvels A.T., Landwehrmeyer B., Gustafson E.L., Durkin M.M., Mengod G., Branchek T.A., Hoyer D., and Palacios J.M. Localization of 5-HT1B, 5-HT1D alpha, 5-HT1E and 5-HT1F receptor messenger RNA in rodent and primate brain. Neuropharmacology 33 (1994) 367-386
7. Bultman S.J., Michaud E.J., and Woychik R.P. Molecular characterization of the mouse agouti locus. Cell 71 (1992) 1195-1204
8. Conn P.J., Sanders-Bush E., Hoffman B.J., and Hartig P. A unique serotonin receptor in choroid plexus is linked to phosphatidylinositol turnover. Proc. Natl. Acad. Sci. USA 83 (1986) 4086-4088
9. Cowley M.A., Smart J.L., Rubinstein M., Cerdan M.G., Diano S., Horvath T.L., Cone R.D., and Low M.J. Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature 411 (2001) 480-484
10. Delay R.J., Kinnamon S.C., and Roper S.D. Serotonin modulates voltage-dependent calcium current in Necturus taste cells. J. Neurophysiol. 77 (1997) 2515-2524
11. Elliott C.J., and Susswein A.J. Comparative neuroethology of feeding control in molluscs. J. Exp. Biol. 205 (2002) 877-896
12. Fan W., Boston B.A., Kesterson R.A., Hruby V.J., and Cone R.D. Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature 385 (1997) 165-168
13. Finger T.E., Danilova V., Barrows J., Bartel D.L., Vigers A.J., Stone L., Hellekant G., and Kinnamon S.C. ATP signaling is crucial for communication from taste buds to gustatory nerves. Science 310 (2005) 1495-1499
14. Foltin R.W., and Moran T.H. Food intake in baboons: effects of a long-acting cholecystokinin analog. Appetite 12 (1989) 145-152
15. Gershon M.D. Plasticity in serotonin control mechanisms in the gut. Curr. Opin. Pharmacol. 3 (2003) 600-607
16. Gershon M.D. Review article: serotonin receptors and transporters-roles in normal and abnormal gastrointestinal motility. Aliment. Pharmacol. Ther. 20 Suppl 7 (2004) 3-14
17. Gershon M.D., and Dreyfus C.F. Stimulation of tryptophan uptake into enteric neurons by 5-hydroxtryptamine: a novel form of neuromodulation. Brain Res. 184 (1980) 229-233
18. Geyer M.A., Puerto A., Menkes D.B., Segal D.S., and Mandell A.J. Behavioral studies following lesions of the mesolimbic and mesostriatal serotonergic pathways. Brain Res. 106 (1976) 257-270
19. Gillette R. Evolution and function in serotonergic systems. Integr. Comp. Biol. 46 (2006) 838-846
20. Grignaschi G., and Samanin R. Role of 5-HT receptors in the effect of d-fenfluramine on feeding patterns in the rat. Eur. J. Pharmacol. 212 (1992) 287-289
21. Grill H.J., and Kaplan J.M. The neuroanatomical axis for control of energy balance. Front. Neuroendocrinol. 23 (2002) 2-40
22. Grill H.J., Donahey J.C., King L., and Kaplan J.M. Contribution of caudal brainstem to d-fenfluramine anorexia. Psychopharmacology (Berl.) 130 (1997) 375-381
23. Grinker J.A., Drewnowski A., Enns M., and Kissileff H. Effects of d-amphetamine and fenfluramine on feeding pattens and activity of obese and lean Zucker rats. Pharmacol. Biochem. Behav. 12 (1980) 265-275
24. Groome J.R., Vaughan D.K., and Lent C.M. Ingestive sensory inputs excite serotonin effector neurones and promote serotonin depletion from the leech central nervous system and periphery. J. Exp. Biol. 198 (1995) 1233-1242
25. Halford J.C., and Blundell J.E. The 5-HT1B receptor agonist CP-94,253 reduces food intake and preserves the behavioural satiety sequence. Physiol. Behav. 60 (1996) 933-939
26. Harris-Warrick R.M., and Marder E. Modulation of neural networks for behavior. Annu. Rev. Neurosci. 14 (1991) 39-57
27. Hedlund P.B., and Sutcliffe J.G. Functional, molecular and pharmacological advances in 5-HT7 receptor research. Trends Pharmacol. Sci. 25 (2004) 481-486
28. Heisler L.K., Cowley M.A., Tecott L.H., Fan W., Low M.J., Smart J.L., Rubinstein M., Tatro J.B., Marcus J.N., Holstege H., et al. Activation of central melanocortin pathways by fenfluramine. Science 297 (2002) 609-611
29. Heisler L.K., Jobst E.E., Sutton G.M., Zhou L., Borok E., Thornton-Jones Z., Liu H.Y., Zigman J.M., Balthasar N., Kishi T., et al. Serotonin reciprocally regulates melanocortin neurons to modulate food intake. Neuron 51 (2006) 239-249
30. Hoffman B.J., and Mezey E. Distribution of serotonin 5-HT1C receptor mRNA in adult rat brain. FEBS Lett. 247 (1989) 453-462
31. Horvitz H.R., Chalfie M., Trent C., Sulston J.E., and Evans P.D. Serotonin and octopamine in the nematode Caenorhabditis elegans. Science 216 (1982) 1012-1014
32. Hoyer D., Clarke D.E., Fozard J.R., Hartig P.R., Martin G.R., Mylecharane E.J., Saxena P.R., and Humphrey P.P. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol. Rev. 46 (1994) 157-203
33. Huang Y.J., Maruyama Y., Lu K.S., Pereira E., Plonsky I., Baur J.E., Wu D., and Roper S.D. Mouse taste buds use serotonin as a neurotransmitter. J. Neurosci. 25 (2005) 843-847
34. Huang Y.J., Maruyama Y., Lu K.S., Pereira E., and Roper S.D. Mouse taste buds release serotonin in response to taste stimuli. Chem. Senses 30 Suppl 1 (2005) i39-i40
35. Hutson P.H., Donohoe T.P., and Curzon G. Infusion of the 5-hydroxytryptamine agonists RU24969 and TFMPP into the paraventricular nucleus of the hypothalamus causes hypophagia. Psychopharmacology (Berl.) 95 (1988) 550-552
36. Imendra K.G., Miyamoto T., Okada Y., and Toda K. Serotonin differentially modulates the electrical properties of different subsets of taste receptor cells in bullfrog. Eur. J. Neurosci. 16 (2002) 629-640
37. Jacobs B.L., Martin-Cora F.J., and Fornal C.A. Activity of medullary serotonergic neurons in freely moving animals. Brain Res. Brain Res. Rev. 40 (2002) 45-52
38. Julius D., MacDermott A.B., Axel R., and Jessell T.M. Molecular characterization of a functional cDNA encoding the serotonin 1c receptor. Science 241 (1988) 558-564
39. Kaplan J.M., Song S., and Grill H.J. Serotonin receptors in the caudal brainstem are necessary and sufficient for the anorectic effect of peripherally administered mCPP. Psychopharmacology (Berl.) 137 (1998) 43-49
40. Kaya N., Shen T., Lu S.G., Zhao F.L., and Herness S. A paracrine signaling role for serotonin in rat taste buds: expression and localization of serotonin receptor subtypes. Am. J. Physiol. Regul. Integr. Comp. Physiol. 286 (2004) R649-R658
41. Kennett G.A., and Curzon G. Evidence that hypophagia induced by mCPP and TFMPP requires 5-HT1B receptors and 5-HT2C receptors; hypophagia induced by RU 24969 only requires 5-HT1B receptors. Psychopharmacology (Berl.) 96 (1988) 93-100
42. Kennett G.A., and Curzon G. Evidence that mCPP may have behavioural effects mediated by central 5-HT1c receptors. Br. J. Pharmacol. 94 (1988) 137-147
43. Kennett G.A., and Curzon G. Potencies of antagonists indicate that 5-HT1c receptors mediate 1-3(chlorophenyl) piperazine-induced hypophagia. Br. J. Pharmacol. 103 (1991) 2016-2020
44. Kim D.J., and Roper S.D. Localization of serotonin in taste buds: a comparative study in four vertebrates. J. Comp. Neurol. 353 (1995) 364-370
45. Kimura K.D., Tissenbaum H.A., Liu Y., and Ruvkun G. daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science 277 (1997) 942-946
46. Kishore S., and Stamm S. The snoRNA HBII-52 regulates alternative splicing of the serotonin receptor 2C. Science 311 (2006) 230-232
47. Kitchener S.J., and Dourish C.T. An examination of the behavioural specificity of hypophagia induced by 5-HT1B, 5-HT1C and 5-HT2 receptor agonists using the post-prandial satiety sequence in rats. Psychopharmacology (Berl.) 113 (1994) 369-377
48. Kolta A., Dubuc R., and Lund J.P. An immunocytochemical and autoradiographic investigation of the serotoninergic innervation of trigeminal mesencephalic and motor nuclei in the rabbit. Neuroscience 53 (1993) 1113-1126
49. Lange A.B., Orchard I., and Barrett F.M. Changes in haemolymph serotonin levels associated with feeding in the blood-sucking bug Rhodnius prolixus. J. Insect Physiol. 35 (1989) 393-399
50. Lee M.D., and Simansky K.J. CP-94,253: a selective serotonin1B (5-HT1B) agonist that promotes satiety. Psychopharmacology (Berl.) 131 (1997) 264-270
51. Leibowitz S.F., Weiss G.F., and Suh J.S. Medial hypothalamic nuclei mediate serotonin's inhibitory effect on feeding behavior. Pharmacol. Biochem. Behav. 37 (1990) 735-742
52. Lent C.M. Serotonergic modulation of the feeding behavior of the medicinal leech. Brain Res. Bull. 14 (1985) 643-655
53. Lent C.M., and Dickinson M.H. Retzius cells retain functional membrane properties following 'ablation' by the neurotoxin 5,7-DHT. Brain Res. 300 (1984) 167-171
54. Lent C.M., Fliegner K.H., Freedman E., and Dickinson M.H. Ingestive behaviour and physiology of the medicinal leech. J. Exp. Biol. 137 (1988) 513-527
55. Lent C.M., Zundel D., Freedman E., and Groome J.R. Serotonin in the leech central nervous system: anatomical correlates and behavioral effects. J. Comp. Physiol. [A] 168 (1991) 191-200
56. Lesurtel M., Graf R., Aleil B., Walther D.J., Tian Y., Jochum W., Gachet C., Bader M., and Clavien P.A. Platelet-derived serotonin mediates liver regeneration. Science 312 (2006) 104-107
57. Li B.H., Spector A.C., and Rowland N.E. Reversal of dexfenfluramine-induced anorexia and c-Fos/c-Jun expression by lesion in the lateral parabrachial nucleus. Brain Res. 640 (1994) 255-267
58. Li Y., Hao Y., Zhu J., and Owyang C. Serotonin released from intestinal enterochromaffin cells mediates luminal non-cholecystokinin-stimulated pancreatic secretion in rats. Gastroenterology 118 (2000) 1197-1207
59. Lu D., Willard D., Patel I.R., Kadwell S., Overton L., Kost T., Luther M., Chen W., Woychik R.P., Wilkison W.O., et al. Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor. Nature 371 (1994) 799-802
60. Lucas J.J., Yamamoto A., Scearce-Levie K., Saudou F., and Hen R. Absence of fenfluramine-induced anorexia and reduced c-Fos induction in the hypothalamus and central amygdaloid complex of serotonin 1B receptor knock-out mice. J. Neurosci. 18 (1998) 5537-5544
61. Lund J.P., Kolta A., Westberg K.G., and Scott G. Brainstem mechanisms underlying feeding behaviors. Curr. Opin. Neurobiol. 8 (1998) 718-724
62. McGuirk J., Goodall E., Silverstone T., and Willner P. Differential effects of d-fenfluramine and d-amphetamine on the microstructure of human eating behavior. Behav. Pharmacol. 2 (1991) 113-119
63. Middlemiss D.N., and Tricklebank M.D. Centrally active 5-HT receptor agonists and antagonists. Neurosci. Biobehav. Rev. 16 (1992) 75-82
64. Mori A., Kogo M., Ishihama K., Tanaka S., Enomoto A., Koizumi H., and Matsuya T. Effect of serotonin (5-HT) on trigeminal rhythmic activities generated in in vitro brainstem block preparations. J. Dent. Res. 81 (2002) 598-602
65. Murphy A.D. The neuronal basis of feeding in the snail, Helisoma, with comparisons to selected gastropods. Prog. Neurobiol. 63 (2001) 383-408
66. Neill J.C., and Cooper S.J. Evidence that d-fenfluramine anorexia is mediated by 5-HT1 receptors. Psychopharmacology (Berl.) 97 (1989) 213-218
67. Nonogaki K., Strack A., Dallman M., and Tecott L.H. Leptin-insensitive hyperphagia and type 2 diabetes in mice with a mutated serotonin 5-HT2C receptor gene. Nat. Med. 4 (1998) 1152-1156
68. Nonogaki K., Abdallah L., Goulding E.H., Bonasera S.J., and Tecott L.H. Hyperactivity and reduced energy cost of physical activity in serotonin 5-HT(2C) receptor mutant mice. Diabetes 52 (2003) 315-320
69. Orchard I. Serotonin: a coordinator of feeding-related physiological events in the blood-gorging bug, Rhodnius prolixus. Comp. Biochem. Physiol. A Mol. Integr. Physiol. 144 (2006) 316-324
70. Paez X., and Leibowitz S.F. Changes in extracellular PVN monoamines and macronutrient intake after idazoxan or fluoxetine injection. Pharmacol. Biochem. Behav. 46 (1993) 933-941
71. Parent A. Comparative anatomy of the serotoninergic systems. J. Physiol. (Paris) 77 (1981) 147-156
72. Pasqualetti M., Ori M., Castagna M., Marazziti D., Cassano G.B., and Nardi I. Distribution and cellular localization of the serotonin type 2C receptor messenger RNA in human brain. Neuroscience 92 (1999) 601-611
73. Pazos A., Hoyer D., and Palacios J.M. The binding of serotonergic ligands to the porcine choroid plexus: characterization of a new type of serotonin recognition site. Eur. J. Pharmacol. 106 (1985) 539-546
74. Petrov T., Krukoff T.L., and Jhamandas J.H. The hypothalamic paraventricular and lateral parabrachial nuclei receive collaterals from raphe nucleus neurons: a combined double retrograde and immunocytochemical study. J. Comp. Neurol. 318 (1992) 18-26
75. Raizen D.M., Lee R.Y., and Avery L. Interacting genes required for pharyngeal excitation by motor neuron MC in Caenorhabditis elegans. Genetics 141 (1995) 1365-1382
76. Rogers P.J., and Blundell J.E. Effect of anorexic drugs on food intake and the micro-structure of eating in human subjects. Psychopharmacology (Berl.) 66 (1979) 159-165
77. Rowland N.E., and Carlton J. Neurobiology of an anorectic drug: fenfluramine. Prog. Neurobiol. 27 (1986) 13-62
78. Saller C.F., and Stricker E.M. Hyperphagia and increased growth in rats after intraventricular injection of 5,7-dihydroxytryptamine. Science 192 (1976) 385-387
79. Saper C.B., and Loewy A.D. Efferent connections of the parabrachial nucleus in the rat. Brain Res. 197 (1980) 291-317
80. Saper C.B., Chou T.C., and Elmquist J.K. The need to feed: homeostatic and hedonic control of eating. Neuron 36 (2002) 199-211
81. Sawin E.R., Ranganathan R., and Horvitz H.R. C. elegans locomotory rate is modulated by the environment through a dopaminergic pathway and by experience through a serotonergic pathway. Neuron 26 (2000) 619-631
82. Schwartz D., Hernandez L., and Hoebel B.G. Fenfluramine administered systemically or locally increases extracellular serotonin in the lateral hypothalamus as measured by microdialysis. Brain Res. 482 (1989) 261-270
83. Shor-Posner G., Grinker J.A., Marinescu C., Brown O., and Leibowitz S.F. Hypothalamic serotonin in the control of meal patterns and macronutrient selection. Brain Res. Bull. 17 (1986) 663-671
84. Shtonda B.B., and Avery L. Dietary choice behavior in Caenorhabditis elegans. J. Exp. Biol. 209 (2006) 89-102
85. Simansky K.J. Serotonergic control of the organization of feeding and satiety. Behav. Brain Res. 73 (1996) 37-42
86. Simansky K.J., and Nicklous D.M. Parabrachial infusion of D-fenfluramine reduces food intake. Blockade by the 5-HT(1B) antagonist SB-216641. Pharmacol. Biochem. Behav. 71 (2002) 681-690
87. Steinbusch H.W., and Nieuwenhuys R. Localization of serotonin-like immunoreactivity in the central nervous system and pituitary of the rat, with special references to the innervation of the hypothalamus. Adv. Exp. Med. Biol. 133 (1981) 7-35
88. Straub V.A., and Benjamin P.R. Extrinsic modulation and motor pattern generation in a feeding network: a cellular study. J. Neurosci. 21 (2001) 1767-1778
89. Sze J.Y., Victor M., Loer C., Shi Y., and Ruvkun G. Food and metabolic signalling defects in a Caenorhabditis elegans serotonin-synthesis mutant. Nature 403 (2000) 560-564
90. Tache Y., Yang H., and Kaneko H. Caudal raphe-dorsal vagal complex peptidergic projections: role in gastric vagal control. Peptides 16 (1995) 431-435
91. Tecott L.H., Sun L.M., Akana S.F., Strack A.M., Lowenstein D.H., Dallman M.F., and Julius D. Eating disorder and epilepsy in mice lacking 5HT2C serotonin receptors. Nature 374 (1995) 542-546
92. Thor K.B., and Helke C.J. Serotonin- and substance P-containing projections to the nucleus tractus solitarii of the rat. J. Comp. Neurol. 265 (1987) 275-293
93. Uchida T. Serotonin-like immunoreactivity in the taste bud of the mouse circumvallate papilla. Jpn. J. Oral. Biol. 27 (1985) 509-521
94. Vickers S.P., Clifton P.G., and Dourish C.T. Behavioural evidence that d-fenfluramine-induced anorexia in the rat is not mediated by the 5-HT1A receptor subtype. Psychopharmacology (Berl.) 125 (1996) 168-175
95. Vickers S.P., Clifton P.G., Dourish C.T., and Tecott L.H. Reduced satiating effect of d-fenfluramine in serotonin 5-HT(2C) receptor mutant mice. Psychopharmacology (Berl.) 143 (1999) 309-314
96. Weiger W.A. Serotonergic modulation of behaviour: a phylogenetic overview. Biol. Rev. Camb. Philos. Soc. 72 (1997) 61-95
97. White Jr. R.L., Rossiter C.D., Hornby P.J., Harmon J.W., Kasbekar D.K., and Gillis R.A. Excitation of neurons in the medullary raphe increases gastric acid and pepsin production in cats. Am. J. Physiol. 260 (1991) G91-G96
98. Wright D.E., Seroogy K.B., Lundgren K.H., Davis B.M., and Jennes L. Comparative localization of serotonin1A,1C, and 2 receptor subtype mRNAs in rat brain. J. Comp. Neurol. 351 (1995) 357-373
99. Yagaloff K.A., and Hartig P.R. 125I-lysergic acid diethylamide binds to a novel serotonergic site on rat choroid plexus epithelial cells. J. Neurosci. 5 (1985) 3178-3183
100. Yee C.L., Yang R., Bottger B., Finger T.E., and Kinnamon J.C. "Type III" cells of rat taste buds: immunohistochemical and ultrastructural studies of neuron-specific enolase, protein gene product 9.5, and serotonin. J. Comp. Neurol. 440 (2001) 97-108
101. Zhang Y., Lu H., and Bargmann C.I. Pathogenic bacteria induce aversive olfactory learning in Caenorhabditis elegans. Nature 438 (2005) 179-184