Tryptophan depletion and aggressive responding in healthy males

Psychopharmacology

Volumn 126, Issue 2, 1996, Pages 97-103

  Moeller, F Gerard ^a   Dougherty, Donald M ^a   Swann, Alan C ^a   Collins, Diana ^a   Davis, Chester M ^a   Cherek, Don R ^a  

^a UNIVERSITY OF TEXAS   (United States)

Author keywords

Aggression; Serotonin; Tryptophan

Indexed keywords

AMINO ACID MIXTURE; SEROTONIN; TRYPTOPHAN;

AGGRESSION; AMINO ACID BLOOD LEVEL; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEPLETION; DIET; HUMAN; HUMAN EXPERIMENT; INSTRUMENTAL CONDITIONING; LABORATORY; MALE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; TRYPTOPHAN METABOLISM;

ADULT; AGGRESSION; HUMANS; MALE; TRYPTOPHAN;

EID: 0030057187     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02246343     Document Type: Article

References (44)

1. Barr LC, Goodman WK, McDougle CJ, Delgado PL, Heninger GR, Charney DS, Price LH (1994) Depletion in patients with obsessive-compulsive disorder who respond to serotonin reuptake inhibitors. Arch Gen Psychiatry 51: 309-317
2. Benkelfat C, Ellenbogen MA, Dean P, Palmour RM, Young SN (1994) Mood-lowering effect of tryptophan depletion. Enhanced susceptibility in young men at genetic risk for major affective disorders. Arch Gen Psychiatry 51:687-697
3. Biggio G, Fadda F, Fanni P, Tagliamonte A, Gessa GL (1974) Rapid depletion of serum tryptophan, brain tryptophan, serotonin and 5-hydroxyindoleacetic acid by a tryptophan-free diet. Life Sci 14: 1321-1329
4. Brown GL, Goodwin FK, Ballenger JC, Goyer PF, Goyer PC, Major LF(1979) Aggression in humans correlates with cerebrospinal fluid metabolites. Psychiatry Res 1: 131-139
5. Buss AH (1961) The psychology of aggression. John Wiley, New York
6. Cherek DR, Steinberg JL, Vines RV (1984) Low doses of alcohol affect human aggressive responses. Biol Psychiatry 19: 263-267
7. Cherek DR, Steinberg JL, Manno BR (1985) Effects of alcohol on human aggressive behavior. J Stud Alcohol 46: 321-328
8. Cherek DR, Steinberg JL (1987) Effects of drugs on human aggressive behavior. In: Burrows GD, Werry JS (eds) Advances in human psychopharmacology, vol. 4. JAI Press, New York
9. Cherek DR, Steinberg JL, Kelly TH, Robinson DE, Spiga R (1990) Effects of acute administration of diazepam and d-amphetamine on aggressive and escape responding of normal male subjects. Psychopharmacology 100: 173-181
10. Cherek DR, Dougherty DM (1995) Provocation frequency and its role in determining the effects of smoked marijuana on human aggressive responding. Behav Pharmacol 6: 405-412
11. Cherek DR, Schnapp W, Moeller FG, Dougherty DM (1996a) Aggressive responding of violent and nonviolent male parolees under laboratory conditions. Aggress Behav 22: 27-36
12. Cherek DR, Moeller FG, Schnapp W, Dougherty DM (1996b) Studies of violent and nonviolent male parolees. I. Laboratory and psychometric measurements of aggression. Biol Psychiatry (in press)
13. Cleare AJ, Bond AJ (1995) The effect of tryptophan depletion and enhancement on subjective and behavioral aggression in normal male subjects. Psychopharmacology 118: 72-81
14. Coccaro EF, Siever LJ, Klar HM, Maurer G, Cochrane K, Cooper TB, Mohs RC, Davis KL (1989) Serotonergic studies in patients with affective and personality disorders. Arch Gen Psychiatry 46: 587-599
15. Copenhaver JH, Schalock RK, Carver MJ (1978) Parachloro-D, L-phenylalanine induced filicidal behavior in the female rat. Pharmacol Biochem Behav 8: 263-270
16. Delgado PL, Price LH, Miller HL, Salomon RM, Aghajanian GK, Heninger GR, Charney DS (1994) Serotonin and the neurobiology of depression. Effects of tryptophan depletion in drugfree depressed patients. Arch Gen Psychiatry 51: 865-874
17. Giammanco S, Ernandes M, Lopez de Onata R, Paderni MA (1990) Short term diet of precooked corn meal almost lacking in tryptophan and interspecific rat-mouse aggressive behavior. Arch Int Physiol Biochim 98: 23-26
18. Gibbons JL, Barr GA, Bridger WH, Liebowitz SF (1979) Manipulation of dietary tryptophan: effect on mouse killing and brain serotonin in the rat. Brain Res 196: 139-153
19. Gibbons JL, Barr GA, Bridger WH, Liebowitz SF (1981) L-Tryptophan's effect on mouse killing, feeding, drinking locomotion and brain serotonin. Pharmacol Biochem Behav 15: 201-206
20. Kantak KM, Hegstrand LR, Whitman J, Eichelman B (1980) Effects of dietary supplements and a tryptophan free diet on aggressive behaviour in rats. Pharmacol Biochem Behav 12: 173-180
21. Katz RJ (1980) Role of serotonergic mechanisms in animal models of predation. Prog Neuropsychopharmacol 4: 219-231
22. Kelly TH, Cherek DR (1993) The effects of alcohol on free-operant aggressive behavior. J Stud Alcohol Suppl 11:40-52
23. Kelly TH, Cherek DR, Steinberg JL, Robinson DE (1988) Effects of provocation and alcohol on human aggressive behavior. Drug Alcohol Depend 21: 105-112
24. Kelly TH, Cherek DR, Steinberg JL (1989) Concurrent reinforcement and alcohol: interactive effects on human aggressive behavior. J Stud Alcohol 50: 399-405
25. Lasley SM, Thurmond JB (1985) Interaction of dietary tryptophan and social isolation on territorial aggression, motor activity, and neurochemistry in mice. Psychopharmacology 87: 313-321
26. Linnoila M, Virkkunen M, Sceinin M, Nuutila A, Rimon R, Goodwin FK (1983) Low cerebrospinal fluid 5-hydroxyin-dolacetic acid differentiates impulsive from non-impulsive aggressive behaviour. Life Sci 33: 2609-2614
27. Menkes DB, Coates DC, Fawcett JP (1994) Acute tryptophan depletion aggravates premenstrual syndrome. J Affect Disord 32: 37-44
28. Modai I, Apter A, Meltzer M, Tyano S, Walevski A, Jerushalmy Z (1989). Serotonin uptake by platelets of suicidal and aggressive adolescent psychiatric inpatients. Neuropsychobiology 21: 9-13
29. Moyer KE (1968) Kinds of aggression and their pathological basis. Commun Behav Biol 2: 65-87
30. Naumenko EV, Popova NK, Nikulina EM, Dygalo NN (1989) Behavior, adrenocortical activity and brain monoamines in Norway rats selected for reduced aggressiveness towards man. Pharmacol Biochem Behav 33: 85-91
31. Raleigh MJ, McGuire MT (1991) Bi-directional relationships between tryptophan and social behavior in vervet monkeys. Adv Exp Med Biol 294: 289-298
32. Reis OJ (1974) Central neurotransmitters in aggression. Res Publ Assoc Res Nerv Ment Disord 52: 119-148
33. Salomon RM, Mazure CM, Delgado PL, Mendia P, Charney DS (1994) Serotonin function in aggression: the effect of acute plasma tryptophan depletion in aggressive patients. Biol Psychiatry 35:570-572
34. Sewell RG, Gallus JA, Gault FP, Cleary JP (1982) p-Chlorophenylalanine effects on shock induced attack and pressing responses in rats. Pharmacol Biochem Behav 17: 945-950
35. Shea MM, Mench JA, Thomas OP (1990) The effect of dietary tryptophan on aggressive behavior in developing and mature broiler breeder males. Poultry Sci 69: 1164-9
36. Smith SE, Pihl RO, Young SN, Ervin FR (1986) Elevation and reduction of plasma tryptophan and their effects on aggression and perceptual sensitivity in normal males. Aggress Behav 12:393-407
37. Spitzer RL, Williams JBW, Gibbon M, First MB (1990) Structured clinical interview for DSM-III-R. American Psychiatric Press, Washington, D.C.
38. Taylor SP (1967) Aggressive behavior and physiological arousal as a function of provocation and the tendency to inhibit aggression. J Person 35: 297-310
39. Valzelli L, Bernasconi S (1979) Aggressiveness by isolation and brain serotonin turnover changes in different strains of mice. Neuropsychobiology 5: 129-135
40. Virkkunen M, Nuutila A, Goodwin FK, Linnoila M (1987) Cerebrospinal fluid metabolites in male arsonists. Arch Gen Psychiatry 44: 241-247
41. Wetzler S, Kahn RS, Asnis GM, Korn M, van Praag HM (1991) Serotonin receptor sensitivity and aggression. Psychiatry Res 37: 271-279
42. Yen CY, Strangler RL, Millman N (1959) Ataractic suppression of isolation induced aggressive behavior. Arch Int Pharmacodyn 123: 185-197
43. Young SN, Smith SE (1985) Tryptophan depletion causes a rapid lowering of mood in normal males. Psychopharmacology 87: 173-177
44. Young SN, Ervin FR, Pihl RO, Finn P (1989) Biochemical aspects of tryptophan depletion in primates. Psychopharmacology 98: 508-511