Uniform Inhibition of Dopamine Neurons in the Ventral Tegmental Area by Aversive Stimuli

Science

Volumn 303, Issue 5666, 2004, Pages 2040-2042

  Ungless, Mark A ^a   Magill, Peter J ^a   Bolam, J Paul ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANESTHESIOLOGY; BIODIVERSITY;

NEURONS;

NEUROLOGY;

DOPAMINE;

BIOLOGY;

ACTION POTENTIAL; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; AVERSIVE BEHAVIOR; CELL FUNCTION; CONTROLLED STUDY; DOPAMINE RELEASE; DOPAMINERGIC NERVE CELL; ELECTROPHYSIOLOGY; IMMUNOFLUORESCENCE TEST; NERVE CELL EXCITABILITY; NONHUMAN; PRIORITY JOURNAL; RAT; REWARD; THEORY; VENTRAL TEGMENTUM;

ACTION POTENTIALS; ANIMALS; DOPAMINE; ELECTROPHYSIOLOGY; MICROELECTRODES; NEURAL INHIBITION; NEURONS; PAIN; PHYSICAL STIMULATION; RATS; REWARD; VENTRAL TEGMENTAL AREA;

ANIMALIA;

EID: 1642404961     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1093360     Document Type: Article

References (29)

1. W. Schultz, Neuron 36, 241 (2002).
2. T. E. Robinson, K. C. Berridge, Brain Res. Brain Res. Rev. 18, 247 (1993).
3. S. M. McClure, N. D. Daw, P. R. Montague, Trends Neurosci. 26, 423 (2003).
4. J. Mirenowicz, W. Schultz, Nature 379, 449 (1996).
5. W. Schultz, R. Romo, J. Neurophysiol. 57, 201 (1987).
6. J. Mantz, A. M. Thierry, J. Glowinski, Brain Res. 476, 377 (1989).
7. L. A. Chiodo, S. M. Antelman, A. R. Caggiula, C. G. Lineberry, Brain Res. 189, 544 (1980).
8. H. Maeda, G. J. Mogenson, Brain Res. Bull. 8, 7 (1982).
9. F. A. Guarraci, B. S. Kapp, Behav. Brain Res. 99, 169 (1999).
10. Properties used to identify dopamine neurons include a broad triphasic extracellular action potential of a width greater than 2 ms and a relatively slow firing rate (<10 Hz).
11. A. A. Grace, B. S. Bunney, Neuroscience 10, 301 (1983).
12. D. L. Cameron, M. W. Wessendorf, J. T. Williams, Neuroscience 77, 155 (1997).
13. Materials and methods are available as supporting material on Science Online.
14. It is difficult to classify stimuli as aversive in the anesthetized preparation, because no behavioral measurements can be made. However, the foot pinch that we used would be aversive in the unanesthetized state, and because the responses of dopamine neurons to aversive stimuli are not strongly dependent on anesthesia, we believe that such a classification in this case is valid.
15. D. Pinault, J. Neurosci. Methods 65, 113 (1996).
16. S. B. Floresco, A. R. West, B. Ash, H. Moore, A. A. Grace, Nature Neurosci. 6, 968 (2003).
17. P. G. Overton, D. Clark, Brain Res. Brain Res. Rev. 25, 312 (1997).
18. F. G. Gonon, Neuroscience 24, 19 (1988).
19. A. A. Grace, B. S. Bunney, J. Neurosci. 4, 2877 (1984).
20. J. C. Horvitz, Neuroscience 96, 651 (2000).
21. J. D. Salamone, Behav. Brain Res. 61, 117 (1994).
22. A. A. Grace, Neuroscience 41, 1 (1991).
23. P. Palij et al., Brain Res. 509, 172 (1990).
24. K. A. Keefe, A. F. Sved, M. J. Zigmond, E. D. Abercrombie, J. Neurochem. 61, 1943 (1993).
25. H. P. Jedema, B. Moghaddam, J. Neurochem. 63, 785 (1994).
26. S. C. Steffensen, A. L. Svingos, V. M. Pickel, S. J. Henriksen, J. Neurosci. 18, 8003 (1998).
27. M. Fa et al., Synapse 48, 1 (2003).
28. A. S. Freeman, B. S. Bunney, Brain Res. 405, 46 (1987).
29. We thank J. Boyes, T. Klausberger, and J. Tepper for comments on this manuscript; M. Melis, B. Schilstrom, and E. Abercrombie for helpful discussions; and A. Baude, P. Cobden, L. Norman, C. Francis, and B. Micklem for technical assistance. Supported by the Medical Research Council of the UK (J.P.B) and the E. P. Abraham Fund (A. D. Smith). P.J.M. holds a Fellowship by Examination at Magdalen College, Oxford.