Synthesis and DNA cleavage activity of 2-hydrazinyl-1,4,5,6-tetrahydropyrimidine containing hydroxy group

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 13, 2009, Pages 4274-4279

  Shao, Ying ^a   Ding, Yong ^a   Jia, Zhao Li ^a   Lu, Xiao Min ^b   Ke, Zhi Hong ^c   Xu, Wei Hong ^a   Lu, Guo Yuan ^a  

^a NANJING UNIVERSITY   (China)

^b MEDICAL SCHOOL OF SOUTHEAST UNIVERSITY   (China)

^c NANJING UNIVERSITY   (China)

Author keywords

Agarose gel electrophoresis; Anti tumor activity; DNA cleavage; Guanidinium; Metal free DNA cleavage

Indexed keywords

2 HYDRAZINYL 1,4,5,6 TETRAHYDROPYRIMIDIN 5 OL; 2 HYDRAZINYL 4,5 DIHYDRO 1H IMIDAZOLE; AMMONIA; GUANIDINE; HYDRAZINE DERIVATIVE; HYDROXYL GROUP; IMIDAZOLE DERIVATIVE; PLASMID DNA; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

AGAR GEL ELECTROPHORESIS; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL STRAIN HL 60; CONTROLLED STUDY; DNA CLEAVAGE; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG SYNTHESIS; HELA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; MICHAELIS MENTEN KINETICS; STRUCTURE ACTIVITY RELATION;

CELL PROLIFERATION; DNA; DNA CLEAVAGE; DRUG DISCOVERY; ELECTROPHORESIS, AGAR GEL; HELA CELLS; HL-60 CELLS; HUMANS; HYDRAZINES; KINETICS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; OSMOLAR CONCENTRATION; PLASMIDS; PYRIMIDINES;

EID: 66449134320     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.05.044     Document Type: Article

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