Efficient enhancement of DNA cleavage activity by introducing guanidinium groups into diiron(III) complex

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 1, 2008, Pages 109-113

  Chen, Xiaoqiang ^a   Wang, Jingyun ^a   Sun, Shiguo ^a   Fan, Jiangli ^a   Wu, Song ^a   Liu, Jianfeng ^a   Ma, Saijian ^a   Zhang, Lizhu ^a   Peng, Xiaojun ^a  

^a DALIAN UNIVERSITY OF TECHNOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

FERRIC ION; GUANIDINE; IRON COMPLEX; LIGAND; NUCLEASE; PLASMID DNA;

ARTICLE; BINDING AFFINITY; CHEMICAL STRUCTURE; DNA BINDING; DNA CLEAVAGE; HYDROLYSIS; NONHUMAN; PLASMID; STRUCTURE ANALYSIS; SYNTHESIS;

BIOMIMETIC MATERIALS; DEOXYRIBONUCLEASES; DNA; ELECTROPHORESIS, AGAR GEL; FERRIC COMPOUNDS; GUANIDINE; KINETICS; PLASMIDS;

EID: 37549047614     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.11.001     Document Type: Article

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32. pBR322 DNA cleavage experiments by binuclear metal complexes: DNA cleavage experiments were performed using pBR 322 (Takara) in 20 mM Hepes buffer, pH 7.0, with incubating DNA (0.4 μg) at 37 °C in the presence and absence of metal complex for the definite time. The cleavage reactions were stopped by addition of 3 μL of loading buffer (0.25% bromophenol blue, 25% glycerol, 1 mM EDTA, 2% SDS). The electrophoresis of DNA cleavage products was performed on 1% agarose gel. The gels were run at 130 V for 45 min in 0.01 M, pH 7.0, TAE buffer. The resolved bands were visualized by ethidium bromide staining and quantified. A correction factor of 1.22 was utilized to account for the decrease in ability of ethidium bromide to intercalate into form I DNA versus forms II and III.
33. -1. A solution (3 ml) of complexes in water was incubated for 30 min at 25 °C. With addition of increasing amounts of DNA, the influence of volume was negligible.