Chemical nucleases

Current Opinion in Chemical Biology

Volumn 5, Issue 6, 2001, Pages 634-642

  Cowan, James A ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LANTHANIDE; LIGAND; METAL COMPLEX; METAL ION; NUCLEASE;

CATALYST; CHEMICAL STRUCTURE; DNA CLEAVAGE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME SUBSTRATE; ENZYME SYNTHESIS; HYDROLYSIS; MOLECULAR RECOGNITION; OXIDATION; REACTION TIME; REVIEW; RNA CLEAVAGE; STOICHIOMETRY;

EID: 0035605906     PISSN: 13675931     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1367-5931(01)00259-9     Document Type: Review

References (35)

1. Lanthanide-mediated DNA hydrolysis
2. Highly specific oxidative damage of double-strand DNA by copper aminoglycosides
3. Double-strand hydrolysis of plasmid DNA by dicerium complexes at 37°C
4. Double-strand DNA hydrolysis by dilanthanide complexes
5. Noncovalently bound cofactors for chemical nucleases
6. DNA cleavage by a chromium(III) complex
7. 4
8. 2-donor close analogue
9. Efficient DNA cleavage with an iron complex without added reductant
10. A simple copper(II)-L-histidine system for efficient hydrolytic cleavage of DNA
11. II complexes
12. Hydrolytic DNA cleavage promoted by a dinuclear iron(III) complex
13. 2+ complexes of synthetic heptapeptides as artificial nucleases
14. Targeted site-specific cleavage of HIV viral rev responsive element by copper aminoglycosides
15. Efficient inorganic deoxyribonucleases. Greater than 50 million-fold rate enhancement in DNA cleavage
16. Novel reagents for targeted cleavage of RNA sequences. Towards a new family of inorganic pharmaceuticals
17. Efficient catalytic cleavage of DNA mediated by metalloaminoglycosides
18. Propargylic sulfone-armed lariat crown ethers: Alkali metal ion-regulated DNA cleavage agents
19. Eu(III) macrocyclic complexes promote cleavage of and bind to models for the 5′-cap of mRNA. Effect of pendent group and a second metal ion
20. Cleavage of the 5′ cap structure of mRNA by a Eu(III) macrocyclic complex with pendant alcohol groups
21. Oligonucleotide conjugates of Eu(III) tetraazamacrocycles with pendent alcohol and amide groups promote sequence-specific RNA cleavage
22. Harnessing thorium(IV) as a catalyst: RNA and phosphate diester cleavage by a thorium(IV) macrocyclic complex
23. Metal activation of enzymes in nucleic acid biochemistry
24. Probing the importance of electrostatic interactions of Ce(III) with the phosphodiester backbone during transesterification using methyl phosphonates
25. Phosphodiester bond cleavage mediated by a cyclic β-sheet peptide-based dinuclear zinc(II) complex
26. An azacrown-functionalized peptide as a metal ion based catalyst for the cleavage of a RNA-model substrate
27. The cleavage of phosphodiester bonds within small RNA bulges in the presence and absence of metal ion catalysts
28. Recognition of a cognate RNA aptamer by neomycin B: Quantitative evaluation of hydrogen bonding and electrostatic interactions
29. The importance of being r: Greater oxidative stability of RNA compared with DNA
30. Hydride transfer in oxidation of nucleic acid sugars: Electronic effects of 2′-substituents on activation of the 1′-C-H bond by oxoruthenium(IV)
31. Origin of rate accelerations in an enzyme model: The p-nitrophenyl ester syndrome
32. Catalytic hydrolysis of 2′,3′-cyclic adenosine monophosphate by aqua(2,2′:6′,2″-terpyridine)copper(II): Breakdown of the analogy between activated phosphodiesters and RNA
33. A continuous assay for DNA cleavage: The application of 'break lights' to enediynes, iron-dependent agents, and nucleases
34. Inert chromium and cobalt complexes as probes of magnesium-dependent enzymes
35. Efficient hydrolysis of RNA by a PNA-diethylenetriamine adduct