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Volumn 217, Issue 1, 1996, Pages 178-190

Targeting of retroviral integrase by fusion to a heterologous DNA binding domain: In vitro activities and incorporation of a fusion protein into viral particles

Author keywords

[No Author keywords available]

Indexed keywords

HYBRID PROTEIN; INTEGRASE;

EID: 0029862622     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1006/viro.1996.0105     Document Type: Article
Times cited : (78)

References (54)
  • 1
    • 0028863151 scopus 로고
    • Multimerization determinants reside in both the catalytic core and C-terminus of ASV integrase
    • 1995
    • Andrake, M., and Skalka, A. M. (1995). Multimerization determinants reside in both the catalytic core and C-terminus of ASV integrase. J. Biol. Chem 270, 29299-29306, 1995.
    • (1995) J. Biol. Chem , vol.270 , pp. 29299-29306
    • Andrake, M.1    Skalka, A.M.2
  • 2
    • 0028097285 scopus 로고
    • Monoclonal antibodies against HIV type 1 integrase: Clues to molecular structure
    • Bizub-Bender, D., Kulkosky, J., and Skalka, A. M. (1994). Monoclonal antibodies against HIV type 1 integrase: Clues to molecular structure. AIDS Res. Hum. Retroviruses 10, 1105-1115.
    • (1994) AIDS Res. Hum. Retroviruses , vol.10 , pp. 1105-1115
    • Bizub-Bender, D.1    Kulkosky, J.2    Skalka, A.M.3
  • 3
    • 0028927643 scopus 로고
    • Genetic selection for balanced retroviral splicing: Novel regulation involving the second step can be mediated by transitions in the polypyrimidine tract
    • Bouck, J., Fu, X-D., Skalka, A. M., and Katz, R. A. (1995). Genetic selection for balanced retroviral splicing: Novel regulation involving the second step can be mediated by transitions in the polypyrimidine tract. Mol. Cell. Biol. 15, 2663-2671.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 2663-2671
    • Bouck, J.1    Fu, X.-D.2    Skalka, A.M.3    Katz, R.A.4
  • 4
    • 0022328481 scopus 로고
    • A eukaryotic transcriptional activator bearing the DNA specificity of a prokaryotic repressor
    • Brent, R., and Ptashne, M. (1985). A eukaryotic transcriptional activator bearing the DNA specificity of a prokaryotic repressor. Cell 43, 729-736.
    • (1985) Cell , vol.43 , pp. 729-736
    • Brent, R.1    Ptashne, M.2
  • 6
    • 0028074881 scopus 로고
    • Tethering human immunodeficiency virus 1 integrase to a DNA site directs integration to nearby sequences
    • Bushman, F. D. (1994). Tethering human immunodeficiency virus 1 integrase to a DNA site directs integration to nearby sequences. Proc. Natl. Acad. Sci. USA 91, 9233-9237.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 9233-9237
    • Bushman, F.D.1
  • 7
    • 0028940992 scopus 로고
    • Targeting retroviral integration
    • Bushman, F. D. (1995). Targeting retroviral integration. Science 267, 1443-1444.
    • (1995) Science , vol.267 , pp. 1443-1444
    • Bushman, F.D.1
  • 8
    • 0027456715 scopus 로고
    • Domains of the integrase protein of human immunodeficiency virus type 1 responsible for polynucleotidyl transfer and zinc binding
    • Bushman, F. D., Engelman, A., Palmer, I., Wingfield, P., and Craigie, R. (1993). Domains of the integrase protein of human immunodeficiency virus type 1 responsible for polynucleotidyl transfer and zinc binding. Proc. Natl. Acad. Sci. USA 90, 3428-3432.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 3428-3432
    • Bushman, F.D.1    Engelman, A.2    Palmer, I.3    Wingfield, P.4    Craigie, R.5
  • 9
    • 0028205117 scopus 로고
    • Rous sarcoma virus integrase protein: Mapping functions for catalysis and substrate binding
    • Bushman, F. D., and Wang, B. (1994). Rous sarcoma virus integrase protein: mapping functions for catalysis and substrate binding. J. Virol. 68, 2215-2223.
    • (1994) J. Virol. , vol.68 , pp. 2215-2223
    • Bushman, F.D.1    Wang, B.2
  • 10
    • 0028225959 scopus 로고
    • Human immunodeficiency virus type 1 integrase: Effect on viral replication of mutations at highly conserved residues
    • Cannon, P., Wilson, W., Byles, E., Kingsman, S. M., and Kingsman, A. J. (1994). Human immunodeficiency virus type 1 integrase: Effect on viral replication of mutations at highly conserved residues. J. Virol. 68, 4768-4775.
    • (1994) J. Virol. , vol.68 , pp. 4768-4775
    • Cannon, P.1    Wilson, W.2    Byles, E.3    Kingsman, S.M.4    Kingsman, A.J.5
  • 11
    • 0026549933 scopus 로고
    • Reversal of integration and DNA splicing mediated by integrase of human immunodeficiency virus
    • Chow, S. A., Vincent, K. A., Ellison, V., and Brown, P. O. (1992). Reversal of integration and DNA splicing mediated by integrase of human immunodeficiency virus. Science 255, 723-726.
    • (1992) Science , vol.255 , pp. 723-726
    • Chow, S.A.1    Vincent, K.A.2    Ellison, V.3    Brown, P.O.4
  • 12
    • 0026637378 scopus 로고
    • Hot spots and warm spots: Integration specificity of retroelements
    • Craigie, R. (1992). Hot spots and warm spots: integration specificity of retroelements. Trends Genet. 8, 187-190.
    • (1992) Trends Genet. , vol.8 , pp. 187-190
    • Craigie, R.1
  • 13
    • 0025031786 scopus 로고
    • The IN protein of Moloney murine leukemia virus processes the viral DNA ends and accomplishes their integration in vitro
    • Craigie, R., Fujiwara, T., and Bushman, F. (1990). The IN protein of Moloney murine leukemia virus processes the viral DNA ends and accomplishes their integration in vitro. Cell 62, 829-837.
    • (1990) Cell , vol.62 , pp. 829-837
    • Craigie, R.1    Fujiwara, T.2    Bushman, F.3
  • 14
    • 0026740842 scopus 로고
    • Identification of amino acid residues critical for endonuclease and integration activities of HIV-1 IN protein in vitro
    • Drelich, M., Wilhelm, R., and Mous, J. (1992). Identification of amino acid residues critical for endonuclease and integration activities of HIV-1 IN protein in vitro. Virology 188, 459-468.
    • (1992) Virology , vol.188 , pp. 459-468
    • Drelich, M.1    Wilhelm, R.2    Mous, J.3
  • 15
    • 0028584269 scopus 로고
    • Crystal structure of the catalytic domain of HIV-1 integrase: Similarity to other polynucleotidyl transferases
    • Dyda, F., Hickman, A. B., Jenkins, T. M., Engelman, A., Craigie, R., and Davies, D. R. (1994). Crystal structure of the catalytic domain of HIV-1 integrase: Similarity to other polynucleotidyl transferases. Science 266, 1981-1986.
    • (1994) Science , vol.266 , pp. 1981-1986
    • Dyda, F.1    Hickman, A.B.2    Jenkins, T.M.3    Engelman, A.4    Craigie, R.5    Davies, D.R.6
  • 16
    • 0028888455 scopus 로고
    • An essential interaction between distinct domains of HIV-1 integrase mediates assembly of the active multimer
    • Ellison, V., Gerton, J., Vincent, K. A., and Brown, P. O. (1995). An essential interaction between distinct domains of HIV-1 integrase mediates assembly of the active multimer. J. Biol. Chem. 270, 3320-3326.
    • (1995) J. Biol. Chem. , vol.270 , pp. 3320-3326
    • Ellison, V.1    Gerton, J.2    Vincent, K.A.3    Brown, P.O.4
  • 17
    • 0026649557 scopus 로고
    • Identification of conserved amino acid residues critical for human immunodeficiency virus type 1 integrase function in vitro
    • Engelman, A., and Craigie, R. (1992). Identification of conserved amino acid residues critical for human immunodeficiency virus type 1 integrase function in vitro. J. Virol. 66, 6361-6369.
    • (1992) J. Virol. , vol.66 , pp. 6361-6369
    • Engelman, A.1    Craigie, R.2
  • 18
    • 0028915128 scopus 로고
    • Multiple effects of mutations in human immunodeficiency virus type 1 integrase on viral replication
    • Engelman, A., Englund, G., Orenstein, J. M., Martin, M. A., and Craigie, R. (1995). Multiple effects of mutations in human immunodeficiency virus type 1 integrase on viral replication. J. Virol. 69, 2729-2736.
    • (1995) J. Virol. , vol.69 , pp. 2729-2736
    • Engelman, A.1    Englund, G.2    Orenstein, J.M.3    Martin, M.A.4    Craigie, R.5
  • 19
    • 0028067324 scopus 로고
    • The core and carboxyl-terminal domains of the integrase protein of human immunodeficiency virus type 1 each contribute to nonspecific DNA binding
    • Engelman, A., Hickman, A. B., and Craigie, R. (1994). The core and carboxyl-terminal domains of the integrase protein of human immunodeficiency virus type 1 each contribute to nonspecific DNA binding. J. Virol. 68, 5911-5917.
    • (1994) J. Virol. , vol.68 , pp. 5911-5917
    • Engelman, A.1    Hickman, A.B.2    Craigie, R.3
  • 20
    • 0027102597 scopus 로고
    • Genetics of retroviral integration
    • Goff, S. P. (1992). Genetics of retroviral integration. Annu. Rev. Genet. 26, 527-544.
    • (1992) Annu. Rev. Genet. , vol.26 , pp. 527-544
    • Goff, S.P.1
  • 21
    • 0026680723 scopus 로고
    • Fused protein domains inhibit DNA binding by LexA
    • Golemis, E. A., and Brent, R. (1992). Fused protein domains inhibit DNA binding by LexA. Mol. Cell. Biol. 12, 3006-3014.
    • (1992) Mol. Cell. Biol. , vol.12 , pp. 3006-3014
    • Golemis, E.A.1    Brent, R.2
  • 22
    • 0028145716 scopus 로고
    • Viral long terminal repeat substrate binding characteristics of the human immunodeficiency virus type 1 integrase
    • Hazuda, D. J., Wolfe, A. L., Hastings, J. C., Robbins, H. L., Graham, P. L., LaFemina, R. L., and Emini, E. A. (1994). Viral long terminal repeat substrate binding characteristics of the human immunodeficiency virus type 1 integrase. J. Biol. Chem. 269, 3999-4004.
    • (1994) J. Biol. Chem. , vol.269 , pp. 3999-4004
    • Hazuda, D.J.1    Wolfe, A.L.2    Hastings, J.C.3    Robbins, H.L.4    Graham, P.L.5    LaFemina, R.L.6    Emini, E.A.7
  • 23
    • 0026665238 scopus 로고
    • Retroviral integrase functions as a multimer and can turn over catalytically
    • Jones, K. S., Coleman, J., Merkel, G. W., Laue, T. M., and Skalka, A. M. (1992). Retroviral integrase functions as a multimer and can turn over catalytically. J. Biol. Chem. 267, 16037-16040.
    • (1992) J. Biol. Chem. , vol.267 , pp. 16037-16040
    • Jones, K.S.1    Coleman, J.2    Merkel, G.W.3    Laue, T.M.4    Skalka, A.M.5
  • 24
    • 0027275702 scopus 로고
    • Role of the His-Cys finger of Moloney murine leukemia virus integrase protein in integration and disintegration
    • Jonsson, C. B., and Roth, M. J. (1993). Role of the His-Cys finger of Moloney murine leukemia virus integrase protein in integration and disintegration. J. Virol. 67, 5562-5571.
    • (1993) J. Virol. , vol.67 , pp. 5562-5571
    • Jonsson, C.B.1    Roth, M.J.2
  • 25
    • 0028566214 scopus 로고
    • Binding and stimulation of HIV-1 integrase by a human homolog of yeast transcription factor SNF5
    • Kalpana, G. V., Marmon, S., Wang, W., Crabtree, G. R., and Goff, S. P. (1994). Binding and stimulation of HIV-1 integrase by a human homolog of yeast transcription factor SNF5. Science 266, 2002-2006.
    • (1994) Science , vol.266 , pp. 2002-2006
    • Kalpana, G.V.1    Marmon, S.2    Wang, W.3    Crabtree, G.R.4    Goff, S.P.5
  • 26
    • 0025011051 scopus 로고
    • The avian retroviral IN protein is both necessary and sufficient for integrative recombination in vitro
    • Katz, R. A., Merkel, G., Kulkosky, J., Leis, J., and Skalka, A. M. (1990). The avian retroviral IN protein is both necessary and sufficient for integrative recombination in vitro. Cell 63, 87-95.
    • (1990) Cell , vol.63 , pp. 87-95
    • Katz, R.A.1    Merkel, G.2    Kulkosky, J.3    Leis, J.4    Skalka, A.M.5
  • 27
    • 0023829564 scopus 로고
    • A C-terminal domain in the avian sarcoma-leukosis virus pol gene product is not essential for viral replication
    • Katz, R. A., and Skalka, A. M. (1988). A C-terminal domain in the avian sarcoma-leukosis virus pol gene product is not essential for viral replication. J. Virol. 62, 528-533.
    • (1988) J. Virol. , vol.62 , pp. 528-533
    • Katz, R.A.1    Skalka, A.M.2
  • 28
    • 0025156779 scopus 로고
    • Control of retroviral RNA splicing through maintenance of suboptimal processing signals
    • Katz, R. A., and Skalka, A. M. (1990). Control of retroviral RNA splicing through maintenance of suboptimal processing signals. Mol. Cell. Biol. 10, 696-704.
    • (1990) Mol. Cell. Biol. , vol.10 , pp. 696-704
    • Katz, R.A.1    Skalka, A.M.2
  • 30
    • 0024431589 scopus 로고
    • The avian retroviral integration protein cleaves the terminal sequences of linear viral DNA at the in vivo sites of integration
    • Katzman, M., Katz, R. A., Skalka, A. M., and Leis, J. (1989). The avian retroviral integration protein cleaves the terminal sequences of linear viral DNA at the in vivo sites of integration. J. Virol. 63, 5319-5327.
    • (1989) J. Virol. , vol.63 , pp. 5319-5327
    • Katzman, M.1    Katz, R.A.2    Skalka, A.M.3    Leis, J.4
  • 31
    • 0026035178 scopus 로고
    • Retroviral integrase domains: DNA binding and the recognition of LTR sequences
    • Khan, E., Mack, J. P., Katz, R. A., Kulkosky, J., and Skalka, A.M. (1991). Retroviral integrase domains: DNA binding and the recognition of LTR sequences. Nucleic Acids Res. 19, 851-860.
    • (1991) Nucleic Acids Res. , vol.19 , pp. 851-860
    • Khan, E.1    Mack, J.P.2    Katz, R.A.3    Kulkosky, J.4    Skalka, A.M.5
  • 32
    • 0026528848 scopus 로고
    • Dimerization of a specific DNA-binding protein on the DNA
    • Kim, B., and Little, J. W. (1992). Dimerization of a specific DNA-binding protein on the DNA. Science 255, 203-235.
    • (1992) Science , vol.255 , pp. 203-235
    • Kim, B.1    Little, J.W.2
  • 33
    • 0028936732 scopus 로고
    • Requirement of RNA polymerase III transcription factors for in vitro position-specific integration of a retrovirus-like element
    • Kirchner, J., Connolly, C. M., and Sandmeyer, S. B. (1995). Requirement of RNA polymerase III transcription factors for in vitro position-specific integration of a retrovirus-like element. Science 267, 1488-1491.
    • (1995) Science , vol.267 , pp. 1488-1491
    • Kirchner, J.1    Connolly, C.M.2    Sandmeyer, S.B.3
  • 34
    • 0026651815 scopus 로고
    • Nonrandom integration of retroviral DNA in vitro: Effect of CpG methylation
    • Kitamura, Y., Lee, Y. M., and Coffin, J. M. (1992). Nonrandom integration of retroviral DNA in vitro: Effect of CpG methylation. Proc. Natl. Acad. Sci. USA 89, 5532-5536.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 5532-5536
    • Kitamura, Y.1    Lee, Y.M.2    Coffin, J.M.3
  • 35
    • 0026719238 scopus 로고
    • Residues critical for retroviral integrative recombination in a region that is highly conserved among retroviral/retrotransposon integrases and bacterial insertion sequence transposases
    • Kulkosky, J., Jones K. S. , Katz, R. A., Mack, J. P., and Skalka, A. M. (1992). Residues critical for retroviral integrative recombination in a region that is highly conserved among retroviral/retrotransposon integrases and bacterial insertion sequence transposases. Mol. Cell. Biol. 12, 2331-2338.
    • (1992) Mol. Cell. Biol. , vol.12 , pp. 2331-2338
    • Kulkosky, J.1    Jones, K.S.2    Katz, R.A.3    Mack, J.P.4    Skalka, A.M.5
  • 36
    • 0028850802 scopus 로고
    • Activities and substrate specificity of the evolutionary conserved central domain of retroviral integrase
    • Kulkosky, J., Katz, R. A., Merkel, G., and Skalka, A. M. (1995). Activities and substrate specificity of the evolutionary conserved central domain of retroviral integrase. Virology 206, 448-456.
    • (1995) Virology , vol.206 , pp. 448-456
    • Kulkosky, J.1    Katz, R.A.2    Merkel, G.3    Skalka, A.M.4
  • 37
    • 0028309772 scopus 로고
    • Molecular mechanism of retroviral DNA integration
    • Kulkosky, J., and Skalka, A. M. (1994). Molecular mechanism of retroviral DNA integration. Pharmacol. Ther. 61, 185-203.
    • (1994) Pharmacol. Ther. , vol.61 , pp. 185-203
    • Kulkosky, J.1    Skalka, A.M.2
  • 38
    • 0027470432 scopus 로고
    • Site-directed mutagenesis of HIV-1 integrase demonstrates differential effects on integrase functions in vitro
    • Leavitt, A. D., Shiue, L., and Varmus, H. E. (1993). Site-directed mutagenesis of HIV-1 integrase demonstrates differential effects on integrase functions in vitro. J. Biol. Chem. 268, 2113-2119.
    • (1993) J. Biol. Chem. , vol.268 , pp. 2113-2119
    • Leavitt, A.D.1    Shiue, L.2    Varmus, H.E.3
  • 39
    • 0028034050 scopus 로고
    • Characterization of the minimal DNA-binding domain of the HIV integrase protein
    • Lutzke, R. A., Vink, C., and Plasterk, R. H. (1994). Characterization of the minimal DNA-binding domain of the HIV integrase protein. Nucleic Acids Res. 22, 4125-4131.
    • (1994) Nucleic Acids Res. , vol.22 , pp. 4125-4131
    • Lutzke, R.A.1    Vink, C.2    Plasterk, R.H.3
  • 40
    • 0028067639 scopus 로고
    • DNA bending creates favored sites for retroviral integration: An explanation for preferred insertion sites in nucleosomes
    • Muller, H. P., and Varmus, H. E. (1994). DNA bending creates favored sites for retroviral integration: An explanation for preferred insertion sites in nucleosomes. EMBO J. 13, 4704-4714.
    • (1994) EMBO J. , vol.13 , pp. 4704-4714
    • Muller, H.P.1    Varmus, H.E.2
  • 41
    • 0026081040 scopus 로고
    • Defining nucleic acid-binding properties of avian retrovirus integrase by deletion analysis
    • Mumm, S. R., and Grandgenett, D. P. (1991). Defining nucleic acid-binding properties of avian retrovirus integrase by deletion analysis. J. Virol. 65, 1160-1167.
    • (1991) J. Virol. , vol.65 , pp. 1160-1167
    • Mumm, S.R.1    Grandgenett, D.P.2
  • 42
    • 0026627824 scopus 로고
    • Isolation and characterization of LexA mutant repressors with enhanced DNA binding affinity
    • Oertel-Buchheit, P., Porte, D., Schnarr, M., and Granger-Schnarr, M. (1992). Isolation and characterization of LexA mutant repressors with enhanced DNA binding affinity. J. Mol. Biol. 255, 609-620.
    • (1992) J. Mol. Biol. , vol.255 , pp. 609-620
    • Oertel-Buchheit, P.1    Porte, D.2    Schnarr, M.3    Granger-Schnarr, M.4
  • 43
    • 0027397740 scopus 로고
    • Spacing requirements between LexA operator half-sites can be relaxed by fusing the LexA DNA binding domain with some alternative dimerization domains
    • Oertel-Buchheit, P., Schmidt-Dörr, T., Granger-Schnarr, M., and Schnarr, M. (1993). Spacing requirements between LexA operator half-sites can be relaxed by fusing the LexA DNA binding domain with some alternative dimerization domains. J. Mol. Biol. 229, 1-7.
    • (1993) J. Mol. Biol. , vol.229 , pp. 1-7
    • Oertel-Buchheit, P.1    Schmidt-Dörr, T.2    Granger-Schnarr, M.3    Schnarr, M.4
  • 44
    • 0028125005 scopus 로고
    • The influence of DNA and nucleosome structure on integration events directed by HIV integrase
    • Pruss, D., Reeves, R., Bushman, F. D., and Wolffe, A. P. (1994). The influence of DNA and nucleosome structure on integration events directed by HIV integrase. J. Biol. Chem. 269, 25031-25041.
    • (1994) J. Biol. Chem. , vol.269 , pp. 25031-25041
    • Pruss, D.1    Reeves, R.2    Bushman, F.D.3    Wolffe, A.P.4
  • 45
    • 0026696624 scopus 로고
    • Nucleosomes, DNA-binding proteins, and DNA sequence modulate retroviral integration target site selection
    • Pryciak, P. M., and Varmus, H. E. (1992). Nucleosomes, DNA-binding proteins, and DNA sequence modulate retroviral integration target site selection. Cell 69, 769-780.
    • (1992) Cell , vol.69 , pp. 769-780
    • Pryciak, P.M.1    Varmus, H.E.2
  • 46
    • 0026634793 scopus 로고
    • The N-terminal region of HIV-1 integrase is required for integration activity, but not for DNA-binding
    • Schauer, M., and Billich, A. (1992). The N-terminal region of HIV-1 integrase is required for integration activity, but not for DNA-binding. Biochem. Biophys. Res. Commun. 185, 874-880.
    • (1992) Biochem. Biophys. Res. Commun. , vol.185 , pp. 874-880
    • Schauer, M.1    Billich, A.2
  • 47
    • 0026060425 scopus 로고
    • trans-Acting viral protease is necessary and sufficient for activation of avian leukosis virus reverse transcriptase
    • Stewart, L., and Vogt, V. M. (1991). trans-Acting viral protease is necessary and sufficient for activation of avian leukosis virus reverse transcriptase. J. Virol. 65, 6218-6231.
    • (1991) J. Virol. , vol.65 , pp. 6218-6231
    • Stewart, L.1    Vogt, V.M.2
  • 48
    • 0023892120 scopus 로고
    • Properties of avian sarcoma-leukosis virus pp32-related pol-endonucleases produced in Escherichia coli
    • Terry, R., Soltis, D. A., Katzman, M., Cobrinik, D., Leis, J., and Skalka, A. M. (1988). Properties of avian sarcoma-leukosis virus pp32-related pol-endonucleases produced in Escherichia coli. J. Virol. 62, 2358-2365.
    • (1988) J. Virol. , vol.62 , pp. 2358-2365
    • Terry, R.1    Soltis, D.A.2    Katzman, M.3    Cobrinik, D.4    Leis, J.5    Skalka, A.M.6
  • 49
    • 0026668776 scopus 로고
    • Mutational analysis of the integrase protein of human immunodeficiency virus type 2
    • van Gent, D. C., Oude Groeneger, A. A. M., and Plasterk, R. H. A. (1992). Mutational analysis of the integrase protein of human immunodeficiency virus type 2. Proc. Natl. Acad. Sci. USA 89, 9598-9602.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 9598-9602
    • Van Gent, D.C.1    Oude Groeneger, A.A.M.2    Plasterk, R.H.A.3
  • 50
    • 0027472085 scopus 로고
    • Characterization of human immunodeficiency virus type 1 integrase expressed in Escherichia coli and analysis of variants with amino-terminal mutations
    • Vincent, K. A., Ellison, V., Chow, S. A., and Brown, P. O. (1993). Characterization of human immunodeficiency virus type 1 integrase expressed in Escherichia coli and analysis of variants with amino-terminal mutations. J. Virol. 67, 425-437.
    • (1993) J. Virol. , vol.67 , pp. 425-437
    • Vincent, K.A.1    Ellison, V.2    Chow, S.A.3    Brown, P.O.4
  • 51
    • 0027210608 scopus 로고
    • Identification of the catalytic and DNA-binding region of the human immunodeficiency virus type I integrase protein
    • Vink, C., Oude Groeneger, A. A. M., and Plasterk, R. H. A. (1993). Identification of the catalytic and DNA-binding region of the human immunodeficiency virus type I integrase protein. Nucleic Acids Res. 21, 1419-1425
    • (1993) Nucleic Acids Res. , vol.21 , pp. 1419-1425
    • Vink, C.1    Oude Groeneger, A.A.M.2    Plasterk, R.H.A.3
  • 52
    • 0021826957 scopus 로고
    • Nucleotide sequence binding specificity of the LexA repressor of Escherichia coli K-12
    • Wertman, K. F., and Mount, D. W. (1985). Nucleotide sequence binding specificity of the LexA repressor of Escherichia coli K-12. J. Bacteriol. 163, 376-384.
    • (1985) J. Bacteriol. , vol.163 , pp. 376-384
    • Wertman, K.F.1    Mount, D.W.2
  • 53
    • 0028340554 scopus 로고
    • Distribution of targets for avian retrovirus DNA integration in vivo
    • Withers-Ward, E. S., Kitamura, Y., Barnes, J. P., and Coffin, J. M. (1994). Distribution of targets for avian retrovirus DNA integration in vivo. Genes Dev. 8, 1473-1487.
    • (1994) Genes Dev. , vol.8 , pp. 1473-1487
    • Withers-Ward, E.S.1    Kitamura, Y.2    Barnes, J.P.3    Coffin, J.M.4
  • 54
    • 0027205243 scopus 로고
    • Characterization of a DNA binding domain in the C-terminus of HIV-1 integrase by deletion mutagenesis
    • Woerner, A. M., and Marcus-Sekura, C. J. (1993). Characterization of a DNA binding domain in the C-terminus of HIV-1 integrase by deletion mutagenesis. Nucleic Acids Res. 21, 3507-3511.
    • (1993) Nucleic Acids Res. , vol.21 , pp. 3507-3511
    • Woerner, A.M.1    Marcus-Sekura, C.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.