Insights into the molecular recognition of the 5'-GNN-3' family of DNA sequences by zinc finger domains

Journal of Molecular Biology

Volumn 303, Issue 4, 2000, Pages 489-502

  Dreier, Birgit ^a   Segal, David J ^a   Barbas III, Carlos F ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Binding specificity; Novel DNA binding proteins; Phage display selection; Protein:nucleic acid computer modeling; Rational design

Indexed keywords

DNA; DNA BINDING PROTEIN; NUCLEIC ACID; ZINC FINGER PROTEIN;

ARTICLE; COMPUTER MODEL; CRYSTAL STRUCTURE; DNA BINDING; DNA SEQUENCE; MOLECULAR MODEL; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; X RAY CRYSTALLOGRAPHY;

EID: 0034602243     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2000.4133     Document Type: Article

References (31)

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2. Positive and negative regulation of endogenous genes by designed transcription factors
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4. Chimeric restriction enzymes: What is next?
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6. Toward a code for the interactions of zinc fingers with DNA: Selection of randomized fingers displayed on phage
7. Redesigning the DNA-binding specificity of a zinc finger protein: A data base-guided approach
8. Length-encoded multiplex binding site determination: Application to zinc finger proteins
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10. High-resolution structures of variant Zif268-DNA complexes: Implications for understanding zinc finger-DNA recognition
11. The crystal structure of a two zinc-finger peptide reveals an extension to the rules for zinc-finger/DNA recognition
12. Domain packing and dynamics in the DNA complex of the N-terminal zinc fingers of TFIIIA
13. Cocrystal structure of YY1 bound to the adeno-associated virus P5 initiator
14. Synergy between adjacent zinc fingers in sequence-specific DNA recognition
15. Comprehensive DNA recognition through concerted interactions from adjacent zinc fingers
16. In vitro selection of zinc fingers with altered DNA-binding specificity
17. Serine at position 2 in the DNA recognition helix of a Cys2-His2 zinc finger peptide is not, in general, responsible for base recognition
18. A 2.2 Å resolution crystal structure of a designed zinc finger protein bound to DNA
19. Three-dimensional solution structure of a single zinc finger DNA-binding domain
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21. Structures of zinc finger domains from transcription factor Sp1. Insights into sequence-specific protein-DNA recognition
22. Zinc finger-DNA recognition: Analysis of base specificity by site-directed mutagenesis
23. Differing roles for zinc fingers in DNA recognition: Structure of a six-finger transcription factor IIIA complex
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25. Crystal structure of a five-finger GLI-DNA complex: New perspectives on zinc fingers
26. Design of novel sequence-specific DNA-binding proteins
27. Toward controlling gene expression at will: Selection and design of zinc finger domains recognizing each of the 5'-GNN-3' DNA target sequences
28. DNA-binding specificity of NGFI-A and related zinc finger transcription factors
29. Analysis of zinc fingers optimized via phage display: Evaluating the utility of a recognition code
30. Building zinc fingers by selection: Toward a therapeutic application
31. Solution structure of the first three zinc fingers of TFIIIA bound to the cognate DNA sequence: Determinants of affinity and sequence specificity