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Volumn 78, Issue 3, 2004, Pages 1301-1313

Fusion Proteins Consisting of Human Immunodeficiency Virus Type 1 Integrase and the Designed Polydactyl Zinc Finger Protein E2C Direct Integration of Viral DNA into Specific Sites

Author keywords

[No Author keywords available]

Indexed keywords

DEOXYRIBONUCLEASE I; DNA BINDING PROTEIN; HYBRID PROTEIN; INTEGRASE; RETROVIRUS VECTOR; UNCLASSIFIED DRUG; VIRUS DNA; ZINC FINGER PROTEIN; ZINC FINGER PROTEIN E2C;

EID: 0347634423     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.78.3.1301-1313.2004     Document Type: Article
Times cited : (85)

References (57)
  • 1
    • 0035824646 scopus 로고    scopus 로고
    • Role of the nonspecific DNA-binding region and alpha helices within the core domain of retroviral integrase in selecting target DNA sites for integration
    • Appa, R. S., C. G. Shin, P. Lee, and S. A. Chow. 2001. Role of the nonspecific DNA-binding region and alpha helices within the core domain of retroviral integrase in selecting target DNA sites for integration. J. Biol. Chem. 276:45848-45855.
    • (2001) J. Biol. Chem. , vol.276 , pp. 45848-45855
    • Appa, R.S.1    Shin, C.G.2    Lee, P.3    Chow, S.A.4
  • 3
    • 0036168937 scopus 로고    scopus 로고
    • Engineering polydactyl zinc-finger transcription factors
    • Beerli, R. R., and C. F. Barbas III. 2002. Engineering polydactyl zinc-finger transcription factors. Nat. Biotechnol. 20:135-141.
    • (2002) Nat. Biotechnol. , vol.20 , pp. 135-141
    • Beerli, R.R.1    Barbas III, C.F.2
  • 4
    • 0034652141 scopus 로고    scopus 로고
    • Positive and negative regulation of encdogenous genes by designed transcription factors
    • Beerli, R. R., B. Dreier, and C. F. Barbas III. 2000. Positive and negative regulation of encdogenous genes by designed transcription factors. Proc. Natl. Acad. Sci. USA 97:1495-1500.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 1495-1500
    • Beerli, R.R.1    Dreier, B.2    Barbas III, C.F.3
  • 5
    • 0032437591 scopus 로고    scopus 로고
    • Toward controlling gene expression at will: Specific regulation of the erbB-2/HER-2 promoter by using polydactyl zinc finger proteins constructed from modular building blocks
    • Beerli, R. R., D. J. Segal, B. Dreier, and C. F. Barbas III. 1998. Toward controlling gene expression at will: specific regulation of the erbB-2/HER-2 promoter by using polydactyl zinc finger proteins constructed from modular building blocks. Proc. Natl. Acad. Sci. USA 95:14628-14633.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 14628-14633
    • Beerli, R.R.1    Segal, D.J.2    Dreier, B.3    Barbas III, C.F.4
  • 6
    • 0001363865 scopus 로고    scopus 로고
    • Integration
    • J. M. Coffin, S. H. Hughes, and H. E. Varmus (ed.). Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
    • Brown, P. O. 1997. Integration, p. 161-204. In J. M. Coffin, S. H. Hughes, and H. E. Varmus (ed.), Retroviruses. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
    • (1997) Retroviruses , pp. 161-204
    • Brown, P.O.1
  • 7
    • 0028074881 scopus 로고
    • Tethering human immunodeficiency virus I integrase to a DNA site directs integration to nearby sequences
    • Bushman, F. D. 1994. Tethering human immunodeficiency virus I integrase to a DNA site directs integration to nearby sequences. Proc. Natl. Acad. Sci. USA 91:9233-9237.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 9233-9237
    • Bushman, F.D.1
  • 8
    • 0031060377 scopus 로고    scopus 로고
    • Tethering human immunodeficiency virus type I preintegration complexes to target DNA promotes integration at nearby sites
    • Bushman, F. D., and M. D. Miller. 1997. Tethering human immunodeficiency virus type I preintegration complexes to target DNA promotes integration at nearby sites. J. Virol. 71:458-464.
    • (1997) J. Virol. , vol.71 , pp. 458-464
    • Bushman, F.D.1    Miller, M.D.2
  • 9
    • 0031957564 scopus 로고    scopus 로고
    • Chromosome structure and human immunodeficiency virus type I cDNA integration: Centromeric alphoid repeats are a disfavored target
    • Carteau, S., C. Hoffmann, and F. Bushman. 1998. Chromosome structure and human immunodeficiency virus type I cDNA integration: centromeric alphoid repeats are a disfavored target. J. Virol. 72:4005-4014.
    • (1998) J. Virol. , vol.72 , pp. 4005-4014
    • Carteau, S.1    Hoffmann, C.2    Bushman, F.3
  • 10
    • 0031592941 scopus 로고    scopus 로고
    • Promoter-specific activation of gene expression directed by bacteriophage-selected zinc fingers
    • Choo, Y., A. Castellanos, B. Garcia-Hernandez, I. Sanchez-Garcia, and A. Klug. 1997. Promoter-specific activation of gene expression directed by bacteriophage-selected zinc fingers. J. Mol. Biol. 273:525-532.
    • (1997) J. Mol. Biol. , vol.273 , pp. 525-532
    • Choo, Y.1    Castellanos, A.2    Garcia-Hernandez, B.3    Sanchez-Garcia, I.4    Klug, A.5
  • 11
    • 0027994717 scopus 로고
    • Toward a code for the interactions of zinc fingers with DNA: Selection of randomized fingers displayed on phage
    • Choo, Y., and A. Klug. 1994. Toward a code for the interactions of zinc fingers with DNA: selection of randomized fingers displayed on phage. Proc. Natl. Acad. Sci. USA 91:11163-11167.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 11163-11167
    • Choo, Y.1    Klug, A.2
  • 12
    • 0028670569 scopus 로고
    • In vivo repression by a site-specific DNA-binding protein designed against an oncogenic sequence
    • Choo, Y., I. Sanchez-Garcia, and A. Klug. 1994. In vivo repression by a site-specific DNA-binding protein designed against an oncogenic sequence. Nature 372:642-645.
    • (1994) Nature , vol.372 , pp. 642-645
    • Choo, Y.1    Sanchez-Garcia, I.2    Klug, A.3
  • 13
    • 0031214288 scopus 로고    scopus 로고
    • In vitro assays for activities of retroviral integrase
    • Chow, S. A. 1997. In vitro assays for activities of retroviral integrase. Methods 12:306-317.
    • (1997) Methods , vol.12 , pp. 306-317
    • Chow, S.A.1
  • 14
    • 0026637378 scopus 로고
    • Hotspots and warm spots: Integration specificity of retroelements
    • Craigie, R. 1992. Hotspots and warm spots: integration specificity of retroelements. Trends Genet. 8:187-190.
    • (1992) Trends Genet. , vol.8 , pp. 187-190
    • Craigie, R.1
  • 15
    • 0028081691 scopus 로고
    • Length-encoded multiplex binding site determination: Application to zinc finger proteins
    • Desjarlais, J. R., and J. M. Berg. 1994. Length-encoded multiplex binding site determination: application to zinc finger proteins. Proc. Natl. Acad. Sci. USA 91:11099-11103.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 11099-11103
    • Desjarlais, J.R.1    Berg, J.M.2
  • 16
    • 0035800769 scopus 로고    scopus 로고
    • Development of zinc finger domains for recognition of the 5'-ANN-3' family of DNA sequences and their use in the construction of artificial transcription factors
    • Dreier, B., R. R. Beerli, D. J. Segal, J. D. Flippin, and C. F. Barbas III. 2001. Development of zinc finger domains for recognition of the 5'-ANN-3' family of DNA sequences and their use in the construction of artificial transcription factors. J. Biol. Chem. 276:29466-29478.
    • (2001) J. Biol. Chem. , vol.276 , pp. 29466-29478
    • Dreier, B.1    Beerli, R.R.2    Segal, D.J.3    Flippin, J.D.4    Barbas III, C.F.5
  • 17
    • 0034602243 scopus 로고    scopus 로고
    • Insights into the molecular recognition of the 5'-GNN-3' family of DNA sequences by zinc finger domains
    • Dreier, B., D. J. Segal, and C. F. Barbas III. 2000. Insights into the molecular recognition of the 5'-GNN-3' family of DNA sequences by zinc finger domains. J. Mol. Biol. 303:489-502.
    • (2000) J. Mol. Biol. , vol.303 , pp. 489-502
    • Dreier, B.1    Segal, D.J.2    Barbas III, C.F.3
  • 18
    • 0030587774 scopus 로고    scopus 로고
    • Zif268 protein-DNA complex refined at 1.6Å: A model system for understanding zinc finger-DNA interactions
    • Elrod-Erickson, M., M. A. Rould, L. Nekludova, and C. O. Pabo. 1996. Zif268 protein-DNA complex refined at 1.6Å: a model system for understanding zinc finger-DNA interactions. Structure 4:1171-1180.
    • (1996) Structure , vol.4 , pp. 1171-1180
    • Elrod-Erickson, M.1    Rould, M.A.2    Nekludova, L.3    Pabo, C.O.4
  • 19
    • 0028067324 scopus 로고
    • The core and carboxy-terminal domains of the integrase protein of human immunodeficiency virus type I each contribute to nonspecific DNA binding
    • Engelman, A., A. B. Hickman, and R. Craigie. 1994. The core and carboxy-terminal domains of the integrase protein of human immunodeficiency virus type I each contribute to nonspecific DNA binding. J. Virol. 68:5911-5917.
    • (1994) J. Virol. , vol.68 , pp. 5911-5917
    • Engelman, A.1    Hickman, A.B.2    Craigie, R.3
  • 20
    • 0029655849 scopus 로고    scopus 로고
    • Directed integration of viral DNA mediated by fusion proteins consisting of human immunodeficiency virus type I integrase and Escherichia coli LexA protein
    • Goulaouic, H., and S. A. Chow. 1996. Directed integration of viral DNA mediated by fusion proteins consisting of human immunodeficiency virus type I integrase and Escherichia coli LexA protein. J. Virol. 70:37-46.
    • (1996) J. Virol. , vol.70 , pp. 37-46
    • Goulaouic, H.1    Chow, S.A.2
  • 23
    • 0030875813 scopus 로고    scopus 로고
    • Mapping features of HIV-I integrase near selected sites on viral and target DNA molecules in an active enzyme-DNA complex by photo-cross-linking
    • Heuer, T. S., and P. O. Brown. 1997. Mapping features of HIV-I integrase near selected sites on viral and target DNA molecules in an active enzyme-DNA complex by photo-cross-linking. Biochemistry 36:10655-10665.
    • (1997) Biochemistry , vol.36 , pp. 10655-10665
    • Heuer, T.S.1    Brown, P.O.2
  • 24
    • 0035220160 scopus 로고    scopus 로고
    • Molecular genetics and target site specificity of retroviral integration
    • Holmes-Son, M. L., R. S, Appa, and S. A. Chow. 2001. Molecular genetics and target site specificity of retroviral integration. Adv. Genet. 43:33-69.
    • (2001) Adv. Genet. , vol.43 , pp. 33-69
    • Holmes-Son, M.L.1    Appa, R.S.2    Chow, S.A.3
  • 25
    • 0018224936 scopus 로고
    • Proviruses of avian sarcoma virus are terminally redundant, co-extensive with unintegrated linear DNA and integrated at many sites
    • Hughes, S. H., P. R. Shank, D. H. Spector, H. J. Kung, J. M. Bishop, H. E. Varmus, P. K. Vogt, and M. L. Breitman. 1978. Proviruses of avian sarcoma virus are terminally redundant, co-extensive with unintegrated linear DNA and integrated at many sites. Cell 15:1397-1410.
    • (1978) Cell , vol.15 , pp. 1397-1410
    • Hughes, S.H.1    Shank, P.R.2    Spector, D.H.3    Kung, H.J.4    Bishop, J.M.5    Varmus, H.E.6    Vogt, P.K.7    Breitman, M.L.8
  • 26
    • 0024284648 scopus 로고
    • Structure of the lambda complex at 2.5 Å resolution: Details of the repressor-operator interactions
    • Jordan, S. R., and C. O. Pabo. 1988. Structure of the lambda complex at 2.5 Å resolution: details of the repressor-operator interactions. Science 242:893-899.
    • (1988) Science , vol.242 , pp. 893-899
    • Jordan, S.R.1    Pabo, C.O.2
  • 27
    • 0026035178 scopus 로고
    • Retroviral integrase domains: DNA binding and recognition of LTR sequences
    • Kahn, E., J. P. G. Mack, R. A. Katz, J. Kulkosky, and A. M. Skalka. 1991. Retroviral integrase domains: DNA binding and recognition of LTR sequences. Nucleic Acids Res. 19:851-860.
    • (1991) Nucleic Acids Res. , vol.19 , pp. 851-860
    • Kahn, E.1    Mack, J.P.G.2    Katz, R.A.3    Kulkosky, J.4    Skalka, A.M.5
  • 28
    • 0001679585 scopus 로고    scopus 로고
    • Zinc finger proteins as designer transcription factors
    • Kang, J. S., and J. S. Kim. 2000. Zinc finger proteins as designer transcription factors. J. Biol. Chem. 275:8742-8748.
    • (2000) J. Biol. Chem. , vol.275 , pp. 8742-8748
    • Kang, J.S.1    Kim, J.S.2
  • 29
    • 0029862622 scopus 로고    scopus 로고
    • Targeting of retroviral integrase by fusion to a heterologous DNA binding domain: In vitro activities and incorporation of a fusion protein into viral particles
    • Katz, R. A., G. Merkel, and A. M. Skalka. 1996. Targeting of retroviral integrase by fusion to a heterologous DNA binding domain: in vitro activities and incorporation of a fusion protein into viral particles. Virology 217:178-190.
    • (1996) Virology , vol.217 , pp. 178-190
    • Katz, R.A.1    Merkel, G.2    Skalka, A.M.3
  • 30
    • 0035135747 scopus 로고    scopus 로고
    • Viral vectors for gene therapy: The art of turning infectious agents into vehicles of therapeutics
    • Kay, M. A., J. C. Glorioso, and L. Naldini. 2001. Viral vectors for gene therapy: the art of turning infectious agents into vehicles of therapeutics. Nat. Med. 7:33-40.
    • (2001) Nat. Med. , vol.7 , pp. 33-40
    • Kay, M.A.1    Glorioso, J.C.2    Naldini, L.3
  • 31
    • 0032539902 scopus 로고    scopus 로고
    • Getting a handhold on DNA: Design of poly-zinc finger proteins with femtomolar dissociation constants
    • Kim, J.-S., and C. O. Pabo. 1998. Getting a handhold on DNA: design of poly-zinc finger proteins with femtomolar dissociation constants. Proc. Natl. Acad. Sci. USA 95:2812-2817.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 2812-2817
    • Kim, J.-S.1    Pabo, C.O.2
  • 32
    • 0030889195 scopus 로고    scopus 로고
    • Design of TATA box-binding protein/zinc finger fusions for targeted regulation of gene expression
    • Kim, J. S., J. Kim, K. L. Cepek, P. A. Sharp, and C. O. Pabo. 1997. Design of TATA box-binding protein/zinc finger fusions for targeted regulation of gene expression. Proc. Natl. Acad. Sci. USA 94:3616-3620.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 3616-3620
    • Kim, J.S.1    Kim, J.2    Cepek, K.L.3    Sharp, P.A.4    Pabo, C.O.5
  • 33
    • 0030697441 scopus 로고    scopus 로고
    • Transcriptional repression by zinc finger peptides. Exploring the potential for applications in gene therapy
    • Kim, J. S., and C. O. Pabo. 1997. Transcriptional repression by zinc finger peptides. Exploring the potential for applications in gene therapy. J. Biol. Chem. 272:29795-29800.
    • (1997) J. Biol. Chem. , vol.272 , pp. 29795-29800
    • Kim, J.S.1    Pabo, C.O.2
  • 34
    • 0024341072 scopus 로고
    • Three-dimensional solution structure of a single zinc finger DNA-binding domain
    • Lee, M. S., G. P. Gippert, K. V. Soman, D. A. Case, and P. E. Wright. 1989. Three-dimensional solution structure of a single zinc finger DNA-binding domain. Science 245:635-637.
    • (1989) Science , vol.245 , pp. 635-637
    • Lee, M.S.1    Gippert, G.P.2    Soman, K.V.3    Case, D.A.4    Wright, P.E.5
  • 35
    • 0027984798 scopus 로고
    • Identification of high affinity binding sites for LexA which define new DNA damage-inducible genes in Escherichia coli
    • Lewis, L. K., G. R. Harlow, L. A. Gregg-Jolly, and D. W. Mount. 1994. Identification of high affinity binding sites for LexA which define new DNA damage-inducible genes in Escherichia coli. J. Mol. Biol. 241:507-523.
    • (1994) J. Mol. Biol. , vol.241 , pp. 507-523
    • Lewis, L.K.1    Harlow, G.R.2    Gregg-Jolly, L.A.3    Mount, D.W.4
  • 38
    • 0030903688 scopus 로고    scopus 로고
    • Design of polydactyl zinc-finger proteins for unique addressing within complex genomes
    • Liu, Q., D. J. Segal, J. B. Ghiara, and C. F. Barbas III. 1997. Design of polydactyl zinc-finger proteins for unique addressing within complex genomes. Proc. Natl. Acad. Sci. USA 94:5525-5530.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 5525-5530
    • Liu, Q.1    Segal, D.J.2    Ghiara, J.B.3    Barbas III, C.F.4
  • 39
    • 0040215628 scopus 로고
    • Repetitive zinc-binding domains in the protein transcription factor IIIA from Xenopus oocytes
    • Miller, J., A. D. McLachlan, and A. Klug. 1985. Repetitive zinc-binding domains in the protein transcription factor IIIA from Xenopus oocytes. EMBO J. 4:1609-1614.
    • (1985) EMBO J. , vol.4 , pp. 1609-1614
    • Miller, J.1    McLachlan, A.D.2    Klug, A.3
  • 40
    • 0029996147 scopus 로고    scopus 로고
    • In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector
    • Naldini, L., U. Blomer, P. Gallay, D. Ory, R. Mulligan, F. H. Gage, I. M. Verma, and D. Trono. 1996. In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science 272:263-267.
    • (1996) Science , vol.272 , pp. 263-267
    • Naldini, L.1    Blomer, U.2    Gallay, P.3    Ory, D.4    Mulligan, R.5    Gage, F.H.6    Verma, I.M.7    Trono, D.8
  • 41
    • 0025773296 scopus 로고
    • Zinc finger-DNA recognition: Crystal structure of a Zif268-DNA complex at 2.1 Å
    • Pavletich, N. P., and C. O. Pabo. 1991. Zinc finger-DNA recognition: crystal structure of a Zif268-DNA complex at 2.1 Å. Science 252:809-817.
    • (1991) Science , vol.252 , pp. 809-817
    • Pavletich, N.P.1    Pabo, C.O.2
  • 43
    • 0031953134 scopus 로고    scopus 로고
    • Efficient transduction of nondividing human cells by feline immunodeficiency virus lentiviral vectors
    • Poeschla, E. M., F. Wong-Staal, and D. J. Looney. 1998. Efficient transduction of nondividing human cells by feline immunodeficiency virus lentiviral vectors. Nat. Med. 4:354-357.
    • (1998) Nat. Med. , vol.4 , pp. 354-357
    • Poeschla, E.M.1    Wong-Staal, F.2    Looney, D.J.3
  • 44
    • 0026696624 scopus 로고
    • Nucleosomes, DNA-binding proteins, and DNA sequence modulate retroviral integration target site selection
    • Pryciak, P. M., and H. E. Varmus. 1992. Nucleosomes, DNA-binding proteins, and DNA sequence modulate retroviral integration target site selection. Cell 69:769-780.
    • (1992) Cell , vol.69 , pp. 769-780
    • Pryciak, P.M.1    Varmus, H.E.2
  • 45
    • 0028034050 scopus 로고
    • Characterization of the minimal DNA-binding domain of the HIV integrase protein
    • Puras Lutzke, R. A., C. Vink, and R. H. A. Plasterk. 1994. Characterization of the minimal DNA-binding domain of the HIV integrase protein. Nucleic Acids Res. 22:4125-4131.
    • (1994) Nucleic Acids Res. , vol.22 , pp. 4125-4131
    • Puras Lutzke, R.A.1    Vink, C.2    Plasterk, R.H.A.3
  • 46
    • 0029942895 scopus 로고    scopus 로고
    • Phage display methods for selecting zinc finger proteins with novel DNA-binding specificities
    • Rebar, E. J., H. A. Greisman, and C. O. Pabo. 1996. Phage display methods for selecting zinc finger proteins with novel DNA-binding specificities. Methods Enzymol. 267:129-149.
    • (1996) Methods Enzymol. , vol.267 , pp. 129-149
    • Rebar, E.J.1    Greisman, H.A.2    Pabo, C.O.3
  • 48
    • 0037162715 scopus 로고    scopus 로고
    • HIV-I integration in the human genome favors active genes and local hotspots
    • Schroder, A. R., P. Shinn, H. Chen, C. Berry, J. R. Ecker, and F. Bushman. 2002. HIV-I integration in the human genome favors active genes and local hotspots. Cell 110:521-529.
    • (2002) Cell , vol.110 , pp. 521-529
    • Schroder, A.R.1    Shinn, P.2    Chen, H.3    Berry, C.4    Ecker, J.R.5    Bushman, F.6
  • 49
    • 0035712253 scopus 로고    scopus 로고
    • Custom DNA-binding proteins come of age: Polydactyl zinc-finger proteins
    • Segal, D. J., and C. F. Barbas III. 2001. Custom DNA-binding proteins come of age: polydactyl zinc-finger proteins. Curr. Opin. Biotechnol. 12:632-637.
    • (2001) Curr. Opin. Biotechnol. , vol.12 , pp. 632-637
    • Segal, D.J.1    Barbas III, C.F.2
  • 50
    • 0032981699 scopus 로고    scopus 로고
    • Toward controlling gene expression at will: Selection and design of zinc finger domains recognizing each of the 5′-GNN-3′ DNA target sequences
    • Segal, D. J., B. Dreier, R. R. Beerli, and C. F. Barbas III. 1999. Toward controlling gene expression at will: selection and design of zinc finger domains recognizing each of the 5′-GNN-3′ DNA target sequences. Proc. Natl. Acad. Sci. USA 96:2758-2763.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 2758-2763
    • Segal, D.J.1    Dreier, B.2    Beerli, R.R.3    Barbas III, C.F.4
  • 51
    • 0030932575 scopus 로고    scopus 로고
    • Central core domain of retroviral integrase is responsible for target site selection
    • Shibagaki, Y., and S. A. Chow. 1997. Central core domain of retroviral integrase is responsible for target site selection. J. Biol. Chem. 272:8361-8369.
    • (1997) J. Biol. Chem. , vol.272 , pp. 8361-8369
    • Shibagaki, Y.1    Chow, S.A.2
  • 52
    • 0024292602 scopus 로고
    • Highly preferred targets for retrovirus integration
    • Shih, C.-C., J. P. Stoye, and J. M. Coffin. 1988. Highly preferred targets for retrovirus integration. Cell 53:531-537.
    • (1988) Cell , vol.53 , pp. 531-537
    • Shih, C.-C.1    Stoye, J.P.2    Coffin, J.M.3
  • 53
    • 0025447655 scopus 로고
    • Safety considerations in somatic gene therapy of human disease with retrovirus vectors
    • Temin, H. M. 1990. Safety considerations in somatic gene therapy of human disease with retrovirus vectors. Hum. Gene Thcr. 1:111-123.
    • (1990) Hum. Gene Ther. , vol.1 , pp. 111-123
    • Temin, H.M.1
  • 54
    • 0030928619 scopus 로고    scopus 로고
    • Gene therapy-promises, problems and prospects
    • Verma, I. M., and N. Somia. 1997. Gene therapy-promises, problems and prospects. Nature 389:239-242.
    • (1997) Nature , vol.389 , pp. 239-242
    • Verma, I.M.1    Somia, N.2
  • 55
    • 0027210608 scopus 로고
    • Identification of the catalytic and DNA-binding region of the human immunodeficiency virus type I integrase protein
    • Vink, C., A. A. M. Oude Groeneger, and R. H. A. Plasterk. 1993. Identification of the catalytic and DNA-binding region of the human immunodeficiency virus type I integrase protein. Nucleic Acids Res. 21:1419-1425.
    • (1993) Nucleic Acids Res. , vol.21 , pp. 1419-1425
    • Vink, C.1    Oude Groeneger, A.A.M.2    Plasterk, R.H.A.3
  • 56
    • 0028340554 scopus 로고
    • Distribution of targets for avian retrovirus DNA integration in vivo
    • Withers-Ward, E. S., Y. Kitamura, J. P. Barnes, and J. M. Coffin. 1994. Distribution of targets for avian retrovirus DNA integration in vivo. Genes Dev. 8:1473-1487.
    • (1994) Genes Dev. , vol.8 , pp. 1473-1487
    • Withers-Ward, E.S.1    Kitamura, Y.2    Barnes, J.P.3    Coffin, J.M.4
  • 57
    • 0027205243 scopus 로고
    • Characterization of a DNA binding domain in the C terminus of HIV-1 integrase by deletion mutagenesis
    • Woerner, A. M., and C. J. Marcus-Sekura. 1993. Characterization of a DNA binding domain in the C terminus of HIV-1 integrase by deletion mutagenesis. Nucleic Acids Res. 21:3507-3511.
    • (1993) Nucleic Acids Res. , vol.21 , pp. 3507-3511
    • Woerner, A.M.1    Marcus-Sekura, C.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.