메뉴 건너뛰기




Volumn 39, Issue 4, 2009, Pages 325-340

Progress toward liver-based gene therapy

Author keywords

Gene therapy; Liver; Non viral vectors; Viral vectors

Indexed keywords

ALPHA FETOPROTEIN; ANTISENSE OLIGONUCLEOTIDE; APOLIPOPROTEIN A1; APOLIPOPROTEIN B; APOLIPOPROTEIN E; BETA 2 MICROGLOBULIN; BETA INTERFERON; BLOOD CLOTTING FACTOR 9; CYTOSINE DEAMINASE; DEATH RECEPTOR; ENDOSTATIN; FLUCYTOSINE; GLUCAN 1,4 ALPHA GLUCOSIDASE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HLA B7 ANTIGEN; INTERLEUKIN 12; INTERLEUKIN 18; LIPOPLEX; NITROREDUCTASE; NV 1020; ONXY 015; ONYX 015; PHENYLALANINE 4 MONOOXYGENASE; PROTEIN P53; RECOMBINANT INTERLEUKIN 12; RIBOZYME; SHORT HAIRPIN RNA; SMALL INTERFERING RNA; THYMIDINE KINASE 1; UNCLASSIFIED DRUG; UNINDEXED DRUG; VIRUS VECTOR;

EID: 63649134433     PISSN: 13866346     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1872-034X.2008.00479.x     Document Type: Review
Times cited : (19)

References (187)
  • 2
    • 0033579358 scopus 로고    scopus 로고
    • Gene therapy death prompts review of adenovirus vector
    • Marshall E. Gene therapy death prompts review of adenovirus vector. Science 1999; 286: 2244-5.
    • (1999) Science , vol.286 , pp. 2244-2245
    • Marshall, E.1
  • 3
    • 0037448352 scopus 로고    scopus 로고
    • A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency
    • Bey H, Abina S, von Kalle C et al. A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency. N Engl J Med 2003; 348: 255-6.
    • (2003) N Engl J Med , vol.348 , pp. 255-256
    • Bey, H.1    Abina, S.2    von Kalle, C.3
  • 4
    • 63649159852 scopus 로고    scopus 로고
    • US Food and Drug Administration. [Cited 22/12/2008.] Available from URL
    • US Food and Drug Administration. FDA Statement on Gene Therapy Clinical Trial. [Cited 22/12/2008.] Available from URL: http://www.fda.gov/bbs/ topics/NEWS/2007/NEW01672.html
    • FDA Statement on Gene Therapy Clinical Trial
  • 5
    • 51349158298 scopus 로고    scopus 로고
    • Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients
    • Howe SJ, Mansour MR, Schwarzwaelder K et al. Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients. J Clin Invest 2008; 118: 3143-50.
    • (2008) J Clin Invest , vol.118 , pp. 3143-3150
    • Howe, S.J.1    Mansour, M.R.2    Schwarzwaelder, K.3
  • 10
    • 5444237545 scopus 로고    scopus 로고
    • Liver gene therapy: Advances and hurdles
    • Nguyen TH, Ferry N. Liver gene therapy: Advances and hurdles. Gene Ther 2004; 11 (Suppl 1): S76-84.
    • (2004) Gene Ther , vol.11 , Issue.SUPPL. 1
    • Nguyen, T.H.1    Ferry, N.2
  • 11
    • 0029061020 scopus 로고
    • In vivo disposition characteristics of plasmid DNA complexed with cationic liposomes
    • Mahato RI, Kawabata K, Takakura Y, Hashida M. In vivo disposition characteristics of plasmid DNA complexed with cationic liposomes. J Drug Target 1995; 3: 149-57.
    • (1995) J Drug Target , vol.3 , pp. 149-157
    • Mahato, R.I.1    Kawabata, K.2    Takakura, Y.3    Hashida, M.4
  • 12
    • 2342625392 scopus 로고    scopus 로고
    • Analysis of adenovirus sequestration in the liver, transduction of hepatic cells, and innate toxicity after injection of fiber-modified vectors
    • Shayakhmetov DM, Li ZY, Ni S, Lieber A. Analysis of adenovirus sequestration in the liver, transduction of hepatic cells, and innate toxicity after injection of fiber-modified vectors. J Virol 2004; 78: 5368-81.
    • (2004) J Virol , vol.78 , pp. 5368-5381
    • Shayakhmetov, D.M.1    Li, Z.Y.2    Ni, S.3    Lieber, A.4
  • 13
    • 34547195831 scopus 로고    scopus 로고
    • The locus control region activates serpin gene expression through recruitment of liver-specific transcription factors and RNA polymerase II
    • Zhao H, Friedman RD, Fournier RE. The locus control region activates serpin gene expression through recruitment of liver-specific transcription factors and RNA polymerase II. Mol Cell Biol 2007; 27: 5286-95.
    • (2007) Mol Cell Biol , vol.27 , pp. 5286-5295
    • Zhao, H.1    Friedman, R.D.2    Fournier, R.E.3
  • 14
    • 0029961248 scopus 로고    scopus 로고
    • HBV-derived promoters direct liver-specific expression of an adenovirally transduced LDL receptor gene
    • Sandig V, Loser P, Lieber A, Kay MA, Strauss M. HBV-derived promoters direct liver-specific expression of an adenovirally transduced LDL receptor gene. Gene Ther 1996; 3: 1002-9.
    • (1996) Gene Ther , vol.3 , pp. 1002-1009
    • Sandig, V.1    Loser, P.2    Lieber, A.3    Kay, M.A.4    Strauss, M.5
  • 15
    • 0038052774 scopus 로고    scopus 로고
    • Apollodorus. Oxford: Oxford University Press
    • Apollodorus. The Library of Greek Mythology. Oxford: Oxford University Press, 1999.
    • (1999) The Library of Greek Mythology
  • 16
    • 39549097751 scopus 로고    scopus 로고
    • Liver: An organ with predominant innate immunity
    • Gao B, Jeong WI, Tian Z. Liver: An organ with predominant innate immunity. Hepatology 2008; 47: 729-36.
    • (2008) Hepatology , vol.47 , pp. 729-736
    • Gao, B.1    Jeong, W.I.2    Tian, Z.3
  • 17
    • 40549090572 scopus 로고    scopus 로고
    • Minimally invasive and selective hydrodynamic gene therapy of liver segments in the pig and human
    • Khorsandi SE, Bachellier P, Weber JC et al. Minimally invasive and selective hydrodynamic gene therapy of liver segments in the pig and human. Cancer Gene Ther 2008; 15: 225-30.
    • (2008) Cancer Gene Ther , vol.15 , pp. 225-230
    • Khorsandi, S.E.1    Bachellier, P.2    Weber, J.C.3
  • 18
    • 22744455256 scopus 로고    scopus 로고
    • Gene therapy progress and prospects: Development of improved lentiviral and retroviral vectors - Design, biosafety, and production
    • Sinn PL, Sauter SL, McCray PB Jr. Gene therapy progress and prospects: development of improved lentiviral and retroviral vectors - design, biosafety, and production. Gene Ther 2005; 12: 1089-98.
    • (2005) Gene Ther , vol.12 , pp. 1089-1098
    • Sinn, P.L.1    Sauter, S.L.2    McCray Jr., P.B.3
  • 20
    • 0028131412 scopus 로고
    • Factors influencing retroviral-mediated gene transfer into hepatocytes in vivo
    • Branchereau S, Calise D, Ferry N. Factors influencing retroviral-mediated gene transfer into hepatocytes in vivo. Hum Gene Ther 1994; 5: 803-8.
    • (1994) Hum Gene Ther , vol.5 , pp. 803-808
    • Branchereau, S.1    Calise, D.2    Ferry, N.3
  • 21
    • 0029010354 scopus 로고
    • Adenovirus-mediated urokinase gene transfer induces liver regeneration and allows for efficient retrovirus transduction of hepatocytes in vivo
    • Lieber A, Vrancken Peeters MJ, Meuse L, Fausto N, Perkins J, Kay MA. Adenovirus-mediated urokinase gene transfer induces liver regeneration and allows for efficient retrovirus transduction of hepatocytes in vivo. Proc Natl Acad Sci USA 1995; 92: 6210-14.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 6210-6214
    • Lieber, A.1    Vrancken Peeters, M.J.2    Meuse, L.3    Fausto, N.4    Perkins, J.5    Kay, M.A.6
  • 22
    • 13744261613 scopus 로고    scopus 로고
    • Follistatin allows efficient retroviral-mediated gene transfer into rat liver
    • Borgnon J, Djamouri F, Lorand I et al. Follistatin allows efficient retroviral-mediated gene transfer into rat liver. Biochem Biophys Res Commun 2005; 328: 937-43.
    • (2005) Biochem Biophys Res Commun , vol.328 , pp. 937-943
    • Borgnon, J.1    Djamouri, F.2    Lorand, I.3
  • 23
    • 0033618547 scopus 로고    scopus 로고
    • Lentiviral vectors - The promise of gene therapy within reach
    • Amado RG, Chen IS. Lentiviral vectors - the promise of gene therapy within reach. Science 1999; 285: 674-6.
    • (1999) Science , vol.285 , pp. 674-676
    • Amado, R.G.1    Chen, I.S.2
  • 24
    • 0030716959 scopus 로고    scopus 로고
    • Sustained expression of genes delivered directly into liver and muscle by lentiviral vectors
    • Kafri T, Blomer U, Peterson DA, Gage FH, Verma IM. Sustained expression of genes delivered directly into liver and muscle by lentiviral vectors. Nat Genet 1997; 17: 314-17.
    • (1997) Nat Genet , vol.17 , pp. 314-317
    • Kafri, T.1    Blomer, U.2    Peterson, D.A.3    Gage, F.H.4    Verma, I.M.5
  • 25
    • 33846650370 scopus 로고    scopus 로고
    • Clinical trial results with oncolytic virotherapy: A century of promise, a decade of progress
    • Liu TC, Galanis E, Kirn D. Clinical trial results with oncolytic virotherapy: A century of promise, a decade of progress. Nat Clin Pract Oncol 2007; 4: 101-17.
    • (2007) Nat Clin Pract Oncol , vol.4 , pp. 101-117
    • Liu, T.C.1    Galanis, E.2    Kirn, D.3
  • 27
  • 28
    • 34547732865 scopus 로고    scopus 로고
    • Emerging adenoviral vectors for stable correction of genetic disorders
    • Jager L, Ehrhardt A. Emerging adenoviral vectors for stable correction of genetic disorders. Curr Gene Ther 2007; 7: 272-83.
    • (2007) Curr Gene Ther , vol.7 , pp. 272-283
    • Jager, L.1    Ehrhardt, A.2
  • 29
    • 24944454988 scopus 로고    scopus 로고
    • Current status of gendicine in China: Recombinant human Ad-p53 agent for treatment of cancers
    • Peng Z. Current status of gendicine in China: Recombinant human Ad-p53 agent for treatment of cancers. Hum Gene Ther 2005; 16: 1016-27.
    • (2005) Hum Gene Ther , vol.16 , pp. 1016-1027
    • Peng, Z.1
  • 30
    • 33745089314 scopus 로고    scopus 로고
    • Adeno-associated virus as a gene therapy vector: Vector development, production and clinical applications
    • Grieger JC, Samulski RJ. Adeno-associated virus as a gene therapy vector: Vector development, production and clinical applications. Adv Biochem Eng Biotechnol 2005; 99: 119-45.
    • (2005) Adv Biochem Eng Biotechnol , vol.99 , pp. 119-145
    • Grieger, J.C.1    Samulski, R.J.2
  • 31
    • 33746874152 scopus 로고    scopus 로고
    • Adeno-associated virus serotypes: Vector toolkit for human gene therapy
    • Wu Z, Asokan A, Samulski RJ. Adeno-associated virus serotypes: Vector toolkit for human gene therapy. Mol Ther 2006; 14: 316-27.
    • (2006) Mol Ther , vol.14 , pp. 316-327
    • Wu, Z.1    Asokan, A.2    Samulski, R.J.3
  • 32
    • 0026070440 scopus 로고
    • Targeted integration of adeno-associated virus (AAV) into human chromosome 19
    • Samulski RJ, Zhu X, Xiao X et al. Targeted integration of adeno-associated virus (AAV) into human chromosome 19. EMBO J 1991; 10: 3941-50.
    • (1991) EMBO J , vol.10 , pp. 3941-3950
    • Samulski, R.J.1    Zhu, X.2    Xiao, X.3
  • 33
    • 0342313708 scopus 로고    scopus 로고
    • Roles of adeno-associated virus Rep protein and human chromosome 19 in site-specific recombination
    • Young SM Jr, McCarty DM, Degtyareva N, Samulski RJ. Roles of adeno-associated virus Rep protein and human chromosome 19 in site-specific recombination. J Virol 2000; 74: 3953-66.
    • (2000) J Virol , vol.74 , pp. 3953-3966
    • Young, S.M.1    McCarty, D.M.2    Degtyareva, N.3    Samulski, R.J.4
  • 34
    • 38349146103 scopus 로고    scopus 로고
    • The transient expression of mRNA coding for Rep protein from AAV facilitates targeted plasmid integration
    • Howden SE, Voullaire L, Vadolas J. The transient expression of mRNA coding for Rep protein from AAV facilitates targeted plasmid integration. J Gene Med 2007; 10: 42-50.
    • (2007) J Gene Med , vol.10 , pp. 42-50
    • Howden, S.E.1    Voullaire, L.2    Vadolas, J.3
  • 35
    • 36749033228 scopus 로고    scopus 로고
    • The state of the art of adeno-associated virus-based vectors in gene therapy
    • Coura Rdos S, Nardi NB. The state of the art of adeno-associated virus-based vectors in gene therapy. Virol J 2007; 4: 99.
    • (2007) Virol J , vol.4 , pp. 99
    • Coura Rdos, S.1    Nardi, N.B.2
  • 36
    • 45449114994 scopus 로고    scopus 로고
    • Reprogrammed viruses as cancer therapeutics: Targeted, armed and shielded
    • Cattaneo R, Miest T, Shashkova EV, Barry MA. Reprogrammed viruses as cancer therapeutics: Targeted, armed and shielded. Nat Rev Microbiol 2008; 6: 529-40.
    • (2008) Nat Rev Microbiol , vol.6 , pp. 529-540
    • Cattaneo, R.1    Miest, T.2    Shashkova, E.V.3    Barry, M.A.4
  • 37
    • 37549027165 scopus 로고    scopus 로고
    • Exponential enhancement of oncolytic vesicular stomatitis virus potency by vector-mediated suppression of inflammatory responses in vivo
    • Altomonte J, Wu L, Chen L et al. Exponential enhancement of oncolytic vesicular stomatitis virus potency by vector-mediated suppression of inflammatory responses in vivo. Mol Ther 2008; 16: 146-53.
    • (2008) Mol Ther , vol.16 , pp. 146-153
    • Altomonte, J.1    Wu, L.2    Chen, L.3
  • 38
    • 33847378044 scopus 로고    scopus 로고
    • Phase 1 clinical experience using intravenous administration of PV701, an oncolytic Newcastle disease virus
    • Lorence RM, Roberts MS, O'Neil JD et al. Phase 1 clinical experience using intravenous administration of PV701, an oncolytic Newcastle disease virus. Curr Cancer Drug Targets 2007; 7: 157-67.
    • (2007) Curr Cancer Drug Targets , vol.7 , pp. 157-167
    • Lorence, R.M.1    Roberts, M.S.2    O'Neil, J.D.3
  • 39
    • 0027723261 scopus 로고
    • New developments in the virus therapy of cancer: A historical review
    • Sinkovics J, Horvath J. New developments in the virus therapy of cancer: a historical review. Intervirology 1993; 36: 193-214.
    • (1993) Intervirology , vol.36 , pp. 193-214
    • Sinkovics, J.1    Horvath, J.2
  • 40
    • 0032515141 scopus 로고    scopus 로고
    • Reovirus therapy of tumors with activated Ras pathway
    • Coffey MC, Strong JE, Forsyth PA, Lee PW. Reovirus therapy of tumors with activated Ras pathway. Science 1998; 282: 1332-4.
    • (1998) Science , vol.282 , pp. 1332-1334
    • Coffey, M.C.1    Strong, J.E.2    Forsyth, P.A.3    Lee, P.W.4
  • 41
    • 32844457481 scopus 로고    scopus 로고
    • Treatment of cholangiocarcinoma with oncolytic herpes simplex virus combined with external beam radiation therapy
    • Jarnagin WR, Zager JS, Hezel M et al. Treatment of cholangiocarcinoma with oncolytic herpes simplex virus combined with external beam radiation therapy. Cancer Gene Ther 2006; 13: 326-34.
    • (2006) Cancer Gene Ther , vol.13 , pp. 326-334
    • Jarnagin, W.R.1    Zager, J.S.2    Hezel, M.3
  • 42
    • 36049009021 scopus 로고    scopus 로고
    • Rational strain selection and engineering creates a broad-spectrum, systemically effective oncolytic poxvirus, JX-963
    • Thorne SH, Hwang TH, O'Gorman WE et al. Rational strain selection and engineering creates a broad-spectrum, systemically effective oncolytic poxvirus, JX-963. J Clin Invest 2007; 117: 3350-8.
    • (2007) J Clin Invest , vol.117 , pp. 3350-3358
    • Thorne, S.H.1    Hwang, T.H.2    O'Gorman, W.E.3
  • 43
    • 0344188096 scopus 로고    scopus 로고
    • An adenovirus mutant that replicates selectively in p53-deficient human tumor cells
    • Bischoff JR, Kirn DH, Williams A et al. An adenovirus mutant that replicates selectively in p53-deficient human tumor cells. Science 1996; 274: 373-6.
    • (1996) Science , vol.274 , pp. 373-376
    • Bischoff, J.R.1    Kirn, D.H.2    Williams, A.3
  • 44
    • 19944363519 scopus 로고    scopus 로고
    • Late viral RNA export, rather than p53 inactivation, determines ONYX-015 tumor selectivity
    • O'Shea CC, Johnson L, Bagus B et al. Late viral RNA export, rather than p53 inactivation, determines ONYX-015 tumor selectivity. Cancer Cell 2004; 6: 611-23.
    • (2004) Cancer Cell , vol.6 , pp. 611-623
    • O'Shea, C.C.1    Johnson, L.2    Bagus, B.3
  • 45
    • 0037805562 scopus 로고    scopus 로고
    • Cationic transfection lipids
    • Liu D, Ren T, Gao X. Cationic transfection lipids. Curr Med Chem 2003; 10: 1307-15.
    • (2003) Curr Med Chem , vol.10 , pp. 1307-1315
    • Liu, D.1    Ren, T.2    Gao, X.3
  • 46
    • 0032518063 scopus 로고    scopus 로고
    • Synthesis, activity, and structure - Activity relationship studies of novel cationic lipids for DNA transfer
    • Byk G, Dubertret C, Escriou V et al. Synthesis, activity, and structure - activity relationship studies of novel cationic lipids for DNA transfer. J Med Chem 1998; 41: 229-35.
    • (1998) J Med Chem , vol.41 , pp. 229-235
    • Byk, G.1    Dubertret, C.2    Escriou, V.3
  • 47
    • 0030813879 scopus 로고    scopus 로고
    • Factors controlling the efficiency of cationic lipid-mediated transfection in vivo via intravenous administration
    • Liu F, Qi H, Huang L, Liu D. Factors controlling the efficiency of cationic lipid-mediated transfection in vivo via intravenous administration. Gene Ther 1997; 4: 517-23.
    • (1997) Gene Ther , vol.4 , pp. 517-523
    • Liu, F.1    Qi, H.2    Huang, L.3    Liu, D.4
  • 48
    • 0030668116 scopus 로고    scopus 로고
    • Characterization of cationic liposome-mediated gene transfer in vivo by intravenous administration
    • Song YK, Liu F, Chu S, Liu D. Characterization of cationic liposome-mediated gene transfer in vivo by intravenous administration. Hum Gene Ther 1997; 8: 1585-94.
    • (1997) Hum Gene Ther , vol.8 , pp. 1585-1594
    • Song, Y.K.1    Liu, F.2    Chu, S.3    Liu, D.4
  • 49
    • 0029160083 scopus 로고
    • A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: Polyethylenimine
    • Boussif O, Lezoualc'h F, Zanta MA et al. A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. Proc Natl Acad Sci USA 1995; 92: 7297-301.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 7297-7301
    • Boussif, O.1    Lezoualc'h, F.2    Zanta, M.A.3
  • 50
    • 0027655718 scopus 로고
    • Polyamidoamine cascade polymers mediate efficient transfection of cells in culture
    • Haensler J, Szoka FC Jr. Polyamidoamine cascade polymers mediate efficient transfection of cells in culture. Bioconjug Chem 1993; 4: 372-9.
    • (1993) Bioconjug Chem , vol.4 , pp. 372-379
    • Haensler, J.1    Szoka Jr., F.C.2
  • 51
    • 0030293017 scopus 로고    scopus 로고
    • In vitro gene delivery by degraded polyamidoamine dendrimers
    • Tang MX, Redemann CT, Szoka FC Jr. In vitro gene delivery by degraded polyamidoamine dendrimers. Bioconjug Chem 1996; 7: 703-14.
    • (1996) Bioconjug Chem , vol.7 , pp. 703-714
    • Tang, M.X.1    Redemann, C.T.2    Szoka Jr., F.C.3
  • 52
    • 0034219238 scopus 로고    scopus 로고
    • In vivo gene delivery to the lung using polyethylenimine and fractured polyamidoamine dendrimers
    • Rudolph C, Lausier J, Naundorf S, Muller RH, Rosenecker J. In vivo gene delivery to the lung using polyethylenimine and fractured polyamidoamine dendrimers. J Gene Med 2000; 2: 269-78.
    • (2000) J Gene Med , vol.2 , pp. 269-278
    • Rudolph, C.1    Lausier, J.2    Naundorf, S.3    Muller, R.H.4    Rosenecker, J.5
  • 53
    • 10044278222 scopus 로고    scopus 로고
    • Preferential liver gene expression with polypropylenimine dendrimers
    • Schatzlein AG, Zinselmeyer BH, Elouzi A et al. Preferential liver gene expression with polypropylenimine dendrimers. J Control Release 2005; 101: 247-58.
    • (2005) J Control Release , vol.101 , pp. 247-258
    • Schatzlein, A.G.1    Zinselmeyer, B.H.2    Elouzi, A.3
  • 54
    • 0742324370 scopus 로고    scopus 로고
    • Dextran-spermine polycation: An efficient non-viral vector for in vitro and in vivo gene transfection
    • Hosseinkhani H, Azzam T, Tabata Y, Domb AJ. Dextran-spermine polycation: an efficient non-viral vector for in vitro and in vivo gene transfection. Gene Ther 2004; 11: 194-203.
    • (2004) Gene Ther , vol.11 , pp. 194-203
    • Hosseinkhani, H.1    Azzam, T.2    Tabata, Y.3    Domb, A.J.4
  • 56
    • 0031722107 scopus 로고    scopus 로고
    • Chitosan-based vector/DNA complexes for gene delivery: Biophysical characteristics and transfection ability
    • Erbacher P, Zou S, Bettinger T, Steffan AM, Remy JS. Chitosan-based vector/DNA complexes for gene delivery: Biophysical characteristics and transfection ability. Pharm Res 1998; 15: 1332-9.
    • (1998) Pharm Res , vol.15 , pp. 1332-1339
    • Erbacher, P.1    Zou, S.2    Bettinger, T.3    Steffan, A.M.4    Remy, J.S.5
  • 57
    • 0034633716 scopus 로고    scopus 로고
    • Histone H2A-mediated transient cytokine gene delivery induces efficient antitumor responses in murine neuroblastoma
    • Balicki D, Reisfeld RA, Pertl U, Beutler E, Lode HN. Histone H2A-mediated transient cytokine gene delivery induces efficient antitumor responses in murine neuroblastoma. Proc Natl Acad Sci USA 2000; 97: 11500-4.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 11500-11504
    • Balicki, D.1    Reisfeld, R.A.2    Pertl, U.3    Beutler, E.4    Lode, H.N.5
  • 58
    • 2342476860 scopus 로고    scopus 로고
    • Low molecular weight protamine as an efficient and nontoxic gene carrier: In vitro study
    • Park YJ, Liang JF, Ko KS, Kim SW, Yang VC. Low molecular weight protamine as an efficient and nontoxic gene carrier: In vitro study. J Gene Med 2003; 5: 700-11.
    • (2003) J Gene Med , vol.5 , pp. 700-711
    • Park, Y.J.1    Liang, J.F.2    Ko, K.S.3    Kim, S.W.4    Yang, V.C.5
  • 59
    • 0036844766 scopus 로고    scopus 로고
    • In vivo characteristics of cationic liposomes as delivery vectors for gene therapy
    • Audouy SA, de Leij LF, Hoekstra D, Molema G. In vivo characteristics of cationic liposomes as delivery vectors for gene therapy. Pharm Res 2002; 19: 1599-605.
    • (2002) Pharm Res , vol.19 , pp. 1599-1605
    • Audouy, S.A.1    de Leij, L.F.2    Hoekstra, D.3    Molema, G.4
  • 60
    • 0036371914 scopus 로고    scopus 로고
    • Side-effects of a systemic injection of linear polyethylenimine-DNA complexes
    • Chollet P, Favrot MC, Hurbin A, Coll JL. Side-effects of a systemic injection of linear polyethylenimine-DNA complexes. J Gene Med 2002; 4: 84-91.
    • (2002) J Gene Med , vol.4 , pp. 84-91
    • Chollet, P.1    Favrot, M.C.2    Hurbin, A.3    Coll, J.L.4
  • 61
    • 0029789793 scopus 로고    scopus 로고
    • Activation of the complement system by synthetic DNA complexes: A potential barrier for intravenous gene delivery
    • Plank C, Mechtler K, Szoka FC Jr, Wagner E. Activation of the complement system by synthetic DNA complexes: A potential barrier for intravenous gene delivery. Hum Gene Ther 1996; 7: 1437-46.
    • (1996) Hum Gene Ther , vol.7 , pp. 1437-1446
    • Plank, C.1    Mechtler, K.2    Szoka Jr., F.C.3    Wagner, E.4
  • 62
    • 0030038942 scopus 로고    scopus 로고
    • Potentiation of cationic liposome-mediated gene delivery by polycations
    • Gao X, Huang L. Potentiation of cationic liposome-mediated gene delivery by polycations. Biochem 1996; 35: 1027-36.
    • (1996) Biochem , vol.35 , pp. 1027-1036
    • Gao, X.1    Huang, L.2
  • 63
    • 0030866647 scopus 로고    scopus 로고
    • Protamine sulfate enhances lipid-mediated gene transfer
    • Sorgi FL, Bhattacharya S, Huang L. Protamine sulfate enhances lipid-mediated gene transfer. Gene Ther 1997; 4: 961-8.
    • (1997) Gene Ther , vol.4 , pp. 961-968
    • Sorgi, F.L.1    Bhattacharya, S.2    Huang, L.3
  • 64
    • 0030866645 scopus 로고    scopus 로고
    • In vivo gene transfer via intravenous administration of cationic lipid-protamine-DNA (LPD) complexes
    • Li S, Huang L. In vivo gene transfer via intravenous administration of cationic lipid-protamine-DNA (LPD) complexes. Gene Ther 1997; 4: 891-900.
    • (1997) Gene Ther , vol.4 , pp. 891-900
    • Li, S.1    Huang, L.2
  • 65
    • 33744543349 scopus 로고    scopus 로고
    • Poly(propylacrylic acid) enhances cationic lipid-mediated delivery of antisense oligonucleotides
    • Lee LK, Williams CL, Devore D, Roth CM. Poly(propylacrylic acid) enhances cationic lipid-mediated delivery of antisense oligonucleotides. Biomacromolecules 2006; 7: 1502-8.
    • (2006) Biomacromolecules , vol.7 , pp. 1502-1508
    • Lee, L.K.1    Williams, C.L.2    Devore, D.3    Roth, C.M.4
  • 66
    • 0036829950 scopus 로고    scopus 로고
    • Specific systemic non-viral gene delivery to human hepatocellular carcinoma xenografts in SCID mice
    • Wolschek MF, Thallinger C, Kursa M et al. Specific systemic non-viral gene delivery to human hepatocellular carcinoma xenografts in SCID mice. Hepatology 2002; 36: 1106-14.
    • (2002) Hepatology , vol.36 , pp. 1106-1114
    • Wolschek, M.F.1    Thallinger, C.2    Kursa, M.3
  • 67
    • 3042783492 scopus 로고    scopus 로고
    • Targeted gene delivery to sinusoidal endothelial cells: DNA nanoassociate bearing hyaluronan-glycocalyx
    • Takei Y, Maruyama A, Ferdous A et al. Targeted gene delivery to sinusoidal endothelial cells: DNA nanoassociate bearing hyaluronan-glycocalyx. FASEB J 2004; 18: 699-701.
    • (2004) FASEB J , vol.18 , pp. 699-701
    • Takei, Y.1    Maruyama, A.2    Ferdous, A.3
  • 68
    • 0032956746 scopus 로고    scopus 로고
    • Gene transfer with synthetic virus-like particles via the integrin-mediated endocytosis pathway
    • Erbacher P, Remy JS, Behr JP. Gene transfer with synthetic virus-like particles via the integrin-mediated endocytosis pathway. Gene Ther 1999; 6: 138-45.
    • (1999) Gene Ther , vol.6 , pp. 138-145
    • Erbacher, P.1    Remy, J.S.2    Behr, J.P.3
  • 69
    • 0035131596 scopus 로고    scopus 로고
    • Polyethylenimine/DNA complexes shielded by transferrin target gene expression to tumors after systemic application
    • Kircheis R, Wightman L, Schreiber A et al. Polyethylenimine/DNA complexes shielded by transferrin target gene expression to tumors after systemic application. Gene Ther 2001; 8: 28-40.
    • (2001) Gene Ther , vol.8 , pp. 28-40
    • Kircheis, R.1    Wightman, L.2    Schreiber, A.3
  • 70
    • 0037072555 scopus 로고    scopus 로고
    • Folate-mediated delivery of macromolecular anticancer therapeutic agents
    • Lu Y, Low PS. Folate-mediated delivery of macromolecular anticancer therapeutic agents. Adv Drug Deliv Rev 2002; 54: 675-93.
    • (2002) Adv Drug Deliv Rev , vol.54 , pp. 675-693
    • Lu, Y.1    Low, P.S.2
  • 72
    • 0642336863 scopus 로고    scopus 로고
    • Antibody targeted gene transfer to endothelium
    • Tan PH, Manunta M, Ardjomand N et al. Antibody targeted gene transfer to endothelium. J Gene Med 2003; 5: 311-23.
    • (2003) J Gene Med , vol.5 , pp. 311-323
    • Tan, P.H.1    Manunta, M.2    Ardjomand, N.3
  • 73
    • 1342290209 scopus 로고    scopus 로고
    • Nerve growth factor receptor-mediated gene transfer
    • Ma N, Wu SS, Ma YX et al. Nerve growth factor receptor-mediated gene transfer. Mol Ther 2004; 9: 270-81.
    • (2004) Mol Ther , vol.9 , pp. 270-281
    • Ma, N.1    Wu, S.S.2    Ma, Y.X.3
  • 74
    • 12344338629 scopus 로고    scopus 로고
    • CTb targeted non-viral cDNA delivery enhances transgene expression in neurons
    • Barrett LB, Berry M, Ying WB et al. CTb targeted non-viral cDNA delivery enhances transgene expression in neurons. J Gene Med 2004; 6: 429-38.
    • (2004) J Gene Med , vol.6 , pp. 429-438
    • Barrett, L.B.1    Berry, M.2    Ying, W.B.3
  • 75
    • 0023811723 scopus 로고
    • Receptor-mediated gene delivery and expression in vivo
    • Wu GY, Wu CH. Receptor-mediated gene delivery and expression in vivo. J Biol Chem 1988; 263: 14621-4.
    • (1988) J Biol Chem , vol.263 , pp. 14621-14624
    • Wu, G.Y.1    Wu, C.H.2
  • 76
    • 34247143765 scopus 로고    scopus 로고
    • Bifunctional compounds for targeted hepatic gene delivery
    • Kim KS, Lei Y, Stolz DB, Liu D. Bifunctional compounds for targeted hepatic gene delivery. Gene Ther 2007; 14: 704-8.
    • (2007) Gene Ther , vol.14 , pp. 704-708
    • Kim, K.S.1    Lei, Y.2    Stolz, D.B.3    Liu, D.4
  • 77
    • 0032805251 scopus 로고    scopus 로고
    • Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA
    • Liu F, Song Y, Liu D. Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA. Gene Ther 1999; 6: 1258-66.
    • (1999) Gene Ther , vol.6 , pp. 1258-1266
    • Liu, F.1    Song, Y.2    Liu, D.3
  • 78
    • 0029382060 scopus 로고
    • Gene transfer by jet injection into differentiated tissues of living animals and in organ culture
    • Furth PA, Kerr D, Wall R. Gene transfer by jet injection into differentiated tissues of living animals and in organ culture. Mol Biotechnol 1995; 4: 121-7.
    • (1995) Mol Biotechnol , vol.4 , pp. 121-127
    • Furth, P.A.1    Kerr, D.2    Wall, R.3
  • 79
    • 33645455926 scopus 로고    scopus 로고
    • In vivo liver electroporation: Optimization and demonstration of therapeutic efficacy
    • Jaichandran S, Yap ST, Khoo AB, Ho LP, Tien SL, Kon OL. In vivo liver electroporation: Optimization and demonstration of therapeutic efficacy. Hum Gene Ther 2006; 17: 362-75.
    • (2006) Hum Gene Ther , vol.17 , pp. 362-375
    • Jaichandran, S.1    Yap, S.T.2    Khoo, A.B.3    Ho, L.P.4    Tien, S.L.5    Kon, O.L.6
  • 80
    • 0033693268 scopus 로고    scopus 로고
    • Ultrasound enhancement of cationic lipid-mediated gene transfer to primary tumors following systemic administration
    • Anwer K, Kao G, Proctor B et al. Ultrasound enhancement of cationic lipid-mediated gene transfer to primary tumors following systemic administration. Gene Ther 2000; 7: 1833-9.
    • (2000) Gene Ther , vol.7 , pp. 1833-1839
    • Anwer, K.1    Kao, G.2    Proctor, B.3
  • 81
    • 0018193856 scopus 로고
    • Magnetic microspheres: A model system of site specific drug delivery in vivo
    • Widder KJ, Senyel AE, Scarpelli GD. Magnetic microspheres: A model system of site specific drug delivery in vivo. Proc Soc Exp Biol Med 1978; 158: 141-6.
    • (1978) Proc Soc Exp Biol Med , vol.158 , pp. 141-146
    • Widder, K.J.1    Senyel, A.E.2    Scarpelli, G.D.3
  • 82
    • 35948985930 scopus 로고    scopus 로고
    • Femtosecond laser: A new intradermal DNA delivery method for efficient, long-term gene expression and genetic immunization
    • Zeira E, Manevitch A, Manevitch Z et al. Femtosecond laser: A new intradermal DNA delivery method for efficient, long-term gene expression and genetic immunization. FASEB J 2007; 21: 3522-33.
    • (2007) FASEB J , vol.21 , pp. 3522-3533
    • Zeira, E.1    Manevitch, A.2    Manevitch, Z.3
  • 83
    • 0035117313 scopus 로고    scopus 로고
    • Non-viral in vivo gene delivery into tumors using a novel low volume jet-injection technology
    • Walther W, Stein U, Fichtner I, Malcherek L, Lemm M, Schlag PM. Non-viral in vivo gene delivery into tumors using a novel low volume jet-injection technology. Gene Ther 2001; 8: 173-80.
    • (2001) Gene Ther , vol.8 , pp. 173-180
    • Walther, W.1    Stein, U.2    Fichtner, I.3    Malcherek, L.4    Lemm, M.5    Schlag, P.M.6
  • 84
  • 85
    • 0033166561 scopus 로고    scopus 로고
    • High levels of foreign gene expression in hepatocytes after tail vein injections of naked plasmid DNA
    • Zhang G, Budker V, Wolff JA. High levels of foreign gene expression in hepatocytes after tail vein injections of naked plasmid DNA. Hum Gene Ther 1999; 10: 1735-7.
    • (1999) Hum Gene Ther , vol.10 , pp. 1735-1737
    • Zhang, G.1    Budker, V.2    Wolff, J.A.3
  • 86
    • 0029070955 scopus 로고
    • A mechanistic study of ultrasonically-enhanced transdermal drug delivery
    • Mitragotri S, Edwards DA, Blankschtein D, Langer R. A mechanistic study of ultrasonically-enhanced transdermal drug delivery. J Pharm Sci 1995; 84: 697-706.
    • (1995) J Pharm Sci , vol.84 , pp. 697-706
    • Mitragotri, S.1    Edwards, D.A.2    Blankschtein, D.3    Langer, R.4
  • 87
    • 13644257020 scopus 로고    scopus 로고
    • Insights into the mechanism of magnetofection using PEI-based magnetofectins for gene transfer
    • Huth S, Lausier J, Gersting SW etal. Insights into the mechanism of magnetofection using PEI-based magnetofectins for gene transfer. J Gene Med 2004; 6: 923-36.
    • (2004) J Gene Med , vol.6 , pp. 923-936
    • Huth, S.1    Lausier, J.2    Gersting, S.W.3
  • 88
    • 0020339802 scopus 로고
    • Gene transfer into mouse lyoma cells by electroporation in high electric fields
    • Neumann E, Schaefer Ridder M, Wang Y, Hofschneider PH. Gene transfer into mouse lyoma cells by electroporation in high electric fields. EMBO J 1982; 1: 841-5.
    • (1982) EMBO J , vol.1 , pp. 841-845
    • Neumann, E.1    Schaefer Ridder, M.2    Wang, Y.3    Hofschneider, P.H.4
  • 89
    • 10744227154 scopus 로고    scopus 로고
    • Femtosecond infrared laser-an efficient and safe in vivo gene delivery system for prolonged expression
    • Zeira E, Manevitch A, Khatchatouriants A et al. Femtosecond infrared laser-an efficient and safe in vivo gene delivery system for prolonged expression. Mol Ther 2003; 8: 342-50.
    • (2003) Mol Ther , vol.8 , pp. 342-350
    • Zeira, E.1    Manevitch, A.2    Khatchatouriants, A.3
  • 90
    • 0033559618 scopus 로고    scopus 로고
    • Photochemical internalization: A novel technology for delivery of macromolecules into cytosol
    • Berg K, Selbo PK, Prasmickaite L et al. Photochemical internalization: A novel technology for delivery of macromolecules into cytosol. Cancer Res 1999; 59: 1180-3.
    • (1999) Cancer Res , vol.59 , pp. 1180-1183
    • Berg, K.1    Selbo, P.K.2    Prasmickaite, L.3
  • 91
    • 0034775290 scopus 로고    scopus 로고
    • Ribozyme-mediated telomerase inhibition induces immediate cell loss but not telomere shortening in ovarian cancer cells
    • Saretzki G, Ludwig A, von Zglinicki T, Runnebaum IB. Ribozyme-mediated telomerase inhibition induces immediate cell loss but not telomere shortening in ovarian cancer cells. Cancer Gene Ther 2001; 8: 827-34.
    • (2001) Cancer Gene Ther , vol.8 , pp. 827-834
    • Saretzki, G.1    Ludwig, A.2    von Zglinicki, T.3    Runnebaum, I.B.4
  • 92
    • 33646564091 scopus 로고    scopus 로고
    • Adenovirus-mediated transfer of siRNA against PTTG1 inhibits liver cancer cell growth in vitro and in vivo
    • Cho Rok J, Yoo J, Jang YJ etal. Adenovirus-mediated transfer of siRNA against PTTG1 inhibits liver cancer cell growth in vitro and in vivo. Hepatology 2006; 43: 1042-52.
    • (2006) Hepatology , vol.43 , pp. 1042-1052
    • Cho Rok, J.1    Yoo, J.2    Jang, Y.J.3
  • 93
    • 0036320613 scopus 로고    scopus 로고
    • Gene therapy by intrahepatic and intratumoral trafficking of p53-VP22 induces regression of liver tumors
    • Zender L, Kock R, Eckhard M et al. Gene therapy by intrahepatic and intratumoral trafficking of p53-VP22 induces regression of liver tumors. Gastroenterology 2002; 123: 608-18.
    • (2002) Gastroenterology , vol.123 , pp. 608-618
    • Zender, L.1    Kock, R.2    Eckhard, M.3
  • 94
    • 0035042611 scopus 로고    scopus 로고
    • SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity
    • Yoshikawa H, Matsubara K, Qian GS et al. SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity. Nat Genet 2001; 28: 29-35.
    • (2001) Nat Genet , vol.28 , pp. 29-35
    • Yoshikawa, H.1    Matsubara, K.2    Qian, G.S.3
  • 95
    • 0037308653 scopus 로고    scopus 로고
    • Regional delivery and selective expression of a high-activity yeast cytosine deaminase in an intrahepatic colon cancer model
    • Zhang M, Li S, Nyati MK et al. Regional delivery and selective expression of a high-activity yeast cytosine deaminase in an intrahepatic colon cancer model. Cancer Res 2003; 63: 658-63.
    • (2003) Cancer Res , vol.63 , pp. 658-663
    • Zhang, M.1    Li, S.2    Nyati, M.K.3
  • 96
    • 7444221297 scopus 로고    scopus 로고
    • Long-term radioiodine retention and regression of liver cancer after sodium iodide symporter gene transfer in wistar rats
    • Faivre J, Clerc J, Gerolami R et al. Long-term radioiodine retention and regression of liver cancer after sodium iodide symporter gene transfer in wistar rats. Cancer Res 2004; 64: 8045-51.
    • (2004) Cancer Res , vol.64 , pp. 8045-8051
    • Faivre, J.1    Clerc, J.2    Gerolami, R.3
  • 97
    • 0034035078 scopus 로고    scopus 로고
    • Selective inhibition of hepatoma cells using diphtheria toxin A under the control of the promoter/enhancer region of the human alpha-fetoprotein gene
    • Kunitomi M, Takayama E, Suzuki S et al. Selective inhibition of hepatoma cells using diphtheria toxin A under the control of the promoter/ enhancer region of the human alpha-fetoprotein gene. Jpn J Cancer Res 2000; 91: 343-50.
    • (2000) Jpn J Cancer Res , vol.91 , pp. 343-350
    • Kunitomi, M.1    Takayama, E.2    Suzuki, S.3
  • 98
    • 19044397444 scopus 로고    scopus 로고
    • Fiber-modified adenoviral vector expressing the tumor necrosis factor-related apoptosis-inducing ligand gene from the human telomerase reverse transcriptase promoter induces apoptosis in human hepatocellular carcinoma cells
    • Jacob D, Schumacher G, Bahra M et al. Fiber-modified adenoviral vector expressing the tumor necrosis factor-related apoptosis-inducing ligand gene from the human telomerase reverse transcriptase promoter induces apoptosis in human hepatocellular carcinoma cells. World J Gastroenterol 2005; 11: 2552-6.
    • (2005) World J Gastroenterol , vol.11 , pp. 2552-2556
    • Jacob, D.1    Schumacher, G.2    Bahra, M.3
  • 99
    • 1642430704 scopus 로고    scopus 로고
    • Antisense oligonucleotide-based therapeutics for cancer
    • Dean NM, Bennett CF. Antisense oligonucleotide-based therapeutics for cancer. Oncogene 2003; 22: 9087-96.
    • (2003) Oncogene , vol.22 , pp. 9087-9096
    • Dean, N.M.1    Bennett, C.F.2
  • 100
    • 20444498521 scopus 로고    scopus 로고
    • Use of adenovirus-delivered siRNA to target oncoprotein p28GANK in hepatocellular carcinoma
    • Li H, Fu X, Chen Y et al. Use of adenovirus-delivered siRNA to target oncoprotein p28GANK in hepatocellular carcinoma. Gastroenterology 2005; 128: 2029-41.
    • (2005) Gastroenterology , vol.128 , pp. 2029-2041
    • Li, H.1    Fu, X.2    Chen, Y.3
  • 101
    • 34547487035 scopus 로고    scopus 로고
    • Lentivirus-mediated RNA interference targeting enhancer of zeste homolog 2 inhibits hepatocellular carcinoma growth through down-regulation of stathmin
    • Chen Y, Lin MC, Yao H et al. Lentivirus-mediated RNA interference targeting enhancer of zeste homolog 2 inhibits hepatocellular carcinoma growth through down-regulation of stathmin. Hepatology 2007; 46: 200-8.
    • (2007) Hepatology , vol.46 , pp. 200-208
    • Chen, Y.1    Lin, M.C.2    Yao, H.3
  • 102
    • 0036789367 scopus 로고    scopus 로고
    • Reversal of drug resistance of hepatocellular carcinoma cells by adenoviral delivery of anti-MDR1 ribozymes
    • Huesker M, Folmer Y, Schneider M, Fulda C, Blum HE, Hafkemeyer P. Reversal of drug resistance of hepatocellular carcinoma cells by adenoviral delivery of anti-MDR1 ribozymes. Hepatology 2002; 36: 874-84.
    • (2002) Hepatology , vol.36 , pp. 874-884
    • Huesker, M.1    Folmer, Y.2    Schneider, M.3    Fulda, C.4    Blum, H.E.5    Hafkemeyer, P.6
  • 103
    • 35348903899 scopus 로고    scopus 로고
    • Adjuvant adenovirus-mediated delivery of herpes simplex virus thymidine kinase administration improves outcome of liver transplantation in patients with advanced hepatocellular carcinoma
    • Li N, Zhou J, Weng D et al. Adjuvant adenovirus-mediated delivery of herpes simplex virus thymidine kinase administration improves outcome of liver transplantation in patients with advanced hepatocellular carcinoma. Clin Cancer Res 2007; 13: 5847-54.
    • (2007) Clin Cancer Res , vol.13 , pp. 5847-5854
    • Li, N.1    Zhou, J.2    Weng, D.3
  • 104
    • 0032717286 scopus 로고    scopus 로고
    • Comparison of gene therapy with the herpes simplex virus thymidine kinase gene and the bacterial cytosine deaminase gene for the treatment of hepatocellular carcinoma
    • Kuriyama S, Mitoro A, Yamazaki M et al. Comparison of gene therapy with the herpes simplex virus thymidine kinase gene and the bacterial cytosine deaminase gene for the treatment of hepatocellular carcinoma. Scand J Gastroenterol 1999; 34: 1033-41.
    • (1999) Scand J Gastroenterol , vol.34 , pp. 1033-1041
    • Kuriyama, S.1    Mitoro, A.2    Yamazaki, M.3
  • 105
    • 0033692861 scopus 로고    scopus 로고
    • Adenovirus-interleukin-12-mediated tumor regression in a murine hepatocellular carcinoma model is not dependent on CD1-restricted natural killer T cells
    • Andrews KJ, Ribas A, Butterfield LH et al. Adenovirus-interleukin-12-mediated tumor regression in a murine hepatocellular carcinoma model is not dependent on CD1-restricted natural killer T cells. Cancer Res 2000; 60: 6457-64.
    • (2000) Cancer Res , vol.60 , pp. 6457-6464
    • Andrews, K.J.1    Ribas, A.2    Butterfield, L.H.3
  • 106
    • 0030766971 scopus 로고    scopus 로고
    • Effects of single-dose interleukin-12 exposure on interleukin-12-associated toxicity and interferon-gamma production
    • Leonard JP, Sherman ML, Fisher GL et al. Effects of single-dose interleukin-12 exposure on interleukin-12-associated toxicity and interferon-gamma production. Blood 1997; 90: 2541-8.
    • (1997) Blood , vol.90 , pp. 2541-2548
    • Leonard, J.P.1    Sherman, M.L.2    Fisher, G.L.3
  • 107
    • 0035197719 scopus 로고    scopus 로고
    • Gene therapy of orthotopic hepatocellular carcinoma in rats using adenovirus coding for interleukin 12
    • Barajas M, Mazzolini G, Genove G et al. Gene therapy of orthotopic hepatocellular carcinoma in rats using adenovirus coding for interleukin 12. Hepatology 2001; 33: 52-61.
    • (2001) Hepatology , vol.33 , pp. 52-61
    • Barajas, M.1    Mazzolini, G.2    Genove, G.3
  • 108
    • 16344387497 scopus 로고    scopus 로고
    • Low-dose adenoviral immunotherapy of rat hepatocellular carcinoma using single-chain interleukin-12
    • Waehler R, Ittrich H, Mueller L, Krupski G, Ameis D, Schnieders F. Low-dose adenoviral immunotherapy of rat hepatocellular carcinoma using single-chain interleukin-12. Hum Gene Ther 2005; 16: 307-17.
    • (2005) Hum Gene Ther , vol.16 , pp. 307-317
    • Waehler, R.1    Ittrich, H.2    Mueller, L.3    Krupski, G.4    Ameis, D.5    Schnieders, F.6
  • 109
    • 32944476780 scopus 로고    scopus 로고
    • Oral adeno-associated virus-sTRAIL gene therapy suppresses human hepatocellular carcinoma growth in mice
    • Ma H, Liu Y, Liu S, Xu R, Zheng D. Oral adeno-associated virus-sTRAIL gene therapy suppresses human hepatocellular carcinoma growth in mice. Hepatology 2005; 42: 1355-63.
    • (2005) Hepatology , vol.42 , pp. 1355-1363
    • Ma, H.1    Liu, Y.2    Liu, S.3    Xu, R.4    Zheng, D.5
  • 110
    • 0033769892 scopus 로고    scopus 로고
    • Mouse alpha-fetoprotein-specific DNA-based immunotherapy of hepatocellular carcinoma leads to tumor regression in mice
    • Grimm CF, Ortmann D, Mohr L et al. Mouse alpha-fetoprotein-specific DNA-based immunotherapy of hepatocellular carcinoma leads to tumor regression in mice. Gastroenterology 2000; 119: 1104-12.
    • (2000) Gastroenterology , vol.119 , pp. 1104-1112
    • Grimm, C.F.1    Ortmann, D.2    Mohr, L.3
  • 111
    • 0035893398 scopus 로고    scopus 로고
    • alpha-Fetoprotein-specific tumor immunity induced by plasmid prime-adenovirus boost genetic vaccination
    • Meng WS, Butterfield LH, Ribas A et al. alpha-Fetoprotein-specific tumor immunity induced by plasmid prime-adenovirus boost genetic vaccination. Cancer Res 2001; 61: 8782-6.
    • (2001) Cancer Res , vol.61 , pp. 8782-8786
    • Meng, W.S.1    Butterfield, L.H.2    Ribas, A.3
  • 112
    • 34247178955 scopus 로고    scopus 로고
    • alpha-fetoprotein and interleukin-18 gene-modified dendritic cells effectively stimulate specific type-1 CD4- and CD8-mediated T-Cell response from hepatocellular carcinoma patients in vitro
    • Cao DY, Yang JY, Dou KF, Ma LY, Teng ZH. alpha-fetoprotein and interleukin-18 gene-modified dendritic cells effectively stimulate specific type-1 CD4- and CD8-mediated T-Cell response from hepatocellular carcinoma patients in vitro. Hum Immunol 2007; 68: 334-41.
    • (2007) Hum Immunol , vol.68 , pp. 334-341
    • Cao, D.Y.1    Yang, J.Y.2    Dou, K.F.3    Ma, L.Y.4    Teng, Z.H.5
  • 113
    • 33747871572 scopus 로고    scopus 로고
    • Oncolytic efficacy and enhanced safety of measles virus activated by tumor-secreted matrix metalloproteinases
    • Springfeld C, von Messling V, Frenzke M, Ungerechts G, Buchholz CJ, Cattaneo R. Oncolytic efficacy and enhanced safety of measles virus activated by tumor-secreted matrix metalloproteinases. Cancer Res 2006; 66: 7694-700.
    • (2006) Cancer Res , vol.66 , pp. 7694-7700
    • Springfeld, C.1    von Messling, V.2    Frenzke, M.3    Ungerechts, G.4    Buchholz, C.J.5    Cattaneo, R.6
  • 114
    • 0037219258 scopus 로고    scopus 로고
    • An oncolytic measles virus engineered to enter cells through the CD20 antigen
    • Bucheit AD, Kumar S, Grote DM et al. An oncolytic measles virus engineered to enter cells through the CD20 antigen. Mol Ther 2003; 7: 62-72.
    • (2003) Mol Ther , vol.7 , pp. 62-72
    • Bucheit, A.D.1    Kumar, S.2    Grote, D.M.3
  • 115
    • 13844254649 scopus 로고    scopus 로고
    • Rescue and propagation of fully retargeted oncolytic measles viruses
    • Nakamura T, Peng KW, Harvey M et al. Rescue and propagation of fully retargeted oncolytic measles viruses. Nat Biotechnol 2005; 23: 209-14.
    • (2005) Nat Biotechnol , vol.23 , pp. 209-214
    • Nakamura, T.1    Peng, K.W.2    Harvey, M.3
  • 116
    • 34848845849 scopus 로고    scopus 로고
    • Polyethylene glycol modification of adenovirus reduces platelet activation, endothelial cell activation, and thrombocytopenia
    • Hofherr SE, Mok H, Gushiken FC, Lopez JA, Barry MA. Polyethylene glycol modification of adenovirus reduces platelet activation, endothelial cell activation, and thrombocytopenia. Hum Gene Ther 2007; 18: 837-48.
    • (2007) Hum Gene Ther , vol.18 , pp. 837-848
    • Hofherr, S.E.1    Mok, H.2    Gushiken, F.C.3    Lopez, J.A.4    Barry, M.A.5
  • 118
    • 34548391914 scopus 로고    scopus 로고
    • Understanding hereditary diseases using the dog and human as companion model systems
    • Tsai KL, Clark LA, Murphy KE. Understanding hereditary diseases using the dog and human as companion model systems. Mamm Genome 2007; 18: 444-51.
    • (2007) Mamm Genome , vol.18 , pp. 444-451
    • Tsai, K.L.1    Clark, L.A.2    Murphy, K.E.3
  • 119
    • 33745712832 scopus 로고    scopus 로고
    • Lentiviral gene transfer ameliorates disease progression in Long-Evans cinnamon rats: An animal model for Wilson disease
    • Merle U, Encke J, Tuma S, Volkmann M, Naldini L, Stremmel W. Lentiviral gene transfer ameliorates disease progression in Long-Evans cinnamon rats: An animal model for Wilson disease. Scand J Gastroenterol 2006; 41: 974-82.
    • (2006) Scand J Gastroenterol , vol.41 , pp. 974-982
    • Merle, U.1    Encke, J.2    Tuma, S.3    Volkmann, M.4    Naldini, L.5    Stremmel, W.6
  • 120
    • 32444436226 scopus 로고    scopus 로고
    • Long-term correction of murine glycogen storage disease type Ia by recombinant adeno-associated virus-1-mediated gene transfer
    • Ghosh A, Allamarvdasht M, Pan CJ et al. Long-term correction of murine glycogen storage disease type Ia by recombinant adeno-associated virus-1-mediated gene transfer. Gene Ther 2006; 13: 321-9.
    • (2006) Gene Ther , vol.13 , pp. 321-329
    • Ghosh, A.1    Allamarvdasht, M.2    Pan, C.J.3
  • 121
    • 33846488084 scopus 로고    scopus 로고
    • Glucose-6-phosphate transporter gene therapy corrects metabolic and myeloid abnormalities in glycogen storage disease type Ib mice
    • Yiu WH, Pan CJ, Allamarvdasht M, Kim SY, Chou JY. Glucose-6-phosphate transporter gene therapy corrects metabolic and myeloid abnormalities in glycogen storage disease type Ib mice. Gene Ther 2007; 14: 219-26.
    • (2007) Gene Ther , vol.14 , pp. 219-226
    • Yiu, W.H.1    Pan, C.J.2    Allamarvdasht, M.3    Kim, S.Y.4    Chou, J.Y.5
  • 122
    • 17644423927 scopus 로고    scopus 로고
    • Neonatal gene therapy of MPS I mice by intravenous injection of a lentiviral vector
    • Kobayashi H, Carbonaro D, Pepper K et al. Neonatal gene therapy of MPS I mice by intravenous injection of a lentiviral vector. Mol Ther 2005; 11: 776-89.
    • (2005) Mol Ther , vol.11 , pp. 776-789
    • Kobayashi, H.1    Carbonaro, D.2    Pepper, K.3
  • 123
    • 20544466985 scopus 로고    scopus 로고
    • Treatment of the mouse model of mucopolysaccharidosis type IIIB with lentiviral-NAGLU vector
    • Di Natale P, Di Domenico C, Gargiulo N et al. Treatment of the mouse model of mucopolysaccharidosis type IIIB with lentiviral-NAGLU vector. Biochem J 2005; 388: 639-46.
    • (2005) Biochem J , vol.388 , pp. 639-646
    • Di Natale, P.1    Di Domenico, C.2    Gargiulo, N.3
  • 124
    • 0036792035 scopus 로고    scopus 로고
    • Therapeutic neonatal hepatic gene therapy in mucopolysaccharidosis VII dogs
    • Ponder KP, Melniczek JR, Xu L et al. Therapeutic neonatal hepatic gene therapy in mucopolysaccharidosis VII dogs. Proc Natl Acad Sci USA 2002; 99: 13102-7.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 13102-13107
    • Ponder, K.P.1    Melniczek, J.R.2    Xu, L.3
  • 125
    • 0029875835 scopus 로고    scopus 로고
    • Hepatocytes corrected by gene therapy are selected in vivo in a murine model of hereditary tyrosinaemia type I
    • Overturf K, Al Dhalimy M, Tanguay R et al. Hepatocytes corrected by gene therapy are selected in vivo in a murine model of hereditary tyrosinaemia type I. Nat Genet 1996; 12: 266-73.
    • (1996) Nat Genet , vol.12 , pp. 266-273
    • Overturf, K.1    Al Dhalimy, M.2    Tanguay, R.3
  • 126
    • 0142181993 scopus 로고    scopus 로고
    • Long-term correction of bilirubin UDP glucuronyltransferase deficiency in rats by in utero lentiviral gene transfer
    • Seppen J, van der Rijt R, Looije N, van Til NP, Lamers WH, Oude Elferink RP. Long-term correction of bilirubin UDP glucuronyltransferase deficiency in rats by in utero lentiviral gene transfer. Mol Ther 2003; 8: 593-9.
    • (2003) Mol Ther , vol.8 , pp. 593-599
    • Seppen, J.1    van der Rijt, R.2    Looije, N.3    van Til, N.P.4    Lamers, W.H.5    Oude Elferink, R.P.6
  • 127
    • 0034950612 scopus 로고    scopus 로고
    • Long-term and therapeutic-level hepatic gene expression of human factor IX after naked plasmid transfer in vivo
    • Miao CH, Thompson AR, Loeb K, Ye X. Long-term and therapeutic-level hepatic gene expression of human factor IX after naked plasmid transfer in vivo. Mol Ther 2001; 3: 947-57.
    • (2001) Mol Ther , vol.3 , pp. 947-957
    • Miao, C.H.1    Thompson, A.R.2    Loeb, K.3    Ye, X.4
  • 128
    • 0141818965 scopus 로고    scopus 로고
    • Complete and sustained phenotypic correction of hemophilia B in mice following hepatic gene transfer of a high-expressing human factor IX plasmid
    • Ye X, Loeb KR, Stafford DW, Thompson AR, Miao CH. Complete and sustained phenotypic correction of hemophilia B in mice following hepatic gene transfer of a high-expressing human factor IX plasmid. J Thromb Haemost 2003; 1: 103-11.
    • (2003) J Thromb Haemost , vol.1 , pp. 103-111
    • Ye, X.1    Loeb, K.R.2    Stafford, D.W.3    Thompson, A.R.4    Miao, C.H.5
  • 129
    • 17444387438 scopus 로고    scopus 로고
    • Long-term correction of canine hemophilia B by gene transfer of blood coagulation factor IX mediated by adeno-associated viral vector
    • Herzog RW, Yang EY, Couto LB et al. Long-term correction of canine hemophilia B by gene transfer of blood coagulation factor IX mediated by adeno-associated viral vector. Nat Med 1999; 5: 56-63.
    • (1999) Nat Med , vol.5 , pp. 56-63
    • Herzog, R.W.1    Yang, E.Y.2    Couto, L.B.3
  • 130
    • 3042815553 scopus 로고    scopus 로고
    • Naked DNA transfer of Factor VIII induced transgene-specific, species-independent immune response in hemophilia A mice
    • Ye P, Thompson AR, Sarkar R et al. Naked DNA transfer of Factor VIII induced transgene-specific, species-independent immune response in hemophilia A mice. Mol Ther 2004; 10: 117-26.
    • (2004) Mol Ther , vol.10 , pp. 117-126
    • Ye, P.1    Thompson, A.R.2    Sarkar, R.3
  • 131
    • 5444227748 scopus 로고    scopus 로고
    • Permanent phenotypic correction of hemophilia B in immunocompetent mice by prenatal gene therapy
    • Waddington SN, Nivsarkar MS, Mistry AR et al. Permanent phenotypic correction of hemophilia B in immunocompetent mice by prenatal gene therapy. Blood 2004; 104: 2714-21.
    • (2004) Blood , vol.104 , pp. 2714-2721
    • Waddington, S.N.1    Nivsarkar, M.S.2    Mistry, A.R.3
  • 132
    • 0035937315 scopus 로고    scopus 로고
    • Intercellular transfer of the virally derived precursor form of acid alpha-glucosidase corrects the enzyme deficiency in inherited cardioskeletal myopathy Pompe disease
    • Pauly DF, Fraites TJ, Toma C et al. Intercellular transfer of the virally derived precursor form of acid alpha-glucosidase corrects the enzyme deficiency in inherited cardioskeletal myopathy Pompe disease. Hum Gene Ther 2001; 12: 527-38.
    • (2001) Hum Gene Ther , vol.12 , pp. 527-538
    • Pauly, D.F.1    Fraites, T.J.2    Toma, C.3
  • 133
    • 10944239670 scopus 로고    scopus 로고
    • Efficacy of an adeno-associated virus 8-pseudotyped vector in glycogen storage disease type II
    • Sun B, Zhang H, Franco LM et al. Efficacy of an adeno-associated virus 8-pseudotyped vector in glycogen storage disease type II. Mol Ther 2005; 11: 57-65.
    • (2005) Mol Ther , vol.11 , pp. 57-65
    • Sun, B.1    Zhang, H.2    Franco, L.M.3
  • 134
    • 0041346233 scopus 로고    scopus 로고
    • Normalization of growth in hypophysectomized mice using hydrodynamic transfer of the human growth hormone gene
    • Sondergaard M, Dagnaes-Hansen F, Flyvbjerg A, Jensen TG. Normalization of growth in hypophysectomized mice using hydrodynamic transfer of the human growth hormone gene. Am J Physiol Endocrinol Metab 2003; 285: E427-32.
    • (2003) Am J Physiol Endocrinol Metab , vol.285
    • Sondergaard, M.1    Dagnaes-Hansen, F.2    Flyvbjerg, A.3    Jensen, T.G.4
  • 135
    • 27344439351 scopus 로고    scopus 로고
    • Complete and persistent phenotypic correction of phenylketonuria in mice by site-specific genome integration of murine phenylalanine hydroxylase cDNA
    • Chen L, Woo SL. Complete and persistent phenotypic correction of phenylketonuria in mice by site-specific genome integration of murine phenylalanine hydroxylase cDNA. Proc Natl Acad Sci USA 2005; 102: 15581-6.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 15581-15586
    • Chen, L.1    Woo, S.L.2
  • 136
    • 0031903608 scopus 로고    scopus 로고
    • Developing adenoviral-mediated in vivo gene therapy for ornithine transcarbamylase deficiency
    • Raper SE, Wilson JM, Yudkoff M, Robinson MB, Ye X, Batshaw ML. Developing adenoviral-mediated in vivo gene therapy for ornithine transcarbamylase deficiency. J Inherit Metab Dis 1998; 21 (Suppl 1): 119-37.
    • (1998) J Inherit Metab Dis , vol.21 , Issue.SUPPL. 1 , pp. 119-137
    • Raper, S.E.1    Wilson, J.M.2    Yudkoff, M.3    Robinson, M.B.4    Ye, X.5    Batshaw, M.L.6
  • 137
    • 20544474017 scopus 로고    scopus 로고
    • An apolipoprotein B antisense oligonucleotide lowers LDL cholesterol in hyperlipidemic mice without causing hepatic steatosis
    • Crooke RM, Graham MJ, Lemonidis KM, Whipple CP, Koo S, Perera RJ. An apolipoprotein B antisense oligonucleotide lowers LDL cholesterol in hyperlipidemic mice without causing hepatic steatosis. J Lipid Res 2005; 46: 872-84.
    • (2005) J Lipid Res , vol.46 , pp. 872-884
    • Crooke, R.M.1    Graham, M.J.2    Lemonidis, K.M.3    Whipple, C.P.4    Koo, S.5    Perera, R.J.6
  • 138
    • 0035818555 scopus 로고    scopus 로고
    • Lifetime correction of genetic deficiency in mice with a single injection of helper-dependent adenoviral vector
    • Kim IH, Jozkowicz A, Piedra PA, Oka K, Chan L. Lifetime correction of genetic deficiency in mice with a single injection of helper-dependent adenoviral vector. Proc Natl Acad Sci USA 2001; 98: 13282-7.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 13282-13287
    • Kim, I.H.1    Jozkowicz, A.2    Piedra, P.A.3    Oka, K.4    Chan, L.5
  • 139
    • 33846554963 scopus 로고    scopus 로고
    • Sustained phenotypic correction in a mouse model of hypoalphalipoproteinemia with a helper-dependent adenovirus vector
    • Oka K, Belalcazar LM, Dieker C et al. Sustained phenotypic correction in a mouse model of hypoalphalipoproteinemia with a helper-dependent adenovirus vector. Gene Ther 2007; 14: 191-202.
    • (2007) Gene Ther , vol.14 , pp. 191-202
    • Oka, K.1    Belalcazar, L.M.2    Dieker, C.3
  • 140
    • 0038023197 scopus 로고    scopus 로고
    • Inhibition of hepatitis B virus in mice by RNA interference
    • McCaffrey AP, Nakai H, Pandey K et al. Inhibition of hepatitis B virus in mice by RNA interference. Nat Biotechnol 2003; 21: 639-44.
    • (2003) Nat Biotechnol , vol.21 , pp. 639-644
    • McCaffrey, A.P.1    Nakai, H.2    Pandey, K.3
  • 142
    • 12144289381 scopus 로고    scopus 로고
    • Alternative approaches for efficient inhibition of hepatitis C virus RNA replication by small interfering RNAs
    • Kronke J, Kittler R, Buchholz F et al. Alternative approaches for efficient inhibition of hepatitis C virus RNA replication by small interfering RNAs. J Virol 2004; 78: 3436-46.
    • (2004) J Virol , vol.78 , pp. 3436-3446
    • Kronke, J.1    Kittler, R.2    Buchholz, F.3
  • 143
    • 24644483623 scopus 로고    scopus 로고
    • Modulation of hepatitis C virus RNA abundance by a liver-specific MicroRNA
    • Jopling CL, Yi M, Lancaster AM, Lemon SM, Sarnow P. Modulation of hepatitis C virus RNA abundance by a liver-specific MicroRNA. Science 2005; 309: 1577-81.
    • (2005) Science , vol.309 , pp. 1577-1581
    • Jopling, C.L.1    Yi, M.2    Lancaster, A.M.3    Lemon, S.M.4    Sarnow, P.5
  • 144
    • 44349178186 scopus 로고    scopus 로고
    • Expressed anti-HBV primary microRNA shuttles inhibit viral replication efficiently in vitro and in vivo
    • Ely A, Naidoo T, Mufamadi S, Crowther C, Arbuthnot P. Expressed anti-HBV primary microRNA shuttles inhibit viral replication efficiently in vitro and in vivo. Mol Ther 2008; 16: 1105-12.
    • (2008) Mol Ther , vol.16 , pp. 1105-1112
    • Ely, A.1    Naidoo, T.2    Mufamadi, S.3    Crowther, C.4    Arbuthnot, P.5
  • 145
    • 33646188259 scopus 로고    scopus 로고
    • 3′UTR seed matches, but not overall identity, are associated with RNAi off-targets
    • Birmingham A, Anderson EM, Reynolds A et al. 3′UTR seed matches, but not overall identity, are associated with RNAi off-targets. Nat Methods 2006; 3: 199-204.
    • (2006) Nat Methods , vol.3 , pp. 199-204
    • Birmingham, A.1    Anderson, E.M.2    Reynolds, A.3
  • 146
    • 0037348329 scopus 로고    scopus 로고
    • RNA interference targeting Fas protects mice from fulminant hepatitis
    • Song E, Lee S-K, Wang J et al. RNA interference targeting Fas protects mice from fulminant hepatitis. Nat Med 2003; 9: 347-51.
    • (2003) Nat Med , vol.9 , pp. 347-351
    • Song, E.1    Lee, S.-K.2    Wang, J.3
  • 147
    • 40049097359 scopus 로고    scopus 로고
    • Liver cirrhosis
    • Schuppan D, Afdhal NH. Liver cirrhosis. Lancet 2008; 371: 838-51.
    • (2008) Lancet , vol.371 , pp. 838-851
    • Schuppan, D.1    Afdhal, N.H.2
  • 148
    • 42949163491 scopus 로고    scopus 로고
    • Mechanisms of hepatic fibrogenesis
    • Friedman SL. Mechanisms of hepatic fibrogenesis. Gastroenterology 2008; 134: 1655-69.
    • (2008) Gastroenterology , vol.134 , pp. 1655-1669
    • Friedman, S.L.1
  • 149
    • 0033607304 scopus 로고    scopus 로고
    • In vivo inhibition of rat stellate cell activation by soluble transforming growth factor beta type II receptor: A potential new therapy for hepatic fibrosis
    • George J, Roulot D, Koteliansky VE, Bissell DM. In vivo inhibition of rat stellate cell activation by soluble transforming growth factor beta type II receptor: A potential new therapy for hepatic fibrosis. Proc Natl Acad Sci USA 1999; 96: 12719-24.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 12719-12724
    • George, J.1    Roulot, D.2    Koteliansky, V.E.3    Bissell, D.M.4
  • 150
    • 0032903634 scopus 로고    scopus 로고
    • Hepatocyte growth factor gene therapy of liver cirrhosis in rats
    • Ueki T, Kaneda Y, Tsutsui H et al. Hepatocyte growth factor gene therapy of liver cirrhosis in rats. Nat Med 1999; 5: 226-30.
    • (1999) Nat Med , vol.5 , pp. 226-230
    • Ueki, T.1    Kaneda, Y.2    Tsutsui, H.3
  • 151
    • 4243344912 scopus 로고    scopus 로고
    • PDGF and signal transduction in hepatic stellate cells
    • Pinzani M. PDGF and signal transduction in hepatic stellate cells. Front Biosci 2002; 7: D1720-6.
    • (2002) Front Biosci , vol.7
    • Pinzani, M.1
  • 152
    • 23044485967 scopus 로고    scopus 로고
    • rAAV-mediated stable expression of heme oxygenase-1 in stellate cells: A new approach to attenuate liver fibrosis in rats
    • Tsui TY, Lau CK, Ma J et al. rAAV-mediated stable expression of heme oxygenase-1 in stellate cells: A new approach to attenuate liver fibrosis in rats. Hepatology 2005; 42: 335-42.
    • (2005) Hepatology , vol.42 , pp. 335-342
    • Tsui, T.Y.1    Lau, C.K.2    Ma, J.3
  • 153
    • 0034567343 scopus 로고    scopus 로고
    • Liver cirrhosis is reverted by urokinase-type plasminogen activator gene therapy
    • Salgado S, Garcia J, Vera J et al. Liver cirrhosis is reverted by urokinase-type plasminogen activator gene therapy. Mol Ther 2000; 2: 545-51.
    • (2000) Mol Ther , vol.2 , pp. 545-551
    • Salgado, S.1    Garcia, J.2    Vera, J.3
  • 154
    • 41849117310 scopus 로고    scopus 로고
    • Resolution of liver cirrhosis using vitamin A-coupled liposomes to deliver siRNA against a collagen-specific chaperone
    • Sato Y, Murase K, Kato J et al. Resolution of liver cirrhosis using vitamin A-coupled liposomes to deliver siRNA against a collagen-specific chaperone. Nat Biotechnol 2008; 26: 431-42.
    • (2008) Nat Biotechnol , vol.26 , pp. 431-442
    • Sato, Y.1    Murase, K.2    Kato, J.3
  • 155
    • 0037423865 scopus 로고    scopus 로고
    • Gene transfer of extracellular superoxide dismutase reduces arterial pressure in spontaneously hypertensive rats: Role of heparin-binding domain
    • Chu Y, Iida S, Lund DD et al. Gene transfer of extracellular superoxide dismutase reduces arterial pressure in spontaneously hypertensive rats: role of heparin-binding domain. Circ Res 2003; 92: 461-8.
    • (2003) Circ Res , vol.92 , pp. 461-468
    • Chu, Y.1    Iida, S.2    Lund, D.D.3
  • 156
    • 23744447639 scopus 로고    scopus 로고
    • Gene transfer of extracellular superoxide dismutase improves endothelial function in rats with heart failure
    • Iida S, Chu Y, Francis J et al. Gene transfer of extracellular superoxide dismutase improves endothelial function in rats with heart failure. Am J Physiol Heart Circ Physiol 2005; 289: H525-32.
    • (2005) Am J Physiol Heart Circ Physiol , vol.289
    • Iida, S.1    Chu, Y.2    Francis, J.3
  • 157
    • 2442696806 scopus 로고    scopus 로고
    • Virus-directed enzyme prodrug therapy: Intratumoral administration of a replication-deficient adenovirus encoding nitroreductase to patients with resectable liver cancer
    • Palmer DH, Mautner V, Mirza D et al. Virus-directed enzyme prodrug therapy: Intratumoral administration of a replication-deficient adenovirus encoding nitroreductase to patients with resectable liver cancer. J Clin Oncol 2004; 22: 1546-52.
    • (2004) J Clin Oncol , vol.22 , pp. 1546-1552
    • Palmer, D.H.1    Mautner, V.2    Mirza, D.3
  • 158
    • 2342570309 scopus 로고    scopus 로고
    • Phase I trial of intratumoral injection of an adenovirus encoding interleukin-12 for advanced digestive tumors
    • Sangro B, Mazzolini G, Ruiz J et al. Phase I trial of intratumoral injection of an adenovirus encoding interleukin-12 for advanced digestive tumors. J Clin Oncol 2004; 22: 1389-97.
    • (2004) J Clin Oncol , vol.22 , pp. 1389-1397
    • Sangro, B.1    Mazzolini, G.2    Ruiz, J.3
  • 159
    • 0033543077 scopus 로고    scopus 로고
    • A phase I/II study of hepatic artery infusion with wtp53-CMV-Ad in metastatic malignant liver tumours
    • Habib NA, Hodgson HJ, Lemoine N, Pignatelli M. A phase I/II study of hepatic artery infusion with wtp53-CMV-Ad in metastatic malignant liver tumours. Hum Gene Ther 1999; 10: 2019-34.
    • (1999) Hum Gene Ther , vol.10 , pp. 2019-2034
    • Habib, N.A.1    Hodgson, H.J.2    Lemoine, N.3    Pignatelli, M.4
  • 160
    • 0034841686 scopus 로고    scopus 로고
    • Intratumoral adenovirus-mediated suicide gene transfer for hepatic metastases from colorectal adenocarcinoma: Results of a phase I clinical trial
    • Sung MW, Yeh HC, Thung SN et al. Intratumoral adenovirus-mediated suicide gene transfer for hepatic metastases from colorectal adenocarcinoma: Results of a phase I clinical trial. Mol Ther 2001; 4: 182-91.
    • (2001) Mol Ther , vol.4 , pp. 182-191
    • Sung, M.W.1    Yeh, H.C.2    Thung, S.N.3
  • 161
    • 8244224532 scopus 로고    scopus 로고
    • Phase I study of immunotherapy of hepatic metastases of colorectal carcinoma by direct gene transfer of an allogeneic histocompatibility antigen, HLA-B7
    • Rubin J, Galanis E, Pitot HC etal. Phase I study of immunotherapy of hepatic metastases of colorectal carcinoma by direct gene transfer of an allogeneic histocompatibility antigen, HLA-B7. Gene Ther 1997; 4: 419-25.
    • (1997) Gene Ther , vol.4 , pp. 419-425
    • Rubin, J.1    Galanis, E.2    Pitot, H.C.3
  • 162
    • 0034885426 scopus 로고    scopus 로고
    • Phase II study of direct intralesional gene transfer of allovectin-7, an HLA-B7/beta2-microglobulin DNA-liposome complex, in patients with metastatic melanoma
    • Stopeck AT, Jones A, Hersh EM et al. Phase II study of direct intralesional gene transfer of allovectin-7, an HLA-B7/ beta2-microglobulin DNA-liposome complex, in patients with metastatic melanoma. Clin Cancer Res 2001; 7: 2285-91.
    • (2001) Clin Cancer Res , vol.7 , pp. 2285-2291
    • Stopeck, A.T.1    Jones, A.2    Hersh, E.M.3
  • 163
    • 34548277477 scopus 로고    scopus 로고
    • A phase I clinical trial of an adenovirus-mediated endostatin gene (E10A) in patients with solid tumors
    • Lin X, Huang H, Li S et al. A phase I clinical trial of an adenovirus-mediated endostatin gene (E10A) in patients with solid tumors. Cancer Biol Ther 2007; 6: 648-53.
    • (2007) Cancer Biol Ther , vol.6 , pp. 648-653
    • Lin, X.1    Huang, H.2    Li, S.3
  • 164
    • 33644820684 scopus 로고    scopus 로고
    • Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response
    • Manno CS, Pierce GF, Arruda VR et al. Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response. Nat Med 2006; 12: 342-7.
    • (2006) Nat Med , vol.12 , pp. 342-347
    • Manno, C.S.1    Pierce, G.F.2    Arruda, V.R.3
  • 165
    • 0036145350 scopus 로고    scopus 로고
    • A pilot study of in vivo liver-directed gene transfer with an adenoviral vector in partial ornithine transcarbamylase deficiency
    • Raper SE, Yudkoff M, Chirmule N et al. A pilot study of in vivo liver-directed gene transfer with an adenoviral vector in partial ornithine transcarbamylase deficiency. Hum Gene Ther 2002; 13: 163-75.
    • (2002) Hum Gene Ther , vol.13 , pp. 163-175
    • Raper, S.E.1    Yudkoff, M.2    Chirmule, N.3
  • 166
    • 0142089747 scopus 로고    scopus 로고
    • Fatal systemic inflammatory response syndrome in a ornithine transcarbamylase deficient patient following adenoviral gene transfer
    • Raper SE, Chirmule N, Lee FS et al. Fatal systemic inflammatory response syndrome in a ornithine transcarbamylase deficient patient following adenoviral gene transfer. Mol Genet Metab 2003; 80: 148-58.
    • (2003) Mol Genet Metab , vol.80 , pp. 148-158
    • Raper, S.E.1    Chirmule, N.2    Lee, F.S.3
  • 167
    • 33750207033 scopus 로고    scopus 로고
    • Potent reduction of apolipoprotein B and low-density lipoprotein cholesterol by short-term administration of an antisense inhibitor of apolipoprotein B
    • Kastelein JJ, Wedel MK, Baker BF et al. Potent reduction of apolipoprotein B and low-density lipoprotein cholesterol by short-term administration of an antisense inhibitor of apolipoprotein B. Circulation 2006; 114: 1729-35.
    • (2006) Circulation , vol.114 , pp. 1729-1735
    • Kastelein, J.J.1    Wedel, M.K.2    Baker, B.F.3
  • 168
    • 50549091297 scopus 로고    scopus 로고
    • The targeted oncolytic poxvirus JX-594 demonstrates antitumoral, antivascular, and Anti-HBV activities in patients with hepatocellular carcinoma
    • Liu TC, Hwang T, Park BH, Bell J, Kirn DH. The targeted oncolytic poxvirus JX-594 demonstrates antitumoral, antivascular, and Anti-HBV activities in patients with hepatocellular carcinoma. Mol Ther 2008; 16: 1637-42.
    • (2008) Mol Ther , vol.16 , pp. 1637-1642
    • Liu, T.C.1    Hwang, T.2    Park, B.H.3    Bell, J.4    Kirn, D.H.5
  • 169
    • 44249100151 scopus 로고    scopus 로고
    • Use of a targeted oncolytic poxvirus, JX-5 9 4, in patients with refractory primary or metastatic liver cancer: A phase I trial
    • Park BH, Hwang T, Liu TC et al. Use of a targeted oncolytic poxvirus, JX-5 9 4, in patients with refractory primary or metastatic liver cancer: A phase I trial. Lancet Oncol 2008; 9: 533-42.
    • (2008) Lancet Oncol , vol.9 , pp. 533-542
    • Park, B.H.1    Hwang, T.2    Liu, T.C.3
  • 170
    • 22944476168 scopus 로고    scopus 로고
    • Effects of Onyx-015 among metastatic colorectal cancer patients that have failed prior treatment with 5-FU/leucovorin
    • Reid TR, Freeman S, Post L, McCormick F, Sze DY. Effects of Onyx-015 among metastatic colorectal cancer patients that have failed prior treatment with 5-FU/leucovorin. Cancer Gene Ther 2005; 12: 673-81.
    • (2005) Cancer Gene Ther , vol.12 , pp. 673-681
    • Reid, T.R.1    Freeman, S.2    Post, L.3    McCormick, F.4    Sze, D.Y.5
  • 171
    • 34547610960 scopus 로고    scopus 로고
    • AAV vector integration sites in mouse hepatocellular carcinoma
    • Donsante A, Miller DG, Li Y et al. AAV vector integration sites in mouse hepatocellular carcinoma. Science 2007; 317: 477.
    • (2007) Science , vol.317 , pp. 477
    • Donsante, A.1    Miller, D.G.2    Li, Y.3
  • 172
    • 35349027352 scopus 로고    scopus 로고
    • Immune responses to AAV in clinical trials
    • Mingozzi F, High KA. Immune responses to AAV in clinical trials. Curr Gene Ther 2007; 7: 316-24.
    • (2007) Curr Gene Ther , vol.7 , pp. 316-324
    • Mingozzi, F.1    High, K.A.2
  • 173
    • 34548068776 scopus 로고    scopus 로고
    • Persistent expression of hF.IX After tolerance induction by in utero or neonatal administration of AAV-1-F.IX in hemophilia B mice
    • Sabatino DE, Mackenzie TC, Peranteau W et al. Persistent expression of hF.IX After tolerance induction by in utero or neonatal administration of AAV-1-F.IX in hemophilia B mice. Mol Ther 2007; 15: 1677-85.
    • (2007) Mol Ther , vol.15 , pp. 1677-1685
    • Sabatino, D.E.1    Mackenzie, T.C.2    Peranteau, W.3
  • 174
    • 3242673224 scopus 로고    scopus 로고
    • Repeated adenoviral administration into the biliary tract can induce repeated expression of the original gene construct in rat livers without immunosuppressive strategies
    • Tominaga K, Kuriyama S, Yoshiji H et al. Repeated adenoviral administration into the biliary tract can induce repeated expression of the original gene construct in rat livers without immunosuppressive strategies. Gut 2004; 53: 1167-73.
    • (2004) Gut , vol.53 , pp. 1167-1173
    • Tominaga, K.1    Kuriyama, S.2    Yoshiji, H.3
  • 175
    • 28844452008 scopus 로고    scopus 로고
    • Biology of AAV serotype vectors in liver-directed gene transfer to nonhuman primates
    • Gao G, Lu Y, Calcedo R et al. Biology of AAV serotype vectors in liver-directed gene transfer to nonhuman primates. Mol Ther 2006; 13: 77-87.
    • (2006) Mol Ther , vol.13 , pp. 77-87
    • Gao, G.1    Lu, Y.2    Calcedo, R.3
  • 176
    • 0030917824 scopus 로고    scopus 로고
    • Adenovirus-mediated gene therapy in a mouse model of hereditary tyrosinemia type I
    • Overturf K, Al Dhalimy M, Ou CN et al. Adenovirus-mediated gene therapy in a mouse model of hereditary tyrosinemia type I. Hum Gene Ther 1997; 8: 513-21.
    • (1997) Hum Gene Ther , vol.8 , pp. 513-521
    • Overturf, K.1    Al Dhalimy, M.2    Ou, C.N.3
  • 177
    • 0031869522 scopus 로고    scopus 로고
    • Therapeutic trials in the murine model of hereditary tyrosinaemia type I: A progress report
    • Grompe M, Overturf K, al Dhalimy M, Finegold M. Therapeutic trials in the murine model of hereditary tyrosinaemia type I: A progress report. J Inherit Metab Dis 1998; 21: 518-31.
    • (1998) J Inherit Metab Dis , vol.21 , pp. 518-531
    • Grompe, M.1    Overturf, K.2    al Dhalimy, M.3    Finegold, M.4
  • 178
    • 63649086953 scopus 로고
    • Doctor tried gene therapy on two humans
    • Jacobs P. Doctor tried gene therapy on two humans. Washington Post 1980; A1: A15.
    • (1980) Washington Post , vol.A1
    • Jacobs, P.1
  • 179
    • 27544513676 scopus 로고    scopus 로고
    • Gutless adenovirus: Last-generation adenovirus for gene therapy
    • Alba R, Bosch A, Chillon M. Gutless adenovirus: Last-generation adenovirus for gene therapy. Gene Ther 2005; 12 (Suppl 1): S18-27.
    • (2005) Gene Ther , vol.12 , Issue.SUPPL. 1
    • Alba, R.1    Bosch, A.2    Chillon, M.3
  • 180
    • 35348954913 scopus 로고    scopus 로고
    • Immune response to helper dependent adenoviral mediated liver gene therapy: Challenges and prospects
    • Seiler MP, Cerullo V, Lee B. Immune response to helper dependent adenoviral mediated liver gene therapy: Challenges and prospects. Curr Gene Ther 2007; 7: 297-305.
    • (2007) Curr Gene Ther , vol.7 , pp. 297-305
    • Seiler, M.P.1    Cerullo, V.2    Lee, B.3
  • 181
    • 43049178300 scopus 로고    scopus 로고
    • Progress and prospects: Gene therapy for genetic diseases with helper-dependent adenoviral vectors
    • Brunetti Pierri N, Ng P. Progress and prospects: Gene therapy for genetic diseases with helper-dependent adenoviral vectors. Gene Ther 2008; 15: 553-60.
    • (2008) Gene Ther , vol.15 , pp. 553-560
    • Brunetti Pierri, N.1    Ng, P.2
  • 182
    • 0000972520 scopus 로고
    • Isolation of a cytopathogenic agent from human adenoids undergoing spontaneous degeneration in tissue culture
    • Rowe WP, Huebner RJ, Gilmore LK, Parrott RH, Ward TG. Isolation of a cytopathogenic agent from human adenoids undergoing spontaneous degeneration in tissue culture. Proc Soc Exp Biol Med 1953; 84: 570-3.
    • (1953) Proc Soc Exp Biol Med , vol.84 , pp. 570-573
    • Rowe, W.P.1    Huebner, R.J.2    Gilmore, L.K.3    Parrott, R.H.4    Ward, T.G.5
  • 183
    • 0001592496 scopus 로고
    • Adenovirus-associated defective virus particles
    • Atchison RW, Casto BC, Hammon WM. Adenovirus-associated defective virus particles. Science 1965; 149: 754-6.
    • (1965) Science , vol.149 , pp. 754-756
    • Atchison, R.W.1    Casto, B.C.2    Hammon, W.M.3
  • 184
    • 4844222269 scopus 로고    scopus 로고
    • Development of stable liquid formulations for adenovirus-based vaccines
    • Evans RK, Nawrocki DK, Isopi LA et al. Development of stable liquid formulations for adenovirus-based vaccines. J Pharm Sci 2004; 93: 2458-75.
    • (2004) J Pharm Sci , vol.93 , pp. 2458-2475
    • Evans, R.K.1    Nawrocki, D.K.2    Isopi, L.A.3
  • 185
    • 63649149911 scopus 로고    scopus 로고
    • Non-viral gene delivery system
    • In: Dropulic B, Carter B, eds. 1st edn. Hoboken, NJ: Wiley
    • Suda T, Liu D. Non-viral gene delivery system. In: Dropulic B, Carter B, eds. Concepts in Genetic Medicine, 1st edn. Hoboken, NJ: Wiley, 2008; 103-22.
    • (2008) Concepts in Genetic Medicine , pp. 103-122
    • Suda, T.1    Liu, D.2
  • 186
    • 44349119297 scopus 로고    scopus 로고
    • Computer-assisted Hydrodynamic Gene Delivery
    • Suda T, Suda K, Liu D. Computer-assisted Hydrodynamic Gene Delivery. Mol Ther 2008; 16: 1098-104.
    • (2008) Mol Ther , vol.16 , pp. 1098-1104
    • Suda, T.1    Suda, K.2    Liu, D.3
  • 187
    • 0141679053 scopus 로고    scopus 로고
    • Phase 1 trial of FVIII gene transfer for severe hemophilia A using a retroviral construct administered by peripheral intravenous infusion
    • Powell JS, Ragni MV, White GC II et al. Phase 1 trial of FVIII gene transfer for severe hemophilia A using a retroviral construct administered by peripheral intravenous infusion. Blood 2003; 102: 2038-45.
    • (2003) Blood , vol.102 , pp. 2038-2045
    • Powell, J.S.1    Ragni, M.V.2    White II, G.C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.