A phase I/II study of hepatic artery infusion with wtp53-CMV-Ad in metastatic malignant liver tumours

Human Gene Therapy

Volumn 10, Issue 12, 1999, Pages 2019-2034

  Habib, N A ^a,b   Hodgson, Hjf ^a,b   Lemoine, N ^a,b   Pignatelli, M ^a,b  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

^b ICSM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53;

APOPTOSIS; CANCER GROWTH; CANCER MORTALITY; CANCER SURVIVAL; CELL PROLIFERATION; CLINICAL ARTICLE; CLINICAL TRIAL; COLORECTAL CANCER; GENE EXPRESSION; HEPATIC ARTERY; HUMAN; INTRAARTERIAL DRUG ADMINISTRATION; LIVER DYSFUNCTION; LIVER TUMOR; PHASE 1 CLINICAL TRIAL; PHASE 2 CLINICAL TRIAL; REVIEW; TUMOR SUPPRESSOR GENE; UNITED KINGDOM; VIRUS REPLICATION;

ADENOVIRIDAE; CLINICAL PROTOCOLS; CLINICAL TRIALS, PHASE I; CLINICAL TRIALS, PHASE II; COLORECTAL NEOPLASMS; CYTOMEGALOVIRUS; GENE THERAPY; GENES, P53; GENETIC VECTORS; HEPATIC ARTERY; HUMANS; INFUSIONS, INTRA-ARTERIAL; LIVER NEOPLASMS; PATIENT SELECTION; RESEARCH DESIGN;

ADENOVIRIDAE; CUCUMBER MOSAIC VIRUS; HUMAN HERPESVIRUS 5;

EID: 0033543077     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/10430349950017383     Document Type: Review

References (29)

1. Badie B, Dazan KE, Kramar MH et al. Adenovirus-mediated p53 gene delivery inhibits 9L glioma growth in rats. Neurol. Res. 1995; 17(3): 209-16.
2. Baker SJ, Markowitz S, Fearon ER, Willson JKV and Vogelstein B. Suppression of human colorectal carcinoma cell growth by wild-type p53. Science 1990; 249: 912-915.
3. Blagosklonny MV and El-Deiry WS. (1996) In vitro evaluation of a p53-expressing adenovirus as an anti-cancer drug. Int. J. Cancer 67: 386-392.
4. Breedis C., Young, G. Blood supply of neoplasms of the liver. Am. J. Pathol USA 1954;30:969-985.
5. Clayman GL, Liu TJ, Overholt SM et al. Gene therapy for head and neck cancer. Comparing the tumor suppressor gene p53 and a cell cycle regulator WAF1/CIP1 (p21). Arch. Otolaryngol. Head Neck Surg. 1996:112(5); 389-93.
6. Clayman GL, El-Naggar AK, Roth JA et al. In vivo molecular therapy with p53 adenovirus for microscopic residual head and neck squamous carcinoma. Cancer Res. 1995; 55(1); 1-6.
7. Cook G., Moose B. Hepatocellular carcinoma; one of the world's most common malignancies. Am. J. Med. 1985; 235:705-8.
8. El-Deiry WS, Tokino T, Velculescu VE, Levy DB, Parsons R, Trent JM, Lin D, Mercer WE, Kinzler KW, and Vogelstein B. (1993) WAF1, a potential mediator of p53 tumor suppression. Cell 75: 817-825.
9. Fujiwara T, Grimm EA, Mukhopadhyay T et al. Induction of chemosensitivity in human cancer cells in vivo by adenovirus-mediated transfer of the wild-type p53 gene. Cancer Res. 1994; 54(9); 2287-91.
10. Gjerset RA, Turla ST, Sobol RE et al. Use of wild-type p53 to achieve complete treatment sensitization of tumor cells expressing endogenous mutant p53. Mol. Carcinog. 1995; 14(4): 275-85.
11. Harris MP, Sutjipto S, Wills KN. Hancock W, Crnell D, Johnson DE, Gregory RJ, Shepard HM, Maneval DC. (1996) Adenovirus-mediated p53 gene transfer inhibits growth of human tumor cells expressing mutant p53 protein. Cancer Gen. Ther. 3(2): 121-130.
12. Kemeny N, Cohen A, Bertino JR, et al. Continuous intrahepatic infusion of floxuridine and leucovorin through an implantable pump for the treatment of hepatic metastases from colorectal carcinoma. Cancer 1990;65:2446-50.
13. Kern SE, Pietenpol JA, Thiagalingain S, Seymour A, Kinzler KW and Vogelstein B. Oncogenic forms of p53 inhibit p53 regulated gene expression. Science 1992; 256: 827-830.
14. Weiss L, Grundmann E. Torhorst J, et al. Haematogenous metastatic patterns in colonie carcinoma: an analysis of 1541 necropsies. J. Pathol. 1986;150:195-203.
15. Kock H., Harris MP., Anderson SC., et al. Adenovirus-mediated p53 gene transfer suppresses growth of human glioblastoma cells in vitro and in vivo. Int. J. Cancer 1996 Sep 17;67(6):808-815.
16. Liu TJ, Zhang WW, Taylor DL et al. Growth suppression of human head and neck cancer cells by the introduction of a wild-type p53 gene via a recombinant adenovirus. Cancer Res. 1994;54(14): 3662-7.
17. Liu TJ, El-Naggar AK, McDonnell TJ et al. Apoptosis induction mediated by wild-type p53 adenoviral gene transfer in squamous cell carcinoma of the head and neck. Cancer Res. 1995: 55(14); 3117-22.
18. Mujoo K., Maneval DC., Anderson SC., Gutterman JU. Adenoviral-mediated p53 tumour suppressor gene therapy of human ovarian carcinoma. Oncogene 1996 Apr 18:12(8):1617-1623.
19. Santoso JT., Tang DC., Lane SB., et al. Adenovirus-based p53 gene therapy in ovarian cancer. Gynecol. Oncol. 1995 Nov;59(2):171-178.
20. Shaw P., Bovey R., Tardy S., Sahli R., Sordat B., Costa J. Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line. Proc. Natl Acad. Sci. USA 1992; 89:4495-9.
21. Spitz FR., Nguyen D., Skibber JM., et al. In vivo adenovirus-mediated p53 tumour suppressor gene therapy for colorectal cancer. Anticancer Res. 1996; 16(6B):3415-3422.
22. Stagg RJ, Venook AP, Chase JL, et al. Alternating hepatic intra-arterial floxuridine and fluorouracil: a less toxic regimen for treatment of liver metastases from colorectal cancer. J, Natl. Cancer Inst. 1991;83:423-428.
23. Venook, A.P. Treatment of hepatocellular carcinoma: too many options? J. Clin. Oncol. 1994;12:1323-34.
24. Wills KN, Maneval DC, Menzel P et al. Development and characterization of recombinant adenoviruses encoding human p53 for gene therapy of cancer. Human Gene Ther. 1994; 5(9); 10.
25. Wilkinson GWG and Akrigg A. Constitutive and enhanced expression from the CMV major IE promoter in a defective adenovirus vector. Nucl. Acids Res. 1992;20:2233-2239.
26. Wang J, Bucana CD, Roth JA et al. Apoptosis in human osteosarcoma cells in one of the mechanisms for the cytocidal effect of AdCMV-p53. Cancer Gene Ther. 1995; 2(1); 9-17.
27. Wood C.B., Gillis C.R., Blumgart L.H. A retrospective study of the natural history of patients with liver metastases from colorectal cancer. Clin. Oncol. 1976; 2:285-288.
28. Zhang WW, Fang X, Mazu W et al. High-efficiency gene transfer and high-level expression of wild-type p53 in human lung cancer cells mediated recombinant adenovirus. Cancer Gene Ther. 1994; 1(1); 5-13.
29. Zhang WW, Alemany R, Wang J et al. Safety evaluation of Ad5CMV-p53 in vitro and in vivo. Human Gene Ther. 1995; 6(2); 155-64.