Inhibition by KMI-574 leads to dislocalization of BACE1 from lipid rafts

Journal of Neuroscience Research

Volumn 87, Issue 2, 2009, Pages 360-368

  Ebina, Maiko ^a   Futai, Eugene ^a   Tanabe, Chiaki ^a   Sasagawa, Noboru ^a   Kiso, Yoshiaki ^b   Ishiura, Shoichi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Alzheimer's disease; BACE1; Inhibitor; Lipid raft; Protein transport

Indexed keywords

ASPARTIC PROTEINASE; BETA SECRETASE 1; BETA SECRETASE INHIBITOR; KMI 444; KMI 446; KMI 510; KMI 574; KMI 575; UNCLASSIFIED DRUG; BACE1 PROTEIN, HUMAN; ENZYME INHIBITOR; SECRETASE;

ARTICLE; CELL STRAIN HEK293; CELL TRANSPORT; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME INHIBITION; ENZYME LOCALIZATION; GOLGI COMPLEX; HUMAN; HUMAN CELL; IC 50; LIPID RAFT; MUTANT; PRIORITY JOURNAL; PROTEIN TRANSPORT; CELL LINE; CELL MEMBRANE; CHEMISTRY; DRUG EFFECT; ENZYME ACTIVATION; ENZYMOLOGY; GENETIC TRANSFECTION; METABOLISM; PHYSIOLOGY; PROTEIN CONFORMATION; WESTERN BLOTTING;

AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ENDOPEPTIDASES; BLOTTING, WESTERN; CELL LINE; ENZYME ACTIVATION; ENZYME INHIBITORS; HUMANS; MEMBRANE MICRODOMAINS; PROTEIN CONFORMATION; PROTEIN TRANSPORT; TRANSFECTION;

EID: 62849090794     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.21858     Document Type: Article

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