β-Secretase inhibitors: Modification at the P4 position and improvement of inhibitory activity in cultured cells

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 16, 2006, Pages 4354-4359

  Hamada, Yoshio ^a   Igawa, Naoto ^a   Ikari, Hayato ^a   Ziora, Zyta ^a   Nguyen, Jeffrey Tri ^a   Yamani, Abdellah ^a   Hidaka, Koushi ^a   Kimura, Tooru ^a   Saito, Kazuki ^b   Hayashi, Yoshio ^a   Ebina, Maiko ^c   Ishiura, Shoichi ^c   Kiso, Yoshiaki ^a  

^a Center for Frontier Research in Medicinal Science   (Japan)

^b KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

Alzheimer's disease; BACE1 inhibitor; Cultured cells

Indexed keywords

BETA SECRETASE INHIBITOR; FUNCTIONAL GROUP; HYDROGEN; KMI 420; KMI 446; KMI 467; KMI 468; KMI 471; KMI 473; KMI 479; KMI 508; KMI 509; KMI 510; KMI 520; KMI 521; KMI 522; KMI 523; KMI 570; KMI 571; KMI 572; KMI 573; KMI 574; KMI 575; TETRAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ACIDITY; ARTICLE; CELL STRAIN HEK293; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG SCREENING; DRUG SYNTHESIS; EMBRYO; ENZYMATIC ASSAY; ENZYME INHIBITION; HUMAN; HUMAN CELL; HYDROGEN BOND; IN VITRO STUDY; STRUCTURE ACTIVITY RELATION;

AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ENDOPEPTIDASES; CARBOXYLIC ACIDS; CELLS, CULTURED; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; ENDOPEPTIDASES; ESTERS; HUMANS; MODELS, CHEMICAL; MODELS, MOLECULAR; PROTEASE INHIBITORS; TETRAZOLES;

EID: 33745713220     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.05.046     Document Type: Article

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