Design and synthesis of potent β-secretase (BACE1) inhibitors with P1′ carboxylic acid bioisosteres

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 9, 2006, Pages 2380-2386

  Kimura, Tooru ^a   Hamada, Yoshio ^a   Stochaj, Monika ^a   Ikari, Hayato ^a   Nagamine, Ayaka ^a   Abdel Rahman, Hamdy ^a   Igawa, Naoto ^a   Hidaka, Koushi ^a   Nguyen, Jeffrey Tri ^a   Saito, Kazuki ^a   Hayashi, Yoshio ^a   Kiso, Yoshiaki ^a  

^a KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Secretase; Alzheimer's disease; BACE1 inhibitor; Bioisostere

Indexed keywords

ANGIOTENSIN II ANTAGONIST; BETA SECRETASE INHIBITOR; CARBOXYLIC ACID; KMI 260; KMI 360; KMI 409; KMI 419; KMI 420; KMI 429; KMI 470; KMI 569; KMI 570; KMI 596; KMI 597; KMI 654; KMI 666; KMI 683; KMI 684; KMI 686; KMI 696; KMI 808; KMI 879; TETRAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ARTICLE; BLOOD BRAIN BARRIER; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; STRUCTURE ACTIVITY RELATION;

ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEIN SECRETASES; CARBOXYLIC ACIDS; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; ENDOPEPTIDASES; ENZYME INHIBITORS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; OLIGOPEPTIDES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33644988047     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.01.108     Document Type: Article

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