Discovery and development of heat shock protein 90 inhibitors

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 6, 2009, Pages 2225-2235

  Taldone, Tony ^a   Sun, Weilin ^a   Chiosis, Gabriela ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

Cancer; Geldanamycin; Isoxazoles; PU class; Purines; Pyrazoles; Radicicol

Indexed keywords

17 DEMETHOXY 17 (2 DIMETHYLAMINOETHYLAMINO)GELDANAMYCIN; 2 CYCLOPROPYLAMINOETHYL DERIVATIVE; 3 (5 CHLORO 2,4 DIHYDROXYPHENYL) N ETHYL 4 (4 METHOXYPHENYL) 5 PYRAZOLECARBOXAMIDE; 4 [4 (1,4 BENZODIOXAN 6 YL) 5 METHYL 1H PYRAZOL 3 YL] 6 ETHYLRESORCINOL; CCT 072440; CCT 08159; CYCLOPROPARADICICOL; G 3129; GELDANAMYCIN; HEAT SHOCK PROTEIN 90; HEAT SHOCK PROTEIN 90 INHIBITOR; ISOXAZOLE DERIVATIVE; KF 25706; KOS 1022; KOSN 1559; NATURAL PRODUCT; NVP AUY 922; OXIME DERIVATIVE; POCHONIN A; POCHONIN D; PURINE DERIVATIVE; PYRAZOLE DERIVATIVE; PYRIDOTHIOPHENE DERIVATIVE; PYRIDYLMETHYL DERIVATIVE; PYRIMIDOTHIOPHENE DERIVATIVE; RADAMIDE; RADESTER; RADICICOL; TANESPIMYCIN; TANESPIMYCIN HYDROQUINONE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VER 50589;

ARTICLE; BREAST CANCER; CLINICAL TRIAL; DRUG DESIGN; DRUG PROTEIN BINDING; DRUG SCREENING; HIGH THROUGHPUT SCREENING; HUMAN; MULTIPLE MYELOMA; NEOPLASM; NONHUMAN; PROTEIN FUNCTION; STRUCTURE ACTIVITY RELATION;

ADENOSINE TRIPHOSPHATE; ANIMALS; BINDING SITES; DRUG DISCOVERY; HSP90 HEAT-SHOCK PROTEINS; HUMANS;

EID: 62149135294     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.10.087     Document Type: Article

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