4-Amino derivatives of the Hsp90 inhibitor CCT018159

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 9, 2006, Pages 2543-2548

  Barril, Xavier ^a   Beswick, Mandy C ^a   Collier, Adam ^a   Drysdale, Martin J ^a   Dymock, Brian W ^a   Fink, Alexandra ^a   Grant, Kate ^a   Howes, Robert ^a   Jordan, Allan M ^a   Massey, Andrew ^a   Surgenor, Allan ^a   Wayne, Joanne ^a   Workman, Paul ^b   Wright, Lisa ^a  

^a Vernalis PLC   (United Kingdom)

^b INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

Cancer; Hsp90; Pyrazole; Structure based drug design; X ray crystallography

Indexed keywords

ANSAMYCIN DERIVATIVE; CCT 018159; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90 INHIBITOR; UNCLASSIFIED DRUG; VER 49009;

AMINO TERMINAL SEQUENCE; ARTICLE; CELL PROLIFERATION; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME BINDING; ENZYME INHIBITION; HUMAN; IC 50; STRUCTURE ACTIVITY RELATION; TUMOR CELL; X RAY CRYSTALLOGRAPHY;

BINDING SITES; CRYSTALLOGRAPHY, X-RAY; HETEROCYCLIC COMPOUNDS, 2-RING; HSP90 HEAT-SHOCK PROTEINS; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PYRAZOLES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33645002986     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.01.099     Document Type: Article

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