A novel class of Hsp90 inhibitors isolated by structure-based virtual screening

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 22, 2007, Pages 6345-6349

  Park, Hwangseo ^a   Kim, Yun Jung ^b   Hahn, Ji Sook ^b  

^a Sejong University   (South Korea)

^b Seoul National University   (South Korea)

Author keywords

3 Phenyl 2 styryl 3H quinazolin 4 one; Cancer; Drug design; Hsp90 inhibitors; Virtual screening

Indexed keywords

2 (3 MORPHOLIN 4 YL PROPYL) 1 PHENYL 1,2 DIHYDRO 4 OXA 2 AZACYCLOPENTA[B]NAPHTHALENE 3,9 DIONE; 2 (BENZO[4,5]FURO[3,2 D]PYRIMIDIN 4 YLAMINO) 3 PHENYLPROPIONIC ACID; 3 PHENYL 2 STYRYL 3H QUINAZOLIN 4 ONE; 3 PHENYLAMINO 2 (4 PHENYLTHIAZOL 2 YL)ACRYLONITRILE; 3,6 DIAMINO 4 (4 METHOXYPHENYL)THIENO[2,3 B]PYRIDINE 5 CARBONITRILE; 4 OXO 4 (3 PHENYL 5 QUINOLIN 3 YL 4,5 DIHYDROPYRAZOL 1 YL)BUTYRIC ACID; 5 BENZYLOXY 2 (4 PHENOXY 1H PYRAZOL 2 YL)PHENOL; 6 BENZYL 2 BENZYLIDENE THIAZOLO[3,2 B][1,2,4]TRIAZINE 3,7 DIONE; ADENOSINE TRIPHOSPHATE; EPIDERMAL GROWTH FACTOR RECEPTOR 2; GELDANAMYCIN; HEAT SHOCK PROTEIN 90; HEAT SHOCK PROTEIN 90 INHIBITOR; QUINAZOLINE DERIVATIVE; STYRENE DERIVATIVE; TUBULIN; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; DRUG ISOLATION; DRUG SCREENING; HUMAN; HUMAN CELL; IN VITRO STUDY; MOLECULAR DOCKING; PROTEIN DEGRADATION; SIMULATION; STRUCTURE ACTIVITY RELATION; YEAST;

ANTINEOPLASTIC AGENTS; BINDING SITES; CELL LINE, TUMOR; CELL PROLIFERATION; COMPUTER SIMULATION; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; FEMALE; HSP90 HEAT-SHOCK PROTEINS; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; QUINAZOLINES; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS;

EID: 35148840116     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.08.069     Document Type: Article

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