Structure-based discovery of a new class of Hsp90 inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 23, 2005, Pages 5187-5191

  Barril, Xavier ^a   Brough, Paul ^a   Drysdale, Martin ^a   Hubbard, Roderick E ^a   Massey, Andrew ^a   Surgenor, Allan ^a   Wright, Lisa ^a  

^a Vernalis PLC   (United Kingdom)

Author keywords

Bis phenol; Docking; Hit identification; Hsp90 inhibitor; Phenol naphthol; Structure based drug discovery; Virtual screening

Indexed keywords

ADENOSINE TRIPHOSPHATE; HEAT SHOCK PROTEIN 90; NAPHTHOL DERIVATIVE; PROTEIN INHIBITOR;

ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG ACTIVITY; DRUG BINDING; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; HUMAN; HUMAN CELL;

HSP90 HEAT-SHOCK PROTEINS; HUMANS; MOLECULAR STRUCTURE; NAPHTHOLS;

EID: 26844524967     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.08.092     Document Type: Article

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