3-(5-chloro-2,4-dihydroxyphenyl)-Pyrazole-4-carboxamides as inhibitors of the Hsp90 molecular chaperone

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 23, 2005, Pages 5197-5201

  Brough, Paul A ^a   Barril, Xavier ^a   Beswick, Mandy ^a   Dymock, Brian W ^a   Drysdale, Martin J ^a   Wright, Lisa ^a   Grant, Kate ^a   Massey, Andrew ^a   Surgenor, Allan ^a   Workman, Paul ^b  

^a Vernalis PLC   (United Kingdom)

^b INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

Cancer; Hsp90; Pyrazole; Structure based drug design; X ray crystallography

Indexed keywords

AMIDE; CHAPERONE; HEAT SHOCK PROTEIN 90; PHENYLALANINE; PROTEIN INHIBITOR;

ARTICLE; COMPARATIVE STUDY; CRYSTAL STRUCTURE; DRUG BINDING; DRUG DESIGN; DRUG POTENCY; PROTEIN INTERACTION; X RAY;

AMIDES; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; HSP90 HEAT-SHOCK PROTEINS; HUMANS; MOLECULAR STRUCTURE; OXAMIC ACID; PYRAZOLES;

EID: 26844468809     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.08.091     Document Type: Article

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