Transdisciplinary perspectives on sweetness

Chemosensory Perception

Volumn 1, Issue 1, 2008, Pages 48-57

  Hayes, John E ^a  

^a BROWN UNIVERSITY   (United States)

Author keywords

Carbohydrates; G protein coupled; Individual differences; Receptors; Structure activity relationship; Sweeteners; Taste

Indexed keywords

EID: 60849138726     PISSN: 19365802     EISSN: 19365810     Source Type: Journal    
DOI: 10.1007/s12078-007-9003-z     Document Type: Article

References (120)

1. Acree TE (1970) A molecular theory of sweet taste—amino acids and peptides. Carbohydrate/Oilseeds Division of the American Association of Cereal Chemists. Excelsior Springs, MO, USA
2. Adler E, Hoon MA, Mueller KL, Chandrashekar J, Ryba NJ, Zuker CS (2000) A novel family of mammalian taste receptors. Cell 100(6):693–702
3. Amrein H, Bray S (2003) Bitter-sweet solution in taste transduction. Cell 112(3):283–284
4. Ayya N, Lawless HT (1992) Quantitative and qualitative evaluation of high-intensity sweeteners and sweetener mixtures. Chem Senses 17(3):245–259
5. Bachmanov AA (2005) Genetic approach to characterize interaction of sweeteners with sweet taste receptors in vivo. Chem Senses 30 (Suppl 1):i82–i83
6. Bachmanov AA, Tordoff MG, Beauchamp GK (2001) Sweetener preference of C57BL/6ByJ and 129P3/J mice. Chem Senses 26 (7):905–913
7. Bachmanov AA, Reed DR, Li X, Beauchamp GK (2002) Genetics of sweet taste preferences. Pure Appl Chem 74(7):1135–1140
8. Bakal AI, Cumberland Packing Corp., assignee (1984) Sweetening foods with non-caloric di- or trisaccharides having L-hexose component. Brooklyn NY patent 426-658-000 127-030-000 424- 361-000 426-804-000 536-001-100
9. Bartoshuk LM, Dateo GP, Vanderbelt DJ, Buttrick RL, Long L (1969) Effect of Gymnema sylvestre and Synsepalum dulcificum on taste in man. In: Pfaffmann (ed) COlfaction and taste. Rockefeller University Press, New York, pp 436–444
10. Bartoshuk LM, Gentile RL, Molkowitz HR, Meiselman HL (1974) Sweet taste induced by miracle fruit (Synsepalum dulcificum). Physiol Behav 12(3):449–456
11. Bartoshuk LM, Fast K, Snyder DJ (2005) Differences in our sensory worlds: invalid comparisons with labeled scales. Curr Dir Psychol Sci 14(3):122–125
12. Bassoli A, Drew MGB, Merlini D, Morini G (2002a) General pseudoreceptor model for sweet compounds: a semiquantitative prediction of binding affinity for sweet-tasting molecules. J Med Chem 45(20):4402–4409
13. Bassoli A, Merlini L, Morini G (2002b) Isovanillyl sweeteners. From molecules to receptors. Pure Appl Chem 74(7):1181–1187
14. Bernhardt SJ, Naim M, Zehavi U, Lindemann B (1996) Changes in IP3 and cytosolic Ca2+ in response to sugars and non-sugar sweeteners in transduction of sweet taste in the rat. J Physiol 490 (Pt 2):325–336
15. Birch GG (1987) Chemical aspects of sweetness. In: Dobbing J, International Life Sciences Institute (ed) Sweetness, Springer New York, pp 3–13
16. Boring EG (1942) Sensation and perception in the history of experimental psychology. Appleton-Century, New York
17. Brand JG, Feigin AM (1996) Biochemistry of sweet taste transduction. Food Chem 56(3):199–207
18. Bray GA, Nielsen SJ, Popkin BM (2004) Consumption of highfructose corn syrup in beverages may play a role in the epidemic of obesity. Am J Clin Nutr 79(4):537–543
19. Breslin PA, Kemp S, Beauchamp GK (1994) Single sweetness signal. Nature 369(6480):447–448
20. Caicedo A, Kim KN, Roper SD (2002) Individual mouse taste cells respond to multiple chemical stimuli. J Physiol 544(Pt 2):501–509
21. Cardello HM, Da Silva MA, Damasio MH (1999) Measurement of the relative sweetness of stevia extract, aspartame and cyclamate/ saccharin blend as compared to sucrose at different concentrations. Plant Foods Hum Nutr 54(2):119–130
22. Cohn G (1914) Die Organischen Geschmackstoffe. F. Siemenroth, Berlin
23. Cruz A, Green BG (2000) Thermal stimulation of taste. Nature 403 (6772) 889–892
24. Danilova V, Danilov Y, Roberts T, Tinti JM, Nofre C, Hellekant G (2002) Sense of taste in a new world monkey, the common marmoset: recordings from the chorda tympani and glossopharyngeal nerves. J Neurophysiol 88(2):579–594
25. Danilova V, Hellekant G (2004) Sense of taste in a New World monkey, the common marmoset. II. Link between behavior and nerve activity. J Neurophysiol 92(2):1067–1076
26. De Francisco JC, Dess NK (1998) Aspartame consumption in rats selectively bred for high versus low saccharin intake. Physiol Behav 65(2):393–396
27. Delwiche J (1996) Are there ‘basic’ tastes? Trends Food Sci Technol 7 (12):411–415
28. DiMeglio DP, Mattes RD (2000) Liquid versus solid carbohydrate: effects on food intake and body weight. Int J Obes Relat Metab Disord 24(6):794–800
29. Duffy VB, Sigmand-Grant M (2004) Position of the American Dietetic Association: use of nutritive and nonnutritive sweeteners. J Am Diet Assoc 104(2):255–275
30. Duffy VB, Hayes JE, Dinehart ME (2006) Genetic differences in sweet taste perception. In: Spillane WJ (ed) Optimising the sweet taste in foods. Woodhead, Cambridge, pp 30–53
31. Eggers SC, Acree TE, Shallenberger RS (2000) Sweetness chemoreception theory and sweetness transduction. Food Chem 68(1):45–49
32. Ennis DM (2002) Molecular mixture models: connect molecular events to perception. In: Given P, Paredes D, American Chemical Society, Division of Agricultural and Food Chemistry (eds) American Chemical Society. Meeting (219th: 2000: San Francisco Calif.) Chemistry of taste: mechanisms, behavior, and mimics. American Chemical Society, Washington, DC, pp 32–38
33. Erickson RP (1977) The role of ‘primaries’ in taste research. In: Le Magnen J, Mac Leod P (eds) Olfaction and taste VI: proceedings of the sixth international symposium held at Gif-sur-Yvette, Paris, France, 15–17th July, 1977 Information RetrievalWashington, DC, USA, pp vii, 527
34. Erickson RP (2000) The evolution of neural coding ideas in the chemical senses. Physiol Behav 69(1–2):3–13
35. Eylam S, Kennedy LM (1998) Identification and characterization of human fructose or glucose taste variants with hypogeusia for one monosaccharide but not for the other. Ann N Y Acad Sci 855:170–174
36. Faurion A (1993) The physiology of sweet taste and molecular receptors. In: Mathlouthi M, Kanters JA, Birch GG (eds) Sweettaste chemoreception. Elsevier Applied Science, New York, pp 291–315
37. Fischer E (1894) Einsfluss der Configuration auf die Wirkung der Enzyme. Ber Dtsch Chem Ges 27:2985–2993
38. Fontvieille AM, Faurion A, Helal I, Rizkalla SW, Falgon S, Letanoux M, Tchobroutsky G, Slama G (1989) Relative sweetness of fructose compared with sucrose in healthy and diabetic subjects. Diabetes Care 12(7):481–486
39. Freeman KB, Riley AL (2005) Conditioned taste aversion: an annotated bibliography. http://www.ctalearning.com.
40. Froloff N, Lloret E, Martinez JM, Faurion A (1998) Cross-adaptation and molecular modeling study of receptor mechanisms common to four taste stimuli in humans. Chem Senses 23(2):197–206
41. Gardner BJ (1984) Investigation of sweet taste mechanism by taste interactions. Purdue University, West Lafayette, IN
42. Gent JF, Hettinger TP, Frank ME, Marks LE (1999) Taste confusions following gymnemic acid rinse. Chem Senses 24(4):393–403
43. Glaser D (1999) The evolution of taste perception. In: Corti A (ed) Lowcalorie sweeteners: present and future. Karger, Basel, pp 18–38
44. Glaser D (2002) Specialization and phyletic trends of sweetness reception in animals. Pure Appl Chem 74(7):1153–1158
45. Glaser D, Tinti JM, Nofre C (1995) Evolution of the sweetness receptor in primates. I. Why does alitame taste sweet in all prosimians and simians, and aspartame only in Old World simians? Chem Senses 20(5):573–584
46. Glaser D, Tinti JM, Nofre C (1996) Gustatory responses of nonhuman primates to dipeptide derivatives or analogues, sweet in man. Food Chem 56(3)313–321
47. Glendinning JI, Hills TT (1997) Electrophysiological evidence for two transduction pathways within a bitter-sensitive taste receptor. J Neurophysiol 78(2):734–745
48. Goodman M, Del Valle JR, Amino Y, Benedetti E (2002) Molecular basis of sweet taste in dipeptide taste ligands. Pure Appl Chem 74(7):1109–1116
49. Green BG, George P (2004) ‘Thermal taste’ predicts higher responsiveness to chemical taste and flavor. Chem Senses 29(7):617–628
50. Halpern BP (1997) Psychophysics of taste. In: Beauchamp GK, Bartoshuk LM (eds) Tasting and smelling. Handbook of perception and cognition. Academic, San Diego, CA, pp 77–123
51. Halpern BP (2002) Taste. In: Stevens SS, Pashler HE (eds) Steven’s handbook of experimental psychology, vol. 1. Sensation and perception, 3rd edn. Wiley, New York, pp 653–690
52. Hayes JE, Duffy VB (2007) Revisiting sugar-fat mixtures: sweetness and creaminess vary with phenotypic markers of oral sensation. Chem Senses 32(3):225–236
53. Hellekant G, Danilova V (1996) Species differences toward sweeteners. Food Chem 56(3):323–328
54. Hiji T (1975) Selective elimination of taste responses to sugars by proteolytic enzymes. Nature 256(5516):427–429
55. Hyvonen L, Kurkela R, Koivistoinen P, Ratilainen A (1978) Fructosesaccharin and xylitol-saccharin synergism. J Food Sci 43:251–254
56. Inoue M, Reed DR, Li X, Tordoff MG, Beauchamp GK, Bachmanov AA (2004) Allelic variation of the Tas1r3 taste receptor gene selectively affects behavioral and neural taste responses to sweeteners in the F2 hybrids between C57BL/6ByJ and 129P3/ J mice. J Neurosci 24(9):2296–303
57. Institute of Medicine of the National Academy of Sciences (2002) Dietary reference intakes for energy, carbohydrate, fiber, fat, fatty acids, cholesterol, protein, and amino acids. National Academy of Sciences, Washington, DC, USA
58. Jakinovich W Jr (1981) Stimulation of the gerbil’s gustatory receptors by artificial sweeteners. Brain Res 210(1–2):69–81
59. Jiang P, Cui M, Zhao B, Liu Z, Snyder LA, Benard LM, Osman R, Margolskee RF, Max M (2005a) Lactisole interacts with the transmembrane domains of human T1R3 to inhibit sweet taste. J Biol Chem 280(15):15238–15246
60. Jiang P, Cui M, Zhao B, Snyder LA, Benard LM, Osman R, Max M, Margolskee RF (2005b) Identification of the cyclamate interaction site within the transmembrane domain of the human sweet taste receptor subunit T1R3. J Biol Chem 280(40):34296–34305
61. Johnson C, Birch GG, MacDougall DB (1994) The effect of the sweetness inhibitor 2(-4-methoxyphenoxy)propanoic acid (sodium salt) (Na-PMP) on the taste of bitter-sweet stimuli. Chem Senses 19(4):349–358
62. Keast RSJ, Breslin PAS (2002) Cross-adaptation and bitterness inhibition of L-tryptophan, L-phenylalanine and urea: Further support for shared peripheral physiology. Chem Senses 27(2):123–131
63. Keast RS, Canty TM, Breslin PA (2004) Oral zinc sulfate solutions inhibit sweet taste perception. Chem Senses 29(6):513–521
64. Kennedy LM, Eylam S, Poskanzer JE, Saikku AR (1997) Genetic analyses of sweet taste transduction. Food Chem 60(3):311–321
65. Keskitalo K, Knaapila A, Kallela M, Palotie A, Wessman M, Sammalisto S, Peltonen L, Tuorila H, Perola M (2007) Sweet taste preferences are partly genetically determined: identification of a trait locus on chromosome 16. Am J Clin Nutr 86(1):55–63
66. Kier LB (1972) A molecular theory of sweet taste. J Pharm Sci 61 (9):1394–1397
67. Kurihara Y, Nirasawa S (1994) Sweet, antisweet and sweetnessinducing substances. Trends in Food Sci Technol 5:37–42
68. Laffort P, Walsh RM, Spillane WJ (2002) Application of the U and gamma’ models in binary sweet taste mixtures. Chem Senses 27 (6):511–520
69. Lancet D, Ben-Arie N (1991) Sweet taste transduction: a molecularbiological analysis. In: Walters DE, Orthoefer FT, DuBois GE (eds) Sweeteners: Discovery, molecular design, and chemoreception. American Chemical Society, Washington, DC, USAx, 333
70. Lawless HT (1979) Evidence for neural inhibition in bittersweet taste mixtures. J Comp Physiol Psychol 93(3):538–547
71. Lawless HT (1998) Theoretical note: tests of synergy in sweetener mixtures. Chem Senses 23(4):447–451
72. Lawless HT, Stevens DA (1983) Cross adaptation of sucrose and intensive sweeteners. Chem Senses 7(3–4):309–315
73. Levin GV; Biospherics Incorporated, assignee (1981) Sweetened edible formulations. Rockville MD patent 426-658-000 426- 804-000 424-361-000
74. Li X, Staszewski L, Xu H, Durick K, Zoller M, Adler E (2002) Human receptors for sweet and umami taste. Proc Natl Acad Sci USA 99(7):4692–4696
75. Lichtenthaler FW, Immel S (1993) Sucrose, sucralose, and fructose: correlations between hydrophobicity potential profiles and AHB- X assignments. In: Mathlouthi M, Kanters JA, Birch GG (eds) Sweet-taste chemoreception. Elsevier Applied Science, New York, pp 21–53
76. Lichtenthaler FW, Immel S (1995) Computer-simulation of chemical and biological properties of sucrose, the cyclodextrins and amylose. Int Sugar J 97(1153):13–22
77. Lichtenthaler FW, Immel S, Kreis U (1991) Evolution of the structural representation of sucrose. Starch/Starke 43:121–132
78. Lindley MG (1991) Phenoxyalkanoic acid sweetness inhibitors. In: Walters DE, Orthoefer FT, DuBois GE (eds) Sweeteners: discovery, molecular design, and chemoreception. American Chemical Society, Washington, DC, pp 251–260
79. Lindley M (2006) Taste-ingredient interactions modulating sweetness. In: Spillane WJ (ed) Optimising the sweet taste in foods. Woodhead, Cambridge, UK
80. Margolskee RF (2002) Molecular mechanisms of bitter and sweet taste transduction. J Biol Chem 277(1):1–4
81. Mathlouthi M, Angiboust JF, Kacurakova M, Hooft RWW, Kanters JA, Kroon J (1994) Structural studies on sweet taste inhibitors - lactisole, Dl-2(4-Methoxyphenoxy)-Propanoic acid. J Mol Struct 326:25–34
82. Mattes R (2005) Soup and satiety. Physiol Behav 83(5):739–747
83. McBurney DH, Smith DV, Shick TR (1972) Gustatory cross adaptation: sourness and bitterness. Percept Psychophys 11(3):228–232
84. Nelson G, Hoon MA, Chandrashekar J, Zhang Y, Ryba NJ, Zuker CS (2001) Mammalian sweet taste receptors. Cell 106(3):381–390
85. Nielsen SJ, Popkin BM (2004) Changes in beverage intake between 1977 and 2001. Am J Prev Med 27(3):205–210
86. Nofre C, Glaser D, Tinti JM, Wanner M (2002) Gustatory responses of pigs to sixty compounds tasting sweet to humans. J Anim Physiol Anim Nutr (Berl) 86(3–4):90–96
87. Nofre C, Tinti JM (1983) US Patent No. 4645678
88. Nofre C, Tinti JM (1987) US Patent No. 4921939
89. Nofre C, Tinti JM (1996) Sweetness reception in man: the multipoint attachment theory. Food Chem 56(3):263–274
90. Nofre C, Tinti JM, Glaser D (1996) Evolution of the sweetness receptor in primates. II. Gustatory responses of non-human primates to nine compounds known to be sweet inman. ChemSenses 21(6):747–762
91. Nowlis GH, Frank ME, Pfaffmann C (1980) Specificity of acquired aversions to taste qualities in hamsters and rats. J Comp Physiol Psychol 94(5):932–942
92. Oertly E, Myers RG (1919) A new theory relating constitution to taste. J Am Chem Soc 41:855–867
93. Pangborn RM (1970) Individual Variation in affective responses to taste stimuli. Psychon Sci 21(2):125–126
94. Reed DR, Li S, Li X, Huang L, Tordoff MG, Starling-Roney R, Taniguchi K, West DB, Ohmen JD, Beauchamp GK et al (2004) Polymorphisms in the taste receptor gene (Tas1r3) region are associated with saccharin preference in 30 mouse strains. J Neurosci 24(4):938–946
95. Reed DR, Li X, Chen Z, Mascioli K, Bachmanov AA, Beauchamp GK, Tordoff MG, Max M, Margolskee R, Bartoshuk LM et al (2002) Alleles of the taste receptor gene TAS1R3 may influence the pleasantness of sucrosee and aspartame in human subjects. Obes Res 10(1):67
96. Richter CP, Campbell KH (1939) Sucrose taste thresholds of rats and humans. Am J Physiol Legacy Content 128(2):291–297
97. Roberts RM (1989) Serendipity: accidental discoveries in science. Wiley, New York
98. Schifferstein HN (1996) An equiratio mixture model for non-additive components: a case study for aspartame/acesulfame-K mixtures. Chem Senses 21(1):1–11
99. Schiffman SS, EricksonRP1971A psychophysical model for gustatory qualityPhysiology and Behavior 7617–633
100. Schiffman SS, Cahn H, Lindley MG (1981) Multiple receptor sites mediate sweetness: evidence from cross adaptation. Pharmacol Biochem Behav 15(3):377–388
101. Schiffman SS, Booth BJ, Carr BT, Losee ML, Sattely-Miller EA, Graham BG (1995) Investigation of synergism in binary mixtures of sweeteners. Brain Res Bull 38(2):105–120
102. Schiffman SS, Booth BJ, Sattely-Miller EA, Graham BG, Gibes KM (1999) Selective inhibition of sweetness by the sodium salt of +/-2-(4- methoxyphenoxy)propanoic acid. Chem Senses 24 (4):439–447
103. Schiffman SS, Sattely-Miller EA, Graham BG, Booth BJ, Gibes KM (2000) Synergism among ternary mixtures of fourteen sweeteners. Chem Senses 25(2):131–140
104. Sclafani A, Abrams M (1986) Rats show only a weak preference for the artificial sweetener aspartame. Physiol Behav 37(2):253–256
105. Shallenberger RS (1997) Taste recognition chemistry. Pure Appl Chem 69(4):659–666
106. Shallenberger RS, Acree TE (1967) Molecular theory of sweet taste. Nature 216(114):480–482
107. Shallenberger RS, Acree TE, Lee CY (1969) Sweet taste of D and Lsugars and amino-acids and the steric nature of their chemoreceptor site. Nature 221(180):555–556
108. Spadaccini R, Trabucco F, Saviano G, Picone D, Crescenzi O, Tancredi T, Temussi PA (2003) The mechanism of interaction of sweet proteins with the T1R2-T1R3 receptor: evidence from the solution structure of G16A-MNEI. J Mol Biol 328(3):683–692
109. Stone H, Oliver SM (1969) Measurement of the relative sweetness of selected sweeteners and sweetenersmixtures. J Food Sci 34:215–222
110. Tancredi T, Pastore A, Salvadori S, Esposito V, Temussi PA (2004) Interaction of sweet proteins with their receptor. A conformational study of peptides corresponding to loops of brazzein, monellin and thaumatin. Eur J Biochem 271(11):2231–2240
111. Tinti J-M, Nofre C (1991a) Design of sweeteners: a rational approach. In: Walters DE, Orthoefer FT, DuBois GE (eds) Sweeteners: discovery, molecular design, and chemoreception. American Chemical Society, Washington, DC, USA, pp 88–99
112. Tinti J-M, Nofre C (1991b) Why does a sweetener taste sweet? A new model. In: Walters DE, Orthoefer FT, DuBois GE (eds) Sweeteners: discovery, molecular design, and chemoreception. American Chemical Society, Washington, DC, USA, pp 209–213
113. Tinti JM, Durozard D, Nofre C (1980) Sweet taste receptor: evidence of separate specific sites for COO- and NO2/CN groups in sweeteners. Naturwissenschaften 67(4)193–194
114. van der Heijden A (1997) Historical overview an structure-activity relationships among sweeteners. Pure Appl Chem 69(4):667–674
115. van der Wel H, Arvidson K (1978) Qualitative psychophysical studies on the gustatory effects of sweet tasting proteins thaumatin and monellin. Chem Senses and Flavour 3(3):291–297
116. Walters DE, Orthoefer FT, DuBois GE, American Chemical Society (1991) Sweeteners: discovery, molecular design, and chemoreception, Division of Agricultural and Food Chemistry and American Chemical Society Meeting. American Chemical Society, Washington, DC, USA
117. Witherly SA, Pangborn RM, Stern JS (1980) Gustatory responses and eating duration of obese and lean adults. Appetite 1:53–63
118. Xu H, Staszewski L, Tang H, Adler E, Zoller M, Li X (2004) Different functional roles of T1R subunits in the heteromeric taste receptors. Proc Natl Acad Sci USA 101(39):14258–14263
119. Zhang Y, Hoon MA, Chandrashekar J, Mueller KL, Cook B, Wu D, Zuker CS, Ryba NJ (2003) Coding of sweet, bitter, and umami tastes. Different receptor cells sharing similar signaling pathways. Cell 112(3):293–301
120. Zhao GQ, Zhang Y, Hoon MA, Chandrashekar J, Erlenbach I, Ryba NJ, Zuker CS (2003) The receptors for mammalian sweet and umami taste. Cell 115(3):255–266