STAT3- and DNA methyltransferase 1-mediated epigenetic silencing of SHP-1 tyrosine phosphatase tumor suppressor gene in malignant T lymphocytes

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 19, 2005, Pages 6948-6953

  Zhang, Qian ^a   Wang, Hong Y ^a   Marzec, Michal ^a   Raghunath, Puthiyaveettil N ^a   Nagasawa, Tomohiko ^a   Wasik, Mariusz A ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

DNMT1; SHP 1; STAT3

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; DNA; DNA METHYLTRANSFERASE 1; HISTONE DEACETYLASE 1; OLIGONUCLEOTIDE; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE SHP 1; SMALL INTERFERING RNA; STAT3 PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CANCER THERAPY; CONTROLLED STUDY; DNA METHYLATION; EPIGENETICS; GENE EXPRESSION; GENE SILENCING; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; T CELL LYMPHOMA; T LYMPHOCYTE; TUMOR SUPPRESSOR GENE;

BASE SEQUENCE; BLOTTING, WESTERN; CELL LINE, TUMOR; CHROMATIN IMMUNOPRECIPITATION; CPG ISLANDS; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; DNA MODIFICATION METHYLASES; DNA-BINDING PROTEINS; DOWN-REGULATION; GENE SILENCING; HISTONE DEACETYLASES; HUMANS; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LYMPHOMA, T-CELL; MODELS, GENETIC; MOLECULAR SEQUENCE DATA; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; PROTEIN-TYROSINE-PHOSPHATASE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, SMALL INTERFERING; SHP1 PROTEIN TYROSINE PHOSPHATASE; STAT3 TRANSCRIPTION FACTOR; T-LYMPHOCYTES; TRANS-ACTIVATORS; TRANSFECTION;

EID: 18744395503     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0501959102     Document Type: Article

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