메뉴 건너뛰기




Volumn 108, Issue 3, 2006, Pages 1058-1064

STAT3 induces transcription of the DNA methyltransferase 1 gene (DNMT1) in malignant T lymphocytes

Author keywords

[No Author keywords available]

Indexed keywords

DNA METHYLTRANSFERASE 1; PROTEIN TYROSINE PHOSPHATASE SHP 1; STAT3 PROTEIN;

EID: 33746651038     PISSN: 00064971     EISSN: 00064971     Source Type: Journal    
DOI: 10.1182/blood-2005-08-007377     Document Type: Article
Times cited : (146)

References (39)
  • 1
    • 0345357773 scopus 로고    scopus 로고
    • Gene silencing in cancer in association with promoter hypermethylation
    • Herman JG, Baylin SB. Gene silencing in cancer in association with promoter hypermethylation. N Engl J Med. 2003;349:2042-2054.
    • (2003) N Engl J Med , vol.349 , pp. 2042-2054
    • Herman, J.G.1    Baylin, S.B.2
  • 2
    • 19644389279 scopus 로고    scopus 로고
    • Interleukin 6 supports the maintenance of p53 tumor suppressor gene promoter methylation
    • Hodge DR, Peng B, Cherry JC, et al. Interleukin 6 supports the maintenance of p53 tumor suppressor gene promoter methylation. Cancer Res. 2005;65:4673-4682.
    • (2005) Cancer Res , vol.65 , pp. 4673-4682
    • Hodge, D.R.1    Peng, B.2    Cherry, J.C.3
  • 3
    • 0037068372 scopus 로고    scopus 로고
    • DNA methylation and chromatin - Unraveling the tangled web
    • Robertson KD. DNA methylation and chromatin - unraveling the tangled web. Oncogene. 2002;21:5361-5379.
    • (2002) Oncogene , vol.21 , pp. 5361-5379
    • Robertson, K.D.1
  • 4
    • 18344390653 scopus 로고    scopus 로고
    • DNMT1 and DNMT3b cooperate to silence genes in human cancer cells
    • Rhee I, Bachman KE, Park BH, et al. DNMT1 and DNMT3b cooperate to silence genes in human cancer cells. Nature. 2002;416:552-556.
    • (2002) Nature , vol.416 , pp. 552-556
    • Rhee, I.1    Bachman, K.E.2    Park, B.H.3
  • 5
    • 0036311256 scopus 로고    scopus 로고
    • Utilization of antisense oligonucleotides to study the role of 5-cytosine DNA methyltransferase in cellular transformation and oncogenesis
    • Szyf M. Utilization of antisense oligonucleotides to study the role of 5-cytosine DNA methyltransferase in cellular transformation and oncogenesis. Methods. 2002;27:184-191.
    • (2002) Methods , vol.27 , pp. 184-191
    • Szyf, M.1
  • 6
    • 0033973226 scopus 로고    scopus 로고
    • Transcriptional regulation of the human DNA methyltransferase (DNMT1) gene
    • Bigey P, Ramchandani S, Theberge J, Araujo FD, Szyf M. Transcriptional regulation of the human DNA methyltransferase (DNMT1) gene. Gene. 2000;242:407-418.
    • (2000) Gene , vol.242 , pp. 407-418
    • Bigey, P.1    Ramchandani, S.2    Theberge, J.3    Araujo, F.D.4    Szyf, M.5
  • 7
    • 0037901839 scopus 로고    scopus 로고
    • Transcription of mouse DNA methyltransferase 1 (Dnmt1) is regulated by both E2FRb-HDAC-dependent and -independent pathways
    • Kimura H, Nakamura T, Ogawa T, Tanaka S, Shiota K. Transcription of mouse DNA methyltransferase 1 (Dnmt1) is regulated by both E2FRb-HDAC-dependent and -independent pathways. Nucleic Acids Res. 2003;31:3101-3113.
    • (2003) Nucleic Acids Res , vol.31 , pp. 3101-3113
    • Kimura, H.1    Nakamura, T.2    Ogawa, T.3    Tanaka, S.4    Shiota, K.5
  • 9
    • 1042302005 scopus 로고    scopus 로고
    • The STATs of cancer - New molecular targets come of age
    • Yu H, Jove R. The STATs of cancer - new molecular targets come of age. Nat Rev Cancer. 2004;4:97-105.
    • (2004) Nat Rev Cancer , vol.4 , pp. 97-105
    • Yu, H.1    Jove, R.2
  • 10
    • 0030978808 scopus 로고    scopus 로고
    • Constitutive activation of a slowly migrating isoform of Stat3 in mycosis fungoides: Tyrphostin AG490 inhibits Stat3 activation and growth of mycosis fungoides tumor cell lines
    • U S A
    • Nielsen M, Kaltoft K, Nordahl M, et al. Constitutive activation of a slowly migrating isoform of Stat3 in mycosis fungoides: tyrphostin AG490 inhibits Stat3 activation and growth of mycosis fungoides tumor cell lines. Proc Natl Acad Sci U S A. 1997;94:6764-6769.
    • (1997) Proc Natl Acad Sci , vol.94 , pp. 6764-6769
    • Nielsen, M.1    Kaltoft, K.2    Nordahl, M.3
  • 11
    • 0029834676 scopus 로고    scopus 로고
    • Activation of the Jak-STAT signal transduction pathway associated with IL-2R common chain in malignant T cells derived from patients with cutaneous anaplastic large T-cell lymphoma and Sézary syndrome
    • U S A
    • Zhang Q, Nowak I, Vonderheid EC, Rook AH, Shaw LM, Wasik MA. Activation of the Jak-STAT signal transduction pathway associated with IL-2R common chain in malignant T cells derived from patients with cutaneous anaplastic large T-cell lymphoma and Sézary syndrome. Proc Natl Acad Sci U S A. 1996;93:9148-9153.
    • (1996) Proc Natl Acad Sci , vol.93 , pp. 9148-9153
    • Zhang, Q.1    Nowak, I.2    Vonderheid, E.C.3    Rook, A.H.4    Shaw, L.M.5    Wasik, M.A.6
  • 12
    • 0036134884 scopus 로고    scopus 로고
    • Multilevel dysregulation of STAT3 activation in ALK+ T/null-cell lymphoma
    • Zhang Q, Raghunath PN, Xue L, et al. Multilevel dysregulation of STAT3 activation in ALK+ T/null-cell lymphoma. J Immunol. 2002;68:466-474.
    • (2002) J Immunol , vol.68 , pp. 466-474
    • Zhang, Q.1    Raghunath, P.N.2    Xue, L.3
  • 13
    • 18744395503 scopus 로고    scopus 로고
    • STAT3- and DNMT1-mediated epigenetic silencing of SHP-1 tyrosine phosphatase tumor suppressor gene in malignant T lymphocytes
    • U S A
    • Zhang Q, Wang HY, Marzec M, Raghunath PN, Nagasawa T, Wasik MA. STAT3- and DNMT1-mediated epigenetic silencing of SHP-1 tyrosine phosphatase tumor suppressor gene in malignant T lymphocytes. Proc Natl Acad Sci U S A. 2005;102:6948-6953.
    • (2005) Proc Natl Acad Sci , vol.102 , pp. 6948-6953
    • Zhang, Q.1    Wang, H.Y.2    Marzec, M.3    Raghunath, P.N.4    Nagasawa, T.5    Wasik, M.A.6
  • 14
    • 0033809993 scopus 로고    scopus 로고
    • Lack of phosphotyrosine phosphatase SHP-1 expression in malignant T cells results from methylation of the SHP-1 promoter
    • Zhang Q, Raghunath PN, Vonderheid E, Odum N, Wasik MA. Lack of phosphotyrosine phosphatase SHP-1 expression in malignant T cells results from methylation of the SHP-1 promoter. Am J Pathol. 2000;157:1137-1146.
    • (2000) Am J Pathol , vol.157 , pp. 1137-1146
    • Zhang, Q.1    Raghunath, P.N.2    Vonderheid, E.3    Odum, N.4    Wasik, M.A.5
  • 15
    • 0037224722 scopus 로고    scopus 로고
    • DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells
    • Robert MF, Morin S, Beaulieu N, et al. DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells. Nat Genet. 2003;33:61-65.
    • (2003) Nat Genet , vol.33 , pp. 61-65
    • Robert, M.F.1    Morin, S.2    Beaulieu, N.3
  • 17
    • 11144357779 scopus 로고    scopus 로고
    • Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells
    • Wang T, Niu G, Kortylewski M, et al. Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells. Nat Med. 2004;10:48-54.
    • (2004) Nat Med , vol.10 , pp. 48-54
    • Wang, T.1    Niu, G.2    Kortylewski, M.3
  • 18
    • 0036274359 scopus 로고    scopus 로고
    • The fundamental role of epigenetic events in cancer
    • Jones PA, Baylin SB. The fundamental role of epigenetic events in cancer. Nat Rev Genet. 2002;3:415-428.
    • (2002) Nat Rev Genet , vol.3 , pp. 415-428
    • Jones, P.A.1    Baylin, S.B.2
  • 19
    • 11144356462 scopus 로고    scopus 로고
    • Epigenetic profiling in chronic lymphocytic leukemia reveals novel methylation targets
    • Rush LJ, Raval A, Funchain P, et al. Epigenetic profiling in chronic lymphocytic leukemia reveals novel methylation targets. Cancer Res. 2004;64:2424-2433.
    • (2004) Cancer Res , vol.64 , pp. 2424-2433
    • Rush, L.J.1    Raval, A.2    Funchain, P.3
  • 20
    • 2942584857 scopus 로고    scopus 로고
    • SOCS1 and SHP1 hypermethylation in multiple myeloma: Implications for epigenetic activation of the Jak/STAT pathway
    • Chim CS, Fung TK, Cheung WC, Liang R, Kwong YL. SOCS1 and SHP1 hypermethylation in multiple myeloma: implications for epigenetic activation of the Jak/STAT pathway. Blood. 2004;103:4630-4635.
    • (2004) Blood , vol.103 , pp. 4630-4635
    • Chim, C.S.1    Fung, T.K.2    Cheung, W.C.3    Liang, R.4    Kwong, Y.L.5
  • 21
    • 0037112439 scopus 로고    scopus 로고
    • Gene silencing of the tyrosine phosphatase SHP1 gene by aberrant methylation in leukemias/lymphomas
    • Oka T, Ouchida M, Koyama M, et al. Gene silencing of the tyrosine phosphatase SHP1 gene by aberrant methylation in leukemias/lymphomas. Cancer Res. 2002;62:6390-6394.
    • (2002) Cancer Res , vol.62 , pp. 6390-6394
    • Oka, T.1    Ouchida, M.2    Koyama, M.3
  • 22
    • 4444257905 scopus 로고    scopus 로고
    • Methylation of SHP1 gene and loss of SHP1 protein expression are frequent in systemic anaplastic large cell lymphoma
    • Khoury JD, Rassidakis GZ, Medeiros LJ, Amin HM, Lai R. Methylation of SHP1 gene and loss of SHP1 protein expression are frequent in systemic anaplastic large cell lymphoma. Blood. 2004;104:1580-1581.
    • (2004) Blood , vol.104 , pp. 1580-1581
    • Khoury, J.D.1    Rassidakis, G.Z.2    Medeiros, L.J.3    Amin, H.M.4    Lai, R.5
  • 23
    • 0033843331 scopus 로고    scopus 로고
    • p16(INK4a) gene alterations are frequent in lesions of mycosis fungoides
    • Navas IC, Ortiz-Romero PL, Villuendas R, et al. p16(INK4a) gene alterations are frequent in lesions of mycosis fungoides. Am J Pathol. 2000;156:1565-1572.
    • (2000) Am J Pathol , vol.156 , pp. 1565-1572
    • Navas, I.C.1    Ortiz-Romero, P.L.2    Villuendas, R.3
  • 24
    • 0036121141 scopus 로고    scopus 로고
    • Frequent abnormalities of the p15 and p16 genes in mycosis fungoides and Sézary syndrome
    • Scarisbrick JJ, Woolford AJ, Calonje E, et al. Frequent abnormalities of the p15 and p16 genes in mycosis fungoides and Sézary syndrome. J Invest Dermatol. 2003;118:493-499.
    • (2003) J Invest Dermatol , vol.118 , pp. 493-499
    • Scarisbrick, J.J.1    Woolford, A.J.2    Calonje, E.3
  • 25
    • 30144437752 scopus 로고    scopus 로고
    • Multi-gene epigenetic silencing of tumor suppressor genes in T-cell lymphoma cells: Delayed expression of the p16 protein upon reversal of the silencing
    • Nagasawa T, Zhang Q, Raghunath PN, et al. Multi-gene epigenetic silencing of tumor suppressor genes in T-cell lymphoma cells: delayed expression of the p16 protein upon reversal of the silencing. Leuk Res. 2006;30:303-312.
    • (2006) Leuk Res , vol.30 , pp. 303-312
    • Nagasawa, T.1    Zhang, Q.2    Raghunath, P.N.3
  • 26
    • 21244458051 scopus 로고    scopus 로고
    • Epigenetic profiling of cutaneous T-cell lymphoma: Promoter hypermethylation of multiple tumor suppressor genes including BCL7a, PTPRG, and p73
    • van Doorn R, Zoutman WH, Dijkman R, et al. Epigenetic profiling of cutaneous T-cell lymphoma: promoter hypermethylation of multiple tumor suppressor genes including BCL7a, PTPRG, and p73. J Clin Oncol. 2005;23:3886-3896.
    • (2005) J Clin Oncol , vol.23 , pp. 3886-3896
    • Van Doorn, R.1    Zoutman, W.H.2    Dijkman, R.3
  • 27
    • 0035955640 scopus 로고    scopus 로고
    • Interleukin-6 regulation of the human DNA methyltransferase (HDNMT) gene in human erythroleukemia cells
    • Hodge DR, Xiao W, Clausen PA, Heidecker G, Szyf M, Farrar WL. Interleukin-6 regulation of the human DNA methyltransferase (HDNMT) gene in human erythroleukemia cells. J Biol Chem. 2001;276:39508-39511.
    • (2001) J Biol Chem , vol.276 , pp. 39508-39511
    • Hodge, D.R.1    Xiao, W.2    Clausen, P.A.3    Heidecker, G.4    Szyf, M.5    Farrar, W.L.6
  • 28
    • 0036318310 scopus 로고    scopus 로고
    • Regulation of transcription of the Dnmt1 gene by Sp1 and Sp3 zinc finger proteins
    • Kishikawa S, Murata T, Kimura H, Shiota K, Yokoyama KK. Regulation of transcription of the Dnmt1 gene by Sp1 and Sp3 zinc finger proteins. Eur J Biochem. 2002;269:2961-2970.
    • (2002) Eur J Biochem , vol.269 , pp. 2961-2970
    • Kishikawa, S.1    Murata, T.2    Kimura, H.3    Shiota, K.4    Yokoyama, K.K.5
  • 29
    • 0242624636 scopus 로고    scopus 로고
    • Epigenetic targets in hematopoietic malignancies
    • Claus R, Lubbert M. Epigenetic targets in hematopoietic malignancies. Oncogene. 2003;22:6489-6496.
    • (2003) Oncogene , vol.22 , pp. 6489-6496
    • Claus, R.1    Lubbert, M.2
  • 30
    • 0037962005 scopus 로고    scopus 로고
    • Results of decitabine (5-aza-2′deoxycytidine) therapy in 130 patients with chronic myelogenous leukemia
    • Kantarjian HM, O'Brien S, Cortes J, et al. Results of decitabine (5-aza-2′deoxycytidine) therapy in 130 patients with chronic myelogenous leukemia. Cancer. 2003;98:522-528.
    • (2003) Cancer , vol.98 , pp. 522-528
    • Kantarjian, H.M.1    O'Brien, S.2    Cortes, J.3
  • 31
    • 0036554816 scopus 로고    scopus 로고
    • Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention
    • Buettner R, Mora LB, Jove R. Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention. Clin Cancer Res. 2002;8:945-954.
    • (2002) Clin Cancer Res , vol.8 , pp. 945-954
    • Buettner, R.1    Mora, L.B.2    Jove, R.3
  • 32
    • 20944441928 scopus 로고    scopus 로고
    • Validating Stat3 in cancer therapy
    • Darnell JE. Validating Stat3 in cancer therapy. Nat Med. 2005;11:595-596.
    • (2005) Nat Med , vol.11 , pp. 595-596
    • Darnell, J.E.1
  • 33
    • 4944239032 scopus 로고    scopus 로고
    • Disruption of Stat3 reveals a critical role in both the initiation and the promotion stages of epithelial carcinogenesis
    • Chan KS, Sano S, Kiguchi K, et al. Disruption of Stat3 reveals a critical role in both the initiation and the promotion stages of epithelial carcinogenesis. J Clin Invest. 2004;114:720-728.
    • (2004) J Clin Invest , vol.114 , pp. 720-728
    • Chan, K.S.1    Sano, S.2    Kiguchi, K.3
  • 34
    • 16844368861 scopus 로고    scopus 로고
    • Knockdown of STAT3 expression by RNA interference inhibits the induction of breast tumors in immunocompetent mice
    • Ling X, Arlinghaus RB. Knockdown of STAT3 expression by RNA interference inhibits the induction of breast tumors in immunocompetent mice. Cancer Res. 2005; 65:2532-2536.
    • (2005) Cancer Res , vol.65 , pp. 2532-2536
    • Ling, X.1    Arlinghaus, R.B.2
  • 35
    • 20944435271 scopus 로고    scopus 로고
    • Stat3 is required for ALK-mediated lymphomagenesis and provides a possible therapeutic target
    • Chiarle R, Simmons WJ, Cai H, et al. Stat3 is required for ALK-mediated lymphomagenesis and provides a possible therapeutic target. Nat Med. 2005;11:623-629.
    • (2005) Nat Med , vol.11 , pp. 623-629
    • Chiarle, R.1    Simmons, W.J.2    Cai, H.3
  • 36
    • 0035977055 scopus 로고    scopus 로고
    • Phosphotyrosyl peptides block Stat3-mediated DNA binding activity, gene regulation, and cell transformation
    • Turkson J, Ryan D, Kim JS, et al. Phosphotyrosyl peptides block Stat3-mediated DNA binding activity, gene regulation, and cell transformation. J Biol Chem. 2001;276:45443-45455.
    • (2001) J Biol Chem , vol.276 , pp. 45443-45455
    • Turkson, J.1    Ryan, D.2    Kim, J.S.3
  • 37
    • 0038664389 scopus 로고    scopus 로고
    • STAT3 ubiquitination and degradation by mumps virus suppress cytokine and oncogene signaling
    • Ulane CM, Rodriguez JJ, Parisien JP, Horvath CM. STAT3 ubiquitination and degradation by mumps virus suppress cytokine and oncogene signaling. J Virol. 2003;77:6385-6393.
    • (2003) J Virol , vol.77 , pp. 6385-6393
    • Ulane, C.M.1    Rodriguez, J.J.2    Parisien, J.P.3    Horvath, C.M.4
  • 38
    • 3543055012 scopus 로고    scopus 로고
    • Novel peptidomimetic inhibitors of signal transducer and activator of transcription 3 dimerization and biological activity
    • Turkson J, Kim JS, Zhang S, et al. Novel peptidomimetic inhibitors of signal transducer and activator of transcription 3 dimerization and biological activity. Mol Cancer Ther. 2004;3:261-269.
    • (2004) Mol Cancer Ther , vol.3 , pp. 261-269
    • Turkson, J.1    Kim, J.S.2    Zhang, S.3
  • 39
    • 0242332186 scopus 로고    scopus 로고
    • Prevention of organ allograft rejection by a specific Janus kinase 3 inhibitor
    • Changelian PS, Flanagan ME, Ball DJ, et al. Prevention of organ allograft rejection by a specific Janus kinase 3 inhibitor. Science. 2003;30:875-878.
    • (2003) Science , vol.30 , pp. 875-878
    • Changelian, P.S.1    Flanagan, M.E.2    Ball, D.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.