Germinal center B-cell-associated DNA hypomethylation at transcriptional regions of the AID gene

Molecular Immunology

Volumn 45, Issue 6, 2008, Pages 1712-1719

  Fujimura, Satoru ^a,b   Matsui, Takeshi ^a,b   Kuwahara, Kazuhiko ^a,b   Maeda, Kazuhiko ^a,b   Sakaguchi, Nobuo ^a,b  

^a KUMAMOTO UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

Activation induced cytidine deaminase; DNA methylation; Plasma cell; Promoter; Transcriptional regulation

Indexed keywords

ACTIVATION INDUCED CYTIDINE DEAMINASE;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; CELL MATURATION; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; GENETIC TRANSCRIPTION; GERMINAL CENTER; MOUSE; NONHUMAN; PLASMACYTOMA; PRIORITY JOURNAL;

5' FLANKING REGION; ANIMALS; B-LYMPHOCYTES; CELL DIFFERENTIATION; CELL LINE; CYTIDINE DEAMINASE; DNA METHYLATION; GERMINAL CENTER; INTERLEUKIN-4; LIPOPOLYSACCHARIDES; MICE; PLASMA CELLS; PLASMACYTOMA; PROMOTER REGIONS (GENETICS); SPLEEN; SYNDECAN-1; TRANSCRIPTION, GENETIC;

EID: 38949112498     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2007.09.023     Document Type: Article

References (29)

1. Amaravadi L., and Klemsz M.J. DNA methylation and chromatin structure regulate PU. 1 expression. DNA Cell Biol. 18 (1999) 875-884
2. Ambrose H.E., and Wagner S.D. Alpha6-integrin is expressed on germinal centre B cells and modifies growth of a B-cell line. Immunology 111 (2004) 400-406
3. Bird A.P., and Wolffe A.P. Methylation-induced repression-belts, braces, and chromatin. Cell 99 (1999) 451-454
4. Cervenak L., Magyar A., Boja R., and Laszlo G. Differential expression of GL7 activation antigen on bone marrow B cell subpopulations and peripheral B cells. Immunol. Lett. 78 (2001) 89-96
5. Christoph T., Rickert R., and Rajewsky K. M17: a novel gene expressed in germinal centers. Int. Immunol. 6 (1994) 1203-1211
6. Cozine C.L., Wolniak K.L., and Waldschmidt T.J. The primary germinal center response in mice. Curr. Opin. Immunol. 17 (2005) 298-302
7. Danbara M., Kameyama K., Higashihara M., and Takagaki Y. DNA methylation dominates transcriptional silencing of Pax5 in terminally differentiated B cell lines. Mol. Immunol. 38 (2002) 1161-1166
8. Dedeoglu F., Horwitz B., Chaudhuri J., Alt F.W., and Geha R.S. Induction of activation-induced cytidine deaminase gene expression by IL-4 and CD40 ligation is dependent on STAT6 and NFkappaB. Int. Immunol. 16 (2004) 395-404
9. Ghosh S., Steere A.C., Stollar B.D., and Huber B.T. In situ diversification of the antibody repertoire in chronic Lyme arthritis synovium. J. Immunol. 174 (2005) 2860-2869
10. Gonda H., Sugai M., Nambu Y., Katakai T., Agata Y., Mori K.J., Yokota Y., and Shimizu A. The balance between Pax5 and Id2 activities is the key to AID gene expression. J. Exp. Med. 198 (2003) 1427-1437
11. Greger V., Passarge E., Hopping W., Messmer E., and Horsthemke B. Epigenetic changes may contribute to the formation and spontaneous regression of retinoblastoma. Hum. Genet. 83 (1989) 155-158
12. Haubold K., Owens G.P., Kaur P., Ritchie A.M., Gilden D.H., and Bennett J.L. B-lymphocyte and plasma cell clonal expansion in monosymptomatic optic neuritis cerebrospinal fluid. Ann. Neurol. 56 (2004) 97-107
13. Herman J.G., Latif F., Weng Y., Lerman M.I., Zbar B., Liu S., Samid D., Duan D.S., Gnarra J.R., Linehan W.M., et al. Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma. Proc. Natl. Acad. Sci. U.S.A. 91 (1994) 9700-9704
14. Herman J.G., Umar A., Polyak K., Graff J.R., Ahuja N., Issa J.P., Markowitz S., Willson J.K., Hamilton S.R., Kinzler K.W., Kane M.F., Kolodner R.D., Vogelstein B., Kunkel T.A., and Baylin S.B. Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma. Proc. Natl. Acad. Sci. U.S.A. 95 (1998) 6870-6875
15. Honjo T., Nagaoka H., Shinkura R., and Muramatsu M. AID to overcome the limitations of genomic information. Nat. Immunol. 6 (2005) 655-661
16. Kuo T.C., and Calame K.L. B lymphocyte-induced maturation protein (Blimp)-1, IFN regulatory factor (IRF)-1, and IRF-2 can bind to the same regulatory sites. J. Immunol. 173 (2004) 5556-5563
17. Ma L., Wortis H.H., and Kenter A.L. Two new isotype-specific switching activities detected for Ig class switching. J. Immunol. 168 (2002) 2835-2846
18. MacLennan I.C. Germinal centers. Annu. Rev. Immunol. 12 (1994) 117-139
19. Maier H., Ostraat R., Gao H., Fields S., Shinton S.A., Medina K.L., Ikawa T., Murre C., Singh H., Hardy R.R., and Hagman J. Early B cell factor cooperates with Runx1 and mediates epigenetic changes associated with mb-1 transcription. Nat. Immunol. 5 (2004) 1069-1077
20. Merlo A., Herman J.G., Mao L., Lee D.J., Gabrielson E., Burger P.C., Baylin S.B., and Sidransky D. 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers. Nat. Med. 1 (1995) 686-692
21. Muramatsu M., Sankaranand V.S., Anant S., Sugai M., Kinoshita K., Davidson N.O., and Honjo T. Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells. J. Biol. Chem. 274 (1999) 18470-18476
22. Muramatsu M., Kinoshita K., Fagarasan S., Yamada S., Shinkai Y., and Honjo T. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell 102 (2000) 553-563
23. Rajewsky K. Clonal selection and learning in the antibody system. Nature 381 (1996) 751-758
24. Revy P., Muto T., Levy Y., Geissmann F., Plebani A., Sanal O., Catalan N., Forveille M., Dufourcq-Labelouse R., Gennery A., Tezcan I., Ersoy F., Kayserili H., Ugazio A.G., Brousse N., Muramatsu M., Notarangelo L.D., Kinoshita K., Honjo T., Fischer A., and Durandy A. Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2). Cell 102 (2000) 565-575
25. Sayegh C.E., Quong M.W., Agata Y., and Murre C. E-proteins directly regulate expression of activation-induced deaminase in mature B cells. Nat. Immunol. 4 (2003) 586-593
26. Schwab J., and Illges H. Regulation of CD21 expression by DNA methylation and histone deacetylation. Int. Immunol. 13 (2001) 705-710
27. Smith K.G., Nossal G.J., and Tarlinton D.M. FAS is highly expressed in the germinal center but is not required for regulation of the B-cell response to antigen. Proc. Natl. Acad. Sci. U.S.A. 92 (1995) 11628-11632
28. Yavuz S., Grammer A.C., Yavuz A.S., Nanki T., and Lipsky P.E. Comparative characteristics of mu chain and alpha chain transcripts expressed by individual tonsil plasma cells. Mol. Immunol. 38 (2001) 19-34
29. Yoshiura K., Kanai Y., Ochiai A., Shimoyama Y., Sugimura T., and Hirohashi S. Silencing of the E-cadherin invasion-suppressor gene by CpG methylation in human carcinomas. Proc. Natl. Acad. Sci. U.S.A. 92 (1995) 7416-7419