Pulsatile insulin release from islets isolated from three subjects with type 2 diabetes

Diabetes

Volumn 51, Issue 4, 2002, Pages 988-993

  Lin, Jian Man ^a   Fabregat, Marta E ^b   Gomis, Ramon ^b   Bergsten, Peter ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b UNIVERSITY OF BARCELONA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN; TOLBUTAMIDE;

ADULT; AGED; ARTICLE; CASE REPORT; CONTROLLED STUDY; DEGRADATION; GLUCOSE METABOLISM; HORMONE ACTION; HUMAN; HUMAN TISSUE; HYPERGLYCEMIA; INSULIN BLOOD LEVEL; INSULIN RELEASE; INSULIN RESISTANCE; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; OSCILLATION; PANCREAS ISLET; PRIORITY JOURNAL; PULSATILE HORMONE RELEASE;

EID: 0036228455     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.51.4.988     Document Type: Article

References (38)

1. Insulin, glucagon, and glucose exhibit synchronous, sustained oscillations in fasting monkeys
2. Cyclic oscillations of basal plasma glucose and insulin concentrations in human beings
3. Brief, irregular oscillations of basal plasma insulin and glucose concentrations in diabetic man
4. Pulsatile insulin has greater hypoglycemic effect than continuous delivery
5. Greater efficacy of pulsatile insulin in type I diabetics critically depends on plasma glucagon levels
6. Pulsatile insulin delivery is more efficient than continuous infusion in modulating islet cell function in normal subjects and patients with type 1 diabetes
7. Pulsatile intravenous insulin replacement in streptozotocin diabetic rats is more efficient than continuous delivery: Effects on glycaemic control, insulin-mediated glucose metabolism and lipolysis
8. Efficacy of pulsatile versus continuous insulin administration on hepatic glucose production and glucose utilization in type I diabetic humans
9. Rapid reduction and return of surface insulin receptors after exposure to brief pulses of insulin in perifused rat hepatocytes
10. 2+ and insulin release in glucosestimulated pancreatic islets
11. 2+ in pancreatic beta-cells exposed to streptozotocin or alloxan
12. +2 response to glucose as an indicator of impairment of the pancreatic beta-cell function
13. 2+
14. 2+
15. Pathophysiology of impaired pulsatile insulin release
16. 2+ oscillations
17. Oscillations in cytoplasmic free calcium concentration in human pancreatic islets from subjects with normal and impaired glucose tolerance
18. Human islet function after automatic isolation and bovine serum albumin gradient purification
19. Prolonged exposure of human pancreatic islets to high glucose concentrations in vitro impairs the beta-cell function
20. Glucose-induced amplitude regulation of pulsatile insulin secretion from individual pancreatic islets
21. 2+ in pancreatic islets correspond to pulsatile insulin release
22. Preserved pulsatile insulin release from prediabetic mouse islets
23. The NOD mouse as a model of type I diabetes
24. Mouse models of insulin dependent diabetes: Low-dose streptozocin-induced diabetes and nonobese diabetic (NOD) mice
25. Phenotyping of individual pancreatic islets locates genetic defects in stimulus secretion coupling to Niddm1i within the major diabetes locus in GK rats
26. The spontaneous-diabetes rat: A model of noninsulin dependent diabetes mellitus
27. Amplitude modulation of pulsatile insulin secretion by intrapancreatic ganglion neurons
28. Inhibition of intrapancreatic ganglia causes sustained and non-oscillatory insulin release from perfused pancreas
29. Pulsatile insulin secretion accounts for 70% of total insulin secretion during fasting
30. Overnight inhibition of insulin secretion restores pulsatility and proinsulin/ insulin ratio in type 2 diabetes
31. Failure of physiological plasma glucose excursions to entrain high-frequency pulsatile insulin secretion in type 2 diabetes
32. Sequence variants in the sulfonylurea receptor (SUR) gene are associated with NIDDM in Caucasians
33. + channels is impaired in beta-cells of the GK rat: A new genetic model of NIDDM
34. Alterations in the ultradian oscillations of insulin secretion and plasma glucose in aging
35. Diabetes mellitus in older persons
36. Cellular composition of the human diabetic pancreas
37. No decrease of the beta-cell mass in type 2 diabetic patients
38. Decreased insulin secretion in type 2 diabetes: A problem of cellular mass or function?