Impaired β-cell regeneration after partial pancreatectomy in the adult Goto-Kakizaki rat, a spontaneous model of type II diabetes

Histochemistry and Cell Biology

Volumn 116, Issue 2, 2001, Pages 131-139

  Plachot, Cedric ^a   Movassat, Jamileh ^a   Portha, Bernard ^a  

^a EUROPEAN SPACE AGENCY   (France)

Author keywords

Apoptosis; Beta cell regeneration; GK rat; Neogenesis; Proliferation; Type II diabetes

Indexed keywords

BROXURIDINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CELL DIVISION; CELL REGENERATION; CONTROLLED STUDY; GENETIC PREDISPOSITION; HYPERGLYCEMIA; IMMUNOCYTOCHEMISTRY; MALE; MORPHOMETRICS; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PANCREAS RESECTION; PRIORITY JOURNAL; RAT; RAT STRAIN;

EID: 0034880689     PISSN: 09486143     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004180100302     Document Type: Article

References (23)

1. Insulin resistance in the GK rat: Decreased receptor number but normal kinase activity in liver
2. Toward understanding pancreatic disease: From architecture to cell signaling
3. Partial pancreatectomy in the rat and subsequent defect in glucose-induced insulin release
4. A second pathway for regeneration of adult exocrine and endocrine pancreas
5. Discordance of exocrine and endocrine growth after 90% pancreatectomy in rats
6. Hyperglycemia-induced β-cell apoptosis in pancreatic islets of Psammomys obesus during development of diabetes
7. Prior streptozotocin treatment does not inhibit pancreas regeneration after 90% pancreatectomy in rats
8. GK rats as a model of non-obese, non-insulin-dependent diabetes: Selective breeding over 35 generations
9. Epithelial cell proliferation and islet neogenesis in IFN-g transgenic mice
10. Chronic hyperglycemia triggers loss of pancreatic β cell differentiation in an animal model of diabetes
11. Modifications of the endocrine pancreas in rats after ethionine destruction of acini
12. Transplanted beta cell response to increased metabolic demand
13. Beta-cell growth in the neonatal Goto-Kakizaki rat and regeneration after treatment with streptozotocin at birth
14. Impaired development of pancreatic beta-cell mass is a primary event during the progression to diabetes in the GK rat
15. Ontogeny, differentiation and growth of the endocrine pancreas
16. Role of apoptosis in failure of β-cell mass compensation for insulin resistance and β-cell defects in the male Zucker diabetic fatty rat
17. β-cell insensitivity to glucose in the GK rat, a spontaneous nonobese model for type II diabetes
18. A new approach to the induction of duct epithelial hyperplasia and nesidioblastosis by cellophane wrapping of the hamster pancreas
19. Enhanced insulin-like growth factor I gene expression in regenerating rat pancreas
20. Pancreatic gastrin stimulates islet differentiation of transforming growth factor α-induced ductular precursor cell
21. Duct-to-islet-cell differentiation and islet growth in the pancreas of duct-ligated adult rats
22. Immunoassay of endogenous plasma insulin in man
23. Poor capacity for proliferation of pancreatic β-cells in Otsuka-Long-Evans-Tokushima fatty rat