Defective IGF2 and IGF1R protein production in embryonic pancreas precedes beta cell mass anomaly in the Goto-Kakizaki rat model of type 2 diabetes

Diabetologia

Volumn 50, Issue 7, 2007, Pages 1463-1471

  Calderari, S ^a   Gangnerau, M N ^a   Thibault, M ^a   Meile, M J ^a   Kassis, N ^a   Alvarez, C ^b   Portha, B ^a   Serradas, P ^a  

^a CNRS   (France)

^b UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

Beta cell mass; Differentiation; GK rat; Growth; IGF; Insulin; Organogenesis; Pancreas; Pancreatic rudiment; Type 2 diabetes

Indexed keywords

INSULIN; SOMATOMEDIN B; SOMATOMEDIN C RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CULTURE; EMBRYO; EMBRYO DEVELOPMENT; FEMALE; FETUS; GOTO KAKIZAKI RAT; HYPERGLYCEMIA; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MESENCHYME; MORPHOMETRICS; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; ORGANOGENESIS; PANCREAS; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; WESTERN BLOTTING; WISTAR RAT;

ANIMALS; BLOOD GLUCOSE; CELL DIFFERENTIATION; DIABETES MELLITUS, TYPE 2; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; INSULIN-LIKE GROWTH FACTOR II; INSULIN-SECRETING CELLS; MICE; NIH 3T3 CELLS; PANCREAS; RATS; RATS, WISTAR; RECEPTOR, IGF TYPE 1;

EID: 34249938679     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-007-0676-2     Document Type: Article

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